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Gene: Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like) Mus musculus
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Symbol: Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Description: Predicted to have ATP binding activity; formate-tetrahydrofolate ligase activity; and protein homodimerization activity. Involved in embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; and neural tube closure. Localizes to the mitochondrion. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410004L15Rik; AI647056; formyltetrahydrofolate synthetase domain containing 1; Fthfsdc1; monofunctional C1-tetrahydrofolate synthase, mitochondrial
Orthologs:
Related Pseudogenes: Gm9194  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38103,972,892 - 4,167,081 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37106,179,460 - 6,373,466 (-)NCBIGRCm37mm9NCBIm37
MGSCv36106,190,430 - 6,373,423 (-)NCBImm8
Celera103,900,899 - 4,096,959 (+)NCBICelera
Cytogenetic Map10 A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Mthfd1l
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550697
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.