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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330
Species: Mus musculus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
Acc ID: CHEBI:17963
Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Definition: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Chemical ID: MESH:D015632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionEXP 6480464CTD1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SOD2 proteinPMID:23562983
Sod2increases expressionEXP 6480464CTD1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SOD2 proteinPMID:19679656
Sod2multiple interactionsEXP 6480464CTD[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SOD2 protein; Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SOD2 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SOD2 protein]PMID:19679656 PMID:23562983
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