RGD Reference Report - Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. - Rat Genome Database

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Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma.

Authors: Liu, X  Wang, A  Lo Muzio, L  Kolokythas, A  Sheng, S  Rubini, C  Ye, H  Shi, F  Yu, T  Crowe, DL  Zhou, X 
Citation: Liu X, etal., BMC Cancer. 2010 Jul 9;10:365. doi: 10.1186/1471-2407-10-365.
RGD ID: 8547519
Pubmed: PMID:20618948   (View Abstract at PubMed)
PMCID: PMC2911422   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2407-10-365   (Journal Full-text)

BACKGROUND: Lymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic information to facilitate clinical decision making. Previous studies showed that deregulation of manganese superoxide dismutase (SOD2) expression is a frequent event in TSCC and may be associated with enhanced cell invasion. The purpose of this study is to further evaluate whether the expression level of SOD2 is correlated with the metastatic status in TSCC patients. METHODS: We first examined the SOD2 expression at mRNA level on 53 TSCC and 22 normal control samples based on pooled-analysis of existing microarray datasets. To confirm our observations, we examined the expression of SOD2 at protein level on an additional TSCC patient cohort (n = 100), as well as 31 premalignant dysplasias, 15 normal tongue mucosa, and 32 lymph node metastatic diseases by immunohistochemistry (IHC). RESULTS: The SOD2 mRNA level in primary TSCC tissue is reversely correlated with lymph node metastasis in the first TSCC patient cohort. The SOD2 protein level in primary TSCC tissue is also reversely correlated with lymph node metastasis in the second TSCC patient cohort. Deregulation of SOD2 expression is a common event in TSCC and appears to be associated with disease progression. Statistical analysis revealed that the reduced SOD2 expression in primary tumor tissue is associated with lymph node metastasis in both TSCC patient cohorts examined. CONCLUSIONS: Our study suggested that the deregulation of SOD2 in TSCC has potential predictive values for lymph node metastasis, and may serve as a therapeutic target for patients at risk of metastasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SOD2HumanLymphatic Metastasis disease_progressionIEP associated with tongue neoplasmsRGD 
Sod2RatLymphatic Metastasis disease_progressionISOSOD2 (Homo sapiens)associated with tongue neoplasmsRGD 
Sod2MouseLymphatic Metastasis disease_progressionISOSOD2 (Homo sapiens)associated with tongue neoplasmsRGD 
SOD2HumanTongue Neoplasms  IEP mRNA and protein:increased expression:tongue:RGD 
Sod2RatTongue Neoplasms  ISOSOD2 (Homo sapiens)mRNA and protein:increased expression:tongue:RGD 
Sod2MouseTongue Neoplasms  ISOSOD2 (Homo sapiens)mRNA and protein:increased expression:tongue:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sod2  (superoxide dismutase 2)

Genes (Mus musculus)
Sod2  (superoxide dismutase 2, mitochondrial)

Genes (Homo sapiens)
SOD2  (superoxide dismutase 2)


Additional Information