GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod2 | affects expression | EXP | | 6480464 | CTD | Estradiol affects the expression of SOD2 mRNA | PMID:16195479 | Sod2 | affects response to substance | EXP | | 6480464 | CTD | SOD2 protein affects the susceptibility to Estradiol | PMID:21484412 | Sod2 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of SOD2 protein | PMID:21215799 | Sod2 | multiple interactions | EXP | | 6480464 | CTD | Estradiol inhibits the reaction [Progesterone results in decreased expression of SOD2 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD2 protein]; SOD2 protein affects the reaction [Estradiol deficiency results in increased expression of MKI67 protein] | PMID:16195479 PMID:21215799 PMID:21484412 | Sod2 | affects response to substance | ISO | Sod2 (Rattus norvegicus) | 6480464 | CTD | SOD2 protein affects the susceptibility to Estradiol | PMID:21484412 | Sod2 | increases activity | ISO | Sod2 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased activity of SOD2 protein | PMID:21966433 | Sod2 | increases expression | ISO | Sod2 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of SOD2 mRNA; Estradiol results in increased expression of SOD2 protein | PMID:12816884 PMID:16195479 PMID:21484412 PMID:21966433 PMID:22070562 PMID:23027624 | Sod2 | increases expression | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of SOD2 mRNA; Estradiol results in increased expression of SOD2 protein | PMID:18191855 PMID:18692832 PMID:23019147 PMID:35747940 | Sod2 | multiple interactions | ISO | Sod2 (Rattus norvegicus) | 6480464 | CTD | 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of SOD2 protein]]; 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [Estradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of SOD2 protein]]; [bisphenol A co-treated with Estradiol] results in decreased expression of SOD2 mRNA; [Medroxyprogesterone Acetate co-treated with Estradiol] affects the expression of SOD2; Estradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] inhibits the reaction [MAPK11 protein binds to SOD2 protein]]; Estradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of SOD2 protein]; Estradiol results in increased expression of and results in increased activity of SOD2 protein; fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD2 mRNA]; KLF4 protein affects the reaction [Estradiol results in increased expression of SOD2]; Progesterone inhibits the reaction [Estradiol results in increased expression of SOD2 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of SOD2 protein] | PMID:12816884 PMID:16195479 PMID:21159850 PMID:21484412 PMID:21966433 PMID:24465521 PMID:26496021 | Sod2 | multiple interactions | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SOD2 protein; [Estradiol co-treated with Medroxyprogesterone Acetate] results in increased activity of SOD2 protein; [Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of SOD2 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of SOD2 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of SOD2 mRNA; protein kinase inhibitor peptide inhibits the reaction [[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased activity of SOD2 protein] | PMID:12093828 PMID:20660070 PMID:30165855 PMID:35747940 | | ||||||||||||||||||||||
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