Mfn1 (mitofusin 1) - Rat Genome Database

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Gene: Mfn1 (mitofusin 1) Chinchilla lanigera
Analyze
Symbol: Mfn1
Name: mitofusin 1
RGD ID: 8735261
Description: ENCODES a protein that exhibits GTPase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to glucose stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN mitochondria fusion pathway; ASSOCIATED WITH Acute Heart Injury (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN membrane (ortholog); mitochondrial inner membrane (ortholog); mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitofusin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,541,936 - 8,594,437 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,541,547 - 8,596,494 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mfn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,541,936 - 8,594,437 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,541,547 - 8,596,494 (+)NCBIChiLan1.0ChiLan1.0
MFN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,347,709 - 179,394,936 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,347,709 - 179,394,936 (+)EnsemblGRCh38hg38GRCh38
GRCh373179,065,497 - 179,112,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,548,174 - 180,593,708 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,548,181 - 180,593,708NCBI
Celera3177,496,491 - 177,542,028 (+)NCBICelera
Cytogenetic Map3q26.33NCBI
HuRef3176,468,758 - 176,514,186 (+)NCBIHuRef
CHM1_13179,028,464 - 179,074,130 (+)NCBICHM1_1
T2T-CHM13v2.03182,151,549 - 182,198,775 (+)NCBIT2T-CHM13v2.0
Mfn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,583,594 - 32,633,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,583,614 - 32,633,388 (+)EnsemblGRCm39 Ensembl
GRCm38332,529,443 - 32,579,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,529,465 - 32,579,239 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,428,404 - 32,478,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,721,035 - 32,769,225 (+)NCBIMGSCv36mm8
Celera332,439,720 - 32,489,477 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.75NCBI
Mfn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,240,525 - 117,288,017 (+)NCBIGRCr8
mRatBN7.22115,313,380 - 115,359,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,313,401 - 115,359,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,929,637 - 121,971,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02120,042,271 - 120,083,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,743,136 - 114,785,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,929,738 - 118,971,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,929,738 - 118,973,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,586,943 - 138,627,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,739,155 - 118,783,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,684,116 - 118,727,999 (+)NCBI
Celera2110,426,431 - 110,467,687 (+)NCBICelera
Cytogenetic Map2q24NCBI
MFN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,214,053 - 177,261,639 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,218,770 - 177,266,371 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,378,175 - 176,423,943 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,552,108 - 184,596,763 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,552,108 - 184,596,763 (+)Ensemblpanpan1.1panPan2
MFN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,785,799 - 12,816,881 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,785,856 - 12,815,994 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,928,972 - 16,960,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,682,636 - 12,715,445 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,682,734 - 12,758,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,735,233 - 12,767,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,717,513 - 12,749,787 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,956,997 - 12,989,281 (+)NCBIUU_Cfam_GSD_1.0
Mfn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,444,823 - 109,485,343 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,737,315 - 3,775,693 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,737,315 - 3,775,894 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,404,699 - 117,442,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,404,637 - 117,441,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MFN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,050,616 - 10,093,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,047,599 - 10,093,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606318,929,780 - 18,974,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473057,110,807 - 57,153,989 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473057,110,669 - 57,154,924 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000023406   ⟹   ENSCLAP00000023185
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554208,541,936 - 8,564,129 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000023407   ⟹   ENSCLAP00000023186
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554208,542,825 - 8,594,437 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000023408   ⟹   ENSCLAP00000023187
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554208,557,054 - 8,587,389 (+)Ensembl
RefSeq Acc Id: XM_013513383   ⟹   XP_013368837
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554208,541,547 - 8,596,494 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013368837 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000023185.1
  ENSCLAP00000023186
  ENSCLAP00000023186.1
  ENSCLAP00000023187.1
Reference Protein Sequences
RefSeq Acc Id: XP_013368837   ⟸   XM_013513383
- UniProtKB: A0A8C2W4Z4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000023185   ⟸   ENSCLAT00000023406
RefSeq Acc Id: ENSCLAP00000023186   ⟸   ENSCLAT00000023407
RefSeq Acc Id: ENSCLAP00000023187   ⟸   ENSCLAT00000023408
Protein Domains
Dynamin-type G   Fzo/mitofusin HR2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015912 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023406.1 UniProtKB/TrEMBL
  ENSCLAT00000023407 ENTREZGENE
  ENSCLAT00000023407.1 UniProtKB/TrEMBL
  ENSCLAT00000023408.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Dynamin_N UniProtKB/TrEMBL
  Fzo/mitofusin_HR2 UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  Mitofusin_fam UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Mfn1 ENTREZGENE
PANTHER PTHR10465 UniProtKB/TrEMBL
  PTHR10465:SF2 UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/TrEMBL
  Fzo_mitofusin UniProtKB/TrEMBL
PROSITE G_DYNAMIN_2 UniProtKB/TrEMBL
Superfamily-SCOP Fzo-like conserved region UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2W019_CHILA UniProtKB/TrEMBL
  A0A8C2W2Y2_CHILA UniProtKB/TrEMBL
  A0A8C2W4Z4 ENTREZGENE, UniProtKB/TrEMBL