SOD2 (superoxide dismutase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: SOD2 (superoxide dismutase 2) Homo sapiens
Analyze
Symbol: SOD2
Name: superoxide dismutase 2
RGD ID: 730872
HGNC Page HGNC:11180
Description: Enables identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including intracellular oxygen homeostasis; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of apoptotic process. Located in mitochondrial matrix. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Biomarker of several diseases, including brain edema; exfoliation syndrome; hematologic cancer (multiple); liver disease (multiple); and urticaria.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: gastric cancer-associated lncRNA 1; GC1; GClnc1; indophenoloxidase B; IPO-B; IPOB; manganese-containing superoxide dismutase; mangano-superoxide dismutase; Mn superoxide dismutase; Mn-SOD; MNSOD; MVCD6; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: SOD2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  (IAGP)
abdominal aortic aneurysm  (EXP,ISO)
Acute Coronary Syndrome  (EXP)
acute kidney tubular necrosis  (EXP)
acute myeloid leukemia  (IAGP,IEP)
adenocarcinoma  (EXP)
adrenoleukodystrophy  (EXP)
adult respiratory distress syndrome  (EXP,ISO)
Albuminuria  (EXP)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (EXP,IAGP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (EXP,IDA)
amyotrophic lateral sclerosis  (EXP)
amyotrophic lateral sclerosis type 1  (ISS)
anaplastic thyroid carcinoma  (EXP)
anemia  (EXP,ISO)
Aortic Calcification  (ISO)
aortic disease  (EXP)
Arsenic Poisoning  (EXP)
asphyxia neonatorum  (EXP)
asthma  (IDA)
atherosclerosis  (EXP)
autoimmune disease  (EXP)
Bacteremia  (ISO)
bilirubin metabolic disorder  (IAGP)
bladder neck obstruction  (ISO)
brain edema  (IEP)
Brain Injuries  (EXP,ISO)
brain ischemia  (EXP,ISO)
Brain Neoplasms  (EXP)
breast cancer  (IAGP)
Breast Neoplasms  (EXP,IDA)
Canavan disease  (ISS)
carcinoma  (EXP)
Cardiac Arrhythmias  (ISO)
Cardiogenic Shock  (EXP)
Cardiomegaly  (EXP)
cardiomyopathy  (EXP,IAGP,ISO)
carotid artery disease  (IAGP)
central nervous system disease  (EXP)
Central Nervous System Infections  (IDA)
Chemical and Drug Induced Liver Injury  (EXP,IAGP,ISO)
chronic progressive external ophthalmoplegia  (EXP)
Colonic Neoplasms  (EXP)
Colorectal Neoplasms  (EXP,IAGP)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (EXP,ISS)
cystitis  (ISO)
diabetic angiopathy  (IAGP)
Diabetic Nephropathies  (EXP,IAGP)
diffuse large B-cell lymphoma  (EXP)
dilated cardiomyopathy  (EXP,IAGP,ISO,ISS)
disease of cellular proliferation  (EXP,ISO)
Disease Progression  (EXP)
Drug-induced Neutropenia  (IAGP)
Endotoxemia  (EXP)
Esophageal Neoplasms  (EXP)
Esophageal Stenosis  (EXP)
esophagitis  (EXP)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (EXP)
exfoliation syndrome  (IEP)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Mammary Neoplasms  (EXP)
Experimental Radiation Injuries  (EXP)
extrinsic allergic alveolitis  (EXP)
familial adenomatous polyposis  (EXP)
Farber lipogranulomatosis  (EXP)
Fever  (EXP)
Fibrosis  (EXP)
gestational diabetes  (EXP)
head and neck squamous cell carcinoma  (EXP)
Hearing Loss, Noise-Induced  (IAGP)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (EXP,IAGP,IDA,IEP)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (EXP,IDA,ISO)
hyperthyroidism  (EXP)
Hypertriglyceridemia  (IAGP)
hypoglycemia  (EXP)
Hypopharyngeal Neoplasms  (IAGP)
hypothyroidism  (ISO)
Hypoxia  (EXP)
inclusion body myositis  (IDA)
infectious mononucleosis  (IDA)
Insulin Resistance  (EXP)
interstitial lung disease  (EXP)
intestinal disease  (ISO)
invasive ductal carcinoma  (EXP)
ischemia  (EXP)
kidney disease  (EXP)
Kidney Neoplasms  (EXP)
Kuhnt-Junius degeneration  (IAGP)
Leber hereditary optic neuropathy  (IDA,ISO)
Leigh disease  (ISS)
Lewy body dementia  (EXP)
liver cirrhosis  (EXP,IAGP)
lung adenocarcinoma  (EXP)
lung cancer  (IDA)
lung disease  (EXP)
lung non-small cell carcinoma  (EXP)
Lymphatic Metastasis  (EXP,IEP)
macular degeneration  (ISO)
major depressive disorder  (EXP)
male infertility  (EXP)
malignant mesothelioma  (EXP)
Marfan syndrome  (EXP)
melanoma  (IEP)
MELAS syndrome  (EXP)
Mesothelioma  (EXP)
metabolic dysfunction-associated steatohepatitis  (IAGP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA,ISO)
Metabolic Syndrome  (ISO)
methylmalonic acidemia  (EXP)
middle cerebral artery infarction  (EXP)
mitochondrial metabolism disease  (EXP)
Mouth Neoplasms  (EXP,IAGP)
multiple chemical sensitivity  (EXP)
multiple myeloma  (EXP,IDA)
mycosis fungoides  (IEP)
myelomeningocele  (EXP)
myocardial infarction  (EXP,IEP,ISO)
Myocardial Ischemia  (EXP,ISO)
Myocardial Reperfusion Injury  (IMP,ISO)
Nasal Polyps  (IEP)
Necrosis  (EXP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP)
Neoplastic Cell Transformation  (EXP)
nephrotic syndrome  (EXP,IEP)
Nerve Degeneration  (EXP)
neurodegenerative disease  (EXP)
neuronal ceroid lipofuscinosis  (IDA)
obesity  (EXP)
optic neuritis  (IDA,ISO)
osteoarthritis  (EXP)
osteoporosis  (EXP,IAGP)
ovarian cancer  (IDA)
Ovarian Neoplasms  (EXP)
pancreatic cancer  (EXP,IAGP,IDA,IEP)
papilloma  (EXP)
Parkinson's disease  (EXP,ISO)
perinatal necrotizing enterocolitis  (EXP)
peripheral nervous system disease  (EXP)
polyneuropathy  (IAGP)
pre-malignant neoplasm  (EXP)
Premature Birth  (EXP)
Presbycusis  (ISO)
primary biliary cholangitis  (IEP)
primary ciliary dyskinesia 32  (IAGP)
primary open angle glaucoma  (IAGP)
Prostatic Neoplasms  (EXP,IDA)
pseudoxanthoma elasticum  (IAGP)
psoriasis  (EXP,IEP)
Pulmonary Arterial Hypertension  (IEP,ISO)
pulmonary hypertension  (EXP)
Radiation Injuries  (EXP)
reactive arthritis  (IDA)
renal cell carcinoma  (EXP)
renal fibrosis  (ISO)
Reperfusion Injury  (EXP,IDA,ISO)
Respiratory Tract Granuloma  (EXP)
Reticulocytosis  (EXP)
Retina Reperfusion Injury  (IDA,ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (EXP)
sarcoidosis  (EXP)
Sengers syndrome  (EXP)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
sideroblastic anemia  (EXP)
Skin Abnormalities  (EXP)
skin disease  (EXP)
Skin Neoplasms  (EXP,IDA,ISO)
squamous cell carcinoma  (EXP)
status epilepticus  (ISO)
steatotic liver disease  (EXP)
stomach cancer  (IDA)
Stomach Neoplasms  (EXP)
substance-induced psychosis  (EXP)
systemic lupus erythematosus  (IAGP)
Tardive Dyskinesia  (IAGP)
Thyroid Neoplasms  (IDA)
Tongue Neoplasms  (EXP,IEP)
transient cerebral ischemia  (EXP,ISO)
Turner syndrome  (EXP)
type 1 diabetes mellitus  (IAGP)
type 2 diabetes mellitus  (EXP,IAGP)
urinary bladder cancer  (EXP,IEP)
urticaria  (IEP)
uveitis  (EXP)
vascular disease  (EXP)
Ventricular Dysfunction, Left  (EXP)
vitiligo  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (EXP)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-sesamin  (ISO)
(+)-taxifolin  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R)-tramadol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (EXP,ISO)
2,3,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (EXP,ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
2-palmitoylglycerol  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3',5'-cyclic AMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,4-dihydroxybenzoate  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-chlorobiphenyl  (EXP)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-Hydroxycapric acid  (ISO)
5-methoxytryptamine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (ISO)
[6]-Shogaol  (EXP)
AACOCF3  (EXP)
acetamiprid  (ISO)
acetic acid  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
Actein  (ISO)
acteoside  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP)
Aflatoxin G1  (ISO)
AICA ribonucleotide  (EXP)
alatrofloxacin  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
Allylamine  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alpha-pinene  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ametryn  (ISO)
aminoacetone  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
ANTIMYCIN  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (EXP)
apocynin  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (EXP)
arjunolic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
astragaloside IV  (ISO)
atazanavir sulfate  (EXP)
atenolol  (EXP,ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrasentan  (ISO)
atrazine  (EXP,ISO)
azathioprine  (EXP)
Bandrowski's base  (EXP)
barium chloride  (ISO)
Bavachalcone  (EXP)
Bay-K-8644  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bortezomib  (EXP)
bosentan  (EXP)
bucladesine  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (EXP)
butyric acid  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
Calphostin C  (EXP)
camphene  (ISO)
camptothecin  (EXP)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carboplatin  (ISO)
carmustine  (EXP)
carnosic acid  (EXP)
carotenoid  (ISO)
carteolol  (EXP)
carvedilol  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
ceric oxide  (EXP)
cerium trichloride  (EXP,ISO)
chenodeoxycholic acid  (EXP)
chicoric acid  (ISO)
Chikusetsusaponin-V  (EXP)
chloramine T  (ISO)
chlorobenzene  (EXP)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
chrysazin  (EXP)
cinnamyl alcohol  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
creatinine  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (EXP,ISO)
curcumin  (EXP,ISO)
Cyanoginosin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
cysteamine  (ISO)
cytochalasin B  (EXP)
D-glucose  (EXP,ISO)
daidzein  (ISO)
dapsone  (ISO)
daunorubicin  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
Decursin  (ISO)
dehydroepiandrosterone  (ISO)
Dendrobine  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dihydrogen  (EXP,ISO)
dimethylarsinous acid  (EXP)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP,ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
dithianon  (EXP)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
docebenone  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
dronedarone  (EXP)
ebselen  (ISO)
eckol  (EXP)
edaravone  (ISO)
elemental selenium  (EXP)
ellagic acid  (ISO)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
enniatin  (ISO)
enzyme inhibitor  (EXP,ISO)
epalrestat  (ISO)
eplerenone  (ISO)
Erythropoietin  (EXP)
ethanol  (ISO)
ethylene glycol dimethacrylate  (EXP)
etoposide  (EXP)
eugenol  (EXP)
febuxostat  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
flutamide  (ISO)
fluvastatin  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fraxetin  (EXP)
fulvestrant  (EXP,ISO)
Fusaric acid  (EXP)
galactose  (ISO)
gallium nitrate  (EXP)
gallocatechin  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glafenine  (ISO)
gliclazide  (ISO)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP)
haloperidol  (ISO)
helenalin  (EXP)
hemin  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (EXP)
Honokiol  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (EXP)
hydroxytyrosol  (EXP,ISO)
ibuprofen  (EXP)
icariin  (EXP,ISO)
idebenone  (ISO)
indirubin-3'-monoxime  (EXP)
indometacin  (EXP,ISO)
ionomycin  (EXP)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoeugenol  (EXP)
isoflavones  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
kaempferol  (ISO)
kainic acid  (ISO)
ketorolac tromethamine  (ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-dehydroascorbic acid  (EXP)
L-methionine  (EXP,ISO)
lanthanum trichloride  (EXP)
lapatinib  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lenvatinib  (ISO)
Leonurine  (ISO)
leptomycin B  (EXP)
linalool  (EXP)
linsidomine  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
loliolide  (EXP)
losartan  (ISO)
lutein  (ISO)
luteolin  (EXP)
luzindole  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
malathion  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
masoprocol  (EXP)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (EXP,ISO)
meloxicam  (EXP)
menadione  (EXP,ISO)
mercaptoethanol  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (ISO)
metam  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP,ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (EXP)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
mitomycin C  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (ISO)
morphine  (EXP,ISO)
myxothiazol  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-acetylsphingosine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-phosphocreatine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
naringin  (ISO)
nebivolol  (ISO)
nefazodone  (EXP,ISO)
nerolidol  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nicorandil  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (ISO)
nitroprusside  (EXP)
nitroxoline  (EXP)
NMN zwitterion  (ISO)
NS-398  (EXP)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (EXP)
oleic acid  (EXP,ISO)
oltipraz  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
paroxetine  (ISO)
pentanal  (EXP)
peptidoglycan  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
peroxynitrous acid  (EXP,ISO)
phenanthrene  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenols  (EXP)
phenylmercury acetate  (EXP)
phenylpropanolamine  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
physostigmine  (ISO)
pifithrin-?  (ISO)
pioglitazone  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (EXP)
porphyrins  (EXP)
potassium atom  (EXP,ISO)
potassium bromate  (EXP)
potassium dichromate  (ISO)
potassium iodide  (EXP)
prednisolone  (EXP)
probucol  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propofol  (ISO)
prostaglandin E2  (EXP)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
purine-6-thiol  (EXP)
Pyridostigmine bromide  (EXP,ISO)
pyridoxamine  (ISO)
pyrrolidine dithiocarbamate  (EXP)
pyrroloquinoline quinone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (EXP,ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
rebaudioside A  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
salicyl alcohol  (ISO)
Salidroside  (ISO)
salsalate  (ISO)
salvianolic acid B  (ISO)
saquinavir  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
selenic acid  (EXP)
selenium atom  (EXP)
selenocystine  (EXP)
selenomethionine  (EXP)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicic acid  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium aurothiomalate  (EXP)
sodium chloride  (ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium nitrate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (ISO)
staurosporine  (ISO)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfamethoxazole  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
superoxide  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
tartrazine  (EXP)
taurocholic acid  (EXP,ISO)
temozolomide  (EXP)
tert-butyl ethyl ether  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thallium  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
thymoquinone  (ISO)
thyroxine  (ISO)
Tiron  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (EXP)
topotecan  (ISO)
tramadol  (ISO)
trandolapril  (ISO)
trans-isoeugenol  (EXP)
trans-piceid  (EXP,ISO)
trazodone  (ISO)
triadimefon  (ISO)
trichlorfon  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trilobatin  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (EXP,ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP)
urea  (EXP)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
vosaroxin  (EXP)
water  (ISO)
withaferin A  (EXP,ISO)
wortmannin  (ISO)
WR-1065  (EXP,ISO)
zearalenone  (ISO)
zebularine  (EXP)
zerumbone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)
zinc(0)  (ISO)
ziram  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IEA,ISO,ISS)
apoptotic mitochondrial changes  (IEA,ISO)
cellular response to ethanol  (IEA,ISO)
cellular response to oxidative stress  (IMP,ISS)
detection of oxygen  (IEA,ISO)
erythrophore differentiation  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
heart development  (IEA,ISO)
hemopoiesis  (IEA,ISO)
hydrogen peroxide biosynthetic process  (IEA,ISO)
hydrogen peroxide metabolic process  (IEA,ISO)
intracellular oxygen homeostasis  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
liver development  (IEA,ISO)
locomotory behavior  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of membrane hyperpolarization  (IEA,ISO)
negative regulation of neuron apoptotic process  (IGI)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IMP)
negative regulation of vascular associated smooth muscle cell proliferation  (IDA)
neuron development  (IEA,ISO)
positive regulation of cell migration  (IMP)
positive regulation of hydrogen peroxide biosynthetic process  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IDA)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (IDA)
post-embryonic development  (IEA,ISO)
protein homotetramerization  (IPI)
reactive oxygen species metabolic process  (IEA)
regulation of blood pressure  (IEA,ISO,ISS)
regulation of mitochondrial membrane potential  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,IMP,ISO,ISS)
release of cytochrome c from mitochondria  (IEA,ISO,ISS)
removal of superoxide radicals  (IEA,IMP,ISO)
respiratory electron transport chain  (IEA,ISO)
response to activity  (IEA,ISO)
response to axon injury  (IEA,ISO)
response to cadmium ion  (IEA,ISO)
response to electrical stimulus  (IEA,ISO)
response to gamma radiation  (IEA,ISO)
response to hydrogen peroxide  (IEA,ISO)
response to hyperoxia  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to immobilization stress  (IEA,ISO)
response to isolation stress  (IEA,ISO)
response to L-ascorbic acid  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to magnetism  (IEA,ISO)
response to manganese ion  (IEA,ISO)
response to nutrient levels  (IEA,ISO)
response to oxidative stress  (IEA,ISO)
response to reactive oxygen species  (IEA,ISO)
response to selenium ion  (IEA,ISO)
response to silicon dioxide  (IEA,ISO)
response to superoxide  (IEA,IMP,ISO)
response to xenobiotic stimulus  (IEA,ISO)
response to zinc ion  (IEA,ISO)
sensory perception of sound  (ISO)
superoxide anion generation  (IEA,ISO)
superoxide metabolic process  (IDA,IEA,ISO)
vasodilation  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Agharazii M, etal., Am J Hypertens. 2015 Jun;28(6):746-55. doi: 10.1093/ajh/hpu225. Epub 2014 Nov 27.
2. Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Alachkar H, etal., Pharmacogenomics J. 2016 Mar 29. doi: 10.1038/tpj.2016.7.
3. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Andreassen OA, etal., Exp Neurol. 2001 Jan;167(1):189-95. doi: 10.1006/exnr.2000.7525.
4. Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia. Aras-Lopez R, etal., Pediatr Surg Int. 2016 Feb;32(2):141-5. doi: 10.1007/s00383-015-3826-5. Epub 2015 Nov 3.
5. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Archer SL, etal., Circulation. 2010 Jun 22;121(24):2661-71. doi: 10.1161/CIRCULATIONAHA.109.916098. Epub 2010 Jun 7.
6. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Asimakis GK, etal., Circulation. 2002 Feb 26;105(8):981-6.
7. Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. Assem M, etal., Am J Pathol. 1997 Aug;151(2):549-55.
8. Nutrition- and virus-induced stress represses the expression of manganese superoxide dismutase in vitro. Berger MM, etal., Exp Biol Med (Maywood). 2004 Sep;229(8):843-9.
9. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. Bergman M, etal., J Cancer Res Clin Oncol. 2005 Jul;131(7):439-44. Epub 2005 May 10.
10. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Bonder CS, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G676-84. Epub 2004 Apr 15.
11. Superoxide Dismutase 2 Polymorphisms and Osteoporosis in Asian Indians: A Genetic Association Analysis. Botre C, etal., Cell Mol Biol Lett. 2015 Dec;20(4):685-97. doi: 10.1515/cmble-2015-0041.
12. Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. Celojevic D, etal., Ophthalmic Genet. 2013 May 2.
13. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, etal., Free Radic Biol Med. 2006 Jun 1;40(11):2028-39. Epub 2006 Feb 21.
14. Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. Cherry AD, etal., J Biol Chem. 2014 Jan 3;289(1):41-52. doi: 10.1074/jbc.M113.512483. Epub 2013 Nov 19.
15. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Comhair SA, etal., Am J Pathol. 2005 Mar;166(3):663-74.
16. Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Connor KM, etal., Cancer Res. 2007 Nov 1;67(21):10260-7.
17. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
18. Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Cullen JJ, etal., Pancreas. 2003 Jan;26(1):23-7.
19. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
20. Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Dhar SK, etal., Cancer Res. 2011 Nov 1;71(21):6684-95. doi: 10.1158/0008-5472.CAN-11-1233. Epub 2011 Oct 18.
21. iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer. Ding F, etal., Int J Biol Markers. 2019 Sep;34(3):221-231. doi: 10.1177/1724600819841619. Epub 2019 May 1.
22. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
23. Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. Flekac M, etal., BMC Med Genet. 2008 Apr 21;9:30.
24. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Fortunato G, etal., Clin Chem. 2004 Nov;50(11):2012-8. Epub 2004 Sep 2.
25. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. Friedman JS, etal., J Exp Med. 2001 Apr 16;193(8):925-34.
26. Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. Fujimoto K, etal., Toxicol Pathol. 2009 Feb;37(2):193-200. doi: 10.1177/0192623308329282.
27. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Fujimura M, etal., J Neurosci. 1999 May 1;19(9):3414-22.
28. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
29. Manganese superoxide dismutase gene (SOD2) polymorphism and exudative age-related macular degeneration in the Japanese population. Gotoh N, etal., Am J Ophthalmol. 2008 Jul;146(1):146; author reply 146-7. doi: 10.1016/j.ajo.2008.03.017.
30. Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway. Guo S, etal., Eur J Pharmacol. 2019 Apr 15;849:50-58. doi: 10.1016/j.ejphar.2019.01.057. Epub 2019 Feb 1.
31. Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. Hakenewerth AM, etal., Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2438-49. doi: 10.1158/1055-9965.EPI-11-0649. Epub 2011 Sep 22.
32. MnSOD antisense treatment and exercise-induced protection against arrhythmias. Hamilton KL, etal., Free Radic Biol Med. 2004 Nov 1;37(9):1360-8.
33. RORalpha decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Han YH, etal., Antioxid Redox Signal. 2014 Nov 20;21(15):2083-94. doi: 10.1089/ars.2013.5655. Epub 2014 Apr 10.
34. Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues. Heine C, etal., Biochem J. 2003 Dec 1;376(Pt 2):369-76.
35. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Hiroi S, etal., Biochem Biophys Res Commun. 1999 Aug 2;261(2):332-9.
36. Molecular structure of a functional rat gene for manganese-containing superoxide dismutase. Ho YS, etal., Am J Respir Cell Mol Biol 1991 Mar;4(3):278-86.
37. Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation. Hodge DR, etal., Cancer Biol Ther. 2005 May;4(5):585-92. Epub 2005 May 5.
38. Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma. Holla LI, etal., Clin Biochem. 2006 Mar;39(3):299-302. Epub 2006 Jan 19.
39. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. Hu Y, etal., J Biol Chem. 2005 Nov 25;280(47):39485-92. Epub 2005 Sep 22.
40. MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. Huang C, etal., BMC Med Genomics. 2014 Jul 28;7:46. doi: 10.1186/1755-8794-7-46.
41. Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice. Huang TT, etal., Free Radic Biol Med. 2001 Nov 1;31(9):1101-10.
42. Superoxide Dismutase 2 Genetic Variation as a Susceptibility Risk Factor for Alcoholic Cirrhosis. Huang YS, etal., Alcohol Alcohol. 2016 Feb 11. pii: agw004.
43. Genetic variations of superoxide dismutase 2 and cytochrome P450 2E1 in non-alcoholic steatohepatitis. Huang YS, etal., Liver Int. 2014 Jul;34(6):931-6. doi: 10.1111/liv.12533. Epub 2014 Apr 4.
44. Time response of carboplatin-induced hearing loss in rat. Husain K, etal., Hear Res. 2004 May;191(1-2):110-8.
45. Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats. Hwang JH, etal., Exp Ther Med. 2018 Jul;16(1):310-320. doi: 10.3892/etm.2018.6190. Epub 2018 May 18.
46. MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury. Jin ZQ, etal., Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2986-94. Epub 2005 Jan 28.
47. SOD2 knockdown mouse model of early AMD. Justilien V, etal., Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4407-20.
48. The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis. Kakko S, etal., Atherosclerosis. 2003 May;168(1):147-52.
49. Serum-manganese-superoxide dismutase: normal values and increased levels in patients with acute myocardial infarction and several malignant diseases determined by an enzyme-linked immunosorbent assay using a monoclonal antibody. Kawaguchi T, etal., J Immunol Methods. 1990 Mar 9;127(2):249-54.
50. Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. Khaper N, etal., Mol Cell Biochem. 2003 Sep;251(1-2):9-15.
51. Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Kim J, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F461-70. Epub 2009 May 20.
52. Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes. Kim JH, etal., Environ Res. 2016 May;147:324-30. doi: 10.1016/j.envres.2016.02.026. Epub 2016 Feb 27.
53. An association between manganese superoxide dismutase polymorphism and outcome of chemotherapy in acute myeloid leukemia. Koistinen P, etal., Haematologica. 2006 Jun;91(6):829-32.
54. MnSOD expression within tumor cells is closely related to mode of invasion in human gastric cancer. Korenaga D, etal., Oncol Rep. 2003 Jan-Feb;10(1):27-30.
55. Involvement of superoxide dismutase isoenzymes and their genetic variants in progression of and higher susceptibility to vitiligo. Laddha NC, etal., Free Radic Biol Med. 2013 Dec;65:1110-25. doi: 10.1016/j.freeradbiomed.2013.08.189. Epub 2013 Sep 12.
56. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Lebovitz RM, etal., Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9782-7.
57. Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice. Lee D, etal., Arch Pharm Res. 2020 Apr;43(4):449-461. doi: 10.1007/s12272-020-01231-4. Epub 2020 Mar 31.
58. Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway. Li P, etal., Expert Opin Ther Targets. 2015 Jul;19(7):997-1010. doi: 10.1517/14728222.2015.1054806.
59. Time dependent bladder apoptosis induced by acute bladder outlet obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2/Bax ratio. Li WJ, etal., J Korean Med Sci. 2010 Nov;25(11):1652-6. Epub 2010 Oct 26.
60. Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor. Lin HI, etal., Chin J Physiol. 2004 Sep 30;47(3):121-7.
61. Proteomic expression analysis of mycosis fungoides (MF) skin tissues: overexpressions of SOD2, S100A8 and FABP5 in MF. Liu J, etal., J Dermatol Sci. 2010 Oct;60(1):42-4. doi: 10.1016/j.jdermsci.2010.07.014. Epub 2010 Aug 10.
62. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Liu KM, etal., Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F318-31. doi: 10.1152/ajprenal.00607.2014. Epub 2015 Jun 24.
63. Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. Liu X, etal., BMC Cancer. 2010 Jul 9;10:365. doi: 10.1186/1471-2407-10-365.
64. Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion. Liu Y, etal., Free Radic Biol Med. 2012 Mar 1;52(5):909-15. doi: 10.1016/j.freeradbiomed.2011.12.013. Epub 2011 Dec 24.
65. SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. Liu YM, etal., Dis Markers. 2010;28(3):137-47. doi: 10.3233/DMA-2010-0693.
66. Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. Lontz W, etal., Free Radic Biol Med. 1995 Feb;18(2):349-55.
67. Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury. Lucena MI, etal., Hepatology. 2010 Jul;52(1):303-12. doi: 10.1002/hep.23668.
68. Differential neuronal expression of manganese superoxide dismutase in Alzheimer's disease. Marcus DL, etal., Med Sci Monit. 2006 Jan;12(1):BR8-14. Epub 2005 Dec 19.
69. Chemoprevention of carcinogenic progression to esophageal adenocarcinoma by the manganese superoxide dismutase supplementation. Martin RC, etal., Clin Cancer Res. 2007 Sep 1;13(17):5176-82.
70. No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1). Martin RC, etal., J Surg Res. 2005 Mar;124(1):92-7.
71. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
72. A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy. Mollsten A, etal., Diabetes. 2007 Jan;56(1):265-9.
73. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Nahon P, etal., Hepatology. 2009 Nov;50(5):1484-93. doi: 10.1002/hep.23187.
74. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. Namikawa C, etal., J Hepatol. 2004 May;40(5):781-6.
75. Elevated serum manganese superoxide dismutase in acute leukemias. Nishiura T, etal., Cancer Lett. 1992 Mar 15;62(3):211-5.
76. In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model. Oberley TD, etal., Antioxid Redox Signal. 2004 Jun;6(3):537-48.
77. Wheat germ supplementation alleviates insulin resistance and cardiac mitochondrial dysfunction in an animal model of diet-induced obesity. Ojo B, etal., Br J Nutr. 2017 Aug;118(4):241-249. doi: 10.1017/S0007114517002082.
78. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
79. Elevated level of serum Mn-superoxide dismutase in patients with primary biliary cirrhosis: possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis. Ono M, etal., J Lab Clin Med. 1991 Nov;118(5):476-83.
80. Reduction in superoxide dismutase expression in the epithelial mucosa of eosinophilic chronic rhinosinusitis with nasal polyps. Ono N, etal., Int Arch Allergy Immunol. 2013;162(2):173-80. doi: 10.1159/000353122. Epub 2013 Jul 31.
81. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
82. Different roles of Sp family members in HIV-1 Tat-mediated manganese superoxide dismutase suppression in hepatocellular carcinoma cells. Porntadavity S, etal., DNA Cell Biol. 2005 May;24(5):299-310.
83. SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I. Qi X, etal., Ann Neurol. 2004 Aug;56(2):182-91.
84. Optic neuropathy induced by reductions in mitochondrial superoxide dismutase. Qi X, etal., Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1088-96.
85. Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis. Qi X, etal., Invest Ophthalmol Vis Sci. 2007 Feb;48(2):681-91.
86. Over-expression of Mn-superoxide dismutase as a marker of oxidative stress in lesional skin of chronic idiopathic urticaria. Raho G, etal., Clin Exp Dermatol. 2003 May;28(3):318-20.
87. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
88. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
89. Diabetic rat testes: morphological and functional alterations. Ricci G, etal., Andrologia. 2009 Dec;41(6):361-8.
90. Manganese superoxide dismutase as a target of autoantibodies in acute Epstein-Barr virus infection. Ritter K, etal., J Exp Med. 1994 Nov 1;180(5):1995-8.
91. Proteomic analysis of human thyroid cell lines reveals reduced nuclear localization of Mn-SOD in poorly differentiated thyroid cancer cells. Russo D, etal., J Endocrinol Invest. 2005 Feb;28(2):137-44.
92. Serum manganese superoxide dismutase is a new tumour marker for malignant melanoma. Schadendorf D, etal., Melanoma Res. 1995 Oct;5(5):351-3.
93. Differential regulation of the superoxide dismutase family in experimental aortic aneurysms and rat aortic explants. Sinha I, etal., J Surg Res. 2007 Apr;138(2):156-62. Epub 2006 Dec 29.
94. Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis. Stewart SF, etal., Hepatology. 2002 Dec;36(6):1355-60.
95. The -9Ala/-9Val polymorphism in the mitochondrial targeting sequence of the manganese superoxide dismutase gene (MnSOD) is associated with age among Hispanics with colorectal carcinoma. Stoehlmacher J, etal., Oncol Rep. 2002 Mar-Apr;9(2):235-8.
96. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Strassburger M, etal., Free Radic Biol Med. 2005 Jun 1;38(11):1458-70.
97. Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome. Strzalka-Mrozik B, etal., Mol Vis. 2013 Jun 12;19:1341-9. Print 2013.
98. Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma. Tsanou E, etal., Histol Histopathol. 2004 Jul;19(3):807-13.
99. Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles. Tsuruta Y, etal., Acta Neuropathol (Berl). 2002 Jan;103(1):59-65.
100. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S, etal., Mol Ther. 2009 May;17(5):778-86. doi: 10.1038/mt.2009.47. Epub 2009 Mar 17.
101. The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis. Valenti L, etal., J Med Genet. 2004 Dec;41(12):946-50.
102. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Van Remmen H, etal., Physiol Genomics. 2003 Dec 16;16(1):29-37.
103. Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia. Venkataraman S, etal., Free Radic Res. 2004 Oct;38(10):1119-32.
104. Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease. Ventriglia M, etal., Aging Clin Exp Res. 2005 Dec;17(6):445-8.
105. Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk. Wang LI, etal., J Occup Environ Med. 2004 Jun;46(6):556-64.
106. Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. Wang R, etal., Aging (Albany NY). 2016 Jun;8(6):1184-200. doi: 10.18632/aging.100967.
107. Oxidative stress in rats with hyperhomo-cysteinemia and intervention effect of lutein. Wang S, etal., Eur Rev Med Pharmacol Sci. 2014;18(3):359-64.
108. Sirtuin 1 activation enhances the PGC-1alpha/mitochondrial antioxidant system pathway in status epilepticus. Wang SJ, etal., Mol Med Rep. 2015 Jan;11(1):521-6. doi: 10.3892/mmr.2014.2724. Epub 2014 Oct 21.
109. Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Weydert C, etal., Mol Cancer Ther. 2003 Apr;2(4):361-9.
110. Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Wheatley-Price P, etal., Cancer. 2008 Mar 1;112(5):1037-42.
111. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. Wheeler MD, etal., J Biol Chem. 2001 Sep 28;276(39):36664-72. Epub 2001 Jul 26.
112. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. Xiong Y, etal., J Neurochem. 2005 Nov;95(3):732-44.
113. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Yang J, etal., Mol Ther. 2003 Mar;7(3):341-53.
114. Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Yao S, etal., Breast Cancer Res Treat. 2010 Nov;124(2):433-9. doi: 10.1007/s10549-010-0840-0. Epub 2010 Mar 23.
115. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. Yen JH, etal., Immunol Lett. 2003 Aug 5;88(2):113-6.
116. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis. Yen JH, etal., Immunol Lett. 2003 Dec 15;90(2-3):151-4.
117. Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus. Yen JH, etal., Immunol Lett. 2003 Nov 15;90(1):19-24.
118. Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat. Yoshikawa Y, etal., Toxicology. 2009 Oct 1;264(1-2):89-95. doi: 10.1016/j.tox.2009.07.017. Epub 2009 Jul 30.
119. Down-regulation of manganese-superoxide dismutase gene expression in idiopathic nephrotic syndrome. Yoshioka T, etal., J Pediatr. 1997 May;130(5):800-7.
120. Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset. Zarbock R, etal., Clin Chem. 2007 Oct;53(10):1734-40. Epub 2007 Aug 10.
121. Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model. Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.
122. Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator. Zeng Z, etal., Oxid Med Cell Longev. 2015;2015:965961. doi: 10.1155/2015/965961. Epub 2015 Aug 2.
123. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Zenkel M, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5558-66.
124. Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. Zhang ZJ, etal., Psychiatr Genet. 2003 Sep;13(3):187-92.
125. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Zhao Y, etal., Oncogene. 2002 May 30;21(24):3836-46.
126. [Association of the SOD2 Ala(-9)Val and SOD3 Arg213Gly polymorphisms with diabetic polyneuropathy in patients with diabetes mellitus type 1] Zotova EV, etal., Mol Biol (Mosk). 2003 May-Jun;37(3):404-8.
Additional References at PubMed
PMID:123234   PMID:752518   PMID:1394426   PMID:1427917   PMID:1699607   PMID:1988135   PMID:2462451   PMID:2738919   PMID:2831093   PMID:3399391   PMID:3684581   PMID:6386798  
PMID:7493016   PMID:7498159   PMID:7702755   PMID:7859743   PMID:7895732   PMID:8395050   PMID:8605177   PMID:8633092   PMID:8806673   PMID:8889548   PMID:8889549   PMID:9110146  
PMID:9150946   PMID:9393747   PMID:9462746   PMID:9484232   PMID:9537987   PMID:9537988   PMID:9882443   PMID:10393559   PMID:10511315   PMID:10748080   PMID:10852710   PMID:11076863  
PMID:11124296   PMID:11299047   PMID:11323405   PMID:11350569   PMID:11481695   PMID:11580280   PMID:11719088   PMID:11721640   PMID:11752456   PMID:11756571   PMID:11849743   PMID:11853549  
PMID:11912921   PMID:11912930   PMID:11977425   PMID:12032830   PMID:12063011   PMID:12078513   PMID:12126755   PMID:12127599   PMID:12161520   PMID:12239572   PMID:12477932   PMID:12517793  
PMID:12540612   PMID:12551919   PMID:12590982   PMID:12592389   PMID:12624725   PMID:12627943   PMID:12644569   PMID:12673575   PMID:12683635   PMID:12684509   PMID:12711112   PMID:12829021  
PMID:12948282   PMID:12963120   PMID:14503839   PMID:14515147   PMID:14574404   PMID:14578853   PMID:14638684   PMID:14643949   PMID:14688256   PMID:14702039   PMID:14704872   PMID:14729580  
PMID:14744747   PMID:14975589   PMID:14980699   PMID:15075214   PMID:15087454   PMID:15088300   PMID:15131792   PMID:15166009   PMID:15184255   PMID:15196853   PMID:15217492   PMID:15223067  
PMID:15247771   PMID:15266664   PMID:15308628   PMID:15330761   PMID:15331175   PMID:15338334   PMID:15342556   PMID:15386537   PMID:15455371   PMID:15489334   PMID:15489336   PMID:15512788  
PMID:15534883   PMID:15535847   PMID:15581626   PMID:15589819   PMID:15598343   PMID:15610954   PMID:15621215   PMID:15673194   PMID:15701646   PMID:15705913   PMID:15706661   PMID:15734083  
PMID:15743756   PMID:15765450   PMID:15767364   PMID:15774926   PMID:15781667   PMID:15809720   PMID:15817612   PMID:15838728   PMID:15878096   PMID:15894290   PMID:15923250   PMID:15933380  
PMID:15951095   PMID:15952740   PMID:16006997   PMID:16047490   PMID:16076760   PMID:16084535   PMID:16107721   PMID:16148556   PMID:16157826   PMID:16166634   PMID:16169070   PMID:16170370  
PMID:16206227   PMID:16215873   PMID:16281056   PMID:16324912   PMID:16344560   PMID:16381901   PMID:16424062   PMID:16458347   PMID:16467073   PMID:16475114   PMID:16510607   PMID:16538174  
PMID:16540901   PMID:16543247   PMID:16626843   PMID:16630148   PMID:16740634   PMID:16780268   PMID:16780879   PMID:16792821   PMID:16807759   PMID:16819819   PMID:16847469   PMID:16859522  
PMID:16868544   PMID:16933053   PMID:16945136   PMID:16956821   PMID:16956909   PMID:16966185   PMID:16966488   PMID:16969494   PMID:17005595   PMID:17018785   PMID:17055157   PMID:17085785  
PMID:17142144   PMID:17145829   PMID:17149600   PMID:17171548   PMID:17186424   PMID:17188257   PMID:17211829   PMID:17217237   PMID:17277236   PMID:17290392   PMID:17291655   PMID:17293864  
PMID:17296902   PMID:17299255   PMID:17299970   PMID:17331249   PMID:17336594   PMID:17340208   PMID:17353931   PMID:17376152   PMID:17400324   PMID:17409931   PMID:17449559   PMID:17453961  
PMID:17459574   PMID:17465268   PMID:17473980   PMID:17491681   PMID:17548672   PMID:17548864   PMID:17567676   PMID:17575500   PMID:17577737   PMID:17582511   PMID:17588204   PMID:17601350  
PMID:17616699   PMID:17617122   PMID:17628794   PMID:17634480   PMID:17646272   PMID:17652337   PMID:17653087   PMID:17719580   PMID:17822322   PMID:17879532   PMID:17922231   PMID:17936883  
PMID:17965603   PMID:17967822   PMID:18023606   PMID:18044968   PMID:18057537   PMID:18095014   PMID:18160848   PMID:18167182   PMID:18167310   PMID:18180754   PMID:18247479   PMID:18258609  
PMID:18291700   PMID:18296681   PMID:18305395   PMID:18327668   PMID:18373354   PMID:18387669   PMID:18396798   PMID:18413745   PMID:18434620   PMID:18460737   PMID:18466086   PMID:18469277  
PMID:18490963   PMID:18553161   PMID:18569577   PMID:18571701   PMID:18582155   PMID:18583979   PMID:18636124   PMID:18646267   PMID:18653258   PMID:18676680   PMID:18676870   PMID:18682580  
PMID:18683149   PMID:18689799   PMID:18720901   PMID:18760346   PMID:18775420   PMID:18784066   PMID:18784358   PMID:18790709   PMID:18821846   PMID:18829485   PMID:18829510   PMID:18834346  
PMID:18845242   PMID:18930810   PMID:18930811   PMID:18930813   PMID:18977034   PMID:18977241   PMID:18987137   PMID:18989629   PMID:18996183   PMID:19012493   PMID:19016244   PMID:19064542  
PMID:19064571   PMID:19074833   PMID:19074884   PMID:19074885   PMID:19100713   PMID:19124506   PMID:19151739   PMID:19156168   PMID:19157724   PMID:19167605   PMID:19170196   PMID:19213780  
PMID:19219857   PMID:19228881   PMID:19242068   PMID:19254215   PMID:19262996   PMID:19265433   PMID:19293328   PMID:19302750   PMID:19306099   PMID:19336475   PMID:19339246   PMID:19339270  
PMID:19368118   PMID:19376215   PMID:19385967   PMID:19405048   PMID:19420105   PMID:19423521   PMID:19423540   PMID:19428448   PMID:19451660   PMID:19467856   PMID:19474327   PMID:19493484  
PMID:19505917   PMID:19509150   PMID:19521720   PMID:19526139   PMID:19528373   PMID:19533864   PMID:19538885   PMID:19558795   PMID:19622717   PMID:19623544   PMID:19625176   PMID:19628492  
PMID:19628738   PMID:19636420   PMID:19641337   PMID:19647296   PMID:19666009   PMID:19692168   PMID:19696404   PMID:19706356   PMID:19712751   PMID:19715479   PMID:19752172   PMID:19753309  
PMID:19754948   PMID:19755112   PMID:19756960   PMID:19778569   PMID:19787204   PMID:19789190   PMID:19822147   PMID:19834686   PMID:19847642   PMID:19863340   PMID:19880028   PMID:19896490  
PMID:19900038   PMID:19902052   PMID:19913121   PMID:19917371   PMID:19929244   PMID:19946932   PMID:19948975   PMID:19949914   PMID:19955594   PMID:19958503   PMID:20000738   PMID:20003469  
PMID:20012093   PMID:20041472   PMID:20043000   PMID:20052533   PMID:20056743   PMID:20061391   PMID:20082261   PMID:20082738   PMID:20082851   PMID:20086011   PMID:20089851   PMID:20097730  
PMID:20107204   PMID:20109103   PMID:20137347   PMID:20139358   PMID:20143154   PMID:20144705   PMID:20150532   PMID:20170971   PMID:20204285   PMID:20204772   PMID:20206073   PMID:20206302  
PMID:20214802   PMID:20226522   PMID:20233853   PMID:20237496   PMID:20301895   PMID:20346360   PMID:20346996   PMID:20357718   PMID:20378690   PMID:20406964   PMID:20416077   PMID:20417703  
PMID:20437850   PMID:20438785   PMID:20441054   PMID:20444272   PMID:20459474   PMID:20461808   PMID:20477822   PMID:20478627   PMID:20485444   PMID:20489163   PMID:20501330   PMID:20514411  
PMID:20536280   PMID:20538313   PMID:20567899   PMID:20598578   PMID:20598694   PMID:20627099   PMID:20628086   PMID:20638682   PMID:20643115   PMID:20644561   PMID:20649542   PMID:20673159  
PMID:20690800   PMID:20712757   PMID:20714737   PMID:20728955   PMID:20734807   PMID:20802415   PMID:20851292   PMID:20856861   PMID:20863520   PMID:20872977   PMID:20877624   PMID:20878976  
PMID:20931825   PMID:20966810   PMID:21052528   PMID:21053180   PMID:21056286   PMID:21056653   PMID:21062213   PMID:21069346   PMID:21072184   PMID:21130430   PMID:21131394   PMID:21143698  
PMID:21167124   PMID:21181397   PMID:21223689   PMID:21268071   PMID:21351093   PMID:21419216   PMID:21434422   PMID:21434856   PMID:21527182   PMID:21536589   PMID:21553226   PMID:21566644  
PMID:21574139   PMID:21619820   PMID:21619840   PMID:21725155   PMID:21727734   PMID:21741706   PMID:21756849   PMID:21773993   PMID:21781513   PMID:21804600   PMID:21829032   PMID:21832049  
PMID:21873635   PMID:21904836   PMID:21988832   PMID:22070905   PMID:22089180   PMID:22108257   PMID:22119635   PMID:22167619   PMID:22170599   PMID:22171130   PMID:22193621   PMID:22206979  
PMID:22218650   PMID:22261313   PMID:22302046   PMID:22330623   PMID:22348527   PMID:22386763   PMID:22429591   PMID:22432908   PMID:22516022   PMID:22517484   PMID:22537351   PMID:22547077  
PMID:22561997   PMID:22580338   PMID:22688013   PMID:22699057   PMID:22704671   PMID:22705344   PMID:22710435   PMID:22710948   PMID:22738689   PMID:22825700   PMID:22829583   PMID:22939629  
PMID:22958044   PMID:22959522   PMID:22972774   PMID:22983815   PMID:23030347   PMID:23033381   PMID:23056314   PMID:23111423   PMID:23138846   PMID:23142385   PMID:23167810   PMID:23168492  
PMID:23212700   PMID:23219743   PMID:23221071   PMID:23237540   PMID:23271813   PMID:23289810   PMID:23315858   PMID:23333304   PMID:23376485   PMID:23500038   PMID:23533145   PMID:23581847  
PMID:23583431   PMID:23588476   PMID:23590434   PMID:23611775   PMID:23620962   PMID:23647424   PMID:23649652   PMID:23679296   PMID:23685312   PMID:23706068   PMID:23725507   PMID:23744526  
PMID:23761047   PMID:23771908   PMID:23773345   PMID:23784082   PMID:23792044   PMID:23834335   PMID:23873331   PMID:23886214   PMID:23928928   PMID:23952573   PMID:23956348   PMID:23964924  
PMID:23990443   PMID:23991909   PMID:24035474   PMID:24037914   PMID:24070129   PMID:24074040   PMID:24119114   PMID:24146173   PMID:24155217   PMID:24161595   PMID:24164232   PMID:24186266  
PMID:24212762   PMID:24219772   PMID:24248464   PMID:24301773   PMID:24448804   PMID:24462872   PMID:24483941   PMID:24498107   PMID:24511533   PMID:24517502   PMID:24529564   PMID:24586301  
PMID:24610415   PMID:24626613   PMID:24651439   PMID:24658925   PMID:24667176   PMID:24667918   PMID:24700636   PMID:24716840   PMID:24736663   PMID:24811984   PMID:24817295   PMID:24819633  
PMID:24865797   PMID:24919441   PMID:24939178   PMID:24953189   PMID:24981860   PMID:24984152   PMID:25039350   PMID:25140979   PMID:25171019   PMID:25224035   PMID:25283363   PMID:25295643  
PMID:25372290   PMID:25388628   PMID:25400754   PMID:25417767   PMID:25430642   PMID:25449296   PMID:25484013   PMID:25497738   PMID:25499851   PMID:25550558   PMID:25619900   PMID:25651975  
PMID:25659582   PMID:25662905   PMID:25684475   PMID:25753816   PMID:25818327   PMID:25858271   PMID:25866291   PMID:25889634   PMID:25894370   PMID:25916115   PMID:25931357   PMID:25933618  
PMID:25948732   PMID:25958349   PMID:26028649   PMID:26120888   PMID:26123268   PMID:26130326   PMID:26137231   PMID:26147925   PMID:26186194   PMID:26208779   PMID:26225747   PMID:26241492  
PMID:26302379   PMID:26344197   PMID:26345792   PMID:26350743   PMID:26351775   PMID:26356408   PMID:26356721   PMID:26359457   PMID:26373864   PMID:26384137   PMID:26388666   PMID:26396584  
PMID:26400460   PMID:26426434   PMID:26436888   PMID:26439801   PMID:26443543   PMID:26446998   PMID:26468117   PMID:26490979   PMID:26505452   PMID:26516986   PMID:26528342   PMID:26535076  
PMID:26535703   PMID:26543228   PMID:26544677   PMID:26558285   PMID:26585352   PMID:26586994   PMID:26596112   PMID:26596265   PMID:26608808   PMID:26608886   PMID:26616112   PMID:26628947  
PMID:26631723   PMID:26636131   PMID:26637092   PMID:26646027   PMID:26664298   PMID:26671656   PMID:26674599   PMID:26674755   PMID:26678158   PMID:26678800   PMID:26679105   PMID:26696693  
PMID:26707081   PMID:26718428   PMID:26754536   PMID:26762997   PMID:26765960   PMID:26770138   PMID:26781513   PMID:26785339   PMID:26787049   PMID:26790968   PMID:26794818   PMID:26821085  
PMID:26823946   PMID:26823947   PMID:26846100   PMID:26847304   PMID:26854822   PMID:26856867   PMID:26857738   PMID:26867320   PMID:26874034   PMID:26881032   PMID:26881045   PMID:26881079  
PMID:26882122   PMID:26885102   PMID:26891959   PMID:26895301   PMID:26898144   PMID:26899340   PMID:26899469   PMID:26906415   PMID:26935174   PMID:26937962   PMID:26940444   PMID:26941203  
PMID:26942626   PMID:26950655   PMID:26957268   PMID:26958937   PMID:26965314   PMID:26970173   PMID:26981165   PMID:26981780   PMID:27021683   PMID:27023521   PMID:27037373   PMID:27055786  
PMID:27057281   PMID:27060086   PMID:27064125   PMID:27067415   PMID:27083052   PMID:27100222   PMID:27107014   PMID:27131313   PMID:27132285   PMID:27161188   PMID:27181103   PMID:27188866  
PMID:27384484   PMID:27534583   PMID:27555600   PMID:27630759   PMID:27751366   PMID:27829319   PMID:27923686   PMID:27925431   PMID:27999194   PMID:28040123   PMID:28087256   PMID:28108513  
PMID:28179340   PMID:28222320   PMID:28272301   PMID:28368283   PMID:28457881   PMID:28461152   PMID:28482710   PMID:28512644   PMID:28514442   PMID:28552711   PMID:28567457   PMID:28574756  
PMID:28587495   PMID:28616679   PMID:28655148   PMID:28658993   PMID:28704037   PMID:28711502   PMID:28801561   PMID:28841898   PMID:28925482   PMID:29046499   PMID:29047081   PMID:29109056  
PMID:29117863   PMID:29180619   PMID:29459008   PMID:29482947   PMID:29550484   PMID:29658251   PMID:29684818   PMID:29745991   PMID:29859283   PMID:29914010   PMID:29936984   PMID:29953407  
PMID:29972711   PMID:30063213   PMID:30107294   PMID:30111255   PMID:30150066   PMID:30165401   PMID:30192404   PMID:30193891   PMID:30217947   PMID:30225256   PMID:30242560   PMID:30245752  
PMID:30358222   PMID:30412732   PMID:30485823   PMID:30529301   PMID:30536754   PMID:30574618   PMID:30600457   PMID:30607774   PMID:30633320   PMID:30736780   PMID:30839355   PMID:30884312  
PMID:30896828   PMID:30975468   PMID:31098737   PMID:31160585   PMID:31189433   PMID:31212050   PMID:31228093   PMID:31340563   PMID:31364751   PMID:31382611   PMID:31415712   PMID:31470840  
PMID:31494578   PMID:31506286   PMID:31512047   PMID:31524543   PMID:31536960   PMID:31591207   PMID:31601079   PMID:31812668   PMID:31861522   PMID:31891227   PMID:31929112   PMID:32031754  
PMID:32149414   PMID:32296183   PMID:32539644   PMID:32620460   PMID:32664606   PMID:32694731   PMID:32707033   PMID:32709094   PMID:32730806   PMID:32885455   PMID:32889510   PMID:33009206  
PMID:33124528   PMID:33234142   PMID:33264651   PMID:33338479   PMID:33359244   PMID:33435582   PMID:33586574   PMID:33646985   PMID:33680286   PMID:33824320   PMID:33924242   PMID:33961781  
PMID:33989902   PMID:34077295   PMID:34090432   PMID:34364045   PMID:34373451   PMID:34387669   PMID:34681918   PMID:34758947   PMID:34808498   PMID:34958669   PMID:34959097   PMID:35029920  
PMID:35145273   PMID:35164076   PMID:35213938   PMID:35253629   PMID:35266053   PMID:35274104   PMID:35337019   PMID:35361071   PMID:35426339   PMID:35580464   PMID:35594792   PMID:35831314  
PMID:35858297   PMID:36008700   PMID:36010644   PMID:36037114   PMID:36074229   PMID:36100117   PMID:36215168   PMID:36229195   PMID:36295574   PMID:36356830   PMID:36676755   PMID:36811699  
PMID:37175412   PMID:37253908   PMID:37312219   PMID:37405601   PMID:37660159   PMID:37698290   PMID:38039740   PMID:38154571   PMID:38310354   PMID:38375721   PMID:38404215   PMID:38412803  


Genomics

Comparative Map Data
SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)EnsemblGRCm39 Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBIMGSCv36mm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,778,227 - 179,792,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,683,324 - 177,697,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,785,674 - 49,797,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,127,570 - 49,139,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,020,475 - 49,139,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,010,294 - 49,022,236 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,881,250 - 48,893,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,447,616 - 49,459,607 (-)NCBIUU_Cfam_GSD_1.0
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,178,015 - 11,191,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,679,352 - 7,689,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,683,827 - 59,727,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,260,809 - 3,271,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOD2
31 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000636.4(SOD2):c.47T>C (p.Val16Ala) single nucleotide variant Microvascular complications of diabetes, susceptibility to, 6 [RCV000015873]|SUPEROXIDE DISMUTASE 2 POLYMORPHISM [RCV000015872] Chr6:159692840 [GRCh38]
Chr6:160113872 [GRCh37]
Chr6:6q25.3		 risk factor|likely risk allele|benign|drug response
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3(chr6:157827805-159726548)x3 copy number gain See cases [RCV000051903] Chr6:157827805..159726548 [GRCh38]
Chr6:158248837..160147580 [GRCh37]
Chr6:158168825..160067570 [NCBI36]
Chr6:6q25.3		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:158664768-170612001)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|See cases [RCV000051904] Chr6:158664768..170612001 [GRCh38]
Chr6:159085800..170921089 [GRCh37]
Chr6:159005788..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159454639-170612001)x1 copy number loss See cases [RCV000052209] Chr6:159454639..170612001 [GRCh38]
Chr6:159875671..170921089 [GRCh37]
Chr6:159795661..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-26(chr6:155378049-163133499)x1 copy number loss See cases [RCV000137831] Chr6:155378049..163133499 [GRCh38]
Chr6:155699183..163554531 [GRCh37]
Chr6:155740875..163474521 [NCBI36]
Chr6:6q25.3-26		 pathogenic
GRCh38/hg38 6q25.3(chr6:159598794-159726489)x3 copy number gain See cases [RCV000140321] Chr6:159598794..159726489 [GRCh38]
Chr6:160019826..160147521 [GRCh37]
Chr6:159939816..160067511 [NCBI36]
Chr6:6q25.3		 likely benign
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27		 pathogenic
GRCh38/hg38 6q25.3-26(chr6:158585724-160899783)x3 copy number gain See cases [RCV000143618] Chr6:158585724..160899783 [GRCh38]
Chr6:159006756..161320815 [GRCh37]
Chr6:158926744..161240805 [NCBI36]
Chr6:6q25.3-26		 uncertain significance
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_000636.4(SOD2):c.656C>T (p.Ala219Val) single nucleotide variant not specified [RCV004321522] Chr6:159682506 [GRCh38]
Chr6:160103538 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.3-27(chr6:159844762-170919482)x3 copy number gain not provided [RCV000682734] Chr6:159844762..170919482 [GRCh37]
Chr6:6q25.3-27		 pathogenic
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:159155998-171054786)x3 copy number gain not provided [RCV000746132] Chr6:159155998..171054786 [GRCh37]
Chr6:6q25.3-27		 pathogenic
NM_000636.4(SOD2):c.579T>C (p.Tyr193=) single nucleotide variant not provided [RCV000927372] Chr6:159682583 [GRCh38]
Chr6:160103615 [GRCh37]
Chr6:6q25.3		 benign|likely benign
GRCh37/hg19 6q25.3(chr6:157262571-160992289)x3 copy number gain not provided [RCV000848057] Chr6:157262571..160992289 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q24.3-25.3(chr6:148195086-160127254)x3 copy number gain not provided [RCV000846496] Chr6:148195086..160127254 [GRCh37]
Chr6:6q24.3-25.3		 pathogenic
GRCh37/hg19 6q25.3(chr6:160025206-160271483)x1 copy number loss not provided [RCV000846782] Chr6:160025206..160271483 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.3-27(chr6:159006336-170713678)x3 copy number gain not provided [RCV003312672] Chr6:159006336..170713678 [GRCh37]
Chr6:6q25.3-27		 uncertain significance
GRCh37/hg19 6q25.3(chr6:160043162-160195268)x1 copy number loss not provided [RCV000845652] Chr6:160043162..160195268 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.216G>A (p.Ala72=) single nucleotide variant not provided [RCV000912324] Chr6:159692671 [GRCh38]
Chr6:160113703 [GRCh37]
Chr6:6q25.3		 benign
GRCh37/hg19 6q25.3(chr6:159998877-160413982)x3 copy number gain not provided [RCV001258756] Chr6:159998877..160413982 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.542G>T (p.Gly181Val) single nucleotide variant not provided [RCV001260971] Chr6:159682620 [GRCh38]
Chr6:160103652 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.2-26(chr6:153207930-164322346) copy number loss not specified [RCV002053640] Chr6:153207930..164322346 [GRCh37]
Chr6:6q25.2-26		 pathogenic
NC_000006.11:g.(?_158532398)_(160114199_?)dup duplication Primary ciliary dyskinesia 32 [RCV001934131] Chr6:158532398..160114199 [GRCh37]
Chr6:6q25.3		 uncertain significance
NC_000006.11:g.(?_158532398)_(162868359_?)del deletion 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome [RCV003122912]|not provided [RCV003122911] Chr6:158532398..162868359 [GRCh37]
Chr6:6q25.3-26		 pathogenic|no classifications from unflagged records
GRCh37/hg19 6q25.3-27(chr6:159121459-170919482) copy number loss Hydrocephalus [RCV002280751] Chr6:159121459..170919482 [GRCh37]
Chr6:6q25.3-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:157318401-165233548)x1 copy number loss See cases [RCV002287557] Chr6:157318401..165233548 [GRCh37]
Chr6:6q25.3-27		 pathogenic
NM_000636.4(SOD2):c.633G>T (p.Glu211Asp) single nucleotide variant not specified [RCV004142793] Chr6:159682529 [GRCh38]
Chr6:160103561 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.550G>A (p.Val184Met) single nucleotide variant not specified [RCV004182302] Chr6:159682612 [GRCh38]
Chr6:160103644 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.412G>T (p.Ala138Ser) single nucleotide variant not specified [RCV004131923] Chr6:159684965 [GRCh38]
Chr6:160105997 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.346G>C (p.Glu116Gln) single nucleotide variant not specified [RCV004209410] Chr6:159685031 [GRCh38]
Chr6:160106063 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.631G>A (p.Glu211Lys) single nucleotide variant not specified [RCV004095340] Chr6:159682531 [GRCh38]
Chr6:160103563 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.424G>T (p.Val142Phe) single nucleotide variant not specified [RCV004205409] Chr6:159684953 [GRCh38]
Chr6:160105985 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.311G>C (p.Ser104Thr) single nucleotide variant not specified [RCV004202353] Chr6:159748228 [GRCh38]
Chr6:160169260 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.182A>C (p.Asn61Thr) single nucleotide variant not specified [RCV004121664] Chr6:159692705 [GRCh38]
Chr6:160113737 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.467G>A (p.Arg156Gln) single nucleotide variant not specified [RCV004081755] Chr6:159684910 [GRCh38]
Chr6:160105942 [GRCh37]
Chr6:6q25.3		 likely benign
NM_000636.4(SOD2):c.113T>A (p.Leu38Gln) single nucleotide variant not specified [RCV004154479] Chr6:159692774 [GRCh38]
Chr6:160113806 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.230A>T (p.Asp77Val) single nucleotide variant not specified [RCV004105592] Chr6:159688239 [GRCh38]
Chr6:160109271 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.850C>T (p.Arg284Cys) single nucleotide variant not specified [RCV004244455] Chr6:159755270 [GRCh38]
Chr6:160176302 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.369A>T (p.Lys123Asn) single nucleotide variant not specified [RCV004134665] Chr6:159748286 [GRCh38]
Chr6:160169318 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.790G>A (p.Glu264Lys) single nucleotide variant not specified [RCV004187344] Chr6:159755210 [GRCh38]
Chr6:160176242 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.793G>A (p.Ala265Thr) single nucleotide variant not specified [RCV004080280] Chr6:159755213 [GRCh38]
Chr6:160176245 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.791A>G (p.Glu264Gly) single nucleotide variant not specified [RCV004187345] Chr6:159755211 [GRCh38]
Chr6:160176243 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q25.2-27(chr6:152853218-170914297)x1 copy number loss See cases [RCV004442824] Chr6:152853218..170914297 [GRCh37]
Chr6:6q25.2-27		 pathogenic
NM_000636.4(SOD2):c.365A>T (p.Lys122Ile) single nucleotide variant not specified [RCV004464807] Chr6:159685012 [GRCh38]
Chr6:160106044 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.367C>T (p.Arg123Cys) single nucleotide variant not specified [RCV004464808] Chr6:159685010 [GRCh38]
Chr6:160106042 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001270531.2(WTAP):c.860C>T (p.Thr287Met) single nucleotide variant not specified [RCV004483248] Chr6:159755280 [GRCh38]
Chr6:160176312 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.131C>G (p.Ala44Gly) single nucleotide variant not specified [RCV004464806] Chr6:159692756 [GRCh38]
Chr6:160113788 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.371A>T (p.Asp124Val) single nucleotide variant not specified [RCV004464809] Chr6:159685006 [GRCh38]
Chr6:160106038 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_000636.4(SOD2):c.399G>C (p.Glu133Asp) single nucleotide variant not specified [RCV004464810] Chr6:159684978 [GRCh38]
Chr6:160106010 [GRCh37]
Chr6:6q25.3		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR222hsa-miR-222-3pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Microarray//qRT-PFunctional MTI19487542
MIR17hsa-miR-17-3pMirtarbaseexternal_infoLuciferase reporter assay//Quantitative proteomic Functional MTI21203553
MIR17hsa-miR-17-3pOncomiRDBexternal_infoNANA21203553

Predicted Target Of
Summary Value
Count of predictions:7946
Count of miRNA genes:1429
Interacting mature miRNAs:1920
Transcripts:ENST00000337404, ENST00000367054, ENST00000367055, ENST00000401980, ENST00000444946, ENST00000452684, ENST00000535372, ENST00000535459, ENST00000535561, ENST00000537657, ENST00000538183, ENST00000540491, ENST00000541573, ENST00000545162, ENST00000546087, ENST00000546260
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1643404BMD3_HBone mineral density QTL 3 (human)2.420.0005Bone mineral density6157563614170805979Human
1643367BW323_HBody weight QTL 323 (human)2.420.0005Body fat amount6157563614170805979Human

Markers in Region
STS-W78148  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,100,257 - 160,100,414UniSTSGRCh37
Build 366160,020,247 - 160,020,404RGDNCBI36
Celera6160,747,710 - 160,747,867RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,570,693 - 157,570,850UniSTS
GeneMap99-GB4 RH Map6618.21UniSTS
D6S1419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,200 - 160,103,524UniSTSGRCh37
Build 366160,023,190 - 160,023,514RGDNCBI36
Celera6160,750,653 - 160,750,977RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,573,636 - 157,573,960UniSTS
TNG Radiation Hybrid Map680117.0UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
Whitehead-YAC Contig Map6 UniSTS
NCBI RH Map61631.6UniSTS
GeneMap99-G3 RH Map66671.0UniSTS
D6S1335  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,412 - 160,103,588UniSTSGRCh37
Build 366160,023,402 - 160,023,578RGDNCBI36
Celera6160,750,865 - 160,751,041RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,573,848 - 157,574,024UniSTS
Whitehead-YAC Contig Map6 UniSTS
SHGC-34268  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,102,238 - 160,102,387UniSTSGRCh37
Build 366160,022,228 - 160,022,377RGDNCBI36
Celera6160,749,691 - 160,749,840RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,572,674 - 157,572,823UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
Whitehead-RH Map6830.6UniSTS
NCBI RH Map61636.2UniSTS
GeneMap99-G3 RH Map66664.0UniSTS
RH16462  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,102,239 - 160,102,362UniSTSGRCh37
Build 366160,022,229 - 160,022,352RGDNCBI36
Celera6160,749,692 - 160,749,815RGD
Cytogenetic Map6q25.3UniSTS
HuRef6157,572,675 - 157,572,798UniSTS
GeneMap99-GB4 RH Map6619.81UniSTS
NCBI RH Map61624.4UniSTS
SOD2_3060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,103,010 - 160,103,635UniSTSGRCh37
Build 366160,023,000 - 160,023,625RGDNCBI36
Celera6160,750,463 - 160,751,088RGD
HuRef6157,573,446 - 157,574,071UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 7 1 1 2 1 250 249 1 6 3 2 3 249
Medium 2380 2892 1684 611 1665 456 4072 1867 3361 414 1294 1594 168 1201 2524 2
Low 51 97 41 11 288 9 34 80 366 5 159 15 4 1 15 3 2
Below cutoff 1 4 3 3 121 3 13 2 13 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001024465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001024466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA126703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL050388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV658055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY267901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY280721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY397775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG699596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM724413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM994509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP289103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU164685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU741675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD367203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA041701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA094180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA318772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ003134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC484629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC484966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC484967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC485226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000337404   ⟹   ENSP00000337127
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,165 - 159,693,278 (-)Ensembl
Ensembl Acc Id: ENST00000367054   ⟹   ENSP00000356021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,116 - 159,693,228 (-)Ensembl
Ensembl Acc Id: ENST00000367055   ⟹   ENSP00000356022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,064 - 159,693,234 (-)Ensembl
Ensembl Acc Id: ENST00000401980   ⟹   ENSP00000384196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,939 - 159,727,353 (-)Ensembl
Ensembl Acc Id: ENST00000444946   ⟹   ENSP00000404804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,139 - 159,693,241 (-)Ensembl
Ensembl Acc Id: ENST00000452684   ⟹   ENSP00000406713
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,690,919 - 159,693,244 (-)Ensembl
Ensembl Acc Id: ENST00000535459
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,461 - 159,688,348 (-)Ensembl
Ensembl Acc Id: ENST00000535561   ⟹   ENSP00000445015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,896 - 159,726,944 (-)Ensembl
Ensembl Acc Id: ENST00000537657   ⟹   ENSP00000439191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,904 - 159,745,186 (-)Ensembl
Ensembl Acc Id: ENST00000538183   ⟹   ENSP00000446252
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,669,069 - 159,693,241 (-)Ensembl
Ensembl Acc Id: ENST00000540491
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,610 - 159,692,650 (-)Ensembl
Ensembl Acc Id: ENST00000541573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,682,482 - 159,692,078 (-)Ensembl
Ensembl Acc Id: ENST00000545162   ⟹   ENSP00000441362
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,684,875 - 159,727,357 (-)Ensembl
Ensembl Acc Id: ENST00000546087   ⟹   ENSP00000442920
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,119 - 159,762,529 (-)Ensembl
Ensembl Acc Id: ENST00000546260   ⟹   ENSP00000440131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6159,679,064 - 159,693,241 (-)Ensembl
RefSeq Acc Id: NM_000636   ⟹   NP_000627
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,022,745 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001024465   ⟹   NP_001019636
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,020,138 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,924,915 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001024466   ⟹   NP_001019637
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,693,241 (-)NCBI
GRCh376160,100,148 - 160,114,353 (-)ENTREZGENE
Build 366160,020,138 - 160,034,343 (-)NCBI Archive
HuRef6157,570,584 - 157,584,704 (-)ENTREZGENE
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,924,915 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322814   ⟹   NP_001309743
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322815   ⟹   NP_001309744
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,693,241 (-)NCBI
CHM1_16160,362,979 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322816   ⟹   NP_001309745
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,690,919 - 159,693,241 (-)NCBI
CHM1_16160,374,828 - 160,377,215 (-)NCBI
T2T-CHM13v2.06160,936,763 - 160,939,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322817   ⟹   NP_001309746
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,679,064 - 159,762,281 (-)NCBI
CHM1_16160,362,979 - 160,445,890 (-)NCBI
T2T-CHM13v2.06160,924,915 - 161,007,912 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322819   ⟹   NP_001309748
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,727,384 (-)NCBI
CHM1_16160,362,979 - 160,410,735 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,973,013 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322820   ⟹   NP_001309749
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,669,069 - 159,726,950 (-)NCBI
CHM1_16160,362,979 - 160,410,324 (-)NCBI
T2T-CHM13v2.06160,914,924 - 160,972,579 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000627 (Get FASTA)   NCBI Sequence Viewer  
  NP_001019636 (Get FASTA)   NCBI Sequence Viewer  
  NP_001019637 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309743 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309744 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309745 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309746 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309748 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36622 (Get FASTA)   NCBI Sequence Viewer  
  AAA83933 (Get FASTA)   NCBI Sequence Viewer  
  AAC15835 (Get FASTA)   NCBI Sequence Viewer  
  AAD14248 (Get FASTA)   NCBI Sequence Viewer  
  AAH12423 (Get FASTA)   NCBI Sequence Viewer  
  AAH16934 (Get FASTA)   NCBI Sequence Viewer  
  AAP03428 (Get FASTA)   NCBI Sequence Viewer  
  AAP34407 (Get FASTA)   NCBI Sequence Viewer  
  AAP34408 (Get FASTA)   NCBI Sequence Viewer  
  AAP34409 (Get FASTA)   NCBI Sequence Viewer  
  AAP34410 (Get FASTA)   NCBI Sequence Viewer  
  AAP35613 (Get FASTA)   NCBI Sequence Viewer  
  AAY21807 (Get FASTA)   NCBI Sequence Viewer  
  ADO22403 (Get FASTA)   NCBI Sequence Viewer  
  BAA18955 (Get FASTA)   NCBI Sequence Viewer  
  BAG35908 (Get FASTA)   NCBI Sequence Viewer  
  BAG53464 (Get FASTA)   NCBI Sequence Viewer  
  BAG59382 (Get FASTA)   NCBI Sequence Viewer  
  BAG65521 (Get FASTA)   NCBI Sequence Viewer  
  BBK63514 (Get FASTA)   NCBI Sequence Viewer  
  BBK63515 (Get FASTA)   NCBI Sequence Viewer  
  BBK63516 (Get FASTA)   NCBI Sequence Viewer  
  BBK63517 (Get FASTA)   NCBI Sequence Viewer  
  BBK63518 (Get FASTA)   NCBI Sequence Viewer  
  BBK63519 (Get FASTA)   NCBI Sequence Viewer  
  BBK63568 (Get FASTA)   NCBI Sequence Viewer  
  BBK63569 (Get FASTA)   NCBI Sequence Viewer  
  CAA30687 (Get FASTA)   NCBI Sequence Viewer  
  CAA32502 (Get FASTA)   NCBI Sequence Viewer  
  CAA33228 (Get FASTA)   NCBI Sequence Viewer  
  CAA42066 (Get FASTA)   NCBI Sequence Viewer  
  CAA68533 (Get FASTA)   NCBI Sequence Viewer  
  CAA68791 (Get FASTA)   NCBI Sequence Viewer  
  CAB62521 (Get FASTA)   NCBI Sequence Viewer  
  EAW47629 (Get FASTA)   NCBI Sequence Viewer  
  EAW47630 (Get FASTA)   NCBI Sequence Viewer  
  EAW47631 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000337127
  ENSP00000337127.4
  ENSP00000356021
  ENSP00000356021.2
  ENSP00000356022
  ENSP00000356022.4
  ENSP00000384196.3
  ENSP00000404804
  ENSP00000404804.2
  ENSP00000406713
  ENSP00000406713.2
  ENSP00000439191.1
  ENSP00000440131.1
  ENSP00000441362.1
  ENSP00000442920
  ENSP00000442920.1
  ENSP00000445015.1
  ENSP00000446252
  ENSP00000446252.1
GenBank Protein P04179 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019637   ⟸   NM_001024466
- Peptide Label: isoform B
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001019636   ⟸   NM_001024465
- Peptide Label: isoform A precursor
- UniProtKB: Q96EE6 (UniProtKB/Swiss-Prot),   Q5TCM1 (UniProtKB/Swiss-Prot),   Q16792 (UniProtKB/Swiss-Prot),   P78434 (UniProtKB/Swiss-Prot),   E1P5A9 (UniProtKB/Swiss-Prot),   B4E3K9 (UniProtKB/Swiss-Prot),   B4DL20 (UniProtKB/Swiss-Prot),   B3KUK2 (UniProtKB/Swiss-Prot),   B2R7R1 (UniProtKB/Swiss-Prot),   Q9P2Z3 (UniProtKB/Swiss-Prot),   P04179 (UniProtKB/Swiss-Prot),   A0A384NL29 (UniProtKB/TrEMBL),   Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000627   ⟸   NM_000636
- Peptide Label: isoform A precursor
- UniProtKB: Q96EE6 (UniProtKB/Swiss-Prot),   Q5TCM1 (UniProtKB/Swiss-Prot),   Q16792 (UniProtKB/Swiss-Prot),   P78434 (UniProtKB/Swiss-Prot),   E1P5A9 (UniProtKB/Swiss-Prot),   B4E3K9 (UniProtKB/Swiss-Prot),   B4DL20 (UniProtKB/Swiss-Prot),   B3KUK2 (UniProtKB/Swiss-Prot),   B2R7R1 (UniProtKB/Swiss-Prot),   Q9P2Z3 (UniProtKB/Swiss-Prot),   P04179 (UniProtKB/Swiss-Prot),   A0A384NL29 (UniProtKB/TrEMBL),   Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309746   ⟸   NM_001322817
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309748   ⟸   NM_001322819
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309749   ⟸   NM_001322820
- Peptide Label: isoform E
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309743   ⟸   NM_001322814
- Peptide Label: isoform B
- UniProtKB: Q7Z7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309744   ⟸   NM_001322815
- Peptide Label: isoform C precursor
- UniProtKB: P04179 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001309745   ⟸   NM_001322816
- Peptide Label: isoform D
- UniProtKB: G5E9P6 (UniProtKB/TrEMBL),   Q96AM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000406713   ⟸   ENST00000452684
Ensembl Acc Id: ENSP00000441362   ⟸   ENST00000545162
Ensembl Acc Id: ENSP00000440131   ⟸   ENST00000546260
Ensembl Acc Id: ENSP00000442920   ⟸   ENST00000546087
Ensembl Acc Id: ENSP00000337127   ⟸   ENST00000337404
Ensembl Acc Id: ENSP00000384196   ⟸   ENST00000401980
Ensembl Acc Id: ENSP00000445015   ⟸   ENST00000535561
Ensembl Acc Id: ENSP00000404804   ⟸   ENST00000444946
Ensembl Acc Id: ENSP00000439191   ⟸   ENST00000537657
Ensembl Acc Id: ENSP00000446252   ⟸   ENST00000538183
Ensembl Acc Id: ENSP00000356021   ⟸   ENST00000367054
Ensembl Acc Id: ENSP00000356022   ⟸   ENST00000367055
Protein Domains
Manganese/iron superoxide dismutase C-terminal   Manganese/iron superoxide dismutase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04179-F1-model_v2 AlphaFold P04179 1-222 view protein structure

Promoters
RGD ID:7209571
Promoter ID:EPDNEW_H10531
Type:initiation region
Name:SOD2_5
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,681,587 - 159,681,647EPDNEW
RGD ID:7209573
Promoter ID:EPDNEW_H10532
Type:initiation region
Name:SOD2_4
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,684,934 - 159,684,994EPDNEW
RGD ID:7209575
Promoter ID:EPDNEW_H10533
Type:initiation region
Name:SOD2_6
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10534  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,688,188 - 159,688,248EPDNEW
RGD ID:7209577
Promoter ID:EPDNEW_H10534
Type:initiation region
Name:SOD2_1
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10536  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,693,241 - 159,693,301EPDNEW
RGD ID:7209579
Promoter ID:EPDNEW_H10536
Type:initiation region
Name:SOD2_3
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10538  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,726,950 - 159,727,010EPDNEW
RGD ID:7209585
Promoter ID:EPDNEW_H10538
Type:initiation region
Name:SOD2_2
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10531  EPDNEW_H10532  EPDNEW_H10533  EPDNEW_H10534  EPDNEW_H10536  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,355 - 159,727,415EPDNEW
RGD ID:6804814
Promoter ID:HG_KWN:55651
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_000636,   NM_001024466,   OTTHUMT00000042922,   UC003QSJ.2
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,034,176 - 160,034,747 (-)MPROMDB
RGD ID:6851922
Promoter ID:EP73767
Type:initiation region
Name:HS_SOD2
Description:Superoxide dismutase 2, mitochondrial.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,034,263 - 160,034,323EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11180 AgrOrtholog
COSMIC SOD2 COSMIC
Ensembl Genes ENSG00000112096 Ensembl
  ENSG00000285441 Ensembl
  ENSG00000291237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000337404 ENTREZGENE
  ENST00000337404.8 UniProtKB/Swiss-Prot
  ENST00000367054 ENTREZGENE
  ENST00000367054.6 UniProtKB/Swiss-Prot
  ENST00000367055 ENTREZGENE
  ENST00000367055.8 UniProtKB/Swiss-Prot
  ENST00000401980.3 UniProtKB/TrEMBL
  ENST00000444946 ENTREZGENE
  ENST00000444946.6 UniProtKB/Swiss-Prot
  ENST00000452684 ENTREZGENE
  ENST00000452684.2 UniProtKB/TrEMBL
  ENST00000535561.5 UniProtKB/TrEMBL
  ENST00000537657.5 UniProtKB/TrEMBL
  ENST00000538183 ENTREZGENE
  ENST00000538183.7 UniProtKB/Swiss-Prot
  ENST00000545162.5 UniProtKB/TrEMBL
  ENST00000546087 ENTREZGENE
  ENST00000546087.5 UniProtKB/Swiss-Prot
  ENST00000546260.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.990 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.55.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000112096 GTEx
  ENSG00000285441 GTEx
  ENSG00000291237 GTEx
HGNC ID HGNC:11180 ENTREZGENE
Human Proteome Map SOD2 Human Proteome Map
InterPro Mn/Fe_SOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6648 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 6648 ENTREZGENE
OMIM 147460 OMIM
PANTHER SUPEROXIDE DISMUTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Fe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sod_Fe_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36017 PharmGKB, RGD
PIRSF SODismutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MNSODISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_MN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46609 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A384NL29 ENTREZGENE, UniProtKB/TrEMBL
  B2R7R1 ENTREZGENE
  B3KUK2 ENTREZGENE
  B4DL20 ENTREZGENE
  B4E3K9 ENTREZGENE
  E1P5A9 ENTREZGENE
  F5GXZ9_HUMAN UniProtKB/TrEMBL
  F5GYZ5_HUMAN UniProtKB/TrEMBL
  F5H3C5_HUMAN UniProtKB/TrEMBL
  F5H4R2_HUMAN UniProtKB/TrEMBL
  G5E9P6 ENTREZGENE, UniProtKB/TrEMBL
  G8JLJ2_HUMAN UniProtKB/TrEMBL
  P04179 ENTREZGENE
  P78434 ENTREZGENE
  Q16792 ENTREZGENE
  Q4ZJI1_HUMAN UniProtKB/TrEMBL
  Q5TCM1 ENTREZGENE
  Q6LE88_HUMAN UniProtKB/TrEMBL
  Q71UR9_HUMAN UniProtKB/TrEMBL
  Q7Z7M4 ENTREZGENE, UniProtKB/TrEMBL
  Q7Z7M5_HUMAN UniProtKB/TrEMBL
  Q7Z7M6_HUMAN UniProtKB/TrEMBL
  Q7Z7M7_HUMAN UniProtKB/TrEMBL
  Q96AM7 ENTREZGENE, UniProtKB/TrEMBL
  Q96EE6 ENTREZGENE
  Q9P2Z3 ENTREZGENE
  Q9UG59_HUMAN UniProtKB/TrEMBL
  SODM_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2R7R1 UniProtKB/Swiss-Prot
  B3KUK2 UniProtKB/Swiss-Prot
  B4DL20 UniProtKB/Swiss-Prot
  B4E3K9 UniProtKB/Swiss-Prot
  E1P5A9 UniProtKB/Swiss-Prot
  P78434 UniProtKB/Swiss-Prot
  Q16792 UniProtKB/Swiss-Prot
  Q5TCM1 UniProtKB/Swiss-Prot
  Q96EE6 UniProtKB/Swiss-Prot
  Q9P2Z3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 SOD2  superoxide dismutase 2  SOD2  superoxide dismutase 2, mitochondrial  Symbol and/or name change 5135510 APPROVED