Cyp2b13 (cytochrome P450, family 2, subfamily b, polypeptide 13) - Rat Genome Database

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Gene: Cyp2b13 (cytochrome P450, family 2, subfamily b, polypeptide 13) Mus musculus
Analyze
Symbol: Cyp2b13
Name: cytochrome P450, family 2, subfamily b, polypeptide 13
RGD ID: 1624099
MGI Page MGI
Description: Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; steroid metabolic process; and xenobiotic catabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome P450, 2b13, phenobarbitol inducible, type c; phenobarbital inducible, type c
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,760,813 - 25,795,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,760,922 - 25,795,622 (+)EnsemblGRCm39 Ensembl
GRCm38726,061,388 - 26,096,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,061,497 - 26,096,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,846,514 - 26,881,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,770,255 - 25,804,956 (+)NCBIMGSCv36mm8
Celera720,663,633 - 20,698,699 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Inflammation  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dioxane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (ISO)
2-nitroanisole  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acephate  (EXP)
aflatoxin B1  (ISO)
alachlor  (ISO)
alpha-hexachlorocyclohexane  (ISO)
amiodarone  (ISO)
amitraz  (ISO)
amitriptyline  (ISO)
amitrole  (ISO)
Aroclor 1254  (ISO)
aspartame  (ISO)
Azoxymethane  (EXP)
benzbromarone  (ISO)
benzene  (ISO)
benzo[b]fluoranthene  (EXP)
benzophenone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bilobalide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bitertanol  (ISO)
bromobenzene  (ISO)
bromodichloromethane  (ISO)
bromuconazole  (ISO)
brucine  (ISO)
C60 fullerene  (ISO)
carbamazepine  (ISO)
chloral hydrate  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (ISO)
cholic acid  (EXP)
choline  (EXP,ISO)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
ciprofibrate  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clothianidin  (ISO)
clotrimazole  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
Diallyl sulfide  (ISO)
diazepam  (ISO)
dibenzofurans  (EXP)
dichloroacetic acid  (EXP)
dicofol  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
disulfiram  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
etofenprox  (ISO)
farnesol  (ISO)
fenarimol  (EXP)
fipronil  (ISO)
fipronil-sulfone  (ISO)
folic acid  (EXP)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gliotoxin  (ISO)
griseofulvin  (EXP)
indole-3-methanol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lansoprazole  (ISO)
linuron  (ISO)
m-xylene  (ISO)
melatonin  (ISO)
metazachlor  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
metyrapone  (ISO)
mifepristone  (ISO)
mirex  (ISO)
Mitotane  (ISO)
monocrotophos  (ISO)
Muraglitazar  (ISO)
musk xylene  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
o-anisidine  (ISO)
octamethylcyclotetrasiloxane  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
oxazepam  (ISO)
oxfendazole  (ISO)
oxycodone  (ISO)
p-xylene  (ISO)
pantoprazole  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
pentobarbital  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (ISO)
propiconazole  (ISO)
propylbenzene  (ISO)
pyrazinecarboxamide  (ISO)
pyrene  (ISO)
pyrethrins  (ISO)
pyridine  (ISO)
pyrrolidines  (ISO)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
Retrorsine  (ISO)
rotenone  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium dodecyl sulfate  (ISO)
stilbene oxide  (ISO)
streptozocin  (EXP)
strychnine  (ISO)
styrene  (ISO)
Sudan III  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tert-butyl ethyl ether  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
Tetramethylthiourea  (ISO)
thiabendazole  (ISO)
thiacloprid  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trans-1,2-dichloroethene  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (EXP)
triclosan  (ISO)
trimethylarsine oxide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP,ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1997326   PMID:6547088   PMID:12477932   PMID:14630516   PMID:17964055   PMID:21677750   PMID:21873635   PMID:22083726   PMID:27197076   PMID:27626380   PMID:29968852   PMID:30973865  
PMID:34215813   PMID:38355793  


Genomics

Comparative Map Data
Cyp2b13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,760,813 - 25,795,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,760,922 - 25,795,622 (+)EnsemblGRCm39 Ensembl
GRCm38726,061,388 - 26,096,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,061,497 - 26,096,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,846,514 - 26,881,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,770,255 - 25,804,956 (+)NCBIMGSCv36mm8
Celera720,663,633 - 20,698,699 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.11NCBI
Cyp2b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,722,243 - 90,736,272 (+)NCBIGRCr8
mRatBN7.2181,594,534 - 81,608,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,594,555 - 81,608,566 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,015,246 - 87,029,282 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,513,596 - 95,527,589 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,771,080 - 88,785,114 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,103,925 - 83,119,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,103,925 - 83,119,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,361,236 - 84,376,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,345,425 - 81,359,415 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,421,142 - 81,423,532 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBICelera
RH 2.0 Map1513.2RGD
Cytogenetic Map1q21NCBI

Variants

.
Variants in Cyp2b13
1542 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:156
Interacting mature miRNAs:160
Transcripts:ENSMUST00000005669
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
BB249608  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38726,074,315 - 26,074,396UniSTSGRCm38
GRCm38826,142,439 - 26,142,519UniSTSGRCm38
MGSCv37726,859,334 - 26,859,415UniSTSGRCm37
MGSCv37827,252,911 - 27,252,991UniSTSGRCm37
Celera720,676,305 - 20,676,386UniSTS
Celera827,612,324 - 27,612,404UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
Whitehead/MRC_RH8292.11UniSTS
AI481227  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38726,075,486 - 26,075,600UniSTSGRCm38
GRCm38826,143,604 - 26,143,718UniSTSGRCm38
MGSCv37726,860,505 - 26,860,619UniSTSGRCm37
MGSCv37827,254,076 - 27,254,190UniSTSGRCm37
Celera720,677,476 - 20,677,590UniSTS
Celera827,613,488 - 27,613,602UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
Whitehead/MRC_RH8313.72UniSTS
Cyp2b10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
UniSTS:235859  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38726,075,489 - 26,075,697UniSTSGRCm38
GRCm38826,143,607 - 26,143,815UniSTSGRCm38
MGSCv37726,860,508 - 26,860,716UniSTSGRCm37
MGSCv37827,254,079 - 27,254,287UniSTSGRCm37
Celera720,677,479 - 20,677,687UniSTS
Celera827,613,491 - 27,613,699UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
UniSTS:235858  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38726,073,529 - 26,073,850UniSTSGRCm38
GRCm38826,141,675 - 26,141,996UniSTSGRCm38
MGSCv37726,858,548 - 26,858,869UniSTSGRCm37
MGSCv37827,252,147 - 27,252,468UniSTSGRCm37
Celera720,675,519 - 20,675,840UniSTS
Celera827,611,558 - 27,611,879UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
UniSTS:488961  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38726,071,855 - 26,073,272UniSTSGRCm38
MGSCv37726,856,874 - 26,858,291UniSTSGRCm37
Celera720,673,845 - 20,675,262UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000005669   ⟹   ENSMUSP00000005669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,760,922 - 25,795,622 (+)Ensembl
GRCm38.p6 Ensembl726,061,497 - 26,096,197 (+)Ensembl
RefSeq Acc Id: NM_007813   ⟹   NP_031839
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,760,920 - 25,795,621 (+)NCBI
GRCm38726,061,495 - 26,096,196 (+)NCBI
MGSCv37726,846,514 - 26,881,215 (+)RGD
Celera720,663,633 - 20,698,699 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539508   ⟹   XP_006539571
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,760,813 - 25,795,622 (+)NCBI
GRCm38726,061,388 - 26,096,197 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539509   ⟹   XP_006539572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,760,813 - 25,795,622 (+)NCBI
GRCm38726,061,388 - 26,096,197 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539510   ⟹   XP_006539573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,760,814 - 25,795,622 (+)NCBI
GRCm38726,061,389 - 26,096,197 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539511   ⟹   XP_006539574
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,761,487 - 25,795,622 (+)NCBI
GRCm38726,062,062 - 26,096,197 (+)NCBI
Sequence:
RefSeq Acc Id: NP_031839   ⟸   NM_007813
- Peptide Label: precursor
- UniProtKB: A6H6J2 (UniProtKB/TrEMBL),   E9Q713 (UniProtKB/TrEMBL),   Q64460 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539572   ⟸   XM_006539509
- Peptide Label: isoform X1
- UniProtKB: Q64460 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539571   ⟸   XM_006539508
- Peptide Label: isoform X1
- UniProtKB: Q64460 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539573   ⟸   XM_006539510
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006539574   ⟸   XM_006539511
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSMUSP00000005669   ⟸   ENSMUST00000005669

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6H6J2-F1-model_v2 AlphaFold A6H6J2 1-491 view protein structure

Promoters
RGD ID:6840905
Promoter ID:MM_KWN:49487
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000005669,   NM_007813
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,846,271 - 26,846,771 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88599 AgrOrtholog
Ensembl Genes ENSMUSG00000040583 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005669 ENTREZGENE
  ENSMUST00000005669.9 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
KEGG Report mmu:13089 UniProtKB/TrEMBL
MGD MGI:88599 ENTREZGENE
NCBI Gene 13089 ENTREZGENE
PANTHER CYTOCHROME P450 2B9-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp2b13 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A6H6J2 ENTREZGENE, UniProtKB/TrEMBL
  E9Q713 ENTREZGENE
  Q61461_MOUSE UniProtKB/TrEMBL
  Q64460 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9Q713 UniProtKB/TrEMBL