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Gene: TPH1 (tryptophan hydroxylase 1) Pan paniscus

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Symbol:

TPH1

Name:

tryptophan hydroxylase 1

RGD ID:

12014489

Description:

ENCODES a protein that exhibits tryptophan 5-monooxygenase activity (ortholog); INVOLVED IN circadian rhythm (ortholog); negative regulation of ossification (ortholog); response to immobilization stress (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN cytoplasm (inferred); neuron projection (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tryptophan 5-hydroxylase 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TPH1 (tryptophan hydroxylase 1)	NCBI	Ortholog
Mus musculus (house mouse):	Tph1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tph1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tph1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TPH1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tph1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TPH1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TPH1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tph1 (tryptophan hydroxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	20,349,567 - 20,378,423 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	20,311,362 - 20,334,990 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	18,070,576 - 18,099,539 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	17,754,885 - 17,778,076 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	17,754,893 - 17,778,076 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TPH1	Bonobo	alcohol use disorder		ISO	TPH1 (Homo sapiens)	9068941		RGD	PMID:15654285 and REF_RGD_ID:1580464
TPH1	Bonobo	Alzheimer's disease		ISO	TPH1 (Homo sapiens)	9068941		RGD	PMID:15182943 and REF_RGD_ID:1580467
TPH1	Bonobo	attention deficit hyperactivity disorder		ISO	TPH1 (Homo sapiens)	9068941	DNA:polymorphisms: :-6526A>G and 218A>C (human)	RGD	PMID:16389593 and REF_RGD_ID:1580457
TPH1	Bonobo	attention deficit hyperactivity disorder		ISO	TPH1 (Homo sapiens)	9068941	DNA:missense mutations:exons:multiple	RGD	PMID:20921119 and REF_RGD_ID:5686345
TPH1	Bonobo	borderline personality disorder		ISO	TPH1 (Homo sapiens)	9068941	DNA:SNPs and haplotypes: :multiple	RGD	PMID:16495936 and REF_RGD_ID:5686357
TPH1	Bonobo	depressive disorder		ISO	Tph1 (Rattus norvegicus)	9068941	mRNA and protein:decreased expression:hippocampus:	RGD	PMID:24495952 and REF_RGD_ID:9681459
TPH1	Bonobo	depressive disorder		ISO	TPH1 (Homo sapiens)	9068941		RGD	PMID:16165107 and REF_RGD_ID:1580459
TPH1	Bonobo	depressive disorder		ISO	TPH1 (Homo sapiens)	9068941	DNA:SNPs more ...	RGD	PMID:17134762 and REF_RGD_ID:5686354
TPH1	Bonobo	Fibrosis		ISO	Tph1 (Mus musculus)	9068941		RGD	PMID:21518801 and REF_RGD_ID:5686344
TPH1	Bonobo	heroin dependence		ISO	TPH2 (Homo sapiens)	9068941	DNA:SNP: :rs1799913	RGD	PMID:18181017 and REF_RGD_ID:597621691
TPH1	Bonobo	nicotine dependence		ISO	TPH1 (Homo sapiens)	9068941		RGD	PMID:15635702 and REF_RGD_ID:1580461
TPH1	Bonobo	postpartum depression		ISO	TPH1 (Homo sapiens)	9068941		RGD	PMID:15544576 and REF_RGD_ID:1580465
TPH1	Bonobo	pulmonary hypertension	severity	ISO	Tph1 (Mus musculus)	9068941		RGD	PMID:17675372 and REF_RGD_ID:5686352
TPH1	Bonobo	schizophrenia		ISO	TPH1 (Homo sapiens)	9068941		RGD	PMID:15211625 and REF_RGD_ID:1580466
TPH1	Bonobo	scoliosis	no_association	ISO	TPH1 (Homo sapiens)	9068941	DNA:SNPs:multiple	RGD	PMID:21192222 and REF_RGD_ID:5686348
TPH1	Bonobo	scoliosis		ISO	TPH1 (Homo sapiens)	9068941	DNA:SNP:promoter: (rs10488682) (human)	RGD	PMID:18794762 and REF_RGD_ID:5686347
TPH1	Bonobo	scoliosis	no_association	ISO	TPH1 (Homo sapiens)	9068941	DNA:SNP:promoter: (rs10488682) (human)	RGD	PMID:21308753 and REF_RGD_ID:5686349

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TPH1	Bonobo	intellectual disability		ISO	TPH1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar
TPH1	Bonobo	progressive myoclonus epilepsy 7		ISO	TPH1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Progressive myoclonic epilepsy type 7	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TPH1	Bonobo	Kidney Neoplasms		ISO	TPH1 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:28321044
TPH1	Bonobo	pulmonary hypertension		ISO	TPH1 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:18506000
TPH1	Bonobo	schizophrenia		ISO	TPH1 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:18583979

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TPH1	Bonobo	aromatic amino acid metabolic process	involved_in	IEA	InterPro:IPR001273 more ...	150520179		InterPro	GO_REF:0000002
TPH1	Bonobo	bone remodeling	acts_upstream_of_or_within	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107
TPH1	Bonobo	circadian rhythm		ISO	Tph1 (Rattus norvegicus)	9068941		RGD	PMID:18705647 and REF_RGD_ID:5686363
TPH1	Bonobo	mammary gland alveolus development	acts_upstream_of_or_within	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107
TPH1	Bonobo	negative regulation of ossification		ISO	Tph1 (Rattus norvegicus)	9068941		RGD	PMID:20139991 and REF_RGD_ID:5686362
TPH1	Bonobo	platelet degranulation	involved_in	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107
TPH1	Bonobo	positive regulation of fat cell differentiation	acts_upstream_of_or_within	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107
TPH1	Bonobo	regulation of hemostasis	involved_in	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107
TPH1	Bonobo	response to immobilization stress		ISO	Tph1 (Rattus norvegicus)	9068941		RGD	PMID:14744469 and REF_RGD_ID:1580443
TPH1	Bonobo	serotonin biosynthetic process	involved_in	IEA	UniPathway:UPA00846	150520179		UniProt	GO_REF:0000041
TPH1	Bonobo	serotonin biosynthetic process	involved_in	IEA	UniProtKB-KW:KW-0724	150520179		UniProt	GO_REF:0000043
TPH1	Bonobo	serotonin biosynthetic process	involved_in	IEA	InterPro:IPR005963	150520179		InterPro	GO_REF:0000002
TPH1	Bonobo	serotonin biosynthetic process	involved_in	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TPH1	Bonobo	cytoplasm	located_in	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107
TPH1	Bonobo	neuron projection	located_in	IEA	PANTHER:PTN000158499 and PANTHER:PTN000895553	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TPH1	Bonobo	iron ion binding	enables	IEA	InterPro:IPR001273 more ...	150520179		InterPro	GO_REF:0000002
TPH1	Bonobo	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
TPH1	Bonobo	monooxygenase activity	enables	IEA	UniProtKB-KW:KW-0503	150520179		UniProt	GO_REF:0000043
TPH1	Bonobo	monooxygenase activity	enables	IEA	InterPro:IPR001273 more ...	150520179		InterPro	GO_REF:0000002
TPH1	Bonobo	oxidoreductase activity	enables	IEA	UniProtKB-KW:KW-0560	150520179		UniProt	GO_REF:0000043
TPH1	Bonobo	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	enables	IEA	InterPro:IPR019773 and InterPro:IPR019774	150520179		InterPro	GO_REF:0000002
TPH1	Bonobo	protein binding	enables	ISO	UniProtKB:Q9UKB3	9068941	PMID:28514442 and PMID:33961781	IntAct	PMID:28514442 and PMID:33961781
TPH1	Bonobo	protein binding	enables	ISO	UniProtKB:O95789-4 more ...	9068941	PMID:32814053	IntAct	PMID:32814053
TPH1	Bonobo	protein binding	enables	ISO	UniProtKB:O43586 and UniProtKB:Q9H8Y8	9068941	PMID:32296183	IntAct	PMID:32296183
TPH1	Bonobo	tryptophan 5-monooxygenase activity		ISO	Tph1 (Rattus norvegicus)	9068941		RGD	PMID:12354109 and REF_RGD_ID:724750
TPH1	Bonobo	tryptophan 5-monooxygenase activity	enables	IEA	PANTHER:PTN000158499 and PANTHER:PTN000895553	150520179		TreeGrafter	GO_REF:0000118
TPH1	Bonobo	tryptophan 5-monooxygenase activity	enables	IEA	UniProtKB:P17532 and ensembl:ENSMUSP00000037752	150520179		Ensembl	GO_REF:0000107
TPH1	Bonobo	tryptophan 5-monooxygenase activity	enables	IEA	EC:1.14.16.4	150520179		UniProt	GO_REF:0000003
TPH1	Bonobo	tryptophan 5-monooxygenase activity	enables	IEA	InterPro:IPR005963	150520179		InterPro	GO_REF:0000002

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TPH1	Bonobo	tryptophan metabolic pathway		ISO	TPH1 (Homo sapiens)	9068941		SMPDB	SMP:00063

PMID:22301074	PMID:30032202

TPH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	20,349,567 - 20,378,423 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	20,311,362 - 20,334,990 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	18,070,576 - 18,099,539 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	17,754,885 - 17,778,076 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	17,754,893 - 17,778,076 (-)	Ensembl	panpan1.1		panPan2

TPH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	18,017,555 - 18,046,269 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	18,017,555 - 18,046,269 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	18,039,102 - 18,067,816 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	17,999,114 - 18,018,885 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	17,999,113 - 18,018,885	NCBI
Celera	11	18,174,092 - 18,194,347 (-)	NCBI		Celera
Cytogenetic Map	11	p15.1	NCBI
HuRef	11	17,724,789 - 17,745,045 (-)	NCBI		HuRef
CHM1_1	11	18,041,619 - 18,061,874 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	18,115,170 - 18,143,890 (-)	NCBI		T2T-CHM13v2.0

Tph1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	46,294,065 - 46,321,961 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	46,294,065 - 46,321,961 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	46,644,641 - 46,672,537 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	46,644,641 - 46,672,537 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	53,902,501 - 53,927,907 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	46,515,218 - 46,540,579 (-)	NCBI		MGSCv36	mm8
Celera	7	42,121,305 - 42,146,712 (-)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	30.43	NCBI

Tph1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	106,293,695 - 106,314,628 (-)	NCBI		GRCr8
mRatBN7.2	1	97,157,375 - 97,178,415 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	97,157,409 - 97,178,344 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	102,543,405 - 102,564,448 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	111,015,397 - 111,036,438 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	104,305,773 - 104,326,712 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	102,669,868 - 102,699,442 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	102,669,868 - 102,699,442 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	103,746,878 - 103,774,100 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	97,186,071 - 97,207,551 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	97,264,181 - 97,285,662 (-)	NCBI
Celera	1	91,404,769 - 91,425,505 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Tph1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	32,800,477 - 32,828,501 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	32,803,417 - 32,828,682 (-)	NCBI	ChiLan1.0	ChiLan1.0

TPH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	40,545,379 - 40,571,620 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	40,547,682 - 40,566,572 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	40,047,325 - 40,065,811 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	41,651,924 - 41,675,891 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	41,651,924 - 41,676,027 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	40,664,759 - 40,683,241 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	40,872,839 - 40,891,326 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	41,211,247 - 41,229,722 (-)	NCBI		UU_Cfam_GSD_1.0

Tph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	45,056,550 - 45,082,283 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936528	1,096,352 - 1,115,688 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936528	1,090,529 - 1,116,081 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TPH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	41,075,628 - 41,109,437 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	41,075,623 - 41,109,005 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	44,133,225 - 44,170,984 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TPH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	46,921,682 - 46,947,906 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	144,311,303 - 144,337,308 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tph1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	9,629,849 - 9,668,393 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	9,629,951 - 9,687,772 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_008971492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034932263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	EU796630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU796675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JARIFH020000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000054706 ⟹ ENSPPAP00000031841

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	11	17,754,893 - 17,778,076 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000054709 ⟹ ENSPPAP00000031844

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	11	17,761,379 - 17,776,448 (-)	Ensembl

RefSeq Acc Id:

XM_008971492 ⟹ XP_008969740

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	9	20,349,567 - 20,378,423 (-)	NCBI
NHGRI_mPanPan1	11	20,311,362 - 20,334,990 (-)	NCBI
Mhudiblu_PPA_v0	11	18,070,576 - 18,095,599 (-)	NCBI
PanPan1.1	11	17,754,885 - 17,778,076 (-)	NCBI

Sequence:

show sequence

AGTCAAGCTTTGAGTGGTAATTGAATGGTTTTAGAGAATTACTCCAAATTCATCATGATTGAAGACAATAAGGAGAACAAAGACCATTCCTTAGAAAGGGGAAGAGCAAGTCTCATTTTTTCCTTAAA
GAATGAAGTTGGAGGACTTATAAAAGCCCTGAAAATCTTTCAGGAGAAGCATGTGAATCTGTTACATATCGAGTCCCGAAAATCAAAAAGAAGAAACTCAGAATTTGAGATTTTTGTTGACTGTGACA
TCAACAGAGAACAATTGAATGATATTTTTCATCTGCTGAAGTCTCATACCAATGTTCTCTCTGTGAATCCACCAGATAATTTTACTTTGAAGGAAGATGGTATGGAAACTGTTCCTTGGTTTCCAAAG
AAGATTTCTGACCTGGACCATTGTGCCAACAGAGTTCTGATGTATGGATCTGAACTAGATGCAGACCATCCTGGCTTCAAAGACAATGTCTACCGTAAACGTCGAAAGTATTTTGCGGACTTGGCTAT
GAACTATAAACATGGAGACCCCATTCCAAAGGTTGAATTCACTGAAGAGGAGATTAAGACCTGGGGAACCGTATTCCAAGAGCTCAACAAACTCTACCCAACCCATGCTTGCAGAGAGTATCTCAAAA
ACTTACCTTTGCTTTCTAAATATTGTGGATATCGGGAGGATAATATCCCACAATTGGAAGATGTCTCCAACTTTTTAAAAGAGCGTACAGGTTTTTCCATCCGTCCTGTGGCTGGTTACTTATCACCA
AGAGATTTCTTATCAGGTTTAGCCTTTCGAGTTTTTCACTGCACTCAATATGTGAGACACAGTTCAGATCCCTTCTATACCCCAGAGCCAGATACCTGCCATGAACTCTTAGGTCATGTCCCGCTTTT
GGCTGAACCTACTTTTGCCCAATTCTCCCAAGAAATTGGCTTGGCTTCTCTTGGCGCTTCAGAGGAGGCTGTTCAAAAACTGGCAACGTGCTACTTTTTCACTGTGGAGTTTGGTCTATGTAAACAAG
ATGGACAGCTAAGAGTCTTTGGTGCTGGCTTACTTTCTTCTATCAGTGAACTCAAACATGCACTTTCTGGACATGCCAAAGTAAAGCCCTTTGATCCCAAGATTACCTGCAAACAGGAATGTCTTATC
ACAACTTTTCAAGATGTCTACTTTGTATCTGAAAGTTTTGAAGATGCAAAGGAGAAGATGAGAGAATTTACCAAAACAATTAAGCGTCCATTTGGAGTGAAGTATAATCCATATACACGGAGTATTCA
GATCCTGAAAGACACCAAGAGCATAACCAGTGCCATGAATGAGCTGCAGCATGATCTCGATGTTGTCAGTGATGCCCTTGCTAAGGTCAGCAGGAAGCCGAGTATCTAACAGTAGCCAGTCATCCAGG
AACATTTGAGCATCAATTCGGAGGCCTCTGGGCCATCTCTTGCTTTTCTTGAACACCTGATCCTGGAGGGACAGCATCTTCTGGCCAAACAATATTATCGAATTCCACTACTTAATGAATCACTAGTC
TTTGAAAATTTGTACCTGGATATTCTATTTACCACTTATTTTTTTGTTTAGTTTTATTTCTTTTTTTTTGGTAGCAGCTTTAATGAGACAATTTATATACCATATAAGCCACTGACCACCCATTTTTA
ATAGAGAAGTTGTTTGACCCAATAGATAGATCTAATCTCAGCCTAACTCTATTTTCCCCAATCCTCCTTGAGTAAAATGACCCTTTAGGATCGCTTAGAATAACTTGAGGAGTATTATGGCGCTGACT
CATATTGTTACCTAAGATCCCCTTATTTCTAAAGTATCTGTTACTTATTGCTGAATTTGTGCCAAGCTCAATCACATTCACACTAAAATTTAACAGGAGACCCTGCTGTCTTTGTTGCTAGCATGAGC
AAAAGTATAGAGGCCTTTGCACATGGAGGATACCTAGTAAAGAGCAAGTAGTCTAGGTTCAAGTGTAGTATCTTGTAGGGAAATGGGAGTAGCTAAGCCTGGAAAGGTTGAATGGGGCATAATCATTA
AGACTAGGCTAAGAATTCGAGACTTTATTTTTTAGGCATTAGGGAGCCCCTTCCCAAGTGACTATCTTCCTTGAAACTTTGTTTTCTTTCAATGACATCACACGATACTGGTTTTATTCTGGACTATC
TATCCTACTCATGGGTCCAAGGGAAACTTAGTAGAGATGCAACTTGCATGGGGCTGTACTCAGACATGTGGTCCTAGGTATTATAATGGGATTGTCCCCAGATTAACAGGAAGCATTGTTATCAAAGG
AAGAGTTCAAACTGAGATAGATAAGAGAAGCACAAAGTAAAAGATAGAAAAAACAGTGCTGAGTACTTTATTTCTAAGCTATAAGGTGAGGCCATAAACAGAAAGGTATGCAATGAGAGTAGAGGCTG
CAGAAAAGGGGAGGAAATAGAATGTCAGAAAGGTCAAGAAGAGTGGTTTAGGACTGAGACTGTAAGTAATGTAAGGATTGCCAAGGAATGGTTTTTATGCAGAGTCAGCTGTGTAGCACAGGGAGTAA
GCAGTCCTGTTATAAATGGGTGAAGCTGAACTCCAAAATACAAACTTATGTCTCTTTAATTTGCCCCTTTCCTCCCTCTAGTCACTAAATGAAGATGTTCTTCAAGTTTCTGTCTTTGCACTTCTACT
CTTTTTGCCATCTCTTCATGGGGAATGTCACCCAGATACATGACTTCAGTTCTTATTTTGAATGACTCCTCTATTTGCAGTTATAACCCTGACATCTTTCTTGAATTTTTTTGCCCCTTAATTCCAAC
GAACTCCTGGATGTCTATGTAGATGTCTCATAATTTAGGCCAATGCTGTACAACTTCATGTGGCATCATCCACATAGAATGAAAAGGGGTTGTTCAATATGACAGCCCTGCCAAGCATCTCAAATTGA
ACAGGTCTATAAAGGAACTCAGAATCACTTGAATATCACAGTCCATCAGCTTCCTTTCCCAGTAATTTAATTTCCATTAATGGTATATTAAACATCGTATTTTCAATCATTTTCAGGTTTAGTCAGCT
ACTTAAAAATAGGCTTTTTTTTCACATAAATAAATTGTATACCATTTAACATGTTTTATTTCAACAGACTAATAGATCTTTTAGCACTTCTTAGTCCTCAAAATAAA

hide sequence


Protein RefSeqs	XP_008969740	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACE96109	(Get FASTA)	NCBI Sequence Viewer
	ACE96114	(Get FASTA)	NCBI Sequence Viewer
	ACE96119	(Get FASTA)	NCBI Sequence Viewer
	ACE96124	(Get FASTA)	NCBI Sequence Viewer
	ACE96129	(Get FASTA)	NCBI Sequence Viewer
	ACE96134	(Get FASTA)	NCBI Sequence Viewer
	ACE96139	(Get FASTA)	NCBI Sequence Viewer
	ACE96144	(Get FASTA)	NCBI Sequence Viewer
	ACE96149	(Get FASTA)	NCBI Sequence Viewer
	ACE96154	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000031841.1
	ENSPPAP00000031844.1

RefSeq Acc Id:

XP_008969740 ⟸ XM_008971492

- UniProtKB:

A0A2R9BQ94 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLENYSKFIMIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNPPDNFTLKEDGMETVPWFPKKISDLDHC
ANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLA
FRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPTFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYF
VSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

hide sequence

Ensembl Acc Id:

ENSPPAP00000031841 ⟸ ENSPPAT00000054706

Ensembl Acc Id:

ENSPPAP00000031844 ⟸ ENSPPAT00000054709

Protein Domains

ACT Biopterin-dependent aromatic amino acid hydroxylase

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038830	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000054706.1	UniProtKB/TrEMBL
	ENSPPAT00000054709.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.800.10	UniProtKB/TrEMBL
	3.30.70.260	UniProtKB/TrEMBL
InterPro	ACT-like_dom_sf	UniProtKB/TrEMBL
	ACT_dom	UniProtKB/TrEMBL
	ArAA_hydroxylase	UniProtKB/TrEMBL
	ArAA_hydroxylase_Fe/CU_BS	UniProtKB/TrEMBL
	ArAA_hydroxylase_sf	UniProtKB/TrEMBL
	Aro-AA_hydroxylase_C_sf	UniProtKB/TrEMBL
	Aromatic-AA_hydroxylase_C	UniProtKB/TrEMBL
	Trp_5_mOase	UniProtKB/TrEMBL
	TrpOH_cat	UniProtKB/TrEMBL
	Tyrosine_3-monooxygenase-like	UniProtKB/TrEMBL
NCBI Gene	TPH1	ENTREZGENE
PANTHER	PTHR11473	UniProtKB/TrEMBL
	TRYPTOPHAN 5-HYDROXYLASE 1	UniProtKB/TrEMBL
Pfam	ACT	UniProtKB/TrEMBL
	Biopterin_H	UniProtKB/TrEMBL
PIRSF	PIRSF000336	UniProtKB/TrEMBL
PRINTS	FYWHYDRXLASE	UniProtKB/TrEMBL
PROSITE	ACT	UniProtKB/TrEMBL
	BH4_AAA_HYDROXYL_1	UniProtKB/TrEMBL
	BH4_AAA_HYDROXYL_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55021	UniProtKB/TrEMBL
	SSF56534	UniProtKB/TrEMBL
UniProt	A0A2R9BQ94	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BTR8_PANPA	UniProtKB/TrEMBL
	B3VRW6_PANPA	UniProtKB/TrEMBL
	B3VRX1_PANPA	UniProtKB/TrEMBL
	B3VRX6_PANPA	UniProtKB/TrEMBL
	B3VRY1_PANPA	UniProtKB/TrEMBL
	B3VRY6_PANPA	UniProtKB/TrEMBL
	B3VRZ1_PANPA	UniProtKB/TrEMBL
	B3VRZ6_PANPA	UniProtKB/TrEMBL
	B3VS01_PANPA	UniProtKB/TrEMBL
	B3VS06_PANPA	UniProtKB/TrEMBL
	B3VS11_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB