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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330
Species: Mus musculus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionEXP 6480464CTDArsenic results in decreased expression of SOD2 proteinPMID:22552367
Sod2multiple interactionsEXP 6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of SOD2 protein; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in increased expression of SOD2 proteinPMID:31238026
Sod2affects expressionISOSOD2 (Homo sapiens)6480464CTDArsenic affects the expression of SOD2PMID:21235219
Sod2affects response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 gene polymorphism affects the susceptibility to ArsenicPMID:16076760
Sod2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDArsenic results in decreased expression of SOD2 mRNAPMID:22434702
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDArsenic results in decreased expression of SOD2 mRNAPMID:16835338 PMID:32539644
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDArsenic results in increased expression of SOD2 mRNAPMID:19945496
Sod2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SOD2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SOD2 mRNAPMID:33127376 PMID:33171135
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SOD2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SOD2 proteinPMID:35747940
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