SOD2 (superoxide dismutase 2) - Rat Genome Database

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Gene: SOD2 (superoxide dismutase 2) Homo sapiens
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Symbol: SOD2
Name: superoxide dismutase 2
RGD ID: 730872
HGNC Page HGNC:11180
Description: Enables identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including intracellular oxygen homeostasis; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of apoptotic process. Located in mitochondrial matrix. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Biomarker of several diseases, including brain edema; exfoliation syndrome; hematologic cancer (multiple); liver disease (multiple); and urticaria.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: gastric cancer-associated lncRNA 1; GC1; GClnc1; indophenoloxidase B; IPO-B; IPOB; manganese-containing superoxide dismutase; mangano-superoxide dismutase; Mn superoxide dismutase; Mn-SOD; MNSOD; MVCD6; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: SOD2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  (IAGP)
abdominal aortic aneurysm  (EXP,ISO)
Acute Coronary Syndrome  (EXP)
acute kidney tubular necrosis  (EXP)
acute myeloid leukemia  (IAGP,IEP)
adenocarcinoma  (EXP)
adrenoleukodystrophy  (EXP)
adult respiratory distress syndrome  (EXP,ISO)
Albuminuria  (EXP)
alcoholic liver cirrhosis  (EXP,IAGP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (EXP,IDA)
amyotrophic lateral sclerosis  (EXP)
amyotrophic lateral sclerosis type 1  (ISS)
anaplastic thyroid carcinoma  (EXP)
anemia  (EXP,ISO)
Aortic Calcification  (ISO)
aortic disease  (EXP)
Arsenic Poisoning  (EXP)
asphyxia neonatorum  (EXP)
asthma  (IDA)
atherosclerosis  (EXP)
autoimmune disease  (EXP)
Bacteremia  (ISO)
bilirubin metabolic disorder  (IAGP)
bladder neck obstruction  (ISO)
brain edema  (IEP)
Brain Injuries  (EXP,ISO)
brain ischemia  (EXP,ISO)
Brain Neoplasms  (EXP)
breast cancer  (IAGP)
Breast Neoplasms  (EXP,IDA)
Canavan disease  (ISS)
carcinoma  (EXP)
Cardiac Arrhythmias  (ISO)
Cardiogenic Shock  (EXP)
Cardiomegaly  (EXP)
cardiomyopathy  (EXP,IAGP,ISO)
carotid artery disease  (IAGP)
central nervous system disease  (EXP)
Central Nervous System Infections  (IDA)
Chemical and Drug Induced Liver Injury  (EXP,IAGP,ISO)
chronic progressive external ophthalmoplegia  (EXP)
Colonic Neoplasms  (EXP)
Colorectal Neoplasms  (EXP,IAGP)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (EXP,ISS)
cystitis  (ISO)
diabetic angiopathy  (IAGP)
Diabetic Nephropathies  (EXP,IAGP)
diffuse large B-cell lymphoma  (EXP)
dilated cardiomyopathy  (EXP,IAGP,ISO,ISS)
disease of cellular proliferation  (EXP,ISO)
Disease Progression  (EXP)
Drug-induced Neutropenia  (IAGP)
Endotoxemia  (EXP)
Esophageal Neoplasms  (EXP)
Esophageal Stenosis  (EXP)
esophagitis  (EXP)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (EXP)
exfoliation syndrome  (IEP)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Mammary Neoplasms  (EXP)
Experimental Radiation Injuries  (EXP)
extrinsic allergic alveolitis  (EXP)
familial adenomatous polyposis  (EXP)
Farber lipogranulomatosis  (EXP)
Fever  (EXP)
Fibrosis  (EXP)
gestational diabetes  (EXP)
head and neck squamous cell carcinoma  (EXP)
Hearing Loss, Noise-Induced  (IAGP)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (EXP,IAGP,IDA,IEP)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (EXP,IDA,ISO)
hyperthyroidism  (EXP)
Hypertriglyceridemia  (IAGP)
hypoglycemia  (EXP)
Hypopharyngeal Neoplasms  (IAGP)
hypothyroidism  (ISO)
Hypoxia  (EXP)
inclusion body myositis  (IDA)
infectious mononucleosis  (IDA)
Insulin Resistance  (EXP)
interstitial lung disease  (EXP)
intestinal disease  (ISO)
invasive ductal carcinoma  (EXP)
ischemia  (EXP)
kidney disease  (EXP)
Kidney Neoplasms  (EXP)
Kuhnt-Junius degeneration  (IAGP)
Leber hereditary optic neuropathy  (IDA,ISO)
Leigh disease  (ISS)
Lewy body dementia  (EXP)
liver cirrhosis  (EXP,IAGP)
lung adenocarcinoma  (EXP)
lung cancer  (IDA)
lung disease  (EXP)
lung non-small cell carcinoma  (EXP)
Lymphatic Metastasis  (EXP,IEP)
macular degeneration  (ISO)
major depressive disorder  (EXP)
male infertility  (EXP)
malignant mesothelioma  (EXP)
Marfan syndrome  (EXP)
melanoma  (IEP)
MELAS syndrome  (EXP)
Mesothelioma  (EXP)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatohepatitis  (IAGP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA,ISO)
Metabolic Syndrome  (ISO)
methylmalonic acidemia  (EXP)
middle cerebral artery infarction  (EXP)
mitochondrial metabolism disease  (EXP)
Mouth Neoplasms  (EXP,IAGP)
multiple chemical sensitivity  (EXP)
multiple myeloma  (EXP,IDA)
mycosis fungoides  (IEP)
myelomeningocele  (EXP)
myocardial infarction  (EXP,IEP,ISO)
Myocardial Ischemia  (EXP,ISO)
Myocardial Reperfusion Injury  (IMP,ISO)
Nasal Polyps  (IEP)
Necrosis  (EXP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP)
Neoplastic Cell Transformation  (EXP)
nephrotic syndrome  (EXP,IEP)
Nerve Degeneration  (EXP)
neurodegenerative disease  (EXP)
neuronal ceroid lipofuscinosis  (IDA)
obesity  (EXP)
optic neuritis  (IDA,ISO)
osteoarthritis  (EXP)
osteoporosis  (EXP,IAGP)
ovarian cancer  (IDA)
Ovarian Neoplasms  (EXP)
pancreatic cancer  (EXP,IAGP,IDA,IEP)
papilloma  (EXP)
Parkinson's disease  (EXP,ISO)
perinatal necrotizing enterocolitis  (EXP)
peripheral nervous system disease  (EXP)
polyneuropathy  (IAGP)
pre-malignant neoplasm  (EXP)
Premature Birth  (EXP)
Presbycusis  (ISO)
primary biliary cholangitis  (IEP)
primary ciliary dyskinesia 32  (IAGP)
primary open angle glaucoma  (IAGP)
Prostatic Neoplasms  (EXP,IDA)
pseudoxanthoma elasticum  (IAGP)
psoriasis  (EXP,IEP)
Pulmonary Arterial Hypertension  (IEP,ISO)
pulmonary hypertension  (EXP)
Radiation Injuries  (EXP)
reactive arthritis  (IDA)
renal cell carcinoma  (EXP)
renal fibrosis  (ISO)
Reperfusion Injury  (EXP,IDA,ISO)
Respiratory Tract Granuloma  (EXP)
Reticulocytosis  (EXP)
Retina Reperfusion Injury  (IDA,ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (EXP)
sarcoidosis  (EXP)
Sengers syndrome  (EXP)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
sideroblastic anemia  (EXP)
Skin Abnormalities  (EXP)
skin disease  (EXP)
Skin Neoplasms  (EXP,IDA,ISO)
squamous cell carcinoma  (EXP)
status epilepticus  (ISO)
steatotic liver disease  (EXP)
stomach cancer  (IDA)
Stomach Neoplasms  (EXP)
substance-induced psychosis  (EXP)
systemic lupus erythematosus  (IAGP)
Tardive Dyskinesia  (IAGP)
Thyroid Neoplasms  (IDA)
Tongue Neoplasms  (EXP,IEP)
transient cerebral ischemia  (EXP,ISO)
Turner syndrome  (EXP)
type 1 diabetes mellitus  (IAGP)
type 2 diabetes mellitus  (EXP,IAGP)
urinary bladder cancer  (EXP,IEP)
urticaria  (IEP)
uveitis  (EXP)
vascular disease  (EXP)
Ventricular Dysfunction, Left  (EXP)
vitiligo  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (EXP)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-sesamin  (ISO)
(+)-taxifolin  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R)-tramadol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (EXP,ISO)
2,3,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (EXP,ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
2-palmitoylglycerol  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3',5'-cyclic AMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,4-dihydroxybenzoate  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-chlorobiphenyl  (EXP)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-Hydroxycapric acid  (ISO)
5-methoxytryptamine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (ISO)
[6]-Shogaol  (EXP)
AACOCF3  (EXP)
acetamiprid  (ISO)
acetic acid  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
Actein  (ISO)
acteoside  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP)
Aflatoxin G1  (ISO)
AICA ribonucleotide  (EXP)
alatrofloxacin  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
Allylamine  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alpha-pinene  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ametryn  (ISO)
aminoacetone  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
ANTIMYCIN  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (EXP)
apocynin  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (EXP)
arjunolic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
astragaloside IV  (ISO)
atazanavir sulfate  (EXP)
atenolol  (EXP,ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrasentan  (ISO)
atrazine  (EXP,ISO)
azathioprine  (EXP)
Bandrowski's base  (EXP)
barium chloride  (ISO)
Bavachalcone  (EXP)
Bay-K-8644  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bortezomib  (EXP)
bosentan  (EXP)
bucladesine  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (EXP)
butyric acid  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
Calphostin C  (EXP)
camphene  (ISO)
camptothecin  (EXP)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carboplatin  (ISO)
carmustine  (EXP)
carnosic acid  (EXP)
carotenoid  (ISO)
carteolol  (EXP)
carvedilol  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
ceric oxide  (EXP)
cerium trichloride  (EXP,ISO)
chenodeoxycholic acid  (EXP)
chicoric acid  (ISO)
Chikusetsusaponin-V  (EXP)
chloramine T  (ISO)
chlorobenzene  (EXP)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
chrysazin  (EXP)
cinnamyl alcohol  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
creatinine  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (EXP,ISO)
curcumin  (EXP,ISO)
Cyanoginosin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
cysteamine  (ISO)
cytochalasin B  (EXP)
D-glucose  (EXP,ISO)
daidzein  (ISO)
dapsone  (ISO)
daunorubicin  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
Decursin  (ISO)
dehydroepiandrosterone  (ISO)
Dendrobine  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dihydrogen  (EXP,ISO)
dimethylarsinous acid  (EXP)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP,ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
dithianon  (EXP)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
docebenone  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
dronedarone  (EXP)
ebselen  (ISO)
eckol  (EXP)
edaravone  (ISO)
elemental selenium  (EXP)
ellagic acid  (ISO)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
enniatin  (ISO)
enzyme inhibitor  (EXP,ISO)
epalrestat  (ISO)
eplerenone  (ISO)
Erythropoietin  (EXP)
ethanol  (ISO)
ethylene glycol dimethacrylate  (EXP)
etoposide  (EXP)
eugenol  (EXP)
febuxostat  (ISO)
fenofibrate  (ISO)
fentanyl  (ISO)
fenthion  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
flutamide  (ISO)
fluvastatin  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fraxetin  (EXP)
fulvestrant  (EXP,ISO)
Fusaric acid  (EXP)
galactose  (ISO)
gallium nitrate  (EXP)
gallocatechin  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glafenine  (ISO)
gliclazide  (ISO)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP)
haloperidol  (ISO)
helenalin  (EXP)
hemin  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (EXP)
Honokiol  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (EXP)
hydroxytyrosol  (EXP,ISO)
ibuprofen  (EXP)
icariin  (EXP,ISO)
idebenone  (ISO)
indirubin-3'-monoxime  (EXP)
indometacin  (EXP,ISO)
ionomycin  (EXP)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoeugenol  (EXP)
isoflavones  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
kaempferol  (ISO)
kainic acid  (ISO)
ketorolac tromethamine  (ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-dehydroascorbic acid  (EXP)
L-methionine  (EXP,ISO)
lanthanum trichloride  (EXP)
lapatinib  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lenvatinib  (ISO)
Leonurine  (ISO)
leptomycin B  (EXP)
linalool  (EXP)
linsidomine  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
loliolide  (EXP)
losartan  (ISO)
lutein  (ISO)
luteolin  (EXP)
luzindole  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
malathion  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
masoprocol  (EXP)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (EXP,ISO)
meloxicam  (EXP)
menadione  (EXP,ISO)
mercaptoethanol  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (ISO)
metam  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP,ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (EXP)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
mitomycin C  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (ISO)
morphine  (EXP,ISO)
myxothiazol  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-acetylsphingosine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-phosphocreatine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
naringin  (ISO)
nebivolol  (ISO)
nefazodone  (EXP,ISO)
nerolidol  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nicorandil  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (ISO)
nitroprusside  (EXP)
nitroxoline  (EXP)
NMN zwitterion  (ISO)
NS-398  (EXP)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (EXP)
oleic acid  (EXP,ISO)
oltipraz  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
paroxetine  (ISO)
pentanal  (EXP)
peptidoglycan  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
peroxynitrous acid  (EXP,ISO)
phenanthrene  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenols  (EXP)
phenylmercury acetate  (EXP)
phenylpropanolamine  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
physostigmine  (ISO)
pifithrin-?  (ISO)
pioglitazone  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(I:C)  (EXP,ISO)
poly(vinylpyrrolidone)  (EXP)
porphyrins  (EXP)
potassium atom  (EXP,ISO)
potassium bromate  (EXP)
potassium dichromate  (ISO)
potassium iodide  (EXP)
prednisolone  (EXP)
probucol  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propofol  (ISO)
prostaglandin E2  (EXP)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
purine-6-thiol  (EXP)
Pyridostigmine bromide  (EXP,ISO)
pyridoxamine  (ISO)
pyrrolidine dithiocarbamate  (EXP)
pyrroloquinoline quinone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (EXP,ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
rebaudioside A  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
salicyl alcohol  (ISO)
Salidroside  (ISO)
salsalate  (ISO)
salvianolic acid B  (ISO)
saquinavir  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
selenic acid  (EXP)
selenium atom  (EXP)
selenocystine  (EXP)
selenomethionine  (EXP)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicic acid  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium aurothiomalate  (EXP)
sodium chloride  (ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium nitrate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (ISO)
staurosporine  (ISO)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfamethoxazole  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
superoxide  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
tartrazine  (EXP)
taurocholic acid  (EXP,ISO)
temozolomide  (EXP)
tert-butyl ethyl ether  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thallium  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
thymoquinone  (ISO)
thyroxine  (ISO)
Tiron  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (EXP)
topotecan  (ISO)
tramadol  (ISO)
trandolapril  (ISO)
trans-isoeugenol  (EXP)
trans-piceid  (EXP,ISO)
trazodone  (ISO)
triadimefon  (ISO)
trichlorfon  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trilobatin  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (EXP,ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP)
urea  (EXP)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
vosaroxin  (EXP)
water  (ISO)
withaferin A  (EXP,ISO)
wortmannin  (ISO)
WR-1065  (EXP,ISO)
zearalenone  (ISO)
zebularine  (EXP)
zerumbone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)
zinc(0)  (ISO)
ziram  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IEA,ISO,ISS)
apoptotic mitochondrial changes  (IEA,ISO)
cellular response to ethanol  (IEA,ISO)
cellular response to oxidative stress  (IMP,ISS)
detection of oxygen  (IEA,ISO)
erythrophore differentiation  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
heart development  (IEA,ISO)
hemopoiesis  (IEA,ISO)
hydrogen peroxide biosynthetic process  (IEA,ISO)
hydrogen peroxide metabolic process  (IEA,ISO)
intracellular oxygen homeostasis  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
liver development  (IEA,ISO)
locomotory behavior  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of membrane hyperpolarization  (IEA,ISO)
negative regulation of neuron apoptotic process  (IGI)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IMP)
negative regulation of vascular associated smooth muscle cell proliferation  (IDA)
neuron development  (IEA,ISO)
positive regulation of cell migration  (IMP)
positive regulation of hydrogen peroxide biosynthetic process  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IDA)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (IDA)
post-embryonic development  (IEA,ISO)
protein homotetramerization  (IPI)
reactive oxygen species metabolic process  (IEA)
regulation of blood pressure  (IEA,ISO,ISS)
regulation of catalytic activity  (ISO)
regulation of mitochondrial membrane potential  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,IMP,ISO,ISS)
release of cytochrome c from mitochondria  (IEA,ISO,ISS)
removal of superoxide radicals  (IEA,IMP,ISO)
respiratory electron transport chain  (IEA,ISO)
response to activity  (IEA,ISO)
response to axon injury  (IEA,ISO)
response to cadmium ion  (IEA,ISO)
response to electrical stimulus  (IEA,ISO)
response to gamma radiation  (IEA,ISO)
response to hydrogen peroxide  (IEA,ISO)
response to hyperoxia  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to immobilization stress  (IEA,ISO)
response to isolation stress  (IEA,ISO)
response to L-ascorbic acid  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to magnetism  (IEA,ISO)
response to manganese ion  (IEA,ISO)
response to nutrient levels  (IEA,ISO)
response to oxidative stress  (IEA,ISO)
response to reactive oxygen species  (IEA,ISO)
response to selenium ion  (IEA,ISO)
response to silicon dioxide  (IEA,ISO)
response to superoxide  (IEA,IMP,ISO)
response to xenobiotic stimulus  (IEA,ISO)
response to zinc ion  (IEA,ISO)
sensory perception of sound  (ISO)
superoxide anion generation  (IEA,ISO)
superoxide metabolic process  (IDA,IEA,ISO)
vasodilation  (IEA,ISO)

Cellular Component
extracellular exosome  (HDA)
mitochondrial matrix  (IDA,IEA,TAS)
mitochondrial nucleoid  (IEA,ISO)
mitochondrion  (HTP,IBA,IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
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2. Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Alachkar H, etal., Pharmacogenomics J. 2016 Mar 29. doi: 10.1038/tpj.2016.7.
3. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Andreassen OA, etal., Exp Neurol. 2001 Jan;167(1):189-95. doi: 10.1006/exnr.2000.7525.
4. Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia. Aras-Lopez R, etal., Pediatr Surg Int. 2016 Feb;32(2):141-5. doi: 10.1007/s00383-015-3826-5. Epub 2015 Nov 3.
5. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Archer SL, etal., Circulation. 2010 Jun 22;121(24):2661-71. doi: 10.1161/CIRCULATIONAHA.109.916098. Epub 2010 Jun 7.
6. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Asimakis GK, etal., Circulation. 2002 Feb 26;105(8):981-6.
7. Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. Assem M, etal., Am J Pathol. 1997 Aug;151(2):549-55.
8. Nutrition- and virus-induced stress represses the expression of manganese superoxide dismutase in vitro. Berger MM, etal., Exp Biol Med (Maywood). 2004 Sep;229(8):843-9.
9. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. Bergman M, etal., J Cancer Res Clin Oncol. 2005 Jul;131(7):439-44. Epub 2005 May 10.
10. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Bonder CS, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G676-84. Epub 2004 Apr 15.
11. Superoxide Dismutase 2 Polymorphisms and Osteoporosis in Asian Indians: A Genetic Association Analysis. Botre C, etal., Cell Mol Biol Lett. 2015 Dec;20(4):685-97. doi: 10.1515/cmble-2015-0041.
12. Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. Celojevic D, etal., Ophthalmic Genet. 2013 May 2.
13. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, etal., Free Radic Biol Med. 2006 Jun 1;40(11):2028-39. Epub 2006 Feb 21.
14. Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. Cherry AD, etal., J Biol Chem. 2014 Jan 3;289(1):41-52. doi: 10.1074/jbc.M113.512483. Epub 2013 Nov 19.
15. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Comhair SA, etal., Am J Pathol. 2005 Mar;166(3):663-74.
16. Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Connor KM, etal., Cancer Res. 2007 Nov 1;67(21):10260-7.
17. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
18. Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Cullen JJ, etal., Pancreas. 2003 Jan;26(1):23-7.
19. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
20. Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Dhar SK, etal., Cancer Res. 2011 Nov 1;71(21):6684-95. doi: 10.1158/0008-5472.CAN-11-1233. Epub 2011 Oct 18.
21. iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer. Ding F, etal., Int J Biol Markers. 2019 Sep;34(3):221-231. doi: 10.1177/1724600819841619. Epub 2019 May 1.
22. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
23. Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. Flekac M, etal., BMC Med Genet. 2008 Apr 21;9:30.
24. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Fortunato G, etal., Clin Chem. 2004 Nov;50(11):2012-8. Epub 2004 Sep 2.
25. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. Friedman JS, etal., J Exp Med. 2001 Apr 16;193(8):925-34.
26. Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. Fujimoto K, etal., Toxicol Pathol. 2009 Feb;37(2):193-200. doi: 10.1177/0192623308329282.
27. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Fujimura M, etal., J Neurosci. 1999 May 1;19(9):3414-22.
28. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
29. Manganese superoxide dismutase gene (SOD2) polymorphism and exudative age-related macular degeneration in the Japanese population. Gotoh N, etal., Am J Ophthalmol. 2008 Jul;146(1):146; author reply 146-7. doi: 10.1016/j.ajo.2008.03.017.
30. Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway. Guo S, etal., Eur J Pharmacol. 2019 Apr 15;849:50-58. doi: 10.1016/j.ejphar.2019.01.057. Epub 2019 Feb 1.
31. Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. Hakenewerth AM, etal., Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2438-49. doi: 10.1158/1055-9965.EPI-11-0649. Epub 2011 Sep 22.
32. MnSOD antisense treatment and exercise-induced protection against arrhythmias. Hamilton KL, etal., Free Radic Biol Med. 2004 Nov 1;37(9):1360-8.
33. RORalpha decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Han YH, etal., Antioxid Redox Signal. 2014 Nov 20;21(15):2083-94. doi: 10.1089/ars.2013.5655. Epub 2014 Apr 10.
34. Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues. Heine C, etal., Biochem J. 2003 Dec 1;376(Pt 2):369-76.
35. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Hiroi S, etal., Biochem Biophys Res Commun. 1999 Aug 2;261(2):332-9.
36. Molecular structure of a functional rat gene for manganese-containing superoxide dismutase. Ho YS, etal., Am J Respir Cell Mol Biol 1991 Mar;4(3):278-86.
37. Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation. Hodge DR, etal., Cancer Biol Ther. 2005 May;4(5):585-92. Epub 2005 May 5.
38. Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma. Holla LI, etal., Clin Biochem. 2006 Mar;39(3):299-302. Epub 2006 Jan 19.
39. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. Hu Y, etal., J Biol Chem. 2005 Nov 25;280(47):39485-92. Epub 2005 Sep 22.
40. MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. Huang C, etal., BMC Med Genomics. 2014 Jul 28;7:46. doi: 10.1186/1755-8794-7-46.
41. Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice. Huang TT, etal., Free Radic Biol Med. 2001 Nov 1;31(9):1101-10.
42. Superoxide Dismutase 2 Genetic Variation as a Susceptibility Risk Factor for Alcoholic Cirrhosis. Huang YS, etal., Alcohol Alcohol. 2016 Feb 11. pii: agw004.
43. Genetic variations of superoxide dismutase 2 and cytochrome P450 2E1 in non-alcoholic steatohepatitis. Huang YS, etal., Liver Int. 2014 Jul;34(6):931-6. doi: 10.1111/liv.12533. Epub 2014 Apr 4.
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PMID:21574139   PMID:21619820   PMID:21619840   PMID:21725155   PMID:21727734   PMID:21741706   PMID:21756849   PMID:21773993   PMID:21781513   PMID:21804600   PMID:21829032   PMID:21832049  
PMID:21873635   PMID:21904836   PMID:21988832   PMID:22070905   PMID:22089180   PMID:22108257   PMID:22119635   PMID:22167619   PMID:22170599   PMID:22171130   PMID:22193621   PMID:22206979  
PMID:22218650   PMID:22261313   PMID:22302046   PMID:22330623   PMID:22348527   PMID:22386763   PMID:22429591   PMID:22432908   PMID:22516022   PMID:22517484   PMID:22537351   PMID:22547077  
PMID:22561997   PMID:22580338   PMID:22688013   PMID:22699057   PMID:22704671   PMID:22705344   PMID:22710435   PMID:22710948   PMID:22738689   PMID:22825700   PMID:22829583   PMID:22939629  
PMID:22958044   PMID:22959522   PMID:22972774   PMID:22983815   PMID:23030347   PMID:23033381   PMID:23056314   PMID:23111423   PMID:23138846   PMID:23142385   PMID:23167810   PMID:23168492  
PMID:23212700   PMID:23219743   PMID:23221071   PMID:23237540   PMID:23271813   PMID:23289810   PMID:23315858   PMID:23333304   PMID:23376485   PMID:23500038   PMID:23533145   PMID:23581847  
PMID:23583431   PMID:23588476   PMID:23590434   PMID:23611775   PMID:23620962   PMID:23647424   PMID:23649652   PMID:23679296   PMID:23685312   PMID:23706068   PMID:23725507   PMID:23744526  
PMID:23761047   PMID:23771908   PMID:23773345   PMID:23784082   PMID:23792044   PMID:23834335   PMID:23873331   PMID:23886214   PMID:23928928   PMID:23952573   PMID:23956348   PMID:23964924  
PMID:23990443   PMID:23991909   PMID:24035474   PMID:24037914   PMID:24070129   PMID:24074040   PMID:24119114   PMID:24146173   PMID:24155217   PMID:24161595   PMID:24164232   PMID:24186266  
PMID:24212762   PMID:24219772   PMID:24248464   PMID:24301773   PMID:24448804   PMID:24462872   PMID:24483941   PMID:24498107   PMID:24511533   PMID:24517502   PMID:24529564   PMID:24586301  
PMID:24610415   PMID:24626613   PMID:24651439   PMID:24658925   PMID:24667176   PMID:24667918   PMID:24700636   PMID:24716840   PMID:24736663   PMID:24811984   PMID:24817295   PMID:24819633  
PMID:24865797   PMID:24919441   PMID:24939178   PMID:24953189   PMID:24981860   PMID:24984152   PMID:25039350   PMID:25140979   PMID:25171019   PMID:25224035   PMID:25283363   PMID:25295643  
PMID:25372290   PMID:25388628   PMID:25400754   PMID:25417767   PMID:25430642   PMID:25449296   PMID:25484013   PMID:25497738   PMID:25499851   PMID:25550558   PMID:25619900   PMID:25651975  
PMID:25659582   PMID:25662905   PMID:25684475   PMID:25753816   PMID:25818327   PMID:25858271   PMID:25866291   PMID:25889634   PMID:25894370   PMID:25916115   PMID:25931357   PMID:25933618  
PMID:25948732   PMID:25958349   PMID:26028649   PMID:26120888   PMID:26123268   PMID:26130326   PMID:26137231   PMID:26147925   PMID:26186194   PMID:26208779   PMID:26225747   PMID:26241492  
PMID:26302379   PMID:26344197   PMID:26345792   PMID:26350743   PMID:26351775   PMID:26356408   PMID:26356721   PMID:26359457   PMID:26373864   PMID:26384137   PMID:26388666   PMID:26396584  
PMID:26400460   PMID:26426434   PMID:26436888   PMID:26439801   PMID:26443543   PMID:26446998   PMID:26468117   PMID:26490979   PMID:26505452   PMID:26516986   PMID:26528342   PMID:26535076  
PMID:26535703   PMID:26543228   PMID:26544677   PMID:26558285   PMID:26585352   PMID:26586994   PMID:26596112   PMID:26596265   PMID:26608808   PMID:26608886   PMID:26616112   PMID:26628947  
PMID:26631723   PMID:26636131   PMID:26637092   PMID:26646027   PMID:26664298   PMID:26671656   PMID:26674599   PMID:26674755   PMID:26678158   PMID:26678800   PMID:26679105   PMID:26696693  
PMID:26707081   PMID:26718428   PMID:26754536   PMID:26762997   PMID:26765960   PMID:26770138   PMID:26781513   PMID:26785339   PMID:26787049   PMID:26790968   PMID:26794818   PMID:26821085  
PMID:26823946   PMID:26823947   PMID:26846100   PMID:26847304   PMID:26854822   PMID:26856867   PMID:26857738   PMID:26867320   PMID:26874034   PMID:26881032   PMID:26881045   PMID:26881079  
PMID:26882122   PMID:26885102   PMID:26891959   PMID:26895301   PMID:26898144   PMID:26899340   PMID:26899469   PMID:26906415   PMID:26935174   PMID:26937962   PMID:26940444   PMID:26941203  
PMID:26942626   PMID:26950655   PMID:26957268   PMID:26958937   PMID:26965314   PMID:26970173   PMID:26981165   PMID:26981780   PMID:27021683   PMID:27023521   PMID:27037373   PMID:27055786  
PMID:27057281   PMID:27060086   PMID:27064125   PMID:27067415   PMID:27083052   PMID:27100222   PMID:27107014   PMID:27131313   PMID:27132285   PMID:27161188   PMID:27181103   PMID:27188866  
PMID:27384484   PMID:27534583   PMID:27555600   PMID:27630759   PMID:27751366   PMID:27829319   PMID:27923686   PMID:27925431   PMID:27999194   PMID:28040123   PMID:28087256   PMID:28108513  
PMID:28179340   PMID:28222320   PMID:28272301   PMID:28368283   PMID:28457881   PMID:28461152   PMID:28482710   PMID:28512644   PMID:28514442   PMID:28524877   PMID:28552711   PMID:28567457  
PMID:28574756   PMID:28587495   PMID:28616679   PMID:28655148   PMID:28658993   PMID:28704037   PMID:28711502   PMID:28801561   PMID:28841898   PMID:28925482   PMID:29046499   PMID:29047081  
PMID:29109056   PMID:29117863   PMID:29180619   PMID:29459008   PMID:29482947   PMID:29550484   PMID:29658251   PMID:29684818   PMID:29745991   PMID:29859283   PMID:29914010   PMID:29936984  
PMID:29953407   PMID:29972711   PMID:30063213   PMID:30107294   PMID:30111255   PMID:30150066   PMID:30165401   PMID:30192404   PMID:30193891   PMID:30217947   PMID:30225256   PMID:30242560  
PMID:30245752   PMID:30358222   PMID:30412732   PMID:30485823   PMID:30529301   PMID:30536754   PMID:30574618   PMID:30600457   PMID:30607774   PMID:30633320   PMID:30736780   PMID:30839355  
PMID:30884312   PMID:30896828   PMID:30975468   PMID:31098737   PMID:31160585   PMID:31189433   PMID:31212050   PMID:31228093   PMID:31340563   PMID:31364751   PMID:31382611   PMID:31415712  
PMID:31470840   PMID:31494578   PMID:31506286   PMID:31512047   PMID:31524543   PMID:31536960   PMID:31591207   PMID:31601079   PMID:31812668   PMID:31861522   PMID:31891227   PMID:31929112  
PMID:32031754   PMID:32149414   PMID:32296183   PMID:32539644   PMID:32620460   PMID:32664606   PMID:32694731   PMID:32707033   PMID:32709094   PMID:32730806   PMID:32885455   PMID:32889510  
PMID:33009206   PMID:33124528   PMID:33234142   PMID:33264651   PMID:33338479   PMID:33359244   PMID:33435582   PMID:33586574   PMID:33646985   PMID:33680286   PMID:33824320   PMID:33924242  
PMID:33961781   PMID:33989902   PMID:34077295   PMID:34090432   PMID:34364045   PMID:34373451   PMID:34387669   PMID:34681918   PMID:34758947   PMID:34800366   PMID:34808498   PMID:34958669  
PMID:34959097   PMID:35029920   PMID:35145273   PMID:35164076   PMID:35213938   PMID:35253629   PMID:35266053   PMID:35274104   PMID:35337019   PMID:35361071   PMID:35426339   PMID:35580464  
PMID:35594792   PMID:35831314   PMID:35858297   PMID:36008700   PMID:36010644   PMID:36037114   PMID:36074229   PMID:36100117   PMID:36215168   PMID:36229195   PMID:36295574   PMID:36356830  
PMID:36676755   PMID:36811699   PMID:37175412   PMID:37253908   PMID:37312219   PMID:37405601   PMID:37660159   PMID:37698290   PMID:37921754   PMID:38039740   PMID:38154571   PMID:38310354  
PMID:38375721   PMID:38404215   PMID:38412803   PMID:39013847   PMID:39038402   PMID:39238192  


Genomics

Comparative Map Data
SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)EnsemblGRCm39 Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBIMGSCv36mm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,778,227 - 179,792,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,683,324 - 177,697,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,785,674 - 49,797,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,127,570 - 49,139,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,020,475 - 49,139,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,010,294 - 49,022,236 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,881,250 - 48,893,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,447,616 - 49,459,607 (-)NCBIUU_Cfam_GSD_1.0
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,178,015 - 11,191,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,679,352 - 7,689,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,683,827 - 59,727,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,260,809 - 3,271,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOD2
37 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000636.4(SOD2):c.47T>C (p.Val16Ala) single nucleotide variant Microvascular complications of diabetes, susceptibility to, 6 [RCV000015873]|SUPEROXIDE DISMUTASE 2 POLYMORPHISM [RCV000015872] Chr6:159692840 [GRCh38]
Chr6:160113872 [GRCh37]
Chr6:6q25.3		 risk factor|likely risk allele|benign|drug response
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3(chr6:157827805-159726548)x3 copy number gain See cases [RCV000051903] Chr6:157827805..159726548 [GRCh38]
Chr6:158248837..160147580 [GRCh37]
Chr6:158168825..160067570 [NCBI36]
Chr6:6q25.3		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:158664768-170612001)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|See cases [RCV000051904] Chr6:158664768..170612001 [GRCh38]
Chr6:159085800..170921089 [GRCh37]
Chr6:159005788..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159454639-170612001)x1 copy number loss See cases [RCV000052209] Chr6:159454639..170612001 [GRCh38]
Chr6:159875671..170921089 [GRCh37]
Chr6:159795661..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-26(chr6:155378049-163133499)x1 copy number loss See cases [RCV000137831] Chr6:155378049..163133499 [GRCh38]
Chr6:155699183..163554531 [GRCh37]
Chr6:155740875..163474521 [NCBI36]
Chr6:6q25.3-26		 pathogenic
GRCh38/hg38 6q25.3(chr6:159598794-159726489)x3 copy number gain See cases [RCV000140321] Chr6:159598794..159726489 [GRCh38]
Chr6:160019826..160147521 [GRCh37]
Chr6:159939816..160067511 [NCBI36]
Chr6:6q25.3		 likely benign
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27		 pathogenic
GRCh38/hg38 6q25.3-26(chr6:158585724-160899783)x3 copy number gain See cases [RCV000143618] Chr6:158585724..160899783 [GRCh38]
Chr6:159006756..161320815 [GRCh37]
Chr6:158926744..161240805 [NCBI36]
Chr6:6q25.3-26		 uncertain significance
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_000636.4(SOD2):c.656C>T (p.Ala219Val) single nucleotide variant not specified [RCV004321522] Chr6:159682506 [GRCh38]
Chr6:160103538 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.3-27(chr6:159844762-170919482)x3 copy number gain not provided [RCV000682734] Chr6:159844762..170919482 [GRCh37]
Chr6:6q25.3-27		 pathogenic
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:159155998-171054786)x3 copy number gain not provided [RCV000746132] Chr6:159155998..171054786 [GRCh37]
Chr6:6q25.3-27		 pathogenic
NM_000636.4(SOD2):c.579T>C (p.Tyr193=) single nucleotide variant not provided [RCV000927372] Chr6:159682583 [GRCh38]
Chr6:160103615 [GRCh37]
Chr6:6q25.3		 benign|likely benign
GRCh37/hg19 6q25.3(chr6:157262571-160992289)x3 copy number gain not provided [RCV000848057] Chr6:157262571..160992289 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q24.3-25.3(chr6:148195086-160127254)x3 copy number gain not provided [RCV000846496] Chr6:148195086..160127254 [GRCh37]
Chr6:6q24.3-25.3		 pathogenic
GRCh37/hg19 6q25.3(chr6:160025206-160271483)x1 copy number loss not provided [RCV000846782] Chr6:160025206..160271483 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.3-27(chr6:159006336-170713678)x3 copy number gain not provided [RCV003312672] Chr6:159006336..170713678 [GRCh37]
Chr6:6q25.3-27		 uncertain significance
GRCh37/hg19 6q25.3(chr6:160043162-160195268)x1 copy number loss not provided [RCV000845652] Chr6:160043162..160195268 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.216G>A (p.Ala72=) single nucleotide variant not provided [RCV000912324] Chr6:159692671 [GRCh38]
Chr6:160113703 [GRCh37]
Chr6:6q25.3		 benign
GRCh37/hg19 6q25.3(chr6:159998877-160413982)x3 copy number gain not provided [RCV001258756] Chr6:159998877..160413982 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.367A>G (p.Lys123Glu) single nucleotide variant not specified [RCV004685620] Chr6:159748284 [GRCh38]
Chr6:160169316 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.1087C>G (p.Gln363Glu) single nucleotide variant not specified [RCV004688796] Chr6:159755507 [GRCh38]
Chr6:160176539 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.542G>T (p.Gly181Val) single nucleotide variant not provided [RCV001260971] Chr6:159682620 [GRCh38]
Chr6:160103652 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.2-26(chr6:153207930-164322346) copy number loss not specified [RCV002053640] Chr6:153207930..164322346 [GRCh37]
Chr6:6q25.2-26		 pathogenic
NC_000006.11:g.(?_158532398)_(160114199_?)dup duplication Primary ciliary dyskinesia 32 [RCV001934131] Chr6:158532398..160114199 [GRCh37]
Chr6:6q25.3		 uncertain significance
NC_000006.11:g.(?_158532398)_(162868359_?)del deletion 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome [RCV003122912]|not provided [RCV003122911] Chr6:158532398..162868359 [GRCh37]
Chr6:6q25.3-26		 pathogenic|no classifications from unflagged records
GRCh37/hg19 6q25.3-27(chr6:159121459-170919482) copy number loss Hydrocephalus [RCV002280751] Chr6:159121459..170919482 [GRCh37]
Chr6:6q25.3-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:157318401-165233548)x1 copy number loss See cases [RCV002287557] Chr6:157318401..165233548 [GRCh37]
Chr6:6q25.3-27		 pathogenic
NM_000636.4(SOD2):c.633G>T (p.Glu211Asp) single nucleotide variant not specified [RCV004142793] Chr6:159682529 [GRCh38]
Chr6:160103561 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.550G>A (p.Val184Met) single nucleotide variant not specified [RCV004182302] Chr6:159682612 [GRCh38]
Chr6:160103644 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.412G>T (p.Ala138Ser) single nucleotide variant not specified [RCV004131923] Chr6:159684965 [GRCh38]
Chr6:160105997 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.346G>C (p.Glu116Gln) single nucleotide variant not specified [RCV004209410] Chr6:159685031 [GRCh38]
Chr6:160106063 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.631G>A (p.Glu211Lys) single nucleotide variant not specified [RCV004095340] Chr6:159682531 [GRCh38]
Chr6:160103563 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.424G>T (p.Val142Phe) single nucleotide variant not specified [RCV004205409] Chr6:159684953 [GRCh38]
Chr6:160105985 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.311G>C (p.Ser104Thr) single nucleotide variant not specified [RCV004202353] Chr6:159748228 [GRCh38]
Chr6:160169260 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.182A>C (p.Asn61Thr) single nucleotide variant not specified [RCV004121664] Chr6:159692705 [GRCh38]
Chr6:160113737 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.467G>A (p.Arg156Gln) single nucleotide variant not specified [RCV004081755] Chr6:159684910 [GRCh38]
Chr6:160105942 [GRCh37]
Chr6:6q25.3		 likely benign
NM_000636.4(SOD2):c.113T>A (p.Leu38Gln) single nucleotide variant not specified [RCV004154479] Chr6:159692774 [GRCh38]
Chr6:160113806 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.230A>T (p.Asp77Val) single nucleotide variant not specified [RCV004105592] Chr6:159688239 [GRCh38]
Chr6:160109271 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.850C>T (p.Arg284Cys) single nucleotide variant not specified [RCV004244455] Chr6:159755270 [GRCh38]
Chr6:160176302 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.369A>T (p.Lys123Asn) single nucleotide variant not specified [RCV004134665] Chr6:159748286 [GRCh38]
Chr6:160169318 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.790G>A (p.Glu264Lys) single nucleotide variant not specified [RCV004187344] Chr6:159755210 [GRCh38]
Chr6:160176242 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.793G>A (p.Ala265Thr) single nucleotide variant not specified [RCV004080280] Chr6:159755213 [GRCh38]
Chr6:160176245 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.791A>G (p.Glu264Gly) single nucleotide variant not specified [RCV004187345] Chr6:159755211 [GRCh38]
Chr6:160176243 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.2-27(chr6:152853218-170914297)x1 copy number loss See cases [RCV004442824] Chr6:152853218..170914297 [GRCh37]
Chr6:6q25.2-27		 pathogenic
NM_000636.4(SOD2):c.365A>T (p.Lys122Ile) single nucleotide variant not specified [RCV004464807] Chr6:159685012 [GRCh38]
Chr6:160106044 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.367C>T (p.Arg123Cys) single nucleotide variant not specified [RCV004464808] Chr6:159685010 [GRCh38]
Chr6:160106042 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.860C>T (p.Thr287Met) single nucleotide variant not specified [RCV004483248] Chr6:159755280 [GRCh38]
Chr6:160176312 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.131C>G (p.Ala44Gly) single nucleotide variant not specified [RCV004464806] Chr6:159692756 [GRCh38]
Chr6:160113788 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.371A>T (p.Asp124Val) single nucleotide variant not specified [RCV004464809] Chr6:159685006 [GRCh38]
Chr6:160106038 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.399G>C (p.Glu133Asp) single nucleotide variant not specified [RCV004464810] Chr6:159684978 [GRCh38]
Chr6:160106010 [GRCh37]
Chr6:6q25.3		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR222hsa-miR-222-3pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Microarray//qRT-PFunctional MTI19487542
MIR17hsa-miR-17-3pMirtarbaseexternal_infoLuciferase reporter assay//Quantitative proteomic Functional MTI21203553
MIR17hsa-miR-17-3pOncomiRDBexternal_infoNANA21203553

Predicted Target Of
Summary Value
Count of predictions:7946
Count of miRNA genes:1429
Interacting mature miRNAs:1920
Transcripts:ENST00000337404, ENST00000367054, ENST00000367055, ENST00000401980, ENST00000444946, ENST00000452684, ENST00000535372, ENST00000535459, ENST00000535561, ENST00000537657, ENST00000538183, ENST00000540491, ENST00000541573, ENST00000545162, ENST00000546087, ENST00000546260
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407125732GWAS774708_Hiron biomarker measurement QTL GWAS774708 (human)0.000001iron biomarker measurement6159716655159716656Human
407314885GWAS963861_Hlipoprotein A measurement QTL GWAS963861 (human)3e-26lipoprotein A measurement6159735912159735913Human
407041222GWAS690198_Hphospholipids in chylomicrons and extremely large VLDL measurement QTL GWAS690198 (human)4e-10phospholipids in chylomicrons and extremely large VLDL measurement 6159672855159672856Human
407088679GWAS737655_Hprostate carcinoma QTL GWAS737655 (human)0.000006prostate carcinoma6159729247159729248Human
407040999GWAS689975_Hconcentration of chylomicrons and extremely large VLDL particles measurement QTL GWAS689975 (human)6e-10concentration of chylomicrons and extremely large VLDL particles measurement 6159672855159672856Human
407041575GWAS690551_Hfree cholesterol in chylomicrons and extremely large VLDL measurement QTL GWAS690551 (human)1e-09free cholesterol in chylomicrons and extremely large VLDL measurement 6159672855159672856Human
407314658GWAS963634_Hlipoprotein A measurement QTL GWAS963634 (human)8e-32lipoprotein A measurement6159758748159758749Human
407038532GWAS687508_Htriglycerides in chylomicrons and extremely large VLDL measurement QTL GWAS687508 (human)1e-11triglycerides in chylomicrons and extremely large VLDL measurement 6159672855159672856Human
406933352GWAS582328_Hprostate carcinoma QTL GWAS582328 (human)4e-13prostate carcinoma6159728430159728431Human
407221580GWAS870556_Heducational attainment QTL GWAS870556 (human)4e-12educational attainment6159727316159727317Human
407204458GWAS853434_Hprostate carcinoma QTL GWAS853434 (human)0.0000001prostate carcinoma6159727316159727317Human
407314645GWAS963621_Hlipoprotein A measurement QTL GWAS963621 (human)2e-42lipoprotein A measurement6159728147159728148Human
407311571GWAS960547_Hlipoprotein A measurement QTL GWAS960547 (human)2e-46lipoprotein A measurement6159678944159678945Human
1643404BMD3_HBone mineral density QTL 3 (human)2.420.0005Bone mineral density6157563614170805979Human
407038391GWAS687367_Htotal lipids in chylomicrons and extremely large VLDL measurement QTL GWAS687367 (human)6e-11total lipids in chylomicrons and extremely large VLDL measurement 6159672855159672856Human
407190067GWAS839043_Hglomerular filtration rate QTL GWAS839043 (human)2e-09glomerular filtration rateglomerular filtration rate (CMO:0000490)6159672855159672856Human
407361073GWAS1010049_Hage at menopause QTL GWAS1010049 (human)8e-08age at menopause6159699767159699768Human
407309118GWAS958094_Hlipoprotein A measurement QTL GWAS958094 (human)2e-20lipoprotein A measurement6159701269159701270Human
407086297GWAS735273_Hprostate carcinoma QTL GWAS735273 (human)5e-18prostate carcinoma6159728430159728431Human
407314652GWAS963628_Hlipoprotein A measurement QTL GWAS963628 (human)6e-36lipoprotein A measurement6159694422159694423Human
407314075GWAS963051_Hlipoprotein A measurement QTL GWAS963051 (human)9e-10lipoprotein A measurement6159745858159745859Human
1643367BW323_HBody weight QTL 323 (human)2.420.0005Body fat amount6157563614170805979Human
407086940GWAS735916_Hprostate carcinoma QTL GWAS735916 (human)3e-16prostate carcinoma6159729247159729248Human
407134971GWAS783947_Hself reported educational attainment QTL GWAS783947 (human)3e-08self reported educational attainment6159670804159670805Human

Markers in Region
STS-W78148  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,100,257 - 160,100,414UniSTSGRCh37
Build 366160,020,247 - 160,020,404RGDNCBI36
Celera6160,747,710 - 160,747,867RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,570,693 - 157,570,850UniSTS
GeneMap99-GB4 RH Map6618.21UniSTS
D6S1419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,200 - 160,103,524UniSTSGRCh37
Build 366160,023,190 - 160,023,514RGDNCBI36
Celera6160,750,653 - 160,750,977RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,573,636 - 157,573,960UniSTS
TNG Radiation Hybrid Map680117.0UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
Whitehead-YAC Contig Map6 UniSTS
NCBI RH Map61631.6UniSTS
GeneMap99-G3 RH Map66671.0UniSTS
D6S1335  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,412 - 160,103,588UniSTSGRCh37
Build 366160,023,402 - 160,023,578RGDNCBI36
Celera6160,750,865 - 160,751,041RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,573,848 - 157,574,024UniSTS
Whitehead-YAC Contig Map6 UniSTS
SHGC-34268  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,102,238 - 160,102,387UniSTSGRCh37
Build 366160,022,228 - 160,022,377RGDNCBI36
Celera6160,749,691 - 160,749,840RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,572,674 - 157,572,823UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
Whitehead-RH Map6830.6UniSTS
NCBI RH Map61636.2UniSTS
GeneMap99-G3 RH Map66664.0UniSTS
RH16462  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,102,239 - 160,102,362UniSTSGRCh37
Build 366160,022,229 - 160,022,352RGDNCBI36
Celera6160,749,692 - 160,749,815RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,572,675 - 157,572,798UniSTS
GeneMap99-GB4 RH Map6619.81UniSTS
NCBI RH Map61624.4UniSTS
SOD2_3060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,010 - 160,103,635UniSTSGRCh37
Build 366160,023,000 - 160,023,625RGDNCBI36
Celera6160,750,463 - 160,751,088RGD
HuRef6157,573,446 - 157,574,071UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2256 4980 1729 2354 6 627 2075 468 2269 7438 6598 53 3741 1 854 1756 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001024465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001024466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA126703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL050388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV658055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY267901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY397775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG699596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM724413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM994509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP289103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU164685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU741675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD367203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA041701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA094180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA318772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ003134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC484629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC484966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC484967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000337404   ⟹   ENSP00000337127
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,165 - 159,693,278 (-)Ensembl
Ensembl Acc Id: ENST00000367054   ⟹   ENSP00000356021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,116 - 159,693,228 (-)Ensembl
Ensembl Acc Id: ENST00000367055   ⟹   ENSP00000356022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,064 - 159,693,234 (-)Ensembl
Ensembl Acc Id: ENST00000401980   ⟹   ENSP00000384196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,939 - 159,727,353 (-)Ensembl
Ensembl Acc Id: ENST00000444946   ⟹   ENSP00000404804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,139 - 159,693,241 (-)Ensembl
Ensembl Acc Id: ENST00000452684   ⟹   ENSP00000406713
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,690,919 - 159,693,244 (-)Ensembl
Ensembl Acc Id: ENST00000535459
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,461 - 159,688,348 (-)Ensembl
Ensembl Acc Id: ENST00000535561   ⟹   ENSP00000445015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,896 - 159,726,944 (-)Ensembl
Ensembl Acc Id: ENST00000537657   ⟹   ENSP00000439191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,904 - 159,745,186 (-)Ensembl
Ensembl Acc Id: ENST00000538183   ⟹   ENSP00000446252
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,669,069 - 159,693,241 (-)Ensembl
Ensembl Acc Id: ENST00000540491
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,610 - 159,692,650 (-)Ensembl
Ensembl Acc Id: ENST00000541573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,482 - 159,692,078 (-)Ensembl
Ensembl Acc Id: ENST00000545162   ⟹   ENSP00000441362
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,875 - 159,727,357 (-)Ensembl
Ensembl Acc Id: ENST00000546087   ⟹   ENSP00000442920
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,119 - 159,762,529 (-)Ensembl
Ensembl Acc Id: ENST00000546260   ⟹   ENSP00000440131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,064 - 159,693,241 (-)Ensembl
RefSeq Acc Id: NM_000636   ⟹   NP_000627
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,022,745 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001024465   ⟹   NP_001019636
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,020,138 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,924,915 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001024466   ⟹   NP_001019637
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,020,138 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,924,915 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322814   ⟹   NP_001309743
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322815   ⟹   NP_001309744
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322816   ⟹   NP_001309745
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,690,919 - 159,693,241 (-)NCBI
CHM1_16160,374,828 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,936,763 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322817   ⟹   NP_001309746
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,762,281 (-)NCBI
CHM1_16160,362,979 - 160,445,890 (-)NCBI
T2T-CHM13v2.06160,924,915 - 161,007,912 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322819   ⟹   NP_001309748
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,727,384 (-)NCBI
CHM1_16160,362,979 - 160,410,735 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,973,013 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322820   ⟹   NP_001309749
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,726,950 (-)NCBI
CHM1_16160,362,979 - 160,410,324 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,972,579 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000627 (Get FASTA)   NCBI Sequence Viewer  
  NP_001019636 (Get FASTA)   NCBI Sequence Viewer  
  NP_001019637 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309743 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309744 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309745 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309746 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309748 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36622 (Get FASTA)   NCBI Sequence Viewer  
  AAA83933 (Get FASTA)   NCBI Sequence Viewer  
  AAC15835 (Get FASTA)   NCBI Sequence Viewer  
  AAD14248 (Get FASTA)   NCBI Sequence Viewer  
  AAH12423 (Get FASTA)   NCBI Sequence Viewer  
  AAH16934 (Get FASTA)   NCBI Sequence Viewer  
  AAP03428 (Get FASTA)   NCBI Sequence Viewer  
  AAP34407 (Get FASTA)   NCBI Sequence Viewer  
  AAP34408 (Get FASTA)   NCBI Sequence Viewer  
  AAP34409 (Get FASTA)   NCBI Sequence Viewer  
  AAP34410 (Get FASTA)   NCBI Sequence Viewer  
  AAP35613 (Get FASTA)   NCBI Sequence Viewer  
  AAY21807 (Get FASTA)   NCBI Sequence Viewer  
  ADO22403 (Get FASTA)   NCBI Sequence Viewer  
  BAA18955 (Get FASTA)   NCBI Sequence Viewer  
  BAG35908 (Get FASTA)   NCBI Sequence Viewer  
  BAG53464 (Get FASTA)   NCBI Sequence Viewer  
  BAG59382 (Get FASTA)   NCBI Sequence Viewer  
  BAG65521 (Get FASTA)   NCBI Sequence Viewer  
  BBK63514 (Get FASTA)   NCBI Sequence Viewer  
  BBK63515 (Get FASTA)   NCBI Sequence Viewer  
  BBK63516 (Get FASTA)   NCBI Sequence Viewer  
  BBK63517 (Get FASTA)   NCBI Sequence Viewer  
  BBK63518 (Get FASTA)   NCBI Sequence Viewer  
  BBK63519 (Get FASTA)   NCBI Sequence Viewer  
  BBK63568 (Get FASTA)   NCBI Sequence Viewer  
  BBK63569 (Get FASTA)   NCBI Sequence Viewer  
  CAA30687 (Get FASTA)   NCBI Sequence Viewer  
  CAA32502 (Get FASTA)   NCBI Sequence Viewer  
  CAA33228 (Get FASTA)   NCBI Sequence Viewer  
  CAA42066 (Get FASTA)   NCBI Sequence Viewer  
  CAA68533 (Get FASTA)   NCBI Sequence Viewer  
  CAA68791 (Get FASTA)   NCBI Sequence Viewer  
  CAB62521 (Get FASTA)   NCBI Sequence Viewer  
  EAW47629 (Get FASTA)   NCBI Sequence Viewer  
  EAW47630 (Get FASTA)   NCBI Sequence Viewer  
  EAW47631 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000337127
  ENSP00000337127.4
  ENSP00000356021
  ENSP00000356021.2
  ENSP00000356022
  ENSP00000356022.4
  ENSP00000384196.3
  ENSP00000404804
  ENSP00000404804.2
  ENSP00000406713
  ENSP00000406713.2
  ENSP00000439191.1
  ENSP00000440131.1
  ENSP00000441362.1
  ENSP00000442920
  ENSP00000442920.1
  ENSP00000445015.1
  ENSP00000446252
  ENSP00000446252.1
GenBank Protein P04179 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019637   ⟸   NM_001024466
- Peptide Label: isoform B
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001019636   ⟸   NM_001024465
- Peptide Label: isoform A precursor
- UniProtKB: Q96EE6 (UniProtKB/Swiss-Prot),   Q5TCM1 (UniProtKB/Swiss-Prot),   Q16792 (UniProtKB/Swiss-Prot),   P78434 (UniProtKB/Swiss-Prot),   E1P5A9 (UniProtKB/Swiss-Prot),   B4E3K9 (UniProtKB/Swiss-Prot),   B4DL20 (UniProtKB/Swiss-Prot),   B3KUK2 (UniProtKB/Swiss-Prot),   B2R7R1 (UniProtKB/Swiss-Prot),   Q9P2Z3 (UniProtKB/Swiss-Prot),   P04179 (UniProtKB/Swiss-Prot),   A0A384NL29 (UniProtKB/TrEMBL),   Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000627   ⟸   NM_000636
- Peptide Label: isoform A precursor
- UniProtKB: Q96EE6 (UniProtKB/Swiss-Prot),   Q5TCM1 (UniProtKB/Swiss-Prot),   Q16792 (UniProtKB/Swiss-Prot),   P78434 (UniProtKB/Swiss-Prot),   E1P5A9 (UniProtKB/Swiss-Prot),   B4E3K9 (UniProtKB/Swiss-Prot),   B4DL20 (UniProtKB/Swiss-Prot),   B3KUK2 (UniProtKB/Swiss-Prot),   B2R7R1 (UniProtKB/Swiss-Prot),   Q9P2Z3 (UniProtKB/Swiss-Prot),   P04179 (UniProtKB/Swiss-Prot),   A0A384NL29 (UniProtKB/TrEMBL),   Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309746   ⟸   NM_001322817
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309748   ⟸   NM_001322819
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309749   ⟸   NM_001322820
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309743   ⟸   NM_001322814
- Peptide Label: isoform B
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309744   ⟸   NM_001322815
- Peptide Label: isoform C precursor
- UniProtKB: P04179 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001309745   ⟸   NM_001322816
- Peptide Label: isoform D
- UniProtKB: G5E9P6 (UniProtKB/TrEMBL),   Q96AM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000406713   ⟸   ENST00000452684
Ensembl Acc Id: ENSP00000441362   ⟸   ENST00000545162
Ensembl Acc Id: ENSP00000440131   ⟸   ENST00000546260
Ensembl Acc Id: ENSP00000442920   ⟸   ENST00000546087
Ensembl Acc Id: ENSP00000337127   ⟸   ENST00000337404
Ensembl Acc Id: ENSP00000384196   ⟸   ENST00000401980
Ensembl Acc Id: ENSP00000445015   ⟸   ENST00000535561
Ensembl Acc Id: ENSP00000404804   ⟸   ENST00000444946
Ensembl Acc Id: ENSP00000439191   ⟸   ENST00000537657
Ensembl Acc Id: ENSP00000446252   ⟸   ENST00000538183
Ensembl Acc Id: ENSP00000356021   ⟸   ENST00000367054
Ensembl Acc Id: ENSP00000356022   ⟸   ENST00000367055
Protein Domains
Manganese/iron superoxide dismutase C-terminal   Manganese/iron superoxide dismutase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04179-F1-model_v2 AlphaFold P04179 1-222 view protein structure

Promoters
RGD ID:7209571
Promoter ID:EPDNEW_H10531
Type:initiation region
Name:SOD2_5
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,681,587 - 159,681,647EPDNEW
RGD ID:7209573
Promoter ID:EPDNEW_H10532
Type:initiation region
Name:SOD2_4
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,684,934 - 159,684,994EPDNEW
RGD ID:7209575
Promoter ID:EPDNEW_H10533
Type:initiation region
Name:SOD2_6
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,688,188 - 159,688,248EPDNEW
RGD ID:7209577
Promoter ID:EPDNEW_H10534
Type:initiation region
Name:SOD2_1
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,693,241 - 159,693,301EPDNEW
RGD ID:7209579
Promoter ID:EPDNEW_H10536
Type:initiation region
Name:SOD2_3
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,726,950 - 159,727,010EPDNEW
RGD ID:7209585
Promoter ID:EPDNEW_H10538
Type:initiation region
Name:SOD2_2
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,355 - 159,727,415EPDNEW
RGD ID:6804814
Promoter ID:HG_KWN:55651
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_000636,   NM_001024466,   OTTHUMT00000042922,   UC003QSJ.2
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,034,176 - 160,034,747 (-)MPROMDB
RGD ID:6851922
Promoter ID:EP73767
Type:initiation region
Name:HS_SOD2
Description:Superoxide dismutase 2, mitochondrial.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,034,263 - 160,034,323EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11180 AgrOrtholog
COSMIC SOD2 COSMIC
Ensembl Genes ENSG00000112096 Ensembl
  ENSG00000285441 Ensembl
  ENSG00000291237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000337404 ENTREZGENE
  ENST00000337404.8 UniProtKB/Swiss-Prot
  ENST00000367054 ENTREZGENE
  ENST00000367054.6 UniProtKB/Swiss-Prot
  ENST00000367055 ENTREZGENE
  ENST00000367055.8 UniProtKB/Swiss-Prot
  ENST00000401980.3 UniProtKB/TrEMBL
  ENST00000444946 ENTREZGENE
  ENST00000444946.6 UniProtKB/Swiss-Prot
  ENST00000452684 ENTREZGENE
  ENST00000452684.2 UniProtKB/TrEMBL
  ENST00000535561.5 UniProtKB/TrEMBL
  ENST00000537657.5 UniProtKB/TrEMBL
  ENST00000538183 ENTREZGENE
  ENST00000538183.7 UniProtKB/Swiss-Prot
  ENST00000545162.5 UniProtKB/TrEMBL
  ENST00000546087 ENTREZGENE
  ENST00000546087.5 UniProtKB/Swiss-Prot
  ENST00000546260.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.990 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.55.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000112096 GTEx
  ENSG00000285441 GTEx
  ENSG00000291237 GTEx
HGNC ID HGNC:11180 ENTREZGENE
Human Proteome Map SOD2 Human Proteome Map
InterPro Fe/Mn_Superoxide_Dismutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6648 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 6648 ENTREZGENE
OMIM 147460 OMIM
PANTHER SUPEROXIDE DISMUTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Fe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sod_Fe_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36017 PharmGKB, RGD
PIRSF SODismutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MNSODISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_MN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46609 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A384NL29 ENTREZGENE, UniProtKB/TrEMBL
  B2R7R1 ENTREZGENE
  B3KUK2 ENTREZGENE
  B4DL20 ENTREZGENE
  B4E3K9 ENTREZGENE
  E1P5A9 ENTREZGENE
  F5GXZ9_HUMAN UniProtKB/TrEMBL
  F5GYZ5_HUMAN UniProtKB/TrEMBL
  F5H3C5_HUMAN UniProtKB/TrEMBL
  F5H4R2_HUMAN UniProtKB/TrEMBL
  G5E9P6 ENTREZGENE, UniProtKB/TrEMBL
  G8JLJ2_HUMAN UniProtKB/TrEMBL
  P04179 ENTREZGENE
  P78434 ENTREZGENE
  Q16792 ENTREZGENE
  Q4ZJI1_HUMAN UniProtKB/TrEMBL
  Q5TCM1 ENTREZGENE
  Q6LE88_HUMAN UniProtKB/TrEMBL
  Q71UR9_HUMAN UniProtKB/TrEMBL
  Q7Z7M4 ENTREZGENE, UniProtKB/TrEMBL
  Q7Z7M5_HUMAN UniProtKB/TrEMBL
  Q7Z7M6_HUMAN UniProtKB/TrEMBL
  Q7Z7M7_HUMAN UniProtKB/TrEMBL
  Q96AM7 ENTREZGENE, UniProtKB/TrEMBL
  Q96EE6 ENTREZGENE
  Q9P2Z3 ENTREZGENE
  Q9UG59_HUMAN UniProtKB/TrEMBL
  SODM_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2R7R1 UniProtKB/Swiss-Prot
  B3KUK2 UniProtKB/Swiss-Prot
  B4DL20 UniProtKB/Swiss-Prot
  B4E3K9 UniProtKB/Swiss-Prot
  E1P5A9 UniProtKB/Swiss-Prot
  P78434 UniProtKB/Swiss-Prot
  Q16792 UniProtKB/Swiss-Prot
  Q5TCM1 UniProtKB/Swiss-Prot
  Q96EE6 UniProtKB/Swiss-Prot
  Q9P2Z3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 SOD2  superoxide dismutase 2  SOD2  superoxide dismutase 2, mitochondrial  Symbol and/or name change 5135510 APPROVED