Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Alpl (alkaline phosphatase, liver/bone/kidney) Mus musculus
Analyze
Symbol: Alpl
Name: alkaline phosphatase, liver/bone/kidney
Description: Exhibits alkaline phosphatase activity and pyrophosphatase activity. Involved in several processes, including cellular response to organic cyclic compound; endochondral ossification; and response to antibiotic. Localizes to the extracellular matrix; extracellular membrane-bounded organelle; and plasma membrane. Used to study adult hypophosphatasia; childhood hypophosphatasia; and infantile hypophosphatasia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and uremia. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skeleton. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Akp-2; Akp2; alkaline phosphatase 2, liver; alkaline phosphatase, tissue-nonspecific isozyme; ALP; AP-TNAP; APTNAP; TNAP; TNSALP
Orthologs:
Related Pseudogenes: Gm8310  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl4137,741,733 - 137,796,384 (-)Ensembl
GRCm384137,741,731 - 137,796,384 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374137,297,647 - 137,352,292 (-)NCBIGRCm37mm9NCBIm37
MGSCv364137,013,815 - 137,068,399 (-)NCBImm8
Celera4135,949,158 - 136,007,420 (-)NCBICelera
Cytogenetic Map4 D3NCBI
cM Map470.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Alpl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731885
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-21
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.