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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:procyclidine
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Accession:CHEBI:8448 term browser browse the term
Definition:A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
Synonyms:exact_synonym: 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol
 related_synonym: 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol;   Formula=C19H29NO;   InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2;   InChIKey=WYDUSKDSKCASEF-UHFFFAOYSA-N;   SMILES=OC(CCN1CCCC1)(C1CCCCC1)c1ccccc1;   Tricyclamol;   prociclidina;   procyclidinum
 xref: CAS:77-37-2;   DrugBank:DB00387;   Drug_Central:2276;   HMDB:HMDB0014531;   KEGG:C07378;   KEGG:D08425;   LINCS:LSM-4396
 xref_mesh: MESH:D011352
 xref: PMID:2878700;   Patent:US2826590;   Patent:US2891890;   Reaxys:88563


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procyclidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Procyclidine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Procyclidine results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Ereg epiregulin increases expression ISO Procyclidine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Procyclidine results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Procyclidine results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 increases expression ISO Procyclidine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Procyclidine results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Procyclidine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Procyclidine results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Procyclidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Procyclidine results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Procyclidine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Procyclidine results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        pharmaceutical 20413
          drug 20413
            antidyskinesia agent 1561
              procyclidine 13
                procyclidine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      p-block molecular entity 20777
                        carbon group molecular entity 20710
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  organic heteromonocyclic compound 18207
                                    pyrrolidines 2347
                                      procyclidine 13
                                        procyclidine hydrochloride 0
paths to the root