Mfge8 (milk fat globule EGF and factor V/VIII domain containing) - Rat Genome Database

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Gene: Mfge8 (milk fat globule EGF and factor V/VIII domain containing) Mus musculus
Analyze
Symbol: Mfge8
Name: milk fat globule EGF and factor V/VIII domain containing
RGD ID: 10895
MGI Page MGI
Description: Exhibits integrin binding activity; phosphatidylethanolamine binding activity; and phosphatidylserine binding activity. Involved in phagocytosis and positive regulation of phagocytosis. Localizes to external side of plasma membrane; extracellular space; and extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; cap mesenchyme; central nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408458; AI325141; EGF/factor VIII; lacta; lactadherin; MFG-E8; Mfgm; milk fat globule glycoprotein; MP47; P47; SED; SED1; sperm surface protein SP47
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,783,516 - 78,798,808 (-)NCBIGRCm39mm39
GRCm39 Ensembl778,783,516 - 78,798,808 (-)Ensembl
GRCm38779,133,768 - 79,149,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,133,768 - 79,149,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,278,654 - 86,293,946 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,007,282 - 79,022,526 (-)NCBImm8
Celera776,533,114 - 76,548,369 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
amphetamine  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
choline  (EXP)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclophosphamide  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
maneb  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP)
nimesulide  (ISO)
orphenadrine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (EXP)
PhIP  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
procyanidin B2  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
sodium fluoride  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:2122462   PMID:7490078   PMID:8541316   PMID:8889548   PMID:9027496   PMID:9101712   PMID:9546740   PMID:9920772   PMID:10349636   PMID:10922068   PMID:10960788   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:12000961   PMID:12477932   PMID:12520002   PMID:12904583   PMID:12941270   PMID:14610273   PMID:15004195   PMID:15114675   PMID:15155946   PMID:15284116  
PMID:15302904   PMID:15489334   PMID:15782199   PMID:15834428   PMID:15951990   PMID:15982908   PMID:16141072   PMID:16141073   PMID:16195353   PMID:16275924   PMID:16401186   PMID:16537572  
PMID:17167398   PMID:17299048   PMID:17322377   PMID:17420351   PMID:17557120   PMID:17620600   PMID:17638889   PMID:18008006   PMID:18083239   PMID:18287559   PMID:18303131   PMID:18392683  
PMID:18485093   PMID:18490487   PMID:18647368   PMID:18725516   PMID:19023116   PMID:19100703   PMID:19109191   PMID:19240116   PMID:19433619   PMID:19454719   PMID:19784740   PMID:19812188  
PMID:19884654   PMID:19892861   PMID:20422713   PMID:20826760   PMID:20837697   PMID:20956946   PMID:21127199   PMID:21267068   PMID:21308148   PMID:21537078   PMID:21677750   PMID:21737783  
PMID:21746895   PMID:21841820   PMID:21868707   PMID:21873192   PMID:21873635   PMID:21901532   PMID:22037761   PMID:22114683   PMID:22159717   PMID:22357850   PMID:22438901   PMID:22487387  
PMID:22558449   PMID:22566632   PMID:22634615   PMID:22723547   PMID:22742657   PMID:22761839   PMID:22770220   PMID:22770563   PMID:23038672   PMID:23132565   PMID:23194669   PMID:23262193  
PMID:23269839   PMID:23405209   PMID:23443560   PMID:23454183   PMID:23454767   PMID:23474305   PMID:23552724   PMID:23647050   PMID:23752130   PMID:23832117   PMID:23874637   PMID:23892722  
PMID:24006456   PMID:24101459   PMID:24154525   PMID:24441829   PMID:24838098   PMID:24911209   PMID:24952961   PMID:24958900   PMID:25006249   PMID:25130376   PMID:25283994   PMID:25493650  
PMID:25596854   PMID:25661589   PMID:25711369   PMID:25867181   PMID:25868798   PMID:26206421   PMID:26376757   PMID:26391522   PMID:26819373   PMID:26902285   PMID:27092791   PMID:27102803  
PMID:27194784   PMID:27197197   PMID:27260955   PMID:27538453   PMID:27768123   PMID:27812539   PMID:27881777   PMID:27918308   PMID:27956229   PMID:28302404   PMID:28432199   PMID:28526301  
PMID:28607102   PMID:28884934   PMID:29162596   PMID:29475373   PMID:29476115   PMID:29507336   PMID:29513653   PMID:29864782   PMID:30076648   PMID:30076715   PMID:30134156   PMID:30174295  
PMID:30175895   PMID:30286201   PMID:30647151   PMID:30743056   PMID:31001372   PMID:31073041   PMID:31447183   PMID:31470852   PMID:31608052   PMID:32253237   PMID:32324268  


Genomics

Comparative Map Data
Mfge8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,783,516 - 78,798,808 (-)NCBIGRCm39mm39
GRCm39 Ensembl778,783,516 - 78,798,808 (-)Ensembl
GRCm38779,133,768 - 79,149,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,133,768 - 79,149,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,278,654 - 86,293,946 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,007,282 - 79,022,526 (-)NCBImm8
Celera776,533,114 - 76,548,369 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.9NCBI
MFGE8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1588,898,683 - 88,913,381 (-)EnsemblGRCh38hg38GRCh38
GRCh381588,898,683 - 88,913,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371589,441,914 - 89,456,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,242,920 - 87,257,614 (-)NCBINCBI36hg18NCBI36
Build 341587,242,919 - 87,257,614NCBI
Celera1565,843,230 - 65,857,979 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1565,554,125 - 65,568,874 (-)NCBIHuRef
CHM1_11589,282,553 - 89,297,318 (-)NCBICHM1_1
Mfge8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21133,064,665 - 133,080,069 (-)NCBI
Rnor_6.0 Ensembl1140,845,465 - 140,860,894 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01140,845,478 - 140,860,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01141,814,239 - 141,829,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,870,029 - 134,885,431 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,948,377 - 134,963,734 (-)NCBI
Celera1125,135,501 - 125,150,920 (-)NCBICelera
Cytogenetic Map1q31NCBI
Mfge8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,091,684 - 16,103,768 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,092,263 - 16,103,097 (+)NCBIChiLan1.0ChiLan1.0
MFGE8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11586,795,135 - 86,809,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,795,135 - 86,809,876 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01567,587,360 - 67,602,029 (-)NCBIMhudiblu_PPA_v0panPan3
MFGE8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,054,243 - 52,064,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,054,831 - 52,080,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,690,614 - 54,716,666 (-)NCBI
ROS_Cfam_1.0352,473,179 - 52,499,328 (-)NCBI
UMICH_Zoey_3.1351,995,688 - 52,008,715 (-)NCBI
UNSW_CanFamBas_1.0352,206,149 - 52,232,464 (-)NCBI
UU_Cfam_GSD_1.0352,544,955 - 52,571,161 (-)NCBI
Mfge8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,453,939 - 131,466,312 (+)NCBI
SpeTri2.0NW_00493648314,868,171 - 14,880,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFGE8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,539,614 - 54,571,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,539,970 - 54,554,885 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,504,870 - 59,518,390 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MFGE8
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Mfge8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476816,173,546 - 16,184,450 (-)NCBI

Position Markers
AI325141  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38779,134,051 - 79,134,131UniSTSGRCm38
MGSCv37786,278,937 - 86,279,017UniSTSGRCm37
Celera776,533,397 - 76,533,477UniSTS
Cytogenetic Map7D3UniSTS
cM Map741.2UniSTS
Whitehead/MRC_RH7774.52UniSTS
RH124717  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38779,133,920 - 79,134,118UniSTSGRCm38
MGSCv37786,278,806 - 86,279,004UniSTSGRCm37
Celera776,533,266 - 76,533,464UniSTS
Cytogenetic Map7D3UniSTS
cM Map741.2UniSTS
Mfge8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D3UniSTS
cM Map741.2UniSTS
Mfge8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D3UniSTS
Mfge8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3033306081485905Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73658059092745138Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73760000087400000Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74560000079600000Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74873471382734859Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74950947983586207Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74954353083543642Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75147520685475345Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75147520685475345Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75250000086500000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75623976087493512Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75767637391676604Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75767637391676604Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75767637391676604Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)762200000103100000Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76448567698485905Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76560000097300000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)766139778100139778Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)766139778100139778Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76680000098700000Mouse
12801463Rta1_mretinal aging 1 (mouse)76751827989440781Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767640886101641032Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767640886101641032Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767640886101641032Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768716387102716494Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7320735792932955Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7467637392745138Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:716
Count of miRNA genes:263
Interacting mature miRNAs:296
Transcripts:ENSMUST00000032825, ENSMUST00000107409
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001045489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB021130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB021648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB025280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD776821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032825   ⟹   ENSMUSP00000032825
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,133,769 - 79,149,060 (-)Ensembl
RefSeq Acc Id: ENSMUST00000107409   ⟹   ENSMUSP00000103032
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,133,768 - 79,149,053 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205494
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,136,534 - 79,142,807 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205526
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,144,920 - 79,148,989 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205563   ⟹   ENSMUSP00000145720
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,134,116 - 79,149,031 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205649
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,134,139 - 79,137,026 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205688
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,142,869 - 79,147,560 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205929
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,141,878 - 79,143,050 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206338
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,133,768 - 79,143,786 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206844
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl779,145,334 - 79,148,231 (-)Ensembl
RefSeq Acc Id: NM_001045489   ⟹   NP_001038954
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39778,783,516 - 78,798,808 (-)NCBI
GRCm38779,133,768 - 79,149,060 (-)ENTREZGENE
MGSCv37786,278,654 - 86,293,946 (-)RGD
Celera776,533,114 - 76,548,369 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008594   ⟹   NP_032620
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39778,783,516 - 78,798,808 (-)NCBI
GRCm38779,133,768 - 79,149,060 (-)ENTREZGENE
MGSCv37786,278,654 - 86,293,946 (-)RGD
Celera776,533,114 - 76,548,369 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001038954   ⟸   NM_001045489
- Peptide Label: isoform 2 precursor
- UniProtKB: Q3TDU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_032620   ⟸   NM_008594
- Peptide Label: isoform 1 precursor
- UniProtKB: P21956 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032825   ⟸   ENSMUST00000032825
RefSeq Acc Id: ENSMUSP00000103032   ⟸   ENSMUST00000107409
RefSeq Acc Id: ENSMUSP00000145720   ⟸   ENSMUST00000205563
Protein Domains
EGF-like   F5/8 type C

Promoters
RGD ID:8664493
Promoter ID:EPDNEW_M10277
Type:initiation region
Name:Mfge8_1
Description:Mus musculus milk fat globule-EGF factor 8 protein , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38779,149,023 - 79,149,083EPDNEW
RGD ID:6848172
Promoter ID:MM_ACW:45032
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:MFGE8.JSEP07,   MFGE8.LSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,278,971 - 86,279,471 (-)MPROMDB
RGD ID:6848171
Promoter ID:MM_ACW:45034
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:MFGE8.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,293,166 - 86,293,666 (-)MPROMDB
RGD ID:6841520
Promoter ID:MM_KWN:51222
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001045489,   NM_008594
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,293,729 - 86,294,229 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102768 AgrOrtholog
Ensembl Genes ENSMUSG00000030605 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032825 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000103032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145720 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032825 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000107409 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000205563 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17304 UniProtKB/Swiss-Prot
MGD MGI:102768 ENTREZGENE
NCBI Gene 17304 ENTREZGENE
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mfge8 PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNV7_MOUSE UniProtKB/TrEMBL
  MFGM_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TDU5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97800 UniProtKB/Swiss-Prot
  Q3TBN5 UniProtKB/Swiss-Prot
  Q3U8S9 UniProtKB/Swiss-Prot
  Q9R1X9 UniProtKB/Swiss-Prot
  Q9WTS3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-11-17 Mfge8  milk fat globule EGF and factor V/VIII domain containing  Mfge8  milk fat globule-EGF factor 8 protein  Symbol and/or name change 5135510 APPROVED