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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11330
Species: Mus musculus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2, mitochondrial
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 proteinPMID:26558463
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 mRNA; 1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 proteinPMID:24399507 PMID:25073091 PMID:36174668
Sod2increases activityISOSOD2 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in increased activity of SOD2 proteinPMID:10737593
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDchikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 mRNA]; MIR29A inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 protein]; SN50 peptide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of SOD2 protein]PMID:10737593 PMID:25073091 PMID:36174668
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