RGD Reference Report - Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. - Rat Genome Database

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Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality.

Authors: Reuter, M  Hennig, J 
Citation: Reuter M and Hennig J, Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134(1):20-4.
RGD ID: 1580461
Pubmed: PMID:15635702   (View Abstract at PubMed)
DOI: DOI:10.1002/ajmg.b.30153   (Journal Full-text)

Recent studies from molecular genetics have suggested an association between the tryptophan hydroxylase 1 (TPH1) gene and nicotine addiction indicating a dysfunction of the serotonergic (5-HT) system in smoking behavior. In a sample of 252 healthy subjects, a significant association between variations observed in nicotine dependence and the heterozygous AC-genotype of the TPH A779C polymorphism could be demonstrated. Moreover, the heterozygous genotype was significantly associated with a personality trait of neurotic aggression (indirect hostility, negativism), as measured by the Buss-Durkee-Hostility-Inventory (BDHI). The positive heterosis effects with respect to nicotine addiction and personality support the idea that the TPH1 gene exerts pleiotropic effects.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
TPH1Humannicotine dependence  IAGP  RGD 
Tph1Ratnicotine dependence  ISOTPH1 (Homo sapiens) RGD 
Tph1Mousenicotine dependence  ISOTPH1 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Tph1  (tryptophan hydroxylase 1)

Genes (Mus musculus)
Tph1  (tryptophan hydroxylase 1)

Genes (Homo sapiens)
TPH1  (tryptophan hydroxylase 1)