Prkaca (protein kinase, cAMP dependent, catalytic, alpha) - Rat Genome Database
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Gene: Prkaca (protein kinase, cAMP dependent, catalytic, alpha) Mus musculus
Analyze
Symbol: Prkaca
Name: protein kinase, cAMP dependent, catalytic, alpha
RGD ID: 1552640
MGI Page MGI
Description: Exhibits several functions, including ATP binding activity; cAMP-dependent protein kinase activity; and metal ion binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; embryonic morphogenesis; and protein phosphorylation. Localizes to several cellular components, including acrosomal vesicle; cAMP-dependent protein kinase complex; and ciliary base. Predicted to colocalize with axoneme. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and musculature. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha isoform; cAMP-dependent protein kinase catalytic subunit C alpha 2; Cs; P; Pk; PKA; PKA C-alpha; Pkaca; PKCD; sperm cAMP-dependent protein kinase catalytic subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Prkaca-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,699,607 - 84,723,073 (+)NCBIGRCm39mm39
GRCm38883,972,978 - 83,996,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,972,993 - 83,996,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,496,877 - 86,520,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv36886,863,093 - 86,886,544 (+)NCBImm8
Celera888,266,474 - 88,289,645 (+)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-tert-butylhydroquinone  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
ammonium chloride  (ISO)
arsenite(3-)  (EXP)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
BAPTA  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
buprenorphine  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
captopril  (ISO)
chaetocin  (ISO)
cisplatin  (ISO)
clenbuterol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
cyanidin 3-O-beta-D-glucoside  (EXP)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dexamethasone  (EXP)
dicrotophos  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroxysafflor yellow A  (ISO)
KT 5720  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
Licarin A  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
ochratoxin A  (ISO)
oxidopamine  (ISO)
oxycodone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregabalin  (ISO)
prostaglandin E2  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
taurolithocholic acid  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
Tylophorine  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
apoptotic cell death pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
dopamine signaling pathway  (ISO)
eicosanoid signaling pathway  (ISO)
Entamoebiasis pathway  (IEA)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (IEA,ISO)
ibutilide pharmacodynamics pathway  (ISO)
insulin signaling pathway  (IEA)
interleukin-3 signaling pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prion disease pathway  (IEA)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
protein kinase A (PKA) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
vasopressin signaling pathway via receptor type 2  (IEA)
verapamil pharmacodynamics pathway  (ISO)
Wnt signaling pathway  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone mineralization  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron specification  (IAGP)
abnormal periosteum morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal sperm motility  (IAGP)
abnormal spine curvature  (IAGP)
abnormal vertebral arch morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
asthenozoospermia  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating insulin level  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver glycogen level  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased urine protein level  (IAGP)
disorganized dorsal root ganglion  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
exencephaly  (IAGP)
impaired fertilization  (IAGP)
impaired glucose tolerance  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased neural tube apoptosis  (IAGP)
increased osteochondroma incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased skeletal tumor incidence  (IAGP)
male infertility  (IAGP)
pericardial edema  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
spina bifida  (IAGP)
References

Additional References at PubMed
PMID:1584809   PMID:1862342   PMID:2342480   PMID:2619996   PMID:2833513   PMID:3023318   PMID:3456589   PMID:7775586   PMID:7873880   PMID:7905001   PMID:8443157   PMID:8548807  
PMID:8793051   PMID:8794865   PMID:8939971   PMID:9109651   PMID:9218452   PMID:9261084   PMID:9413984   PMID:9688563   PMID:9916858   PMID:10349636   PMID:10593917   PMID:10767319  
PMID:10805756   PMID:10841548   PMID:10862698   PMID:10913627   PMID:10922068   PMID:10945997   PMID:10982398   PMID:11042159   PMID:11050131   PMID:11076861   PMID:11141074   PMID:11217851  
PMID:11559352   PMID:11698644   PMID:11799117   PMID:11804588   PMID:11875122   PMID:11886853   PMID:12004056   PMID:12034735   PMID:12051828   PMID:12123716   PMID:12139926   PMID:12180908  
PMID:12193547   PMID:12200423   PMID:12372837   PMID:12453050   PMID:12477932   PMID:12614615   PMID:12646569   PMID:12801936   PMID:12837291   PMID:12931191   PMID:14673008   PMID:14681479  
PMID:14724137   PMID:14757059   PMID:14967031   PMID:15023366   PMID:15039079   PMID:15039316   PMID:15111495   PMID:15133036   PMID:15212707   PMID:15340140   PMID:15345747   PMID:15347661  
PMID:15465019   PMID:15489334   PMID:15529118   PMID:15550674   PMID:15557275   PMID:15580572   PMID:15590926   PMID:15618230   PMID:15649893   PMID:15663937   PMID:15692043   PMID:15724149  
PMID:15741175   PMID:15753322   PMID:15782199   PMID:15851520   PMID:15860459   PMID:15889150   PMID:16129693   PMID:16141072   PMID:16141073   PMID:16155866   PMID:16169904   PMID:16172130  
PMID:16280415   PMID:16289764   PMID:16303765   PMID:16436600   PMID:16481613   PMID:16484320   PMID:16514061   PMID:16602821   PMID:16625003   PMID:16707791   PMID:16782699   PMID:16785309  
PMID:16793902   PMID:16835269   PMID:16924114   PMID:16956882   PMID:16966355   PMID:16973906   PMID:16990513   PMID:17043310   PMID:17053039   PMID:17075052   PMID:17079783   PMID:17149706  
PMID:17279627   PMID:17290424   PMID:17296605   PMID:17301223   PMID:17322895   PMID:17407158   PMID:17464208   PMID:17478427   PMID:17557924   PMID:17585336   PMID:17651699   PMID:17855365  
PMID:17923693   PMID:17938178   PMID:17972919   PMID:18048352   PMID:18191828   PMID:18202122   PMID:18305402   PMID:18310078   PMID:18316483   PMID:18338389   PMID:18353144   PMID:18367160  
PMID:18380891   PMID:18387001   PMID:18463244   PMID:18467503   PMID:18565730   PMID:18583710   PMID:18633139   PMID:18727045   PMID:18758906   PMID:18762248   PMID:18799693   PMID:18829456  
PMID:19035343   PMID:19056373   PMID:19074277   PMID:19113914   PMID:19138662   PMID:19144927   PMID:19223768   PMID:19229884   PMID:19234474   PMID:19356238   PMID:19389706   PMID:19389708  
PMID:19447092   PMID:19560455   PMID:19601643   PMID:19647741   PMID:19706446   PMID:19706594   PMID:19706882   PMID:19723499   PMID:19924297   PMID:20045463   PMID:20067919   PMID:20103769  
PMID:20107112   PMID:20207816   PMID:20363288   PMID:20421483   PMID:20442403   PMID:20525692   PMID:20542497   PMID:20591207   PMID:20615971   PMID:20630779   PMID:20637325   PMID:20716686  
PMID:20940146   PMID:21209912   PMID:21267068   PMID:21300294   PMID:21306750   PMID:21406180   PMID:21430226   PMID:21533282   PMID:21559296   PMID:21614075   PMID:21808064   PMID:21808067  
PMID:21835884   PMID:21852354   PMID:21873635   PMID:21888435   PMID:21896757   PMID:21911379   PMID:22007132   PMID:22138346   PMID:22195961   PMID:22267325   PMID:22323819   PMID:22493239  
PMID:22496451   PMID:22645447   PMID:22658979   PMID:22733971   PMID:22751671   PMID:22771957   PMID:22797923   PMID:22815846   PMID:22954688   PMID:23028418   PMID:23028752   PMID:23049792  
PMID:23055522   PMID:23104882   PMID:23116618   PMID:23159612   PMID:23238728   PMID:23275441   PMID:23324178   PMID:23329830   PMID:23349500   PMID:23362255   PMID:23393127   PMID:23456795  
PMID:23458248   PMID:23507145   PMID:23583750   PMID:23593352   PMID:23647065   PMID:23709216   PMID:23965992   PMID:23981281   PMID:24058535   PMID:24086441   PMID:24101724   PMID:24128762  
PMID:24211434   PMID:24260568   PMID:24464040   PMID:24512487   PMID:24556414   PMID:24560667   PMID:24643070   PMID:24687590   PMID:24691407   PMID:24713698   PMID:24786636   PMID:24828496  
PMID:24831015   PMID:24842369   PMID:24905167   PMID:24952961   PMID:25073061   PMID:25193703   PMID:25275314   PMID:25418045   PMID:25475437   PMID:25512381   PMID:25933021   PMID:25961040  
PMID:25970584   PMID:26030372   PMID:26060254   PMID:26158466   PMID:26203188   PMID:26278174   PMID:26305972   PMID:26387949   PMID:26488807   PMID:26582204   PMID:26618408   PMID:26626075  
PMID:26743816   PMID:26833386   PMID:26992826   PMID:27105888   PMID:27156838   PMID:27160897   PMID:27245613   PMID:27353657   PMID:27498419   PMID:27624192   PMID:27720745   PMID:28115705  
PMID:28119464   PMID:28119465   PMID:28420713   PMID:28556983   PMID:28636612   PMID:28661131   PMID:28671696   PMID:28706196   PMID:28911199   PMID:28923495   PMID:28973931   PMID:29038164  
PMID:29162699   PMID:29183804   PMID:29473541   PMID:29581285   PMID:30026308   PMID:30068389   PMID:30457570   PMID:30468265   PMID:30652267   PMID:31078384   PMID:31176020   PMID:31545012  
PMID:31935860   PMID:32325033   PMID:32873725  


Genomics

Comparative Map Data
Prkaca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,699,607 - 84,723,073 (+)NCBIGRCm39mm39
GRCm38883,972,978 - 83,996,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,972,993 - 83,996,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,496,877 - 86,520,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv36886,863,093 - 86,886,544 (+)NCBImm8
Celera888,266,474 - 88,289,645 (+)NCBICelera
Cytogenetic Map8C2NCBI
PRKACA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,091,688 - 14,118,084 (-)EnsemblGRCh38hg38GRCh38
GRCh381914,091,688 - 14,117,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,202,500 - 14,228,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,063,500 - 14,089,559 (-)NCBINCBI36hg18NCBI36
Build 341914,063,508 - 14,085,992NCBI
Celera1914,096,777 - 14,122,833 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,774,379 - 13,800,126 (-)NCBIHuRef
CHM1_11914,202,926 - 14,228,985 (-)NCBICHM1_1
Prkaca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,095,089 - 25,118,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,095,089 - 25,118,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,073,104 - 36,096,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,840,795 - 25,864,786 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,845,620 - 25,861,927 (-)NCBI
Celera1923,703,180 - 23,726,723 (-)NCBICelera
Cytogenetic Map19q11NCBI
Prkaca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,793,718 - 32,812,930 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,794,172 - 32,807,944 (-)NCBIChiLan1.0ChiLan1.0
PRKACA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,385,183 - 14,406,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,385,191 - 14,406,205 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01913,657,344 - 13,683,864 (-)NCBIMhudiblu_PPA_v0panPan3
PRKACA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2048,409,045 - 48,426,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12048,416,730 - 48,425,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Prkaca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,750,015 - 2,765,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,074,870 - 65,095,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,074,876 - 65,095,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,350,544 - 65,371,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,743,752 - 12,759,155 (-)NCBI
Prkaca
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,319,426 - 1,336,848 (-)NCBI

Position Markers
RH128078  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38883,996,060 - 83,996,278UniSTSGRCm38
MGSCv37886,519,959 - 86,520,177UniSTSGRCm37
Celera888,289,260 - 88,289,478UniSTS
Cytogenetic Map8C3UniSTS
RH94810  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X161,484,061 - 161,484,176UniSTSGRCm38
GRCm38883,995,965 - 83,996,079UniSTSGRCm38
MGSCv37886,519,864 - 86,519,978UniSTSGRCm37
MGSCv37X157,921,993 - 157,922,108UniSTSGRCm37
Celera888,289,165 - 88,289,279UniSTS
CeleraX144,721,668 - 144,721,783UniSTS
Cytogenetic Map8C3UniSTS
Prkaca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37X157,921,884 - 157,922,048UniSTSGRCm37
MGSCv37886,519,923 - 86,520,106UniSTSGRCm37
Celera888,289,224 - 88,289,407UniSTS
CeleraX144,721,559 - 144,721,723UniSTS
Cytogenetic Map8C3UniSTS
cM Map8 UniSTS
PMC18620P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38883,976,823 - 83,977,094UniSTSGRCm38
MGSCv37886,500,722 - 86,500,993UniSTSGRCm37
Celera888,270,321 - 88,270,593UniSTS
Cytogenetic Map8C3UniSTS
Prkaca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
Prkaca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38883,996,024 - 83,996,207UniSTSGRCm38
GRCm38X161,483,952 - 161,484,116UniSTSGRCm38
MGSCv37X157,921,884 - 157,922,048UniSTSGRCm37
MGSCv37886,519,923 - 86,520,106UniSTSGRCm37
Celera888,289,224 - 88,289,407UniSTS
CeleraX144,721,559 - 144,721,723UniSTS
Cytogenetic Map8C3UniSTS
cM Map8 UniSTS
Prkaca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:420
Count of miRNA genes:275
Interacting mature miRNAs:324
Transcripts:ENSMUST00000005606
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF224719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ031203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU059097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB248596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD807077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN566056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000005606   ⟹   ENSMUSP00000005606
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl883,972,993 - 83,996,443 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211558   ⟹   ENSMUSP00000147256
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl883,976,883 - 83,995,594 (+)Ensembl
RefSeq Acc Id: NM_001277898   ⟹   NP_001264827
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,703,512 - 84,723,073 (+)NCBI
GRCm38883,976,883 - 83,996,444 (+)NCBI
Celera888,266,474 - 88,289,644 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008854   ⟹   NP_032880
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,699,607 - 84,723,073 (+)NCBI
GRCm38883,972,978 - 83,996,444 (+)NCBI
MGSCv37886,496,877 - 86,520,344 (+)RGD
Celera888,266,474 - 88,289,644 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032880   ⟸   NM_008854
- Peptide Label: isoform 1
- UniProtKB: P05132 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264827   ⟸   NM_001277898
- Peptide Label: isoform 2
- UniProtKB: P05132 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000147256   ⟸   ENSMUST00000211558
RefSeq Acc Id: ENSMUSP00000005606   ⟸   ENSMUST00000005606
Promoters
RGD ID:8667641
Promoter ID:EPDNEW_M11846
Type:initiation region
Name:Prkaca_1
Description:Mus musculus protein kinase, cAMP dependent, catalytic, alpha, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38883,972,982 - 83,973,042EPDNEW
RGD ID:6843631
Promoter ID:MM_KWN:55037
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:NM_008854
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,496,176 - 86,496,902 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97592 AgrOrtholog
Ensembl Genes ENSMUSG00000005469 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000005606 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147256 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000005606 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000211558 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKA_C-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_PKA UniProtKB/Swiss-Prot
KEGG Report mmu:18747 UniProtKB/Swiss-Prot
MGD MGI:97592 ENTREZGENE
NCBI Gene 18747 ENTREZGENE
PANTHER PTHR24353:SF82 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkaca PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt J9JDU9_MOUSE UniProtKB/TrEMBL
  KAPCA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9JID0 UniProtKB/Swiss-Prot