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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731664
Species: Mus musculus
RGD Object: Gene
Symbol: Mfn1
Name: mitofusin 1
Acc ID: CHEBI:68647
Term: regorafenib
Definition: A pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy.
Chemical ID: MESH:C559147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mfn1increases expressionISOMfn1 (Rattus norvegicus)6480464CTDregorafenib results in increased expression of MFN1 mRNAPMID:33166663
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