Mfn1 (mitofusin 1) - Rat Genome Database

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Gene: Mfn1 (mitofusin 1) Mus musculus
Analyze
Symbol: Mfn1
Name: mitofusin 1
RGD ID: 731664
MGI Page MGI
Description: Predicted to enable GTPase activity and identical protein binding activity. Involved in mitochondrial fusion and positive regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in early conceptus; embryo; heart; and placenta. Orthologous to human MFN1 (mitofusin 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310002F04Rik; 6330416C07Rik; D3Ertd265; D3Ertd265e; HR; HR2; KIAA4032; mitofusin-1; mKIAA4032; transmembrane GTPase MFN1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,583,594 - 32,633,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,583,614 - 32,633,388 (+)EnsemblGRCm39 Ensembl
GRCm38332,529,443 - 32,579,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,529,465 - 32,579,239 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,428,404 - 32,478,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,721,035 - 32,769,225 (+)NCBIMGSCv36mm8
Celera332,439,720 - 32,489,477 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylglutaric acid  (ISO)
3-nitropropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-DAMP(1+)  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
aconitine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (EXP,ISO)
azide  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
bupivacaine  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbidopa  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clorgyline  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenthion  (EXP)
fructose  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
glucose  (ISO)
hemin  (ISO)
heptanal  (ISO)
hexadecanoic acid  (ISO)
hexanal  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
lamivudine  (EXP)
leflunomide  (ISO)
lenvatinib  (ISO)
lipopolysaccharide  (ISO)
melatonin  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nitrogen dioxide  (EXP)
nonanal  (ISO)
octanal  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
Salvianolic acid A  (EXP,ISO)
sarin  (ISO)
sarpogrelate  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sulfur dioxide  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
valproic acid  (EXP,ISO)
zidovudine  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
2. Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension. Batt J, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):74-86. doi: 10.1165/rcmb.2012-0506OC.
3. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. Chen H, etal., J Cell Biol 2003 Jan 20;160(2):189-200. Epub 2003 Jan 13.
4. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Chen Y, etal., Circ Res. 2011 Dec 9;109(12):1327-31. doi: 10.1161/CIRCRESAHA.111.258723. Epub 2011 Nov 3.
5. Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model. Córdova-Dávalos L, etal., Epilepsy Res. 2016 Jul;123:11-9. doi: 10.1016/j.eplepsyres.2016.03.007. Epub 2016 Mar 29.
6. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
7. Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine. Dong X, etal., Neurosci Lett. 2017 Jan 1;636:127-133. doi: 10.1016/j.neulet.2016.10.054. Epub 2016 Oct 29.
8. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Fields JA, etal., Neurobiol Dis. 2016 Feb;86:154-69. doi: 10.1016/j.nbd.2015.11.015. Epub 2015 Nov 22.
9. PM2.5-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats. Guo Z, etal., Int J Environ Res Public Health. 2017 Jan 29;14(2). pii: E134. doi: 10.3390/ijerph14020134.
10. Time representation of mitochondrial morphology and function after acute spinal cord injury. Jia ZQ, etal., Neural Regen Res. 2016 Jan;11(1):137-43. doi: 10.4103/1673-5374.175061.
11. MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension. Joshi SR, etal., Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H689-98. doi: 10.1152/ajpheart.00264.2016. Epub 2016 Jul 15.
12. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
13. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
14. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
15. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. Li R, etal., J Hazard Mater. 2015 Apr 28;287:392-401. doi: 10.1016/j.jhazmat.2015.02.006. Epub 2015 Feb 4.
16. Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats. Liu Q, etal., PLoS One. 2015 Oct 19;10(10):e0140906. doi: 10.1371/journal.pone.0140906. eCollection 2015.
17. Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. Liu W and Zhou C, Psychoneuroendocrinology. 2012 Jul;37(7):1057-70. doi: 10.1016/j.psyneuen.2011.12.003. Epub 2012 Jan 14.
18. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner. Meng G, etal., Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.
19. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
22. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
23. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Sun W, etal., Neuropharmacology. 2017 Feb;113(Pt A):556-566. doi: 10.1016/j.neuropharm.2016.11.010. Epub 2016 Nov 12.
27. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
28. Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKß/AMPK pathway in isoproterenol-induced myocardial ischaemia. Xue RQ, etal., J Cell Mol Med. 2017 Jan;21(1):58-71. doi: 10.1111/jcmm.12938. Epub 2016 Aug 5.
29. Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats. Yu J, etal., Sci Rep. 2016 Nov 10;6:36530. doi: 10.1038/srep36530.
30. Acetyl-L-carnitine ameliorates mitochondrial damage and apoptosis following spinal cord injury in rats. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11950885   PMID:12477932   PMID:14610273   PMID:15297672   PMID:15489334   PMID:15509649   PMID:15782199  
PMID:15899901   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17296794   PMID:17606912   PMID:17693261   PMID:18614015   PMID:18799693   PMID:18974884   PMID:19052620   PMID:19168699  
PMID:19360003   PMID:19445933   PMID:19477917   PMID:19578372   PMID:19690333   PMID:20403324   PMID:20671748   PMID:20974255   PMID:21149566   PMID:21160028   PMID:21245373   PMID:21267068  
PMID:21285412   PMID:21873635   PMID:22037195   PMID:22511781   PMID:22777004   PMID:22859504   PMID:22904094   PMID:22914740   PMID:23620051   PMID:23727017   PMID:24074867   PMID:24074868  
PMID:24091702   PMID:24127597   PMID:24282027   PMID:24513856   PMID:24615014   PMID:24686499   PMID:24710686   PMID:24722297   PMID:24751540   PMID:24813948   PMID:25271058   PMID:25348719  
PMID:25482509   PMID:25600785   PMID:25801171   PMID:26375863   PMID:26446920   PMID:26472072   PMID:26598616   PMID:26603188   PMID:26711011   PMID:26711429   PMID:27166947   PMID:27228353  
PMID:27404125   PMID:27613809   PMID:27689697   PMID:27713096   PMID:27997827   PMID:28348166   PMID:28378742   PMID:28413018   PMID:28591639   PMID:28729291   PMID:29107503   PMID:29787809  
PMID:30084972   PMID:30260752   PMID:30333037   PMID:30527740   PMID:30690319   PMID:30882371   PMID:30936207   PMID:31170154   PMID:31332167   PMID:31358769   PMID:31431479   PMID:31596236  
PMID:31675497   PMID:31903137   PMID:31938072   PMID:32165499   PMID:32220306   PMID:32236517   PMID:32281181   PMID:32315597   PMID:32330448   PMID:32846136   PMID:33074106   PMID:33674260  
PMID:33762690   PMID:33924585   PMID:34948301   PMID:35172139   PMID:35293971   PMID:35472764   PMID:35730364   PMID:36050466   PMID:36125902   PMID:36167966   PMID:36473917   PMID:36598990  
PMID:36609505   PMID:36754021   PMID:37493331   PMID:37698549   PMID:38088064  


Genomics

Comparative Map Data
Mfn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,583,594 - 32,633,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,583,614 - 32,633,388 (+)EnsemblGRCm39 Ensembl
GRCm38332,529,443 - 32,579,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,529,465 - 32,579,239 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,428,404 - 32,478,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,721,035 - 32,769,225 (+)NCBIMGSCv36mm8
Celera332,439,720 - 32,489,477 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.75NCBI
MFN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,347,709 - 179,394,936 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,347,709 - 179,394,936 (+)EnsemblGRCh38hg38GRCh38
GRCh373179,065,497 - 179,112,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,548,174 - 180,593,708 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,548,181 - 180,593,708NCBI
Celera3177,496,491 - 177,542,028 (+)NCBICelera
Cytogenetic Map3q26.33NCBI
HuRef3176,468,758 - 176,514,186 (+)NCBIHuRef
CHM1_13179,028,464 - 179,074,130 (+)NCBICHM1_1
T2T-CHM13v2.03182,151,549 - 182,198,775 (+)NCBIT2T-CHM13v2.0
Mfn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,240,525 - 117,288,017 (+)NCBIGRCr8
mRatBN7.22115,313,380 - 115,359,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,313,401 - 115,359,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,929,637 - 121,971,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02120,042,271 - 120,083,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,743,136 - 114,785,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,929,738 - 118,971,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,929,738 - 118,973,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,586,943 - 138,627,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,739,155 - 118,783,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,684,116 - 118,727,999 (+)NCBI
Celera2110,426,431 - 110,467,687 (+)NCBICelera
Cytogenetic Map2q24NCBI
Mfn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,541,936 - 8,594,437 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,541,547 - 8,596,494 (+)NCBIChiLan1.0ChiLan1.0
MFN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,214,053 - 177,261,639 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,218,770 - 177,266,371 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,378,175 - 176,423,943 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,552,108 - 184,596,763 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,552,108 - 184,596,763 (+)Ensemblpanpan1.1panPan2
MFN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,785,799 - 12,816,881 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,785,856 - 12,815,994 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,928,972 - 16,960,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,682,636 - 12,715,445 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,682,734 - 12,758,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,735,233 - 12,767,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,717,513 - 12,749,787 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,956,997 - 12,989,281 (+)NCBIUU_Cfam_GSD_1.0
Mfn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,444,823 - 109,485,343 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,737,315 - 3,775,693 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,737,315 - 3,775,894 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,404,699 - 117,442,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,404,637 - 117,441,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MFN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,050,616 - 10,093,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,047,599 - 10,093,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606318,929,780 - 18,974,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473057,110,807 - 57,153,989 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473057,110,669 - 57,154,924 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mfn1
1878 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1146
Count of miRNA genes:643
Interacting mature miRNAs:773
Transcripts:ENSMUST00000091257, ENSMUST00000118286, ENSMUST00000125182, ENSMUST00000137565, ENSMUST00000140328, ENSMUST00000147350, ENSMUST00000151320
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse

Markers in Region
RH126680  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38332,577,322 - 32,577,540UniSTSGRCm38
MGSCv37332,476,244 - 32,476,462UniSTSGRCm37
Celera332,487,578 - 32,487,796UniSTS
Cytogenetic Map3BUniSTS
cM Map313.0UniSTS
Whitehead/MRC_RH3355.43UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001783736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000091257   ⟹   ENSMUSP00000088801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,583,614 - 32,633,388 (+)Ensembl
GRCm38.p6 Ensembl332,529,465 - 32,579,239 (+)Ensembl
RefSeq Acc Id: ENSMUST00000118286   ⟹   ENSMUSP00000113251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,585,703 - 32,631,502 (+)Ensembl
GRCm38.p6 Ensembl332,531,554 - 32,577,353 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125182
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,583,680 - 32,601,095 (+)Ensembl
GRCm38.p6 Ensembl332,529,531 - 32,546,946 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137565   ⟹   ENSMUSP00000117411
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,585,694 - 32,598,246 (+)Ensembl
GRCm38.p6 Ensembl332,531,545 - 32,544,097 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140328
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,600,644 - 32,617,283 (+)Ensembl
GRCm38.p6 Ensembl332,546,495 - 32,563,134 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147350   ⟹   ENSMUSP00000116380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,583,688 - 32,600,808 (+)Ensembl
GRCm38.p6 Ensembl332,529,539 - 32,546,659 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151320   ⟹   ENSMUSP00000120960
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,615,695 - 32,624,479 (+)Ensembl
GRCm38.p6 Ensembl332,561,546 - 32,570,330 (+)Ensembl
RefSeq Acc Id: ENSMUST00000191661
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,617,057 - 32,617,949 (+)Ensembl
GRCm38.p6 Ensembl332,562,908 - 32,563,800 (+)Ensembl
RefSeq Acc Id: ENSMUST00000194384
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,608,215 - 32,617,551 (+)Ensembl
GRCm38.p6 Ensembl332,554,066 - 32,563,402 (+)Ensembl
RefSeq Acc Id: ENSMUST00000195334
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,628,367 - 32,631,306 (+)Ensembl
GRCm38.p6 Ensembl332,574,218 - 32,577,157 (+)Ensembl
RefSeq Acc Id: NM_024200   ⟹   NP_077162
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,583,622 - 32,633,384 (+)NCBI
GRCm38332,529,482 - 32,579,225 (+)NCBI
MGSCv37332,428,404 - 32,478,147 (+)RGD
Celera332,439,720 - 32,489,477 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001783736
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,583,594 - 32,631,828 (+)NCBI
GRCm38332,529,443 - 32,577,679 (+)NCBI
Sequence:
RefSeq Acc Id: NP_077162   ⟸   NM_024200
- UniProtKB: Q99M10 (UniProtKB/Swiss-Prot),   Q8CEY6 (UniProtKB/Swiss-Prot),   Q811D5 (UniProtKB/Swiss-Prot),   Q3URC4 (UniProtKB/Swiss-Prot),   Q9D395 (UniProtKB/Swiss-Prot),   Q811U4 (UniProtKB/Swiss-Prot),   Q571M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000088801   ⟸   ENSMUST00000091257
RefSeq Acc Id: ENSMUSP00000113251   ⟸   ENSMUST00000118286
RefSeq Acc Id: ENSMUSP00000116380   ⟸   ENSMUST00000147350
RefSeq Acc Id: ENSMUSP00000120960   ⟸   ENSMUST00000151320
RefSeq Acc Id: ENSMUSP00000117411   ⟸   ENSMUST00000137565
Protein Domains
Dynamin-type G   Fzo/mitofusin HR2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811U4-F1-model_v2 AlphaFold Q811U4 1-741 view protein structure

Promoters
RGD ID:6834083
Promoter ID:MM_KWN:33998
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000068847,   OTTMUST00000069320,   UC008OWH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36332,428,199 - 32,428,699 (+)MPROMDB
RGD ID:6834084
Promoter ID:MM_KWN:34000
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000069322
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36332,444,366 - 32,444,866 (+)MPROMDB
RGD ID:6880446
Promoter ID:EPDNEW_M3673
Type:initiation region
Name:Mfn1_1
Description:Mus musculus mitofusin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38332,529,481 - 32,529,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914664 AgrOrtholog
Ensembl Genes ENSMUSG00000027668 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000091257 ENTREZGENE
  ENSMUST00000091257.11 UniProtKB/Swiss-Prot
  ENSMUST00000118286.8 UniProtKB/Swiss-Prot
  ENSMUST00000137565.8 UniProtKB/TrEMBL
  ENSMUST00000147350.8 UniProtKB/TrEMBL
  ENSMUST00000151320.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo/mitofusin_HR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitofusin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67414 UniProtKB/Swiss-Prot
MGD MGI:1914664 ENTREZGENE
NCBI Gene 67414 ENTREZGENE
PANTHER PTHR10465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10465:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fzo_mitofusin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mfn1 PhenoGen
PROSITE G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Fzo-like conserved region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z4L5_MOUSE UniProtKB/TrEMBL
  D3Z5P8_MOUSE UniProtKB/TrEMBL
  F6XRI9_MOUSE UniProtKB/TrEMBL
  MFN1_MOUSE UniProtKB/Swiss-Prot
  Q3URC4 ENTREZGENE
  Q571M0 ENTREZGENE, UniProtKB/TrEMBL
  Q811D5 ENTREZGENE
  Q811U4 ENTREZGENE
  Q8CEY6 ENTREZGENE
  Q99M10 ENTREZGENE
  Q9D395 ENTREZGENE
UniProt Secondary Q3URC4 UniProtKB/Swiss-Prot
  Q811D5 UniProtKB/Swiss-Prot
  Q8CEY6 UniProtKB/Swiss-Prot
  Q99M10 UniProtKB/Swiss-Prot
  Q9D395 UniProtKB/Swiss-Prot