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Gene: Htr1a (5-hydroxytryptamine (serotonin) receptor 1A) Mus musculus
Symbol: Htr1a
Name: 5-hydroxytryptamine (serotonin) receptor 1A
Description: Exhibits G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; regulation of serotonin secretion; and serotonin metabolic process. Predicted to localize to several cellular components, including GABA-ergic synapse; axon hillock; and integral component of presynaptic membrane. Is expressed in several structures, including central nervous system; exocrine gland; eye; genitourinary system; and intestine. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 8-OH-DPAT; apocynin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-HT-1A; 5-HT1A receptor; 5-hydroxytryptamine receptor 1A; G-protein coupled receptor 18; Gpcr18; serotonin receptor 1A
Homo sapiens (human) : HTR1A (5-hydroxytryptamine receptor 1A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Htr1a (5-hydroxytryptamine receptor 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr1a (5-hydroxytryptamine receptor 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR1A (5-hydroxytryptamine receptor 1A)
Canis lupus familiaris (dog) : HTR1A (5-hydroxytryptamine receptor 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr1a (5-hydroxytryptamine receptor 1A)
Sus scrofa (pig) : HTR1A (5-hydroxytryptamine receptor 1A)
Chlorocebus sabaeus (African green monkey) : HTR1A (5-hydroxytryptamine receptor 1A)
Heterocephalus glaber (naked mole-rat) : Htr1a (5-hydroxytryptamine receptor 1A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl13105,443,639 - 105,448,122 (+)EnsemblGRCm38mm10GRCm38
GRCm3813105,443,693 - 105,448,133 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3713106,233,773 - 106,238,213 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613106,564,148 - 106,568,501 (+)NCBImm8
Celera13109,835,550 - 109,839,989 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1356.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Htr1a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10745
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.