RGD Reference Report - Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease. - Rat Genome Database

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Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease.

Authors: Craig, D  Hart, DJ  Carson, R  McIlroy, SP  Passmore, AP 
Citation: Craig D, etal., Neurosci Lett. 2004 Jun 17;363(3):199-202.
RGD ID: 1580467
Pubmed: PMID:15182943   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2004.02.054   (Journal Full-text)

The behavioural and psychological symptoms of dementia are common, distressing to carers, and directly linked to the requirement for institutional care. Symptoms of aggression and agitation are particularly difficult for carers to tolerate. The origin of these features is unclear although genetic and environmental modification of pre-frontal serotonergic circuitry which regulates the control of negative emotions is proposed. Following the suggestion that the A218C intronic polymorphism of the tryptophan hydroxylase gene influences aggression and anger in non-demented individuals, we tested the influence of A218C on symptoms of agitation/aggression in 396 Alzheimer's disease patients using the Neuropsychiatric Inventory. Overall, 50% of participants experienced agitation/aggression in the month prior to interview. It was observed that male patients with a history of agitation/aggression were more likely to possess C-containing genotypes (P = 0.044, OR = 1.65, CI = 0.98-2.76). We conclude that aggression in male subjects with Alzheimer's disease may be genetically linked to polymorphic variation at the tryptophan hydroxylase gene.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IAGP 1580467 RGD 
Alzheimer's disease  ISOTPH1 (Homo sapiens)1580467; 1580467 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tph1  (tryptophan hydroxylase 1)

Genes (Mus musculus)
Tph1  (tryptophan hydroxylase 1)

Genes (Homo sapiens)
TPH1  (tryptophan hydroxylase 1)


Additional Information