Sod2 (superoxide dismutase 2) - Rat Genome Database

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Gene: Sod2 (superoxide dismutase 2) Ictidomys tridecemlineatus
Symbol: Sod2
Name: superoxide dismutase 2
RGD ID: 12669266
Description: ENCODES a protein that exhibits DNA binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); age-dependent response to oxidative stress (ortholog); age-dependent response to reactive oxygen species (ortholog); PARTICIPATES IN hypertension pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); acute kidney tubular necrosis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial matrix (ortholog); mitochondrial nucleoid (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBI
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anemia  (ISO)
Aortic Calcification  (ISO)
aortic disease  (ISO)
Arsenic Poisoning  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bilirubin metabolic disorder  (ISO)
bladder neck obstruction  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiogenic Shock  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
Central Nervous System Infections  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
cystitis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Esophageal Stenosis  (ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis  (ISO)
Farber lipogranulomatosis  (ISO)
fatty liver disease  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gestational diabetes  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypoglycemia  (ISO)
Hypopharyngeal Neoplasms  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
intestinal disease  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Leber hereditary optic neuropathy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
major depressive disorder  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Marfan syndrome  (ISO)
melanoma  (ISO)
MELAS syndrome  (ISO)
Mesothelioma  (ISO)
Metabolic Syndrome  (ISO)
methylmalonic acidemia  (ISO)
middle cerebral artery infarction  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (ISO)
multiple chemical sensitivity  (ISO)
multiple myeloma  (ISO)
mycosis fungoides  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
optic neuritis  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papilloma  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
pre-malignant neoplasm  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Radiation Injuries, Experimental  (ISO)
reactive arthritis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
Respiratory Tract Granuloma  (ISO)
Reticulocytosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sengers syndrome  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
sideroblastic anemia  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
systemic lupus erythematosus  (ISO)
Tardive Dyskinesia  (ISO)
thyroid gland anaplastic carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular disease  (ISO)
Ventricular Dysfunction, Left  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
age-dependent response to oxidative stress  (ISO)
age-dependent response to reactive oxygen species  (ISO)
aging  (ISO)
apoptotic mitochondrial changes  (ISO)
cellular response to ethanol  (ISO)
detection of oxygen  (ISO)
erythrophore differentiation  (ISO)
glutathione metabolic process  (ISO)
heart development  (ISO)
hemopoiesis  (ISO)
hydrogen peroxide biosynthetic process  (ISO)
hydrogen peroxide metabolic process  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
iron ion homeostasis  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
mitochondrion organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of membrane hyperpolarization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron development  (ISO)
oxygen homeostasis  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
post-embryonic development  (ISO)
protein homotetramerization  (ISO)
regulation of blood pressure  (ISO)
regulation of catalytic activity  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (ISO)
respiratory electron transport chain  (ISO)
response to activity  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to cold  (ISO)
response to electrical stimulus  (ISO)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to isolation stress  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to magnetism  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to reactive oxygen species  (ISO)
response to selenium ion  (ISO)
response to silicon dioxide  (ISO)
response to superoxide  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
sensory perception of sound  (ISO)
superoxide anion generation  (ISO)
superoxide metabolic process  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBI
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBImm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)Ensembl
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,785,674 - 49,797,617 (-)NCBI
ROS_Cfam_1.0149,127,570 - 49,139,634 (-)NCBI
UMICH_Zoey_3.1149,010,294 - 49,022,236 (-)NCBI
UNSW_CanFamBas_1.0148,881,250 - 48,893,258 (-)NCBI
UU_Cfam_GSD_1.0149,447,616 - 49,459,607 (-)NCBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl17,651,280 - 7,691,723 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11387,284,537 - 87,297,998 (-)NCBI
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)Ensembl
Vero_WHO_p1.0NW_02366604059,683,827 - 59,727,382 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBI



Nucleotide Sequences
RefSeq Transcripts XM_005321415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005321415   ⟹   XP_005321472
RefSeq Status:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBI
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005321472 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3290520 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321472   ⟸   XM_005321415
- UniProtKB: I3MC61 (UniProtKB/TrEMBL)
- Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008738 ENTREZGENE
Ensembl Protein ENSSTOP00000007817 ENTREZGENE