SOD2 (superoxide dismutase 2) - Rat Genome Database

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Gene: SOD2 (superoxide dismutase 2) Homo sapiens
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Symbol: SOD2
Name: superoxide dismutase 2
RGD ID: 730872
HGNC Page HGNC:11180
Description: Enables identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including intracellular oxygen homeostasis; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of apoptotic process. Located in mitochondrial matrix. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Biomarker of several diseases, including brain edema; exfoliation syndrome; hematologic cancer (multiple); liver disease (multiple); and urticaria.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: gastric cancer-associated lncRNA 1; GC1; GClnc1; indophenoloxidase B; IPO-B; IPOB; lncRNA-GC1; manganese-containing superoxide dismutase; mangano-superoxide dismutase; Mn superoxide dismutase; Mn-SOD; MNSOD; MVCD6; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: SOD2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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SOD2Humanabdominal aortic aneurysm  ISOSod2 (Rattus norvegicus)1625699mRNA and protein:increased expression:aortaRGD 
SOD2Humanacute myeloid leukemia  IEP 11035286protein:increased expression:serumRGD 
SOD2Humanacute myeloid leukemia disease_progressionIAGP 11035289 RGD 
SOD2Humanadult respiratory distress syndrome  ISOSod2 (Rattus norvegicus)11035305mRNA:increased expression:lungRGD 
SOD2Humanalcoholic liver cirrhosis susceptibilityIAGP 11060603DNA:SNP: : 47T>C(human)RGD 
SOD2HumanAlcoholic Liver Diseases treatmentISOSod2 (Mus musculus)27095880 RGD 
SOD2HumanAlzheimer's disease  IDA 1579972 RGD 
SOD2Humananemia  ISOSod2 (Mus musculus)1581262 RGD 
SOD2HumanAortic Calcification  ISOSod2 (Rattus norvegicus)11038653associated with Renal Insufficiency more ...RGD 
SOD2Humanasthma  IDA 1581231 RGD 
SOD2HumanBacteremia  ISOSod2 (Mus musculus)26923958mRNA:increased expression:liver:RGD 
SOD2Humanbilirubin metabolic disorder treatmentIAGP 11060605associated with acute lymphoblastic leukemia and DNA:SNP: :(rs4880)(human)RGD 
SOD2Humanbladder neck obstruction  ISOSod2 (Rattus norvegicus)7175518 RGD 
SOD2Humanbrain edema  IEP 329969876mRNA:increased expression:neocortex and Pyramidal cells (human)RGD 
SOD2HumanBrain Injuries  ISOSod2 (Mus musculus)1581214 RGD 
SOD2Humanbrain ischemia  ISOSod2 (Mus musculus)1625695 RGD 
SOD2Humanbreast cancer  IAGP 1581240 RGD 
SOD2HumanBreast Neoplasms  IDA 1581248 RGD 
SOD2HumanCardiac Arrhythmias  ISOSod2 (Rattus norvegicus)1581234 RGD 
SOD2Humancardiomyopathy  IAGP 1580836associated with hemochromatosis and DNA:polymorphism: :p.A16V (human)RGD 
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SOD2Human3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: 3-methylglutaconic aciduria with deafness more ...ClinVarPMID:15220921 more ...
SOD2Humandiabetic angiopathy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Microvascular complications of diabetes more ...ClinVarPMID:10425186 more ...
SOD2HumanDiabetic Nephropathies  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: SOD2 POLYMORPHISMClinVarPMID:10425186 more ...
SOD2Humanprimary ciliary dyskinesia 32  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesia 32ClinVarPMID:28492532
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SOD2Humanabdominal aortic aneurysm  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17196988
SOD2HumanAcute Coronary Syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21751358
SOD2Humanacute kidney tubular necrosis  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:19917352
SOD2Humanadenocarcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12907644
SOD2Humanadrenoleukodystrophy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16319717
SOD2Humanadult respiratory distress syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
SOD2HumanAlbuminuria  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17942768
SOD2Humanalcoholic liver cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19731237
SOD2HumanAlzheimer's disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19374891
SOD2Humanamyotrophic lateral sclerosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:8866423
SOD2Humananaplastic thyroid carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15887859
SOD2Humananemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20800516
SOD2Humanaortic disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25101153
SOD2HumanArsenic Poisoning  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16835338
SOD2Humanasphyxia neonatorum  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17963755
SOD2Humanatherosclerosis  EXP 11554173CTD more ...CTDPMID:12677255 and PMID:20720404
SOD2Humanautoimmune disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21850155
SOD2HumanBrain Injuries  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:24462953
SOD2Humanbrain ischemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15060315 more ...
SOD2HumanBrain Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21749277
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SOD2Humanamyotrophic lateral sclerosis type 1  ISSSod2 (Mus musculus)13592920OMIM:105400MouseDO 
SOD2HumanCanavan disease  ISSSod2 (Mus musculus)13592920OMIM:271900MouseDO 
SOD2Humancongestive heart failure  ISSSod2 (Mus musculus)13592920 MouseDO 
SOD2Humandilated cardiomyopathy  ISSSod2 (Mus musculus)13592920 MouseDO 
SOD2HumanLeigh disease  ISSSod2 (Mus musculus)13592920OMIM:220111 more ...MouseDO 
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SOD2Humandiabetic angiopathy  IAGP 7240710 OMIM 

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SOD2Human(+)-albicanol multiple interactionsISOSod2 (Mus musculus)6480464albicanol inhibits the reaction [Galactose results in decreased expression of SOD2 protein]CTDPMID:33761044
SOD2Human(+)-catechin multiple interactionsEXP 6480464[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] results in increased activity of SOD2 proteinCTDPMID:26187476
SOD2Human(+)-catechin multiple interactionsISOSod2 (Mus musculus)6480464[Catechin co-treated with Benzo(a)pyrene] results in increased expression of SOD2 mRNACTDPMID:28533128
SOD2Human(+)-catechin increases activityEXP 6480464Catechin analog results in increased activity of SOD2 proteinCTDPMID:26187476
SOD2Human(+)-epicatechin-3-O-gallate multiple interactionsEXP 6480464[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] results in increased activity of SOD2 proteinCTDPMID:26187476
SOD2Human(+)-pilocarpine increases expressionISOSod2 (Rattus norvegicus)6480464Pilocarpine results in increased expression of SOD2 proteinCTDPMID:20446108
SOD2Human(+)-schisandrin B multiple interactionsISOSod2 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SOD2 mRNA]CTDPMID:31150632
SOD2Human(+)-sesamin multiple interactionsISOSod2 (Rattus norvegicus)64804646-chloro-2 more ...CTDPMID:24211423
SOD2Human(+)-taxifolin multiple interactionsISOSod2 (Rattus norvegicus)6480464taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA] and taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]CTDPMID:32525071 and PMID:36198370
SOD2Human(-)-cotinine multiple interactionsISOSod2 (Rattus norvegicus)6480464[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 proteinCTDPMID:29617909
SOD2Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] results in increased activity of SOD2 protein more ...CTDPMID:16115949 more ...
SOD2Human(-)-epigallocatechin 3-gallate multiple interactionsISOSod2 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]CTDPMID:36056792
SOD2Human(-)-epigallocatechin 3-gallate increases expressionISOSod2 (Mus musculus)6480464epigallocatechin gallate results in increased expression of SOD2 mRNA and epigallocatechin gallate results in increased expression of SOD2 proteinCTDPMID:29175576 and PMID:36056792
SOD2Human(-)-epigallocatechin 3-gallate decreases expressionISOSod2 (Mus musculus)6480464epigallocatechin gallate results in decreased expression of SOD2 mRNACTDPMID:29175576
SOD2Human(-)-epigallocatechin 3-gallate increases activityEXP 6480464epigallocatechin gallate results in increased activity of SOD2 proteinCTDPMID:26187476
SOD2Human(-)-epigallocatechin 3-gallate affects activityISOSod2 (Mus musculus)6480464epigallocatechin gallate affects the activity of SOD2 proteinCTDPMID:25955525
SOD2Human(-)-epigallocatechin 3-gallate multiple interactionsISOSod2 (Rattus norvegicus)6480464epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of and affects the activity of SOD2 protein]CTDPMID:20666448
SOD2Human(1->4)-beta-D-glucan multiple interactionsISOSod2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SOD2 mRNACTDPMID:36331819
SOD2Human(E)-cinnamyl alcohol increases expressionEXP 6480464cinnamyl alcohol results in increased expression of SOD2 mRNACTDPMID:20566472
SOD2Human(R)-adrenaline multiple interactionsEXP 64804646-hydroxy-2 more ...CTDPMID:11163531

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Biological Process
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SOD2Humanacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure involved_inISSUniProtKB:P09671150520179 BHF-UCLGO_REF:0000024
SOD2Humanacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanapoptotic mitochondrial changes acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humancellular response to ethanol  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:19703426 and REF_RGD_ID:2317384
SOD2Humancellular response to ethanol involved_inIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humancellular response to oxidative stress involved_inIMP 150520179 PMID:14980699GO_CentralPMID:14980699
SOD2Humancellular response to oxidative stress involved_inISSUniProtKB:P04179150520179 UniProtGO_REF:0000024
SOD2Humandetection of oxygen acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanerythrophore differentiation acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanglutathione metabolic process acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanheart development acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanhemopoiesis acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanhydrogen peroxide biosynthetic process  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:15642720 and REF_RGD_ID:2291946
SOD2Humanhydrogen peroxide biosynthetic process involved_inIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanhydrogen peroxide metabolic process  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:16716903 and REF_RGD_ID:1580833
SOD2Humanhydrogen peroxide metabolic process involved_inIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanintracellular oxygen homeostasis involved_inIMP 150520179 PMID:16179351BHF-UCLPMID:16179351
SOD2Humanintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanintrinsic apoptotic signaling pathway in response to oxidative stress acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanliver development acts_upstream_of_or_withinIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
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Cellular Component
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SOD2Humanextracellular exosome located_inHDA 150520179 PMID:23533145UniProtPMID:23533145
SOD2Humanmitochondrial matrix located_inIEAUniProtKB-SubCell:SL-0170150520179 UniProtGO_REF:0000044
SOD2Humanmitochondrial matrix located_inTAS 150520179 PMID:10511315ReactomePMID:10511315 more ...
SOD2Humanmitochondrial matrix located_inIDA 150520179 PMID:23168492UniProtPMID:23168492
SOD2Humanmitochondrial nucleoid  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:19228881 and REF_RGD_ID:2306615
SOD2Humanmitochondrial nucleoid located_inIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanmitochondrion located_inIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanmitochondrion is_active_inIBACGD:CAL0000191321 more ...150520179 GO_CentralGO_REF:0000033
SOD2Humanmitochondrion located_inIDA 150520179 PMID:12551919BHF-UCLGO_REF:0000052 and PMID:12551919
SOD2Humanmitochondrion located_inHTP 150520179 PMID:34800366FlyBasePMID:34800366
SOD2Humanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
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Molecular Function
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SOD2HumanDNA binding  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:19228881 and REF_RGD_ID:2306615
SOD2HumanDNA binding enablesIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanenzyme binding  ISOSirt3 (Rattus norvegicus)9068941 RGDPMID:24505357 and REF_RGD_ID:8158103
SOD2Humanenzyme binding enablesIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanidentical protein binding  ISOSod2 (Rattus norvegicus)9068941homooligomerizationRGDPMID:19384983 and REF_RGD_ID:2317389
SOD2Humanidentical protein binding enablesIPIUniProtKB:P04179150520179 PMID:19822147 and PMID:21988832IntActPMID:19822147 and PMID:21988832
SOD2Humanidentical protein binding enablesIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanmanganese ion binding enablesTAS 150520179 PMID:10511315BHF-UCLPMID:10511315
SOD2Humanmanganese ion binding enablesIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanmanganese ion binding enablesIBAPANTHER:PTN004256454 more ...150520179 GO_CentralGO_REF:0000033
SOD2Humanmanganese ion binding enablesIDA 150520179 PMID:19265433UniProtPMID:19265433
SOD2Humanmanganese ion binding  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:19384983 and REF_RGD_ID:2317389
SOD2Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
SOD2Humanmetal ion binding enablesIEAInterPro:IPR001189 more ...150520179 InterProGO_REF:0000002
SOD2Humanoxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
SOD2Humanoxidoreductase activity enablesIEAUniProtKB:P09671 and ensembl:ENSMUSP00000007012150520179 EnsemblGO_REF:0000107
SOD2Humanoxygen binding  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:12107766 more ...
SOD2Humanoxygen binding enablesIEAUniProtKB:P07895 and ensembl:ENSRNOP00000111176150520179 EnsemblGO_REF:0000107
SOD2Humanprotein binding enablesIPIUniProtKB:Q8NHQ1150520179 PMID:32296183IntActPMID:32296183
SOD2Humansuperoxide dismutase activity  ISOSod2 (Rattus norvegicus)9068941 RGDPMID:12107766 more ...
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RGD Manual Annotations


  
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SOD2Humanhypertension pathway  IDA 1580833 RGD 

Imported Annotations - KEGG (archival)

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SOD2HumanHuntington's disease pathway   IEA 6907045 KEGGhsa:05016
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SOD2HumanDecreased liver function  IAGP 11061089DNA:SNPs:exon more ...RGD 
SOD2HumanElevated hepatic iron concentration susceptibilityIAGP 26923907associated with liver cirrhosis and DNA:SNP:cds:p.Ala16Val(rs1799725)(human)RGD 
SOD2HumanNeutropenia susceptibilityIAGP 11035278associated with female breast cancer and DNA:missense mutation:cds:p.V16A (rs4880) RGD 
SOD2HumanOsteoporosis susceptibilityIAGP 11035299DNA:SNPs:intron more ...RGD 
SOD2HumanOsteoporosis no_associationIAGP 11035299DNA:SNPs:5' utr more ...RGD 
SOD2HumanYoung adult onset  IAGP 1581258 RGD 

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Reference Title
Reference Citation
1. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Agharazii M, etal., Am J Hypertens. 2015 Jun;28(6):746-55. doi: 10.1093/ajh/hpu225. Epub 2014 Nov 27.
2. Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Alachkar H, etal., Pharmacogenomics J. 2016 Mar 29. doi: 10.1038/tpj.2016.7.
3. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Andreassen OA, etal., Exp Neurol. 2001 Jan;167(1):189-95. doi: 10.1006/exnr.2000.7525.
4. Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia. Aras-Lopez R, etal., Pediatr Surg Int. 2016 Feb;32(2):141-5. doi: 10.1007/s00383-015-3826-5. Epub 2015 Nov 3.
5. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Archer SL, etal., Circulation. 2010 Jun 22;121(24):2661-71. doi: 10.1161/CIRCULATIONAHA.109.916098. Epub 2010 Jun 7.
6. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Asimakis GK, etal., Circulation. 2002 Feb 26;105(8):981-6.
7. Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. Assem M, etal., Am J Pathol. 1997 Aug;151(2):549-55.
8. Nutrition- and virus-induced stress represses the expression of manganese superoxide dismutase in vitro. Berger MM, etal., Exp Biol Med (Maywood). 2004 Sep;229(8):843-9.
9. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. Bergman M, etal., J Cancer Res Clin Oncol. 2005 Jul;131(7):439-44. Epub 2005 May 10.
10. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Bonder CS, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G676-84. Epub 2004 Apr 15.
11. Superoxide Dismutase 2 Polymorphisms and Osteoporosis in Asian Indians: A Genetic Association Analysis. Botre C, etal., Cell Mol Biol Lett. 2015 Dec;20(4):685-97. doi: 10.1515/cmble-2015-0041.
12. Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. Celojevic D, etal., Ophthalmic Genet. 2013 May 2.
13. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, etal., Free Radic Biol Med. 2006 Jun 1;40(11):2028-39. Epub 2006 Feb 21.
14. Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. Cherry AD, etal., J Biol Chem. 2014 Jan 3;289(1):41-52. doi: 10.1074/jbc.M113.512483. Epub 2013 Nov 19.
15. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Comhair SA, etal., Am J Pathol. 2005 Mar;166(3):663-74.
16. Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Connor KM, etal., Cancer Res. 2007 Nov 1;67(21):10260-7.
17. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
18. Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Cullen JJ, etal., Pancreas. 2003 Jan;26(1):23-7.
19. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
20. Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Dhar SK, etal., Cancer Res. 2011 Nov 1;71(21):6684-95. doi: 10.1158/0008-5472.CAN-11-1233. Epub 2011 Oct 18.
1 to 20 of 126 rows
1 to 10 of 78 rows
PMID:123234   PMID:752518   PMID:1394426   PMID:1427917   PMID:1699607   PMID:1988135   PMID:2462451   PMID:2738919   PMID:2831093   PMID:3399391   PMID:3684581   PMID:6386798  
PMID:7493016   PMID:7498159   PMID:7702755   PMID:7859743   PMID:7895732   PMID:8395050   PMID:8605177   PMID:8633092   PMID:8806673   PMID:8889548   PMID:8889549   PMID:9110146  
PMID:9150946   PMID:9393747   PMID:9462746   PMID:9484232   PMID:9537987   PMID:9537988   PMID:9882443   PMID:10393559   PMID:10511315   PMID:10748080   PMID:10852710   PMID:11076863  
PMID:11124296   PMID:11299047   PMID:11323405   PMID:11350569   PMID:11481695   PMID:11580280   PMID:11719088   PMID:11721640   PMID:11752456   PMID:11756571   PMID:11849743   PMID:11853549  
PMID:11912921   PMID:11912930   PMID:11977425   PMID:12032830   PMID:12063011   PMID:12078513   PMID:12126755   PMID:12127599   PMID:12161520   PMID:12239572   PMID:12477932   PMID:12517793  
PMID:12540612   PMID:12551919   PMID:12590982   PMID:12592389   PMID:12624725   PMID:12627943   PMID:12644569   PMID:12673575   PMID:12683635   PMID:12684509   PMID:12711112   PMID:12829021  
PMID:12948282   PMID:12963120   PMID:14503839   PMID:14515147   PMID:14574404   PMID:14578853   PMID:14638684   PMID:14643949   PMID:14688256   PMID:14702039   PMID:14704872   PMID:14729580  
PMID:14744747   PMID:14975589   PMID:14980699   PMID:15075214   PMID:15087454   PMID:15088300   PMID:15131792   PMID:15166009   PMID:15184255   PMID:15196853   PMID:15217492   PMID:15223067  
PMID:15247771   PMID:15266664   PMID:15308628   PMID:15330761   PMID:15331175   PMID:15338334   PMID:15342556   PMID:15386537   PMID:15455371   PMID:15489334   PMID:15489336   PMID:15512788  
PMID:15534883   PMID:15535847   PMID:15581626   PMID:15589819   PMID:15598343   PMID:15610954   PMID:15621215   PMID:15673194   PMID:15701646   PMID:15705913   PMID:15706661   PMID:15734083  
1 to 10 of 78 rows



SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)EnsemblGRCm39 Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBIMGSCv36mm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,778,227 - 179,792,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,683,324 - 177,697,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,785,674 - 49,797,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,127,570 - 49,139,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,020,475 - 49,139,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,010,294 - 49,022,236 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,881,250 - 48,893,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,447,616 - 49,459,607 (-)NCBIUU_Cfam_GSD_1.0
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,178,015 - 11,191,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,679,352 - 7,689,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,683,827 - 59,727,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,260,809 - 3,271,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in SOD2
43 total Variants

1 to 10 of 71 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_000636.4(SOD2):c.47T>C (p.Val16Ala) single nucleotide variant Microvascular complications of diabetes, susceptibility to, 6 [RCV000015873]|SOD2 POLYMORPHISM [RCV000015872] Chr6:159692840 [GRCh38]
Chr6:160113872 [GRCh37]
Chr6:6q25.3		 risk factor|likely risk allele|benign|drug response
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3(chr6:157827805-159726548)x3 copy number gain See cases [RCV000051903] Chr6:157827805..159726548 [GRCh38]
Chr6:158248837..160147580 [GRCh37]
Chr6:158168825..160067570 [NCBI36]
Chr6:6q25.3		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:158664768-170612001)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|See cases [RCV000051904] Chr6:158664768..170612001 [GRCh38]
Chr6:159085800..170921089 [GRCh37]
Chr6:159005788..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159454639-170612001)x1 copy number loss See cases [RCV000052209] Chr6:159454639..170612001 [GRCh38]
Chr6:159875671..170921089 [GRCh37]
Chr6:159795661..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-26(chr6:155378049-163133499)x1 copy number loss See cases [RCV000137831] Chr6:155378049..163133499 [GRCh38]
Chr6:155699183..163554531 [GRCh37]
Chr6:155740875..163474521 [NCBI36]
Chr6:6q25.3-26		 pathogenic
GRCh38/hg38 6q25.3(chr6:159598794-159726489)x3 copy number gain See cases [RCV000140321] Chr6:159598794..159726489 [GRCh38]
Chr6:160019826..160147521 [GRCh37]
Chr6:159939816..160067511 [NCBI36]
Chr6:6q25.3		 likely benign
1 to 10 of 71 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR222hsa-miR-222-3pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Microarray//qRT-PFunctional MTI19487542
MIR17hsa-miR-17-3pMirtarbaseexternal_infoLuciferase reporter assay//Quantitative proteomic Functional MTI21203553
MIR17hsa-miR-17-3pOncomiRDBexternal_infoNANA21203553

Predicted Target Of
Summary Value
Count of predictions:7946
Count of miRNA genes:1429
Interacting mature miRNAs:1920
Transcripts:ENST00000337404, ENST00000367054, ENST00000367055, ENST00000401980, ENST00000444946, ENST00000452684, ENST00000535372, ENST00000535459, ENST00000535561, ENST00000537657, ENST00000538183, ENST00000540491, ENST00000541573, ENST00000545162, ENST00000546087, ENST00000546260
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597503391GWAS1599465_Heducational attainment QTL GWAS1599465 (human)4e-12educational attainment6159727316159727317Human
597494494GWAS1590568_Hprostate carcinoma QTL GWAS1590568 (human)5e-18prostate carcinoma6159728430159728431Human
597097621GWAS1193695_Hprostate carcinoma QTL GWAS1193695 (human)3e-16prostate carcinoma6159729247159729248Human
597181905GWAS1277979_Hconcentration of chylomicrons and extremely large VLDL particles measurement QTL GWAS1277979 (human)6e-10concentration of chylomicrons and extremely large VLDL particles measurement 6159672855159672856Human
597423122GWAS1519196_Hlipoprotein A measurement QTL GWAS1519196 (human)6e-36lipoprotein A measurement6159694422159694423Human
597376274GWAS1472348_Hiron biomarker measurement QTL GWAS1472348 (human)0.000001iron biomarker measurement6159716655159716656Human
597180562GWAS1276636_Hfree cholesterol in chylomicrons and extremely large VLDL measurement QTL GWAS1276636 (human)1e-09blood cholesterol amount (VT:0000180)6159672855159672856Human
597423121GWAS1519195_Hlipoprotein A measurement QTL GWAS1519195 (human)2e-42lipoprotein A measurement6159728147159728148Human
597473938GWAS1570012_Hprostate carcinoma QTL GWAS1570012 (human)0.0000001prostate carcinoma6159727316159727317Human
597496339GWAS1592413_Hprostate carcinoma QTL GWAS1592413 (human)4e-13prostate carcinoma6159728430159728431Human

1 to 10 of 25 rows
STS-W78148  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,100,257 - 160,100,414UniSTSGRCh37
Build 366160,020,247 - 160,020,404RGDNCBI36
Celera6160,747,710 - 160,747,867RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,570,693 - 157,570,850UniSTS
GeneMap99-GB4 RH Map6618.21UniSTS
D6S1419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,200 - 160,103,524UniSTSGRCh37
Build 366160,023,190 - 160,023,514RGDNCBI36
Celera6160,750,653 - 160,750,977RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,573,636 - 157,573,960UniSTS
TNG Radiation Hybrid Map680117.0UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
Whitehead-YAC Contig Map6 UniSTS
NCBI RH Map61631.6UniSTS
GeneMap99-G3 RH Map66671.0UniSTS
D6S1335  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,412 - 160,103,588UniSTSGRCh37
Build 366160,023,402 - 160,023,578RGDNCBI36
Celera6160,750,865 - 160,751,041RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,573,848 - 157,574,024UniSTS
Whitehead-YAC Contig Map6 UniSTS
SHGC-34268  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,102,238 - 160,102,387UniSTSGRCh37
Build 366160,022,228 - 160,022,377RGDNCBI36
Celera6160,749,691 - 160,749,840RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,572,674 - 157,572,823UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
Whitehead-RH Map6830.6UniSTS
NCBI RH Map61636.2UniSTS
GeneMap99-G3 RH Map66664.0UniSTS
RH16462  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,102,239 - 160,102,362UniSTSGRCh37
Build 366160,022,229 - 160,022,352RGDNCBI36
Celera6160,749,692 - 160,749,815RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,572,675 - 157,572,798UniSTS
GeneMap99-GB4 RH Map6619.81UniSTS
NCBI RH Map61624.4UniSTS
SOD2_3060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,010 - 160,103,635UniSTSGRCh37
Build 366160,023,000 - 160,023,625RGDNCBI36
Celera6160,750,463 - 160,751,088RGD
HuRef6157,573,446 - 157,574,071UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2256 4980 1729 2354 6 627 2075 468 2269 7438 6598 53 3741 1 854 1756 1617 175 1


1 to 30 of 67 rows
RefSeq Transcripts NG_008729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001024465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001024466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA126703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL050388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV658055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY267901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY397775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 67 rows

Ensembl Acc Id: ENST00000337404   ⟹   ENSP00000337127
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,165 - 159,693,278 (-)Ensembl
Ensembl Acc Id: ENST00000367054   ⟹   ENSP00000356021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,116 - 159,693,228 (-)Ensembl
Ensembl Acc Id: ENST00000367055   ⟹   ENSP00000356022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,064 - 159,693,234 (-)Ensembl
Ensembl Acc Id: ENST00000401980   ⟹   ENSP00000384196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,939 - 159,727,353 (-)Ensembl
Ensembl Acc Id: ENST00000444946   ⟹   ENSP00000404804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,139 - 159,693,241 (-)Ensembl
Ensembl Acc Id: ENST00000452684   ⟹   ENSP00000406713
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,690,919 - 159,693,244 (-)Ensembl
Ensembl Acc Id: ENST00000535459
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,461 - 159,688,348 (-)Ensembl
Ensembl Acc Id: ENST00000535561   ⟹   ENSP00000445015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,896 - 159,726,944 (-)Ensembl
Ensembl Acc Id: ENST00000537657   ⟹   ENSP00000439191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,904 - 159,745,186 (-)Ensembl
Ensembl Acc Id: ENST00000538183   ⟹   ENSP00000446252
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,669,069 - 159,693,241 (-)Ensembl
Ensembl Acc Id: ENST00000540491
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,610 - 159,692,650 (-)Ensembl
Ensembl Acc Id: ENST00000541573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,482 - 159,692,078 (-)Ensembl
Ensembl Acc Id: ENST00000545162   ⟹   ENSP00000441362
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,875 - 159,727,357 (-)Ensembl
Ensembl Acc Id: ENST00000546087   ⟹   ENSP00000442920
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,119 - 159,762,529 (-)Ensembl
Ensembl Acc Id: ENST00000546260   ⟹   ENSP00000440131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,064 - 159,693,241 (-)Ensembl
RefSeq Acc Id: NM_000636   ⟹   NP_000627
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,022,745 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001024465   ⟹   NP_001019636
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,020,138 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,924,915 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001024466   ⟹   NP_001019637
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,020,138 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,924,915 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322814   ⟹   NP_001309743
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322815   ⟹   NP_001309744
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322816   ⟹   NP_001309745
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,690,919 - 159,693,241 (-)NCBI
CHM1_16160,374,828 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,936,763 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322817   ⟹   NP_001309746
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,762,281 (-)NCBI
CHM1_16160,362,979 - 160,445,890 (-)NCBI
T2T-CHM13v2.06160,924,915 - 161,007,912 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322819   ⟹   NP_001309748
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,727,384 (-)NCBI
CHM1_16160,362,979 - 160,410,735 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,973,013 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322820   ⟹   NP_001309749
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,726,950 (-)NCBI
CHM1_16160,362,979 - 160,410,324 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,972,579 (-)NCBI
Sequence:
1 to 30 of 60 rows
Protein RefSeqs NP_000627 (Get FASTA)   NCBI Sequence Viewer  
  NP_001019636 (Get FASTA)   NCBI Sequence Viewer  
  NP_001019637 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309743 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309744 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309745 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309746 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309748 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36622 (Get FASTA)   NCBI Sequence Viewer  
  AAA83933 (Get FASTA)   NCBI Sequence Viewer  
  AAC15835 (Get FASTA)   NCBI Sequence Viewer  
  AAD14248 (Get FASTA)   NCBI Sequence Viewer  
  AAH12423 (Get FASTA)   NCBI Sequence Viewer  
  AAH16934 (Get FASTA)   NCBI Sequence Viewer  
  AAP03428 (Get FASTA)   NCBI Sequence Viewer  
  AAP34407 (Get FASTA)   NCBI Sequence Viewer  
  AAP34408 (Get FASTA)   NCBI Sequence Viewer  
  AAP34409 (Get FASTA)   NCBI Sequence Viewer  
  AAP34410 (Get FASTA)   NCBI Sequence Viewer  
  AAP35613 (Get FASTA)   NCBI Sequence Viewer  
  AAY21807 (Get FASTA)   NCBI Sequence Viewer  
  ADO22403 (Get FASTA)   NCBI Sequence Viewer  
  BAA18955 (Get FASTA)   NCBI Sequence Viewer  
  BAG35908 (Get FASTA)   NCBI Sequence Viewer  
  BAG53464 (Get FASTA)   NCBI Sequence Viewer  
  BAG59382 (Get FASTA)   NCBI Sequence Viewer  
  BAG65521 (Get FASTA)   NCBI Sequence Viewer  
  BBK63514 (Get FASTA)   NCBI Sequence Viewer  
  BBK63515 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 60 rows
1 to 5 of 21 rows
1 to 5 of 21 rows
RefSeq Acc Id: NP_001019637   ⟸   NM_001024466
- Peptide Label: isoform B
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001019636   ⟸   NM_001024465
- Peptide Label: isoform A precursor
- UniProtKB: Q96EE6 (UniProtKB/Swiss-Prot),   Q5TCM1 (UniProtKB/Swiss-Prot),   Q16792 (UniProtKB/Swiss-Prot),   P78434 (UniProtKB/Swiss-Prot),   E1P5A9 (UniProtKB/Swiss-Prot),   B4E3K9 (UniProtKB/Swiss-Prot),   B4DL20 (UniProtKB/Swiss-Prot),   B3KUK2 (UniProtKB/Swiss-Prot),   B2R7R1 (UniProtKB/Swiss-Prot),   Q9P2Z3 (UniProtKB/Swiss-Prot),   P04179 (UniProtKB/Swiss-Prot),   A0A384NL29 (UniProtKB/TrEMBL),   Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000627   ⟸   NM_000636
- Peptide Label: isoform A precursor
- UniProtKB: Q96EE6 (UniProtKB/Swiss-Prot),   Q5TCM1 (UniProtKB/Swiss-Prot),   Q16792 (UniProtKB/Swiss-Prot),   P78434 (UniProtKB/Swiss-Prot),   E1P5A9 (UniProtKB/Swiss-Prot),   B4E3K9 (UniProtKB/Swiss-Prot),   B4DL20 (UniProtKB/Swiss-Prot),   B3KUK2 (UniProtKB/Swiss-Prot),   B2R7R1 (UniProtKB/Swiss-Prot),   Q9P2Z3 (UniProtKB/Swiss-Prot),   P04179 (UniProtKB/Swiss-Prot),   A0A384NL29 (UniProtKB/TrEMBL),   Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309746   ⟸   NM_001322817
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309748   ⟸   NM_001322819
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
Manganese/iron superoxide dismutase C-terminal   Manganese/iron superoxide dismutase N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P04179-F1-model_v2 AlphaFold P04179 1-222 view protein structure

RGD ID:7209571
Promoter ID:EPDNEW_H10531
Type:initiation region
Name:SOD2_5
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,681,587 - 159,681,647EPDNEW
RGD ID:7209573
Promoter ID:EPDNEW_H10532
Type:initiation region
Name:SOD2_4
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,684,934 - 159,684,994EPDNEW
RGD ID:7209575
Promoter ID:EPDNEW_H10533
Type:initiation region
Name:SOD2_6
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,688,188 - 159,688,248EPDNEW
RGD ID:7209577
Promoter ID:EPDNEW_H10534
Type:initiation region
Name:SOD2_1
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,693,241 - 159,693,301EPDNEW
RGD ID:7209579
Promoter ID:EPDNEW_H10536
Type:initiation region
Name:SOD2_3
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,726,950 - 159,727,010EPDNEW
RGD ID:7209585
Promoter ID:EPDNEW_H10538
Type:initiation region
Name:SOD2_2
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,355 - 159,727,415EPDNEW
RGD ID:6804814
Promoter ID:HG_KWN:55651
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_000636,   NM_001024466,   OTTHUMT00000042922,   UC003QSJ.2
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,034,176 - 160,034,747 (-)MPROMDB
RGD ID:6851922
Promoter ID:EP73767
Type:initiation region
Name:HS_SOD2
Description:Superoxide dismutase 2, mitochondrial.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,034,263 - 160,034,323EPD


1 to 40 of 82 rows
Database
Acc Id
Source(s)
COSMIC SOD2 COSMIC
Ensembl Genes ENSG00000112096 Ensembl
  ENSG00000285441 Ensembl
  ENSG00000291237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000337404 ENTREZGENE
  ENST00000337404.8 UniProtKB/Swiss-Prot
  ENST00000367054 ENTREZGENE
  ENST00000367054.6 UniProtKB/Swiss-Prot
  ENST00000367055 ENTREZGENE
  ENST00000367055.8 UniProtKB/Swiss-Prot
  ENST00000444946 ENTREZGENE
  ENST00000444946.6 UniProtKB/Swiss-Prot
  ENST00000452684 ENTREZGENE
  ENST00000538183 ENTREZGENE
  ENST00000538183.7 UniProtKB/Swiss-Prot
  ENST00000546087 ENTREZGENE
  ENST00000546087.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.990 UniProtKB/Swiss-Prot
  3.55.40.20 UniProtKB/Swiss-Prot
GTEx ENSG00000112096 GTEx
  ENSG00000285441 GTEx
  ENSG00000291237 GTEx
HGNC ID HGNC:11180 ENTREZGENE
Human Proteome Map SOD2 Human Proteome Map
InterPro Fe/Mn_Superoxide_Dismutase UniProtKB/Swiss-Prot
  Mn/Fe_SOD UniProtKB/Swiss-Prot
  Mn/Fe_SOD_BS UniProtKB/Swiss-Prot
  Mn/Fe_SOD_C UniProtKB/Swiss-Prot
  Mn/Fe_SOD_N UniProtKB/Swiss-Prot
  Mn/Fe_SOD_N_sf UniProtKB/Swiss-Prot
  SOD_C_sf UniProtKB/Swiss-Prot
KEGG Report hsa:6648 UniProtKB/Swiss-Prot
NCBI Gene 6648 ENTREZGENE
OMIM 147460 OMIM
PANTHER SUPEROXIDE DISMUTASE 2 UniProtKB/Swiss-Prot
  SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Sod_Fe_C UniProtKB/Swiss-Prot
  Sod_Fe_N UniProtKB/Swiss-Prot
PharmGKB PA36017 PharmGKB, RGD
PIRSF SODismutase UniProtKB/Swiss-Prot
1 to 40 of 82 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 SOD2  superoxide dismutase 2  SOD2  superoxide dismutase 2, mitochondrial  Symbol and/or name change 5135510 APPROVED