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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330
Species: Mus musculus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
Acc ID: CHEBI:46938
Term: zebularine
Definition: A pyrimidine ribonucleoside that has formula C9H12N2O5.
Chemical ID: MESH:C009131
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases methylationISOSOD2 (Homo sapiens)6480464CTDpyrimidin-2-one beta-ribofuranoside results in decreased methylation of SOD2 promoterPMID:15908783 PMID:17895890
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[pyrimidin-2-one beta-ribofuranoside results in decreased methylation of SOD2 gene] which results in increased expression of SOD2 protein; [pyrimidin-2-one beta-ribofuranoside results in decreased methylation of SOD2 promoter] which results in increased expression of SOD2 mRNA; [pyrimidin-2-one beta-ribofuranoside results in decreased methylation of SOD2 promoter] which results in increased expression of SOD2 proteinPMID:15908783 PMID:17895890
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