Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330
Species: Mus musculus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
Acc ID: CHEBI:6716
Term: medroxyprogesterone acetate
Definition: An acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.
Chemical ID: MESH:D017258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2affects expressionISOSod2 (Rattus norvegicus)6480464CTDMedroxyprogesterone Acetate affects the expression of SOD2PMID:21159850
Sod2increases activityISOSOD2 (Homo sapiens)6480464CTDMedroxyprogesterone Acetate results in increased activity of SOD2 proteinPMID:11756571
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDMedroxyprogesterone Acetate results in increased expression of SOD2 mRNAPMID:11756571 PMID:20685861
Sod2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTD[Medroxyprogesterone Acetate co-treated with Estradiol] affects the expression of SOD2PMID:21159850
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased activity of SOD2 protein; [Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of SOD2 mRNA; [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SOD2 mRNA; [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SOD2 protein; FOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SOD2 mRNA]; Medroxyprogesterone Acetate promotes the reaction [CREBBP protein binds to SOD2 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of SOD2 mRNA]; protein kinase inhibitor peptide inhibits the reaction [[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased activity of SOD2 protein]; WNT5A protein affects the reaction [[Medroxyprogesterone Acetate results in increased abundance of Cyclic AMP] which results in increased expression of SOD2 mRNA]PMID:12093828 PMID:16709600 PMID:20685861
Go Back to source page   Continue to Ontology report