Srpr (signal recognition particle receptor ('docking protein')) - Rat Genome Database

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Gene: Srpr (signal recognition particle receptor ('docking protein')) Mus musculus
Analyze
Symbol: Srpr
Name: signal recognition particle receptor ('docking protein')
RGD ID: 1322998
MGI Page MGI
Description: Predicted to have GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Predicted to localize to endoplasmic reticulum membrane. Is expressed in cap mesenchyme; female associated reproductive structure; male associated reproductive structure; renal interstitium; and testis. Orthologous to human SRPRA (SRP receptor subunit alpha); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1300011P19Rik; D11Mgi2; D11Mgi27; docking protein alpha; DP-alpha; signal recognition particle receptor subunit alpha; SR-alpha; Srpra
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm21051   Gm6733   Gm7593  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,122,499 - 35,128,299 (+)NCBIGRCm39mm39
GRCm39 Ensembl935,111,471 - 35,159,269 (+)Ensembl
GRCm38935,211,203 - 35,217,003 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,200,175 - 35,247,973 (+)EnsemblGRCm38mm10GRCm38
MGSCv37935,018,788 - 35,024,588 (+)NCBIGRCm37mm9NCBIm37
MGSCv36934,960,874 - 34,966,674 (+)NCBImm8
Celera932,447,922 - 32,453,726 (+)NCBICelera
Cytogenetic Map9A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:17967808   PMID:18287559   PMID:18799693   PMID:19336533   PMID:21267068   PMID:21873635   PMID:22375059   PMID:30196744   PMID:30550785   PMID:32325033  


Genomics

Comparative Map Data
Srpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,122,499 - 35,128,299 (+)NCBIGRCm39mm39
GRCm39 Ensembl935,111,471 - 35,159,269 (+)Ensembl
GRCm38935,211,203 - 35,217,003 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,200,175 - 35,247,973 (+)EnsemblGRCm38mm10GRCm38
MGSCv37935,018,788 - 35,024,588 (+)NCBIGRCm37mm9NCBIm37
MGSCv36934,960,874 - 34,966,674 (+)NCBImm8
Celera932,447,922 - 32,453,726 (+)NCBICelera
Cytogenetic Map9A4NCBI
SRPRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11126,262,938 - 126,269,144 (-)EnsemblGRCh38hg38GRCh38
GRCh3811126,255,151 - 126,268,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711126,132,833 - 126,138,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,638,043 - 125,643,960 (-)NCBINCBI36hg18NCBI36
Build 3411125,638,042 - 125,643,960NCBI
Celera11123,297,838 - 123,303,901 (-)NCBI
Cytogenetic Map11q24.2NCBI
HuRef11122,075,206 - 122,081,269 (-)NCBIHuRef
CHM1_111126,019,105 - 126,025,168 (-)NCBICHM1_1
Srpra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2833,560,365 - 33,566,458 (+)NCBI
Rnor_6.0 Ensembl836,410,683 - 36,416,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0836,410,683 - 36,416,766 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0836,428,866 - 36,434,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4834,992,187 - 34,998,270 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1835,000,954 - 35,007,031 (+)NCBI
Celera834,979,915 - 34,986,044 (+)NCBICelera
Cytogenetic Map8q21NCBI
Srpra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541227,287,368 - 27,293,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541227,287,359 - 27,293,362 (-)NCBIChiLan1.0ChiLan1.0
SRPRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111124,987,307 - 124,993,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11124,987,307 - 124,993,347 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011121,071,054 - 121,083,106 (-)NCBIMhudiblu_PPA_v0panPan3
SRPRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.158,247,608 - 8,253,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl58,224,416 - 8,254,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha58,308,830 - 8,314,605 (+)NCBI
ROS_Cfam_1.058,203,219 - 8,208,993 (+)NCBI
UMICH_Zoey_3.158,272,836 - 8,278,587 (+)NCBI
UNSW_CanFamBas_1.058,246,523 - 8,252,291 (+)NCBI
UU_Cfam_GSD_1.058,280,726 - 8,286,491 (+)NCBI
Srpra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947108,493,753 - 108,499,710 (-)NCBI
SpeTri2.0NW_0049365725,950,608 - 5,956,620 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRPRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl953,358,531 - 53,375,548 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1953,358,522 - 53,365,085 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2958,968,922 - 58,974,223 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRPRA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11117,388,341 - 117,394,358 (-)NCBI
ChlSab1.1 Ensembl1117,387,044 - 117,394,415 (-)Ensembl
Srpra
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624812416,727 - 422,820 (-)NCBI

Position Markers
UniSTS:236631  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38935,213,989 - 35,214,883UniSTSGRCm38
GRCm381172,834,453 - 72,834,845UniSTSGRCm38
MGSCv371172,647,955 - 72,648,347UniSTSGRCm37
MGSCv37935,021,574 - 35,022,468UniSTSGRCm37
Celera1180,363,288 - 80,363,680UniSTS
Celera932,450,712 - 32,451,606UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map11B4UniSTS
GDB:197863  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381172,834,421 - 72,834,570UniSTSGRCm38
GRCm38935,213,957 - 35,214,237UniSTSGRCm38
MGSCv37935,021,542 - 35,021,822UniSTSGRCm37
MGSCv371172,647,923 - 72,648,072UniSTSGRCm37
Celera1180,363,256 - 80,363,405UniSTS
Celera932,450,680 - 32,450,960UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map11B4UniSTS
UniSTS:236630  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38935,211,258 - 35,212,432UniSTSGRCm38
MGSCv37935,018,843 - 35,020,017UniSTSGRCm37
Celera932,447,977 - 32,449,155UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map9A5.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756137395074Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9999947243999472Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91550045549500594Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91550045549500594Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91550045549500594Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91550045549500594Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91583833149838331Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91583833149838331Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91583833149838331Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91610000050100000Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91610000050100000Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
14700787Ncdq1_mnevus cell density QTL 1 (mouse)92820000036200000Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92859203741888030Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1558949Igan3_mIgA nephropathy 3 (mouse)Not determined93050339840654618Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
4142455Elnv_mepilepsy naive (mouse)Not determined93136026237395074Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93419332342853570Mouse
1300868Tlf_mT lymphocyte fraction (mouse)Not determined93492645237395074Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:597
Count of miRNA genes:422
Interacting mature miRNAs:482
Transcripts:ENSMUST00000034541, ENSMUST00000132799, ENSMUST00000138287, ENSMUST00000154005
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034541   ⟹   ENSMUSP00000034541
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl935,211,155 - 35,217,014 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132799   ⟹   ENSMUSP00000115104
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl935,214,899 - 35,247,973 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138287   ⟹   ENSMUSP00000149923
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl935,200,175 - 35,213,536 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154005
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl935,211,894 - 35,212,851 (+)Ensembl
RefSeq Acc Id: NM_026130   ⟹   NP_080406
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39935,122,499 - 35,128,299 (+)NCBI
GRCm38935,211,203 - 35,217,003 (+)ENTREZGENE
MGSCv37935,018,788 - 35,024,588 (+)RGD
Celera932,447,922 - 32,453,726 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080406   ⟸   NM_026130
- UniProtKB: Q9DBG7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000149923   ⟸   ENSMUST00000138287
RefSeq Acc Id: ENSMUSP00000115104   ⟸   ENSMUST00000132799
RefSeq Acc Id: ENSMUSP00000034541   ⟸   ENSMUST00000034541
Protein Domains
SRP-alpha_N   SRP54

Promoters
RGD ID:6844537
Promoter ID:MM_KWN:56783
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000078230,   OTTMUST00000078231,   OTTMUST00000086277,   OTTMUST00000086278,   OTTMUST00000086279,   OTTMUST00000086280,   OTTMUST00000086281,   OTTMUST00000086282,   OTTMUST00000086283,   OTTMUST00000086284,   OTTMUST00000086285,   OTTMUST00000086286
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36935,017,561 - 35,019,502 (-)MPROMDB
RGD ID:6845215
Promoter ID:MM_KWN:56784
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   Brain
Transcripts:UC009OSZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36935,019,696 - 35,020,757 (+)MPROMDB
RGD ID:6845217
Promoter ID:MM_KWN:56785
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Lung
Transcripts:OTTMUST00000078232
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36935,021,846 - 35,022,557 (+)MPROMDB
RGD ID:8669154
Promoter ID:EPDNEW_M12608
Type:initiation region
Name:Srpr_1
Description:Mus musculus signal recognition particle receptor ('docking protein'), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38935,211,203 - 35,211,263EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914648 AgrOrtholog
Ensembl Genes ENSMUSG00000032042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034541 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000115104 UniProtKB/TrEMBL
  ENSMUSP00000149923 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034541 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000132799 UniProtKB/TrEMBL
  ENSMUST00000138287 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.140 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  Longin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sig_recog_particle_rcpt_asu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Signal_recog_particl_SRP54_hlx UniProtKB/Swiss-Prot
  SRP/SRP_N UniProtKB/Swiss-Prot
  SRP54_GTPase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRP54_N_sf UniProtKB/Swiss-Prot
KEGG Report mmu:67398 UniProtKB/Swiss-Prot
MGD MGI:1914648 ENTREZGENE
NCBI Gene 67398 ENTREZGENE
Pfam SRP-alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRP54 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRP54_N UniProtKB/Swiss-Prot
PhenoGen Srpr PhenoGen
PROSITE SRP54 UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
  SRP54 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRP54_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47364 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SSI7_MOUSE UniProtKB/TrEMBL
  C3VDI1_MOUSE UniProtKB/TrEMBL
  F6VF36_MOUSE UniProtKB/TrEMBL
  Q9CVL8_MOUSE UniProtKB/TrEMBL
  Q9DBG7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8VC45 UniProtKB/Swiss-Prot
  Q921H1 UniProtKB/Swiss-Prot