Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like) - Rat Genome Database

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Gene: Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like) Mus musculus
Analyze
Symbol: Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
RGD ID: 1550697
MGI Page MGI
Description: Predicted to enable ATP binding activity; formate-tetrahydrofolate ligase activity; and protein homodimerization activity. Involved in embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; and neural tube closure. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410004L15Rik; AI647056; formyltetrahydrofolate synthetase domain containing 1; Fthfsdc; Fthfsdc1; monofunctional C1-tetrahydrofolate synthase, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm9194  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39103,918,282 - 4,117,081 (+)NCBIGRCm39mm39
GRCm39 Ensembl103,923,118 - 4,117,081 (+)Ensembl
GRCm38103,972,892 - 4,167,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl103,973,118 - 4,167,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37106,179,460 - 6,373,466 (-)NCBIGRCm37mm9NCBIm37
MGSCv36106,190,430 - 6,373,423 (-)NCBImm8
Celera103,900,899 - 4,096,959 (+)NCBICelera
Cytogenetic Map10A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chloroprene  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
glycine betaine  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
mitochondrion  (HDA,IBA,IDA,ISO)

References

Additional References at PubMed
PMID:8049528   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:16512683   PMID:17062627   PMID:18614015   PMID:18799693   PMID:19525957   PMID:19948730   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24457600   PMID:24733394   PMID:28378742  
PMID:29483189   PMID:30333137   PMID:30457570   PMID:30550785   PMID:31518072   PMID:32581705  


Genomics

Comparative Map Data
Mthfd1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39103,918,282 - 4,117,081 (+)NCBIGRCm39mm39
GRCm39 Ensembl103,923,118 - 4,117,081 (+)Ensembl
GRCm38103,972,892 - 4,167,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl103,973,118 - 4,167,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37106,179,460 - 6,373,466 (-)NCBIGRCm37mm9NCBIm37
MGSCv36106,190,430 - 6,373,423 (-)NCBImm8
Celera103,900,899 - 4,096,959 (+)NCBICelera
Cytogenetic Map10A1NCBI
MTHFD1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6150,865,679 - 151,101,887 (+)EnsemblGRCh38hg38GRCh38
GRCh386150,865,684 - 151,101,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376151,186,838 - 151,423,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,228,384 - 151,464,716 (+)NCBINCBI36hg18NCBI36
Build 346151,278,804 - 151,515,135NCBI
Celera6151,920,551 - 152,156,863 (+)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6148,750,394 - 148,986,848 (+)NCBIHuRef
CHM1_16151,450,554 - 151,687,113 (+)NCBICHM1_1
Mthfd1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2140,443,926 - 40,632,911 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl140,444,008 - 40,632,905 (+)Ensembl
Rnor_6.0140,529,092 - 40,719,232 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,529,045 - 40,719,391 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0141,876,363 - 42,065,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,759,445 - 34,800,865 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1134,690,706 - 34,876,868 (+)NCBI
Celera136,135,294 - 36,323,637 (+)NCBICelera
Cytogenetic Map1p11-q11NCBI
Mthfd1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,438,883 - 10,621,768 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,432,732 - 10,621,991 (-)NCBIChiLan1.0ChiLan1.0
MTHFD1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16153,384,532 - 153,619,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,390,498 - 153,619,884 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06148,679,587 - 148,919,002 (+)NCBIMhudiblu_PPA_v0panPan3
MTHFD1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,316,247 - 41,495,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,309,419 - 41,495,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,149,900 - 42,336,703 (+)NCBI
ROS_Cfam_1.0141,493,594 - 41,680,491 (+)NCBI
UMICH_Zoey_3.1141,368,435 - 41,555,234 (+)NCBI
UNSW_CanFamBas_1.0141,212,380 - 41,399,156 (+)NCBI
UU_Cfam_GSD_1.0141,717,070 - 41,904,119 (+)NCBI
Mthfd1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,625,481 - 136,807,195 (+)NCBI
SpeTri2.0NW_0049364893,877,423 - 4,060,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,140,898 - 15,329,966 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,140,929 - 15,330,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,550,520 - 17,655,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,306,770 - 78,539,884 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1378,306,821 - 78,477,200 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604050,602,217 - 50,869,140 (+)NCBIVero_WHO_p1.0
Mthfd1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247857,129,969 - 7,328,331 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH126561  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38103,994,759 - 3,994,968UniSTSGRCm38
GRCm38534,353,211 - 34,353,420UniSTSGRCm38
MGSCv37534,695,860 - 34,696,069UniSTSGRCm37
MGSCv37106,351,573 - 6,351,782UniSTSGRCm37
Celera103,922,536 - 3,922,745UniSTS
Celera531,823,815 - 31,824,024UniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map5B2UniSTS
AI647056  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38104,155,946 - 4,156,065UniSTSGRCm38
MGSCv37106,190,476 - 6,190,595UniSTSGRCm37
Celera104,085,690 - 4,085,809UniSTS
Cytogenetic Map10A1UniSTS
UniSTS:236298  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38103,993,206 - 3,993,299UniSTSGRCm38
GRCm38534,351,647 - 34,351,740UniSTSGRCm38
MGSCv37534,694,296 - 34,694,389UniSTSGRCm37
MGSCv37106,353,242 - 6,353,335UniSTSGRCm37
Celera103,920,983 - 3,921,076UniSTS
Celera531,822,251 - 31,822,344UniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map5B2UniSTS
UniSTS:236302  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38104,155,605 - 4,155,804UniSTSGRCm38
MGSCv37106,190,737 - 6,190,936UniSTSGRCm37
Celera104,085,349 - 4,085,548UniSTS
Cytogenetic Map10A1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126413521Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126413521Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126413521Mouse
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126413521Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126413521Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126413521Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126413521Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126413521Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126413521Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126413521Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126413521Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131403386Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1047525334475253Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10340743937407588Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10393427237934396Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:552
Count of miRNA genes:298
Interacting mature miRNAs:333
Transcripts:ENSMUST00000043735, ENSMUST00000117291, ENSMUST00000120585, ENSMUST00000154517
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001170785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001170786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000043735   ⟹   ENSMUSP00000036178
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl103,923,144 - 4,106,111 (+)Ensembl
GRCm38.p6 Ensembl103,973,144 - 4,156,111 (+)Ensembl
RefSeq Acc Id: ENSMUST00000117291   ⟹   ENSMUSP00000112870
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl103,923,118 - 4,106,111 (+)Ensembl
GRCm38.p6 Ensembl103,973,118 - 4,156,111 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120585   ⟹   ENSMUSP00000112897
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl103,923,131 - 4,117,081 (+)Ensembl
GRCm38.p6 Ensembl103,973,131 - 4,167,081 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154517
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl103,982,280 - 3,998,951 (+)Ensembl
GRCm38.p6 Ensembl104,032,280 - 4,048,951 (+)Ensembl
RefSeq Acc Id: NM_001170785   ⟹   NP_001164256
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39103,923,075 - 4,117,081 (+)NCBI
GRCm38103,973,075 - 4,167,081 (+)NCBI
MGSCv37106,179,460 - 6,373,466 (-)RGD
Celera103,900,899 - 4,096,959 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001170786   ⟹   NP_001164257
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39103,923,075 - 4,106,130 (+)NCBI
GRCm38103,973,075 - 4,156,130 (+)NCBI
MGSCv37106,179,460 - 6,373,466 (-)RGD
Celera103,900,899 - 4,096,959 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_172308   ⟹   NP_758512
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39103,923,075 - 4,106,130 (+)NCBI
GRCm38103,973,075 - 4,156,130 (+)NCBI
MGSCv37106,179,460 - 6,373,466 (-)RGD
Celera103,900,899 - 4,096,959 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036155795   ⟹   XP_036011688
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39103,997,843 - 4,106,114 (+)NCBI
RefSeq Acc Id: XM_036155796   ⟹   XP_036011689
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,025,280 - 4,106,114 (+)NCBI
RefSeq Acc Id: XR_004936188
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39103,918,282 - 4,106,114 (+)NCBI
RefSeq Acc Id: XR_004936189
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39103,918,282 - 4,106,114 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_758512   ⟸   NM_172308
- Peptide Label: precursor
- UniProtKB: Q3V3R1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001164256   ⟸   NM_001170785
- Peptide Label: precursor
- UniProtKB: Q3V3R1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001164257   ⟸   NM_001170786
- Peptide Label: precursor
- UniProtKB: Q3V3R1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000112897   ⟸   ENSMUST00000120585
RefSeq Acc Id: ENSMUSP00000112870   ⟸   ENSMUST00000117291
RefSeq Acc Id: ENSMUSP00000036178   ⟸   ENSMUST00000043735
RefSeq Acc Id: XP_036011688   ⟸   XM_036155795
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036011689   ⟸   XM_036155796
- Peptide Label: isoform X1

Promoters
RGD ID:8671398
Promoter ID:EPDNEW_M13730
Type:initiation region
Name:Mthfd1l_1
Description:Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent)1-like , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13731  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38103,973,125 - 3,973,185EPDNEW
RGD ID:8671400
Promoter ID:EPDNEW_M13731
Type:initiation region
Name:Mthfd1l_2
Description:Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent)1-like , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13730  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38103,973,231 - 3,973,291EPDNEW
RGD ID:6819629
Promoter ID:MM_KWN:3461
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001170785,   NM_001170786,   NM_172308
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36106,373,061 - 6,374,122 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924836 AgrOrtholog
Ensembl Genes ENSMUSG00000040675 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000036178 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112870 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112897 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000043735 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000117291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000120585 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro Formate_THF_ligase UniProtKB/Swiss-Prot
  Formate_THF_ligase_CS UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  THF_DH/CycHdrlase UniProtKB/Swiss-Prot
  THF_DH/CycHdrlase_cat_dom UniProtKB/Swiss-Prot
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/Swiss-Prot
KEGG Report mmu:270685 UniProtKB/Swiss-Prot
MGD MGI:1924836 ENTREZGENE
NCBI Gene 270685 ENTREZGENE
Pfam FTHFS UniProtKB/Swiss-Prot
  THF_DHG_CYH UniProtKB/Swiss-Prot
  THF_DHG_CYH_C UniProtKB/Swiss-Prot
PhenoGen Mthfd1l PhenoGen
PRINTS THFDHDRGNASE UniProtKB/Swiss-Prot
PROSITE FTHFS_1 UniProtKB/Swiss-Prot
  FTHFS_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt C1TM_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TVQ0 UniProtKB/Swiss-Prot
  Q3V402 UniProtKB/Swiss-Prot
  Q80V98 UniProtKB/Swiss-Prot
  Q8CAL0 UniProtKB/Swiss-Prot
  Q8K2N5 UniProtKB/Swiss-Prot