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Gene: Car2 (carbonic anhydrase 2) Mus musculus
Symbol: Car2
Name: carbonic anhydrase 2
Description: Exhibits carbonate dehydratase activity. Involved in several processes, including positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and positive regulation of dipeptide transmembrane transport. Localizes to cytosol and myelin sheath. Used to study autosomal recessive osteopetrosis 3. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Orthologous to human CA2 (carbonic anhydrase 2); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI131712; CA II; CA-II; Ca2; CAII; Car-2; carbonate dehydratase II; carbonic anhydrase II; Ltw-5; Lvtw-5
Homo sapiens (human) : CA2 (carbonic anhydrase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Car2 (carbonic anhydrase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ca2 (carbonic anhydrase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CA2 (carbonic anhydrase 2)
Canis lupus familiaris (dog) : CA2 (carbonic anhydrase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ca2 (carbonic anhydrase 2)
Sus scrofa (pig) : CA2 (carbonic anhydrase 2)
Chlorocebus sabaeus (African green monkey) : CA2 (carbonic anhydrase 2)
Heterocephalus glaber (naked mole-rat) : Ca2 (carbonic anhydrase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl314,886,273 - 14,900,770 (+)EnsemblGRCm38mm10GRCm38
GRCm38314,886,269 - 14,900,770 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37314,886,426 - 14,900,770 (+)NCBIGRCm37mm9NCBIm37
MGSCv36314,863,469 - 14,877,513 (+)NCBImm8
Celera314,899,001 - 14,912,886 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Car2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732618
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.