Stac3 (SH3 and cysteine rich domain 3) - Rat Genome Database

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Gene: Stac3 (SH3 and cysteine rich domain 3) Mus musculus
Analyze
Symbol: Stac3
Name: SH3 and cysteine rich domain 3
RGD ID: 1615660
MGI Page MGI
Description: Predicted to enable identical protein binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Acts upstream of or within skeletal muscle fiber development. Located in cytosol. Is extrinsic component of cytoplasmic side of plasma membrane. Part of voltage-gated calcium channel complex. Is expressed in limb musculature; somite; and tongue. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC3 (SH3 and cysteine rich domain 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; pioglitazone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9830125E18; SH3 and cysteine-rich domain-containing protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,337,505 - 127,344,692 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,337,555 - 127,344,692 (+)Ensembl
GRCm3810127,501,617 - 127,508,823 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,501,686 - 127,508,823 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,938,773 - 126,945,871 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,904,666 - 126,911,764 (+)NCBImm8
Celera10129,893,229 - 129,900,583 (+)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:23076145   PMID:23626854   PMID:23818578   PMID:24788338   PMID:26951610   PMID:27073615   PMID:27184118   PMID:27621462   PMID:28112192   PMID:29467163   PMID:30071129  


Genomics

Comparative Map Data
Stac3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,337,505 - 127,344,692 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,337,555 - 127,344,692 (+)Ensembl
GRCm3810127,501,617 - 127,508,823 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,501,686 - 127,508,823 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,938,773 - 126,945,871 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,904,666 - 126,911,764 (+)NCBImm8
Celera10129,893,229 - 129,900,583 (+)NCBICelera
Cytogenetic Map10D3NCBI
STAC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,243,453 - 57,251,188 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,243,453 - 57,251,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,637,241 - 57,644,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,923,509 - 55,931,236 (-)NCBINCBI36hg18NCBI36
Build 341255,923,508 - 55,931,236NCBI
Celera1257,291,469 - 57,299,250 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,676,118 - 54,683,830 (-)NCBIHuRef
CHM1_11257,605,339 - 57,613,080 (-)NCBICHM1_1
Stac3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,343,078 - 63,350,590 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl770,807,867 - 70,815,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,807,427 - 70,815,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0770,981,174 - 70,988,656 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,478,506 - 67,485,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,500,312 - 67,506,640 (+)NCBI
Celera760,482,101 - 60,489,521 (+)NCBICelera
Cytogenetic Map7q22NCBI
Stac3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,971,450 - 4,980,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,971,450 - 4,980,262 (-)NCBIChiLan1.0ChiLan1.0
STAC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,928,955 - 31,936,257 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,928,955 - 31,936,251 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,674,537 - 31,683,917 (+)NCBIMhudiblu_PPA_v0panPan3
STAC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,370,340 - 1,377,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,434,018 - 1,441,443 (-)NCBI
ROS_Cfam_1.0101,380,726 - 1,388,155 (-)NCBI
UMICH_Zoey_3.1101,357,308 - 1,364,738 (-)NCBI
UNSW_CanFamBas_1.0101,599,294 - 1,606,729 (-)NCBI
UU_Cfam_GSD_1.0101,724,219 - 1,731,673 (-)NCBI
Stac3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,424,374 - 57,433,731 (+)NCBI
SpeTri2.0NW_0049366461,436,505 - 1,444,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,549,008 - 22,556,194 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,549,008 - 22,556,330 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,376,741 - 24,390,343 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,149,572 - 53,163,036 (-)NCBI
ChlSab1.1 Ensembl1153,154,755 - 53,163,090 (-)Ensembl
Vero_WHO_p1.0NW_023666037192,809,786 - 192,817,153 (+)NCBI
Stac3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,694,539 - 10,704,320 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108680038130694993Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105205399130694993Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10103011947130694993Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099384730130694993Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099384730130694993Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125797802129630506Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101661259130694993Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105205399130694993Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105343808130694993Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101661259130694993Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10101150611130694993Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97922739130694993Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097700000130694993Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108739225130694993Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099384730130694993Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122950065129631127Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10101150611130694993Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097381196130694993Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122950065129631127Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
14746996Manh69_mmandible shape 69 (mouse)10104927733130694993Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397381196130694993Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10103066603130694993Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097381196130694993Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104274116130694993Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103407822130694993Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102671003130694993Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097381196130694993Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122950065129631127Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105205399130694993Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108739225130694993Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108739225130694993Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108680038130694993Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105343808130694993Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108739225130694993Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105343808130694993Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:826
Count of miRNA genes:414
Interacting mature miRNAs:484
Transcripts:ENSMUST00000035839, ENSMUST00000160019, ENSMUST00000160610, ENSMUST00000160760, ENSMUST00000162302
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035839   ⟹   ENSMUSP00000048148
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,501,717 - 127,508,815 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160019   ⟹   ENSMUSP00000125124
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,501,686 - 127,508,823 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160610   ⟹   ENSMUSP00000124638
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,501,694 - 127,502,838 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160760
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,504,491 - 127,507,488 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162302
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,507,225 - 127,507,992 (+)Ensembl
RefSeq Acc Id: NM_001359751   ⟹   NP_001346680
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,337,555 - 127,344,687 (+)NCBI
GRCm3810127,501,686 - 127,508,818 (+)NCBI
Sequence:
RefSeq Acc Id: NM_177707   ⟹   NP_808375
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,337,586 - 127,344,687 (+)NCBI
GRCm3810127,501,717 - 127,508,818 (+)NCBI
MGSCv3710126,938,773 - 126,945,871 (+)RGD
Celera10129,893,229 - 129,900,583 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513640   ⟹   XP_006513703
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,337,505 - 127,344,692 (+)NCBI
GRCm3810127,501,617 - 127,508,823 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_808375   ⟸   NM_177707
- UniProtKB: Q8BZ71 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513703   ⟸   XM_006513640
- Peptide Label: isoform X1
- UniProtKB: Q8BZ71 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346680   ⟸   NM_001359751
RefSeq Acc Id: ENSMUSP00000125124   ⟸   ENSMUST00000160019
RefSeq Acc Id: ENSMUSP00000124638   ⟸   ENSMUST00000160610
RefSeq Acc Id: ENSMUSP00000048148   ⟸   ENSMUST00000035839
Protein Domains
SH3

Promoters
RGD ID:6819960
Promoter ID:MM_KWN:5903
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung,   MEF_B6
Transcripts:NM_177707,   OTTMUST00000068567,   OTTMUST00000068569
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,937,776 - 126,938,347 (+)MPROMDB
RGD ID:6819963
Promoter ID:MM_KWN:5904
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000070098
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,940,696 - 126,941,547 (+)MPROMDB
RGD ID:6819961
Promoter ID:MM_KWN:5905
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000068571
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,944,246 - 126,944,746 (+)MPROMDB
RGD ID:8673512
Promoter ID:EPDNEW_M14786
Type:initiation region
Name:Stac3_1
Description:Mus musculus SH3 and cysteine rich domain 3 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,501,717 - 127,501,777EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3606571 AgrOrtholog
Ensembl Genes ENSMUSG00000040287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000048148 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000124638 UniProtKB/TrEMBL
  ENSMUSP00000125124 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035839 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000160019 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000160610 UniProtKB/TrEMBL
InterPro PE/DAG-bd UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  STAC1/2/3 UniProtKB/Swiss-Prot
  Stac3_SH3_1 UniProtKB/Swiss-Prot
KEGG Report mmu:237611 UniProtKB/Swiss-Prot
MGD MGI:3606571 ENTREZGENE
NCBI Gene 237611 ENTREZGENE
PANTHER PTHR15135 UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Stac3 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE SH3 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
SMART SH3 UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
UniProt E0CXX9_MOUSE UniProtKB/TrEMBL
  Q8BZ71 ENTREZGENE, UniProtKB/Swiss-Prot