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Gene: Nrg1 (neuregulin 1) Mus musculus
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Symbol: Nrg1
Name: neuregulin 1
RGD ID: 735609
Description: Exhibits ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including nervous system development; positive regulation of intracellular signal transduction; and positive regulation of protein phosphorylation. Localizes to several cellular components, including GABA-ergic synapse; axolemma; and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; dementia; middle cerebral artery infarction; myocardial infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGFII; hereg; heregulin; HG; Hgl; HR; HRG; HRGalpha; ND; NDF; pro-neuregulin-1, membrane-bound isoform; SMD; SMDF; type I neuregulin 1; type III neuregulin 1
Orthologs:
Homo sapiens (human) : NRG1 (neuregulin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nrg1 (neuregulin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nrg1 (neuregulin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NRG1 (neuregulin 1)
Canis lupus familiaris (dog) : NRG1 (neuregulin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrg1 (neuregulin 1)
Sus scrofa (pig) : NRG1 (neuregulin 1)
Chlorocebus sabaeus (African green monkey) : NRG1 (neuregulin 1)
Heterocephalus glaber (naked mole-rat) : Nrg1 (neuregulin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39832,299,493 - 33,381,858 (-)NCBI
GRCm38831,807,452 - 32,891,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,814,551 - 32,884,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv37832,928,500 - 33,028,675 (-)NCBIGRCm37mm9NCBIm37
MGSCv36833,280,406 - 33,475,426 (-)NCBImm8
Celera833,340,249 - 33,441,164 (-)NCBICelera
Cytogenetic Map8A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences