Pmp22 (peripheral myelin protein 22) - Rat Genome Database

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Gene: Pmp22 (peripheral myelin protein 22) Mus musculus
Analyze
Symbol: Pmp22
Name: peripheral myelin protein 22
RGD ID: 11125
MGI Page MGI
Description: Exhibits motor activity. Involved in several processes, including nervous system development; regulation of apoptotic process; and regulation of gene expression. Localizes to several cellular components, including compact myelin; integrin complex; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; intraembryonic coelom; lung; musculoskeletal system; and nervous system. Used to study Charcot-Marie-Tooth disease type 1A; Charcot-Marie-Tooth disease type 1E; Charcot-Marie-Tooth disease type 3; and hereditary neuropathy with liability to pressure palsies. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); Guillain-Barre syndrome; and hereditary neuropathy with liability to pressure palsies. Orthologous to human PMP22 (peripheral myelin protein 22); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 22kDa; Gas; Gas-3; growth arrest-specific protein 3; HNPP; peripheral myelin protein, 22 kDa; PMP-22; Tr; TRE00; TRE002; trembler
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD-Tg(Pmp22)Kan  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,019,808 - 63,050,373 (+)NCBIGRCm39mm39
GRCm39 Ensembl1163,019,808 - 63,050,373 (+)Ensembl
GRCm381163,128,982 - 63,159,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1163,128,982 - 63,159,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,945,012 - 62,973,048 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,947,705 - 62,975,741 (+)NCBImm8
Celera1170,064,333 - 70,092,386 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1138.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
casticin  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dieldrin  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
graphite  (ISO)
hemin  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP)
lithium chloride  (EXP)
mitomycin C  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP)
nitroglycerin  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thyroxine  (EXP,ISO)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IMP)
adult locomotory behavior  (IMP)
adult walking behavior  (IMP)
aggresome assembly  (IMP)
autophagy  (IMP)
axon development  (IMP)
basement membrane organization  (IMP)
bleb assembly  (ISO)
cell adhesion  (IMP)
cell death  (ISO)
cell differentiation  (ISO)
cellular lipid metabolic process  (IMP)
cellular localization  (IMP)
cellular response to heat  (IMP)
cellular response to unfolded protein  (IMP)
cholesterol metabolic process  (IMP)
fibroblast migration  (IMP)
gliogenesis  (IMP)
immune response  (IMP)
lamellipodium assembly  (IMP)
mating  (IMP)
membrane raft organization  (IMP)
motor behavior  (IMP)
multicellular organism aging  (IMP)
multicellular organism growth  (IMP)
muscle fiber development  (IMP)
myelin assembly  (IBA,IMP)
myelination  (IMP,ISO)
myelination in peripheral nervous system  (IGI,IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of neuron projection development  (ISO)
neuromuscular junction development, skeletal muscle fiber  (IMP)
neuromuscular process  (IMP)
neuronal action potential  (IMP)
neuronal action potential propagation  (IMP)
neuronal ion channel clustering  (IMP)
paranodal junction assembly  (IMP)
peripheral nervous system development  (IMP)
peripheral nervous system neuron axonogenesis  (IMP)
positive regulation of gene expression  (IMP)
proteasomal protein catabolic process  (IMP)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IMP)
regulation of apoptotic signaling pathway  (IMP)
regulation of cell cycle  (IEA)
regulation of gene expression  (IMP)
regulation of glial cell apoptotic process  (IMP)
regulation of inflammatory response  (IMP)
regulation of protein serine/threonine kinase activity  (IMP)
regulation of Schwann cell proliferation  (IMP)
response to bacterium  (IEP)
response to endoplasmic reticulum stress  (IMP)
Schwann cell development  (IMP)
Schwann cell differentiation  (IMP)
Schwann cell migration  (IMP)
striated muscle cell differentiation  (IMP)
transmission of nerve impulse  (IGI,IMP)
vestibular reflex  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:173808   PMID:187739   PMID:189201   PMID:855650   PMID:971429   PMID:1007905   PMID:1303228   PMID:1303231   PMID:1303281   PMID:1303282   PMID:1306159   PMID:1341967  
PMID:1347472   PMID:1352160   PMID:1374899   PMID:1377062   PMID:1384766   PMID:1552943   PMID:1629735   PMID:1692961   PMID:1725581   PMID:1781329   PMID:1981050   PMID:2022965  
PMID:2482246   PMID:2547434   PMID:2579197   PMID:2851124   PMID:2896141   PMID:2993648   PMID:3388045   PMID:3402356   PMID:3408474   PMID:3409319   PMID:3429842   PMID:3955368  
PMID:3978415   PMID:5980117   PMID:6194264   PMID:6282388   PMID:6313422   PMID:6313869   PMID:6681440   PMID:7074355   PMID:7127148   PMID:7499407   PMID:7515304   PMID:7522610  
PMID:7535200   PMID:7568881   PMID:7568894   PMID:7581438   PMID:7581450   PMID:7613613   PMID:7686535   PMID:7745607   PMID:7783943   PMID:7807578   PMID:7996186   PMID:8268657  
PMID:8275092   PMID:8422677   PMID:8439732   PMID:8464923   PMID:8520722   PMID:8520723   PMID:8527854   PMID:8535974   PMID:8552310   PMID:8662541   PMID:8757247   PMID:8757248  
PMID:8833093   PMID:8845157   PMID:8847735   PMID:8884260   PMID:9070927   PMID:9113128   PMID:9120057   PMID:9147228   PMID:9151736   PMID:9168970   PMID:9169527   PMID:9177778  
PMID:9204477   PMID:9204931   PMID:9219937   PMID:9335255   PMID:9416828   PMID:9418989   PMID:9425015   PMID:10066256   PMID:10087306   PMID:10349636   PMID:10363833   PMID:10430839  
PMID:10464095   PMID:10505644   PMID:10521561   PMID:10559784   PMID:10580849   PMID:10586240   PMID:10586249   PMID:10586256   PMID:10638493   PMID:10797391   PMID:10915775   PMID:10932191  
PMID:10959245   PMID:11042159   PMID:11076861   PMID:11114256   PMID:11217851   PMID:11331611   PMID:11673320   PMID:11700294   PMID:11749965   PMID:11752407   PMID:11814678   PMID:12056842  
PMID:12090404   PMID:12119418   PMID:12127149   PMID:12359155   PMID:12421361   PMID:12466851   PMID:12477932   PMID:12668174   PMID:14627652   PMID:14664827   PMID:15312649   PMID:15363066  
PMID:15474367   PMID:15489334   PMID:15703401   PMID:15748170   PMID:15755691   PMID:16141072   PMID:16141073   PMID:16405874   PMID:16436605   PMID:16602821   PMID:17174099   PMID:17701891  
PMID:17971504   PMID:18166079   PMID:19244508   PMID:19290556   PMID:19349584   PMID:19493167   PMID:19805360   PMID:20071523   PMID:20427655   PMID:20553714   PMID:20731761   PMID:20805985  
PMID:21267068   PMID:21411665   PMID:21670407   PMID:21677750   PMID:21824506   PMID:21873635   PMID:22258617   PMID:22337502   PMID:22527485   PMID:22560297   PMID:22688009   PMID:23012479  
PMID:23127255   PMID:23847051   PMID:24175617   PMID:24339129   PMID:24446165   PMID:24539699   PMID:25014022   PMID:25150498   PMID:25429154   PMID:25446378   PMID:25453108   PMID:27288457  
PMID:27418600   PMID:27583434   PMID:28108290   PMID:28288114   PMID:28535371   PMID:29315582   PMID:30239155   PMID:30931926   PMID:31032403   PMID:31061090   PMID:31173167   PMID:31213528  
PMID:31386828   PMID:31388039   PMID:31624071   PMID:31713617   PMID:31924792   PMID:32356557  


Genomics

Comparative Map Data
Pmp22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,019,808 - 63,050,373 (+)NCBIGRCm39mm39
GRCm39 Ensembl1163,019,808 - 63,050,373 (+)Ensembl
GRCm381163,128,982 - 63,159,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1163,128,982 - 63,159,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,945,012 - 62,973,048 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,947,705 - 62,975,741 (+)NCBImm8
Celera1170,064,333 - 70,092,386 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1138.99NCBI
PMP22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1715,229,777 - 15,265,326 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1715,229,773 - 15,272,292 (-)EnsemblGRCh38hg38GRCh38
GRCh381715,229,779 - 15,265,326 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371715,133,096 - 15,168,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361715,073,821 - 15,109,369 (-)NCBINCBI36hg18NCBI36
Build 341715,073,821 - 15,104,818NCBI
Celera1715,157,676 - 15,193,224 (-)NCBI
Cytogenetic Map17p12NCBI
HuRef1715,027,217 - 15,062,782 (-)NCBIHuRef
CHM1_11715,141,853 - 15,177,435 (-)NCBICHM1_1
Pmp22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21047,795,709 - 47,825,715 (+)NCBI
Rnor_6.0 Ensembl1049,538,588 - 49,568,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01049,538,588 - 49,568,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01049,317,000 - 49,346,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41049,305,835 - 49,335,864 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11049,319,457 - 49,349,487 (+)NCBI
Celera1047,038,544 - 47,068,443 (+)NCBICelera
Cytogenetic Map10q23NCBI
Pmp22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554672,423,659 - 2,457,307 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554672,422,181 - 2,456,925 (+)NCBIChiLan1.0ChiLan1.0
PMP22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11741,038,286 - 41,073,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1741,038,302 - 41,073,872 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01736,389,549 - 36,425,161 (+)NCBIMhudiblu_PPA_v0panPan3
PMP22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1538,806,731 - 38,839,002 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl538,807,826 - 38,838,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha538,951,486 - 38,983,753 (-)NCBI
ROS_Cfam_1.0538,914,812 - 38,947,091 (-)NCBI
UMICH_Zoey_3.1538,887,774 - 38,920,037 (-)NCBI
UNSW_CanFamBas_1.0538,833,093 - 38,865,352 (-)NCBI
UU_Cfam_GSD_1.0539,021,339 - 39,053,622 (-)NCBI
Pmp22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560257,777,101 - 57,810,336 (-)NCBI
SpeTri2.0NW_0049367241,747,015 - 1,780,298 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMP22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,679,776 - 58,707,953 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,679,773 - 58,734,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PMP22
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11614,527,892 - 14,563,223 (-)NCBI
ChlSab1.1 Ensembl1614,527,672 - 14,563,171 (-)Ensembl
Pmp22
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248773,293,980 - 3,328,337 (-)NCBI

Position Markers
D11Mit88  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,151,287 - 63,151,537UniSTSGRCm38
MGSCv371162,964,789 - 62,965,039UniSTSGRCm37
Celera1170,084,127 - 70,084,377UniSTS
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Whitehead Genetic1131.7UniSTS
M32240  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,158,872 - 63,158,975UniSTSGRCm38
MGSCv371162,972,374 - 62,972,477UniSTSGRCm37
Celera1170,091,712 - 70,091,815UniSTS
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Whitehead/MRC_RH11831.16UniSTS
RH138695  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,158,252 - 63,158,477UniSTSGRCm38
MGSCv371162,971,754 - 62,971,979UniSTSGRCm37
Celera1170,091,092 - 70,091,317UniSTS
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Pmp22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,158,665 - 63,159,293UniSTSGRCm38
MGSCv371162,972,167 - 62,972,795UniSTSGRCm37
Celera1170,091,505 - 70,092,133UniSTS
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Pmp22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,158,253 - 63,158,578UniSTSGRCm38
MGSCv371162,971,755 - 62,972,080UniSTSGRCm37
Celera1170,091,093 - 70,091,418UniSTS
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Pmp22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Pmp22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,153,153 - 63,153,592UniSTSGRCm38
MGSCv371162,966,655 - 62,967,094UniSTSGRCm37
Celera1170,085,993 - 70,086,432UniSTS
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Pmp22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B3UniSTS
cM Map1134.45UniSTS
Pmp22-rs  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,159,196 - 63,159,399UniSTSGRCm38
MGSCv371162,972,698 - 62,972,901UniSTSGRCm37
Celera1170,092,036 - 70,092,239UniSTS
Cytogenetic Map11B3UniSTS
cM Map461.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5417484463428696Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115419011565213015Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
4141642Ltxs2_mlethal factor toxin susceptibility 2 (mouse)Not determined116315128768609504Mouse


Related Rat Strains
The following Strains have been annotated to Pmp22

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1193
Count of miRNA genes:479
Interacting mature miRNAs:558
Transcripts:ENSMUST00000018361, ENSMUST00000108700, ENSMUST00000108701, ENSMUST00000108702, ENSMUST00000140648
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001302255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA795914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY092580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY234063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY235328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY235583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z38110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000018361   ⟹   ENSMUSP00000018361
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1163,131,512 - 63,159,547 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108700   ⟹   ENSMUSP00000104340
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1163,133,068 - 63,158,566 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108701   ⟹   ENSMUSP00000104341
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1163,132,569 - 63,158,484 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108702   ⟹   ENSMUSP00000104342
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1163,128,982 - 63,159,546 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140648
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1163,132,803 - 63,134,489 (+)Ensembl
RefSeq Acc Id: NM_001302255   ⟹   NP_001289184
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,022,283 - 63,050,373 (+)NCBI
GRCm381163,131,457 - 63,159,547 (+)NCBI
Celera1170,061,805 - 70,092,387 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302257   ⟹   NP_001289186
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,019,808 - 63,050,373 (+)NCBI
GRCm381163,128,982 - 63,159,547 (+)NCBI
Celera1170,061,805 - 70,092,387 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302258   ⟹   NP_001289187
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,019,808 - 63,050,373 (+)NCBI
GRCm381163,128,982 - 63,159,547 (+)NCBI
Celera1170,061,805 - 70,092,387 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302259   ⟹   NP_001289188
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,023,395 - 63,050,373 (+)NCBI
GRCm381163,132,569 - 63,159,547 (+)NCBI
Celera1170,061,805 - 70,092,387 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302260   ⟹   NP_001289189
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,023,629 - 63,050,373 (+)NCBI
GRCm381163,132,803 - 63,159,547 (+)NCBI
Celera1170,061,805 - 70,092,387 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302261   ⟹   NP_001289190
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,019,808 - 63,050,373 (+)NCBI
GRCm381163,128,982 - 63,159,547 (+)NCBI
Celera1170,061,805 - 70,092,387 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008885   ⟹   NP_032911
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,022,283 - 63,050,373 (+)NCBI
GRCm381163,131,457 - 63,159,547 (+)NCBI
MGSCv371162,945,012 - 62,973,048 (+)RGD
Celera1170,061,805 - 70,092,387 (+)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030245661   ⟹   XP_030101521
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,023,247 - 63,050,373 (+)NCBI
GRCm381163,132,568 - 63,159,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245662   ⟹   XP_030101522
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,023,520 - 63,050,373 (+)NCBI
GRCm381163,132,694 - 63,159,547 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032911   ⟸   NM_008885
- Peptide Label: isoform 1
- UniProtKB: P16646 (UniProtKB/Swiss-Prot),   Q5SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289186   ⟸   NM_001302257
- Peptide Label: isoform 1
- UniProtKB: P16646 (UniProtKB/Swiss-Prot),   Q5SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289187   ⟸   NM_001302258
- Peptide Label: isoform 1
- UniProtKB: P16646 (UniProtKB/Swiss-Prot),   Q5SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289190   ⟸   NM_001302261
- Peptide Label: isoform 2
- UniProtKB: Q5SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289184   ⟸   NM_001302255
- Peptide Label: isoform 1
- UniProtKB: P16646 (UniProtKB/Swiss-Prot),   Q5SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289188   ⟸   NM_001302259
- Peptide Label: isoform 1
- UniProtKB: P16646 (UniProtKB/Swiss-Prot),   Q5SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289189   ⟸   NM_001302260
- Peptide Label: isoform 1
- UniProtKB: P16646 (UniProtKB/Swiss-Prot),   Q5SXS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030101521   ⟸   XM_030245661
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101522   ⟸   XM_030245662
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000104340   ⟸   ENSMUST00000108700
RefSeq Acc Id: ENSMUSP00000104341   ⟸   ENSMUST00000108701
RefSeq Acc Id: ENSMUSP00000104342   ⟸   ENSMUST00000108702
RefSeq Acc Id: ENSMUSP00000018361   ⟸   ENSMUST00000018361

Promoters
RGD ID:6821575
Promoter ID:MM_KWN:7862
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B4
Transcripts:OTTMUST00000013101
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361162,944,461 - 62,945,152 (+)MPROMDB
RGD ID:6821574
Promoter ID:MM_KWN:7863
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000108700,   ENSMUST00000108701,   OTTMUST00000013104
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361162,945,161 - 62,946,727 (+)MPROMDB
RGD ID:8675018
Promoter ID:EPDNEW_M15540
Type:initiation region
Name:Pmp22_2
Description:Mus musculus peripheral myelin protein 22 , transcript variant5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15541  EPDNEW_M15542  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381163,128,982 - 63,129,042EPDNEW
RGD ID:8675020
Promoter ID:EPDNEW_M15541
Type:initiation region
Name:Pmp22_1
Description:Mus musculus peripheral myelin protein 22 , transcript variant5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15540  EPDNEW_M15542  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381163,131,525 - 63,131,585EPDNEW
RGD ID:8675022
Promoter ID:EPDNEW_M15542
Type:multiple initiation site
Name:Pmp22_3
Description:Mus musculus peripheral myelin protein 22 , transcript variant5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15540  EPDNEW_M15541  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381163,133,104 - 63,133,164EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97631 AgrOrtholog
Ensembl Genes ENSMUSG00000018217 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000018361 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000104340 UniProtKB/TrEMBL
  ENSMUSP00000104341 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000104342 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018361 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000108700 UniProtKB/TrEMBL
  ENSMUST00000108701 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000108702 ENTREZGENE, UniProtKB/TrEMBL
InterPro PMP22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22_EMP_MP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18858 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97631 ENTREZGENE
NCBI Gene 18858 ENTREZGENE
PANTHER PTHR10671:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pmp22 PhenoGen
PRINTS EPMEMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMYELIN22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PMP22_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P16646 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5SXS3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q91XF9 UniProtKB/Swiss-Prot