Tph1 (tryptophan hydroxylase 1) - Rat Genome Database

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Gene: Tph1 (tryptophan hydroxylase 1) Mus musculus
Analyze
Symbol: Tph1
Name: tryptophan hydroxylase 1
RGD ID: 735483
MGI Page MGI
Description: Enables tryptophan 5-monooxygenase activity. Involved in platelet degranulation; regulation of hemostasis; and serotonin biosynthetic process. Acts upstream of or within bone remodeling; mammary gland alveolus development; and positive regulation of fat cell differentiation. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; ovary; retina; and trunk. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Tph; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,294,065 - 46,321,961 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,294,065 - 46,321,961 (-)EnsemblGRCm39 Ensembl
GRCm38746,644,641 - 46,672,537 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,644,641 - 46,672,537 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,902,501 - 53,927,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,515,218 - 46,540,579 (-)NCBIMGSCv36mm8
Celera742,121,305 - 42,146,712 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dibromoethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-nitrotoluene  (EXP)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-hydroxytryptophan  (ISO)
5-methoxytryptamine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
carbidopa  (EXP)
cefaloridine  (ISO)
chitosan  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
curcumin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dieldrin  (ISO)
endosulfan  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycidol  (EXP)
granisetron  (EXP)
hydrogen peroxide  (ISO)
L-tryptophan  (ISO)
lidocaine  (ISO)
lithium chloride  (EXP)
methoxychlor  (ISO)
methyl carbamate  (EXP)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
perfluorooctanoic acid  (ISO)
PhIP  (ISO)
reserpine  (ISO)
sarpogrelate  (EXP,ISO)
serotonin  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
taurine  (EXP)
tetrachloromethane  (EXP,ISO)
trametinib  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease. Craig D, etal., Neurosci Lett. 2004 Jun 17;363(3):199-202.
2. Platelet-derived serotonin links vascular disease and tissue fibrosis. Dees C, etal., J Exp Med. 2011 May 9;208(5):961-72. Epub 2011 Apr 25.
3. Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Gizatullin R, etal., Biol Psychiatry. 2006 Feb 15;59(4):295-300. Epub 2005 Sep 13.
4. Attention-deficit/hyperactivity disorder symptoms in offspring of mothers with impaired serotonin production. Halmoy A, etal., Arch Gen Psychiatry. 2010 Oct;67(10):1033-43.
5. No association between the tryptophan hydroxylase gene polymorphism and major depressive disorders and antidepressant response in a Korean population. Ham BJ, etal., Psychiatr Genet. 2005 Dec;15(4):299-301.
6. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. Izikki M, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3.
7. Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults. Jokela M, etal., J Affect Disord. 2007 Jun;100(1-3):191-7. Epub 2006 Nov 28.
8. Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan. Lai TJ, etal., BMC Med Genet. 2005 Mar 31;6:14.
9. Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population. Li J, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141(2):126-9.
10. Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats. Liu D, etal., Exp Biol Med (Maywood). 2014 Mar;239(3):330-6. doi: 10.1177/1535370213513987. Epub 2014 Feb 4.
11. Lack of association between the serotonin transporter and tryptophan hydroxylase gene polymorphisms and completed suicide. Mergen H, etal., Psychiatr Genet. 2006 Apr;16(2):53.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis. Nelson LM, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):37-40.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. Reuter M and Hennig J, Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134(1):20-4.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis. Rujescu D, etal., Biol Psychiatry. 2003 Aug 15;54(4):465-73.
22. Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism. Sekizawa T, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128(1):24-6.
23. A functional polymorphism in the promoter region of the tryptophan hydroxylase gene is associated with alcohol dependence in one aboriginal group in Taiwan. Sun HS, etal., Alcohol Clin Exp Res. 2005 Jan;29(1):1-7.
24. Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. Sun HS, etal., Genes Brain Behav. 2004 Dec;3(6):328-36.
25. Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. Takahashi Y, etal., J Orthop Res. 2011 Jul;29(7):1055-8. doi: 10.1002/jor.21347. Epub 2011 Feb 9.
26. Lack of association between the tryptophan hydroxylase gene A218C polymorphism and attention-deficit hyperactivity disorder in Chinese Han population. Tang G, etal., Am J Med Genet. 2001 Aug 8;105(6):485-8.
27. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Walther DJ, etal., Science 2003 Jan 3;299(5603):76.
28. Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese. Wang H, etal., Spine (Phila Pa 1976). 2008 Sep 15;33(20):2199-203.
29. Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. You JS, etal., Psychiatr Genet. 2005 Mar;15(1):7-11.
30. Tryptophan hydroxylase-1 gene variants associate with a group of suicidal borderline women. Zaboli G, etal., Neuropsychopharmacology. 2006 Sep;31(9):1982-90. Epub 2006 Feb 22.
31. Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6. Zhang Q, etal., Nat Genet 2003 Feb;33(2):145-53.
Additional References at PubMed
PMID:1387105   PMID:1714508   PMID:2110547   PMID:7552299   PMID:7698755   PMID:7835903   PMID:7920633   PMID:7968351   PMID:8018917   PMID:8601494   PMID:8889548   PMID:8903735  
PMID:9398437   PMID:9558376   PMID:10320783   PMID:10349636   PMID:10615124   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12406341   PMID:12466851   PMID:12477932   PMID:12546819  
PMID:12777963   PMID:14563478   PMID:14597720   PMID:14681479   PMID:14697203   PMID:14960274   PMID:15146950   PMID:15226823   PMID:15489334   PMID:15610158   PMID:15820717   PMID:15858217  
PMID:16141072   PMID:16141073   PMID:16407550   PMID:16581041   PMID:16601191   PMID:16602821   PMID:16926160   PMID:16989820   PMID:17130306   PMID:17151281   PMID:17182745   PMID:17681180  
PMID:17706959   PMID:18267982   PMID:18304982   PMID:18506000   PMID:18593914   PMID:18923670   PMID:18987169   PMID:19041748   PMID:19064621   PMID:19181488   PMID:19228979   PMID:19426283  
PMID:19737523   PMID:19859528   PMID:20107080   PMID:20364088   PMID:20719859   PMID:20818386   PMID:20938637   PMID:20950489   PMID:21150899   PMID:21281798   PMID:21390323   PMID:21464983  
PMID:21512572   PMID:21602802   PMID:21677183   PMID:21677750   PMID:21788492   PMID:21873635   PMID:22013016   PMID:22308416   PMID:22318950   PMID:22387004   PMID:22609381   PMID:22674259  
PMID:22797248   PMID:22843703   PMID:23008335   PMID:23085101   PMID:23243271   PMID:23328530   PMID:23395646   PMID:23500099   PMID:23516593   PMID:23532063   PMID:23754283   PMID:24077408  
PMID:24127620   PMID:24163148   PMID:24358245   PMID:24520366   PMID:24952961   PMID:25091505   PMID:25098329   PMID:25192038   PMID:25299122   PMID:25426873   PMID:25485911   PMID:25600870  
PMID:25864946   PMID:25892224   PMID:26136513   PMID:26202070   PMID:26220976   PMID:26235267   PMID:26273529   PMID:26968113   PMID:27238716   PMID:27550733   PMID:27595322   PMID:27626491  
PMID:28031476   PMID:28109119   PMID:28512916   PMID:28774871   PMID:28855642   PMID:29123193   PMID:29386381   PMID:29866843   PMID:30058725   PMID:30446669   PMID:30518775   PMID:30893598  
PMID:30931940   PMID:30952815   PMID:31038736   PMID:31315055   PMID:31523009   PMID:31614319   PMID:31668390   PMID:31806625   PMID:31974364   PMID:31989744   PMID:32102567   PMID:32160524  
PMID:32350130   PMID:32641826   PMID:32641996   PMID:32978487   PMID:33046550   PMID:33220232   PMID:33427054   PMID:33993565   PMID:34379673   PMID:34524861   PMID:34739317   PMID:34871362  
PMID:35148838   PMID:35550066   PMID:35614045   PMID:36200294   PMID:36323317   PMID:36343752   PMID:37279752   PMID:37354904   PMID:37963876   PMID:38427721   PMID:38837989  


Genomics

Comparative Map Data
Tph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,294,065 - 46,321,961 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,294,065 - 46,321,961 (-)EnsemblGRCm39 Ensembl
GRCm38746,644,641 - 46,672,537 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,644,641 - 46,672,537 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,902,501 - 53,927,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,515,218 - 46,540,579 (-)NCBIMGSCv36mm8
Celera742,121,305 - 42,146,712 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.43NCBI
TPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,017,555 - 18,046,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,017,555 - 18,046,269 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,039,102 - 18,067,816 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,999,114 - 18,018,885 (-)NCBINCBI36Build 36hg18NCBI36
Build 341117,999,113 - 18,018,885NCBI
Celera1118,174,092 - 18,194,347 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,724,789 - 17,745,045 (-)NCBIHuRef
CHM1_11118,041,619 - 18,061,874 (-)NCBICHM1_1
T2T-CHM13v2.01118,115,170 - 18,143,890 (-)NCBIT2T-CHM13v2.0
Tph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,293,695 - 106,314,628 (-)NCBIGRCr8
mRatBN7.2197,157,375 - 97,178,415 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,157,409 - 97,178,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,543,405 - 102,564,448 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,015,397 - 111,036,438 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,305,773 - 104,326,712 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
Tph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,800,477 - 32,828,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,803,417 - 32,828,682 (-)NCBIChiLan1.0ChiLan1.0
TPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,349,567 - 20,378,423 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,311,362 - 20,334,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,070,576 - 18,099,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,754,885 - 17,778,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,754,893 - 17,778,076 (-)Ensemblpanpan1.1panPan2
TPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,545,379 - 40,571,620 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,547,682 - 40,566,572 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,047,325 - 40,065,811 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,651,924 - 41,675,891 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,651,924 - 41,676,027 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,664,759 - 40,683,241 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,872,839 - 40,891,326 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,211,247 - 41,229,722 (-)NCBIUU_Cfam_GSD_1.0
Tph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,056,550 - 45,082,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,096,352 - 1,115,688 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,090,529 - 1,116,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,075,628 - 41,109,437 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,075,623 - 41,109,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,133,225 - 44,170,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,921,682 - 46,947,906 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038144,311,303 - 144,337,308 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,629,849 - 9,668,393 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,629,951 - 9,687,772 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1131
Count of miRNA genes:538
Interacting mature miRNAs:637
Transcripts:ENSMUST00000049298, ENSMUST00000107669, ENSMUST00000110264, ENSMUST00000163468, ENSMUST00000168335, ENSMUST00000170045, ENSMUST00000170251, ENSMUST00000172386
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse

Markers in Region
Tph1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B4UniSTS
cM Map723.5UniSTS
PMC263847P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38746,647,188 - 46,647,428UniSTSGRCm38
MGSCv37753,902,558 - 53,902,798UniSTSGRCm37
Celera742,121,362 - 42,121,602UniSTS
Cytogenetic Map7B4UniSTS
cM Map723.5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001136084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011250846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC090122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF273257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM932391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC008513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000049298   ⟹   ENSMUSP00000037752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,294,065 - 46,321,961 (-)Ensembl
GRCm38.p6 Ensembl746,644,641 - 46,672,537 (-)Ensembl
Ensembl Acc Id: ENSMUST00000107669   ⟹   ENSMUSP00000103296
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,296,554 - 46,316,801 (-)Ensembl
GRCm38.p6 Ensembl746,647,130 - 46,667,377 (-)Ensembl
Ensembl Acc Id: ENSMUST00000110264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,299,165 - 46,300,843 (-)Ensembl
GRCm38.p6 Ensembl746,649,741 - 46,651,419 (-)Ensembl
Ensembl Acc Id: ENSMUST00000163468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,309,443 - 46,311,739 (-)Ensembl
GRCm38.p6 Ensembl746,660,019 - 46,662,315 (-)Ensembl
Ensembl Acc Id: ENSMUST00000168335   ⟹   ENSMUSP00000128107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,309,761 - 46,316,767 (-)Ensembl
GRCm38.p6 Ensembl746,660,337 - 46,667,343 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170045
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,306,286 - 46,310,092 (-)Ensembl
GRCm38.p6 Ensembl746,656,862 - 46,660,668 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170251   ⟹   ENSMUSP00000132489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,296,850 - 46,314,725 (-)Ensembl
GRCm38.p6 Ensembl746,647,426 - 46,665,301 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172386   ⟹   ENSMUSP00000128727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,296,850 - 46,314,712 (-)Ensembl
GRCm38.p6 Ensembl746,647,426 - 46,665,288 (-)Ensembl
RefSeq Acc Id: NM_001136084   ⟹   NP_001129556
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39746,294,065 - 46,316,801 (-)NCBI
GRCm38746,644,641 - 46,667,377 (-)NCBI
MGSCv37753,902,501 - 53,927,907 (-)RGD
Celera742,118,815 - 42,146,712 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001276372   ⟹   NP_001263301
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39746,309,761 - 46,316,801 (-)NCBI
GRCm38746,660,337 - 46,667,377 (-)NCBI
Celera742,118,815 - 42,146,712 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009414   ⟹   NP_033440
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39746,294,065 - 46,321,961 (-)NCBI
GRCm38746,644,641 - 46,672,537 (-)NCBI
MGSCv37753,902,501 - 53,927,907 (-)RGD
Celera742,118,815 - 42,146,712 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011250846   ⟹   XP_011249148
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39746,294,070 - 46,314,728 (-)NCBI
GRCm38746,644,646 - 46,665,304 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152912   ⟹   XP_036008805
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39746,294,065 - 46,321,894 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033440   ⟸   NM_009414
- Peptide Label: isoform 1
- UniProtKB: P17532 (UniProtKB/Swiss-Prot),   Q3UK52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129556   ⟸   NM_001136084
- Peptide Label: isoform 1
- UniProtKB: P17532 (UniProtKB/Swiss-Prot),   Q3UK52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263301   ⟸   NM_001276372
- Peptide Label: isoform 2
- UniProtKB: Q3TZH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011249148   ⟸   XM_011250846
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000132489   ⟸   ENSMUST00000170251
Ensembl Acc Id: ENSMUSP00000128727   ⟸   ENSMUST00000172386
Ensembl Acc Id: ENSMUSP00000037752   ⟸   ENSMUST00000049298
Ensembl Acc Id: ENSMUSP00000103296   ⟸   ENSMUST00000107669
Ensembl Acc Id: ENSMUSP00000128107   ⟸   ENSMUST00000168335
RefSeq Acc Id: XP_036008805   ⟸   XM_036152912
- Peptide Label: isoform X1
- UniProtKB: P17532 (UniProtKB/Swiss-Prot),   Q3UK52 (UniProtKB/TrEMBL)
Protein Domains
ACT   Biopterin-dependent aromatic amino acid hydroxylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17532-F1-model_v2 AlphaFold P17532 1-447 view protein structure

Promoters
RGD ID:8664127
Promoter ID:EPDNEW_M10094
Type:multiple initiation site
Name:Tph1_1
Description:Mus musculus tryptophan hydroxylase 1 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10095  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38746,667,377 - 46,667,437EPDNEW
RGD ID:8664129
Promoter ID:EPDNEW_M10095
Type:multiple initiation site
Name:Tph1_2
Description:Mus musculus tryptophan hydroxylase 1 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10094  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38746,672,393 - 46,672,453EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98796 AgrOrtholog
Ensembl Genes ENSMUSG00000040046 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049298 ENTREZGENE
  ENSMUST00000049298.15 UniProtKB/Swiss-Prot
  ENSMUST00000107669 ENTREZGENE
  ENSMUST00000107669.9 UniProtKB/Swiss-Prot
  ENSMUST00000168335 ENTREZGENE
  ENSMUST00000168335.3 UniProtKB/TrEMBL
  ENSMUST00000170251.8 UniProtKB/TrEMBL
  ENSMUST00000172386.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp_5_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrpOH_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21990 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98796 ENTREZGENE
NCBI Gene 21990 ENTREZGENE
PANTHER PTHR11473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPTOPHAN 5-HYDROXYLASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biopterin_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TPH1 RGD
PhenoGen Tph1 PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FYWHYDRXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q060_MOUSE UniProtKB/TrEMBL
  F7BYX2_MOUSE UniProtKB/TrEMBL
  P17532 ENTREZGENE
  Q3TZH2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UK52 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHZ8_MOUSE UniProtKB/TrEMBL
  TPH1_MOUSE UniProtKB/Swiss-Prot