Car2 (carbonic anhydrase 2) - Rat Genome Database

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Gene: Car2 (carbonic anhydrase 2) Mus musculus
Analyze
Symbol: Car2
Name: carbonic anhydrase 2
RGD ID: 732618
MGI Page MGI
Description: Enables carbonate dehydratase activity. Involved in positive regulation of dipeptide transmembrane transport and regulation of intracellular pH. Acts upstream of or within several processes, including carbon dioxide transport; positive regulation of GABAergic synaptic transmission; and positive regulation of cellular pH reduction. Located in cytosol and myelin sheath. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Used to study autosomal recessive osteopetrosis 3. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (carbonic anhydrase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI131712; C; CA II; CA-II; Ca2; CAII; Car; Car-2; carbonate dehydratase II; carbonic anhydrase II; cyanamide hydratase CA2; Ltw-; Ltw-5; Lvtw; Lvtw-5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,951,329 - 14,965,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,951,333 - 14,965,830 (+)EnsemblGRCm39 Ensembl
GRCm38314,886,269 - 14,900,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,886,273 - 14,900,770 (+)EnsemblGRCm38mm10GRCm38
MGSCv37314,886,426 - 14,900,770 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36314,863,469 - 14,877,513 (+)NCBIMGSCv36mm8
Celera314,899,001 - 14,912,886 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(R)-adrenaline  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-1,2,4-triazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-di-tert-butylphenol  (ISO)
2,6-Dimethylphenol  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenyl acetate  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acetazolamide  (ISO)
aconitine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alachlor  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
anthracen-2-amine  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benomyl  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
brinzolamide  (ISO)
bromobenzene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP)
calcitriol  (ISO)
captopril  (EXP)
carbonates  (ISO)
carnosic acid  (EXP)
celecoxib  (ISO)
chalcone  (ISO)
chlordecone  (EXP)
chloric acid  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenamide  (ISO)
diethylstilbestrol  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
dorzolamide hydrochloride  (ISO)
enalapril  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
ethoxzolamide  (ISO)
famotidine  (ISO)
fenamidone  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (EXP,ISO)
furosemide  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
guaiacol  (ISO)
hydrazinecarbothioamide  (ISO)
hydrogencarbonate  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
malvidin 3-O-beta-D-glucoside  (ISO)
malvin  (ISO)
medroxyprogesterone acetate  (ISO)
merbromin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Methazolamide  (ISO)
methylamines  (ISO)
methylglyoxal  (EXP)
methylisothiazolinone  (ISO)
molybdate  (ISO)
Monobutylphthalate  (EXP)
monosodium L-glutamate  (ISO)
morphine  (EXP)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
N-phenylthiourea  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric acid  (ISO)
nitrofen  (ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
oryzalin  (ISO)
oxaliplatin  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pelargonidin 3-O-beta-D-glucoside  (ISO)
pelargonidin 3-O-beta-D-glucoside chloride  (ISO)
pentachlorophenol  (EXP)
perchlorate  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP,ISO)
prontosil  (ISO)
propofol  (ISO)
pyrimidines  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rubiadin  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silychristin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hydrogencarbonate  (ISO)
sulfamic acid  (ISO)
sulfates  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
synephrine  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thiazolidines  (ISO)
thioacetamide  (ISO)
thiophenes  (ISO)
thiourea  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
tioxolone  (ISO)
titanium dioxide  (EXP,ISO)
topiramate  (ISO)
topotecan  (ISO)
trans-chalcone  (ISO)
triazoles  (ISO)
trichloroethene  (ISO)
tungstate  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
voriconazole  (ISO)
xanthohumol  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of macrophages in nephrolithiasis in rats: an analysis of the renal interstitium. de Water R, etal., Am J Kidney Dis. 2000 Sep;36(3):615-25.
2. Analysis of the tissue-specific expression, developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein. Heuckeroth RO, etal., J Biol Chem 1987 Jul 15;262(20):9709-17.
3. A splice junction mutation in intron 2 of the carbonic anhydrase II gene of osteopetrosis patients from Arabic countries. Hu PY, etal., Hum Mutat. 1992;1(4):288-92.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Niemelä AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. doi: 10.1158/1055-9965.EPI-07-0080.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas. Viikilä P, etal., World J Gastroenterol. 2016 Sep 28;22(36):8168-77. doi: 10.3748/wjg.v22.i36.8168.
Additional References at PubMed
PMID:447069   PMID:820740   PMID:825106   PMID:1381098   PMID:1477475   PMID:1617216   PMID:1686722   PMID:1765271   PMID:1916807   PMID:1916821   PMID:2040456   PMID:2111277  
PMID:2165966   PMID:2296080   PMID:2383242   PMID:2451911   PMID:2495727   PMID:2574151   PMID:2897103   PMID:2995362   PMID:3000449   PMID:3126501   PMID:3408670   PMID:6187736  
PMID:6331255   PMID:6375655   PMID:6410391   PMID:6420240   PMID:6440531   PMID:6529441   PMID:7387621   PMID:7616606   PMID:7743211   PMID:7774558   PMID:7956345   PMID:8100556  
PMID:8163345   PMID:8207439   PMID:8229043   PMID:8268662   PMID:8358947   PMID:8453949   PMID:8463242   PMID:8594870   PMID:8630490   PMID:8889548   PMID:9027408   PMID:9084825  
PMID:9277584   PMID:9482254   PMID:9486217   PMID:9525974   PMID:9605187   PMID:10087289   PMID:10333352   PMID:10349636   PMID:10712260   PMID:10792952   PMID:10866045   PMID:10922068  
PMID:11042159   PMID:11044609   PMID:11076861   PMID:11217851   PMID:11268514   PMID:11276178   PMID:11532192   PMID:11698654   PMID:12411514   PMID:12466851   PMID:12477932   PMID:12930737  
PMID:14600151   PMID:14660577   PMID:14675051   PMID:14681479   PMID:15218065   PMID:15226823   PMID:15328023   PMID:15332441   PMID:15385584   PMID:15788756   PMID:16141072   PMID:16141073  
PMID:16177003   PMID:16217040   PMID:16247769   PMID:16396925   PMID:16408247   PMID:16586439   PMID:16601982   PMID:16603319   PMID:16918699   PMID:17298961   PMID:17362527   PMID:17626619  
PMID:17634366   PMID:17702944   PMID:17890222   PMID:18083150   PMID:18163532   PMID:18175028   PMID:18209476   PMID:18270576   PMID:18287559   PMID:18945877   PMID:19210546   PMID:19423573  
PMID:19521566   PMID:19622732   PMID:19855135   PMID:19865483   PMID:19898483   PMID:20150244   PMID:20533306   PMID:20637621   PMID:20820888   PMID:21267068   PMID:21873635   PMID:22237799  
PMID:22451434   PMID:23233153   PMID:23665500   PMID:23684747   PMID:23737439   PMID:23881097   PMID:24154525   PMID:24233434   PMID:24361611   PMID:24429824   PMID:24583262   PMID:24789143  
PMID:24904084   PMID:24952961   PMID:25127994   PMID:25143453   PMID:26449520   PMID:26487715   PMID:26551457   PMID:27160897   PMID:27526715   PMID:28215940   PMID:28254758   PMID:28577314  
PMID:29124201   PMID:29354070   PMID:29382714   PMID:30068389   PMID:30333137   PMID:30562941   PMID:31391582   PMID:31518570   PMID:32325033   PMID:32554809   PMID:33315499   PMID:33536341  
PMID:33707239   PMID:34630045   PMID:36293324   PMID:36293380   PMID:36709914  


Genomics

Comparative Map Data
Car2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,951,329 - 14,965,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,951,333 - 14,965,830 (+)EnsemblGRCm39 Ensembl
GRCm38314,886,269 - 14,900,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,886,273 - 14,900,770 (+)EnsemblGRCm38mm10GRCm38
MGSCv37314,886,426 - 14,900,770 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36314,863,469 - 14,877,513 (+)NCBIMGSCv36mm8
Celera314,899,001 - 14,912,886 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.23NCBI
CA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38885,464,007 - 85,481,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl885,463,968 - 85,481,493 (+)EnsemblGRCh38hg38GRCh38
GRCh37886,376,236 - 86,393,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,563,383 - 86,580,973 (+)NCBINCBI36Build 36hg18NCBI36
Build 34886,563,497 - 86,580,973NCBI
Celera882,381,194 - 82,398,781 (+)NCBICelera
Cytogenetic Map8q21.2NCBI
HuRef881,870,322 - 81,887,902 (+)NCBIHuRef
CHM1_1886,427,817 - 86,445,411 (+)NCBICHM1_1
T2T-CHM13v2.0885,902,727 - 85,920,191 (+)NCBIT2T-CHM13v2.0
Car2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,741,625 - 86,756,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,741,626 - 86,756,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx293,060,690 - 93,075,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,181,691 - 91,196,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,238,526 - 86,253,627 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,097,740 - 88,112,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,097,720 - 88,113,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02107,871,654 - 107,886,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,077,095 - 88,092,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1288,022,060 - 88,037,185 (-)NCBI
Celera282,339,410 - 82,354,537 (-)NCBICelera
Cytogenetic Map2q23NCBI
Ca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,386,087 - 3,402,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554173,388,110 - 3,402,798 (+)NCBIChiLan1.0ChiLan1.0
CA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1876,834,337 - 76,852,343 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0881,991,037 - 82,009,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1883,601,163 - 83,618,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl883,597,440 - 83,632,580 (+)Ensemblpanpan1.1panPan2
CA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,959,225 - 31,975,309 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,935,172 - 31,980,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2932,190,440 - 32,197,007 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02932,108,070 - 32,124,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2932,107,905 - 32,129,372 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12932,159,433 - 32,175,512 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02932,180,668 - 32,196,793 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02932,567,770 - 32,583,867 (+)NCBIUU_Cfam_GSD_1.0
Ca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,413,843 - 47,429,881 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936544362,591 - 380,223 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936544362,591 - 379,151 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,193,756 - 51,211,259 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,194,686 - 51,211,436 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,157,606 - 56,174,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,830,963 - 80,848,245 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl880,830,939 - 80,848,707 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603960,251,073 - 60,269,156 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247446,167,606 - 6,183,538 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247446,168,030 - 6,183,407 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Car2
517 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:141
Interacting mature miRNAs:146
Transcripts:ENSMUST00000029078
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301256Skmw1_mskeletal muscle weight 1 (mouse)Not determined3125786432Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
12798540Scvg2_msubcutaneous vessel growth QTL 2 (mouse)3744981526249645Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse
12738410Lfibq2_mliver fibrosis QTL 2 (mouse)31206506020755242Mouse
13452403Rmerr1_mradial maze error rate 1 (mouse)31266506015954164Mouse

Markers in Region
AI131712  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38314,900,285 - 14,900,370UniSTSGRCm38
MGSCv37314,900,285 - 14,900,370UniSTSGRCm37
Celera314,912,401 - 14,912,486UniSTS
Cytogenetic Map3A1UniSTS
cM Map310.5UniSTS
K00811  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38314,900,206 - 14,900,352UniSTSGRCm38
MGSCv37314,900,206 - 14,900,352UniSTSGRCm37
Celera314,912,322 - 14,912,468UniSTS
Cytogenetic Map3A1UniSTS
cM Map310.5UniSTS
Car2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3A1UniSTS
cM Map310.5UniSTS
AW533290  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38314,887,924 - 14,888,021UniSTSGRCm38
MGSCv37314,887,924 - 14,888,021UniSTSGRCm37
Celera314,900,499 - 14,900,596UniSTS
Cytogenetic Map3A1UniSTS
cM Map310.5UniSTS
Car2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3A1UniSTS
cM Map10 UniSTS
Car2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3A1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU946040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD774528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK618053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000029078   ⟹   ENSMUSP00000029078
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl314,951,488 - 14,965,830 (+)Ensembl
GRCm38.p6 Ensembl314,886,428 - 14,900,770 (+)Ensembl
RefSeq Acc Id: ENSMUST00000192609   ⟹   ENSMUSP00000141876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl314,951,333 - 14,960,194 (+)Ensembl
GRCm38.p6 Ensembl314,886,273 - 14,895,134 (+)Ensembl
RefSeq Acc Id: ENSMUST00000195520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl314,951,699 - 14,953,626 (+)Ensembl
GRCm38.p6 Ensembl314,886,639 - 14,888,566 (+)Ensembl
RefSeq Acc Id: NM_001357334   ⟹   NP_001344263
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39314,951,329 - 14,965,830 (+)NCBI
GRCm38314,886,269 - 14,900,770 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009801   ⟹   NP_033931
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39314,951,348 - 14,965,830 (+)NCBI
GRCm38314,886,288 - 14,900,770 (+)NCBI
MGSCv37314,886,426 - 14,900,770 (+)RGD
Celera314,899,001 - 14,912,886 (+)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033931   ⟸   NM_009801
- UniProtKB: Q9DCT3 (UniProtKB/Swiss-Prot),   Q7TPE1 (UniProtKB/Swiss-Prot),   Q6LDQ7 (UniProtKB/Swiss-Prot),   Q9DCY9 (UniProtKB/Swiss-Prot),   P00920 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344263   ⟸   NM_001357334
- UniProtKB: Q9DCT3 (UniProtKB/Swiss-Prot),   Q7TPE1 (UniProtKB/Swiss-Prot),   Q6LDQ7 (UniProtKB/Swiss-Prot),   P00920 (UniProtKB/Swiss-Prot),   Q9DCY9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000029078   ⟸   ENSMUST00000029078
RefSeq Acc Id: ENSMUSP00000141876   ⟸   ENSMUST00000192609
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00920-F1-model_v2 AlphaFold P00920 1-260 view protein structure

Promoters
RGD ID:6833534
Promoter ID:MM_KWN:33799
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_009801
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36314,886,429 - 14,886,929 (+)MPROMDB
RGD ID:6880270
Promoter ID:EPDNEW_M3586
Type:initiation region
Name:Car2_2
Description:Mus musculus carbonic anhydrase 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3587  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38314,886,444 - 14,886,504EPDNEW
RGD ID:6880272
Promoter ID:EPDNEW_M3587
Type:multiple initiation site
Name:Car2_1
Description:Mus musculus carbonic anhydrase 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3586  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38314,886,691 - 14,886,751EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88269 AgrOrtholog
Ensembl Genes ENSMUSG00000027562 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000192609.6 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
KEGG Report mmu:12349 UniProtKB/Swiss-Prot
MGD MGI:88269 ENTREZGENE
NCBI Gene 12349 ENTREZGENE
PANTHER CARBONIC ANHYDRASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car2 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YX78_MOUSE UniProtKB/TrEMBL
  CAH2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LDQ7 ENTREZGENE
  Q7TPE1 ENTREZGENE
  Q9DCT3 ENTREZGENE
  Q9DCY9 ENTREZGENE
UniProt Secondary Q6LDQ7 UniProtKB/Swiss-Prot
  Q7TPE1 UniProtKB/Swiss-Prot
  Q9DCT3 UniProtKB/Swiss-Prot
  Q9DCY9 UniProtKB/Swiss-Prot