Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | affects expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of SREK1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SREK1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | ISO | SREK1 (Homo sapiens) | 6480464 | Estradiol affects the expression of SREK1 mRNA | CTD | PMID:22574217 | 17beta-estradiol | decreases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of SREK1 mRNA | CTD | PMID:35192832 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SREK1 mRNA | CTD | PMID:21354282 | 2,4-dinitrotoluene | affects expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of SREK1 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of SREK1 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | SREK1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of SREK1 mRNA | CTD | PMID:21179406 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of SREK1 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of SREK1 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of SREK1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of SREK1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | SREK1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SREK1 gene | CTD | PMID:27153756 | alpha-pinene | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of SREK1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of SREK1 mRNA | CTD | PMID:32699268 | amitrole | decreases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of SREK1 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of SREK1 mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SREK1 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SREK1 mRNA | CTD | PMID:33212167 | benzatropine | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Benztropine results in decreased expression of SREK1 protein | CTD | PMID:34122009 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SREK1 mRNA | CTD | PMID:19770486 | bisphenol A | decreases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SREK1 mRNA | CTD | PMID:25181051 more ... | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SREK1 mRNA | CTD | PMID:32156529 and PMID:33221593 | bisphenol A | increases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of SREK1 mRNA | CTD | PMID:27571134 | cadmium atom | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Cadmium results in decreased expression of SREK1 mRNA | CTD | PMID:23369406 | cadmium dichloride | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of SREK1 mRNA | CTD | PMID:26472689 | caffeine | increases phosphorylation | ISO | SREK1 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of SREK1 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes and Carbon results in decreased expression of SREK1 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SREK1 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of SREK1 mRNA | CTD | PMID:37019170 | clofibric acid | affects expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Clofibric Acid affects the expression of SREK1 mRNA | CTD | PMID:17602206 | copper atom | increases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Copper results in increased expression of SREK1 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Copper results in increased expression of SREK1 mRNA | CTD | PMID:30556269 | copper(II) sulfate | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SREK1 mRNA | CTD | PMID:19549813 | crocidolite asbestos | decreases expression | EXP | | 6480464 | Asbestos and Crocidolite results in decreased expression of SREK1 mRNA | CTD | PMID:29279043 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of SREK1 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREK1 mRNA | CTD | PMID:27188386 | enzyme inhibitor | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SREK1 protein | CTD | PMID:23301498 | folic acid | increases expression | EXP | | 6480464 | Folic Acid results in increased expression of SREK1 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SREK1 mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SREK1 mRNA | CTD | PMID:27905399 | gentamycin | increases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of SREK1 mRNA | CTD | PMID:33387578 | glyphosate | increases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Glyphosate results in increased expression of SREK1 mRNA | CTD | PMID:26302742 | hydrogen peroxide | affects expression | ISO | SREK1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of SREK1 mRNA | CTD | PMID:21179406 | ivermectin | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SREK1 protein | CTD | PMID:32959892 | methapyrilene | decreases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of SREK1 mRNA | CTD | PMID:30467583 | methimazole | decreases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of SREK1 mRNA | CTD | PMID:30047161 | methyl methanesulfonate | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SREK1 mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of SREK1 mRNA | CTD | PMID:23179753 and PMID:27188386 | methylparaben | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | methylparaben results in increased expression of SREK1 mRNA | CTD | PMID:31745603 | miconazole | decreases expression | EXP | | 6480464 | Miconazole results in decreased expression of SREK1 mRNA | CTD | PMID:27462272 | N-methyl-4-phenylpyridinium | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of SREK1 mRNA | CTD | PMID:24810058 | ozone | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of SREK1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SREK1 mRNA | CTD | PMID:27153767 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of SREK1 mRNA | CTD | PMID:23091169 | potassium dichromate | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of SREK1 protein | CTD | PMID:23718831 | resveratrol | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of SREK1 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREK1 mRNA | CTD | PMID:27188386 | sodium arsenate | decreases expression | EXP | | 6480464 | sodium arsenate results in decreased expression of SREK1 mRNA | CTD | PMID:21795629 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of SREK1 mRNA | CTD | PMID:21795629 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of SREK1 mRNA | CTD | PMID:36209798 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SREK1 mRNA | CTD | PMID:21641980 | torcetrapib | increases expression | ISO | SREK1 (Homo sapiens) | 6480464 | torcetrapib results in increased expression of SREK1 mRNA | CTD | PMID:23228038 | trichloroethene | increases methylation | ISO | Srek1 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased methylation of SREK1 gene | CTD | PMID:27618143 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of SREK1 mRNA | CTD | PMID:33045310 | triticonazole | decreases expression | ISO | Srek1 (Rattus norvegicus) | 6480464 | triticonazole results in decreased expression of SREK1 mRNA | CTD | PMID:36084822 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of SREK1 mRNA | CTD | PMID:30912803 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of SREK1 mRNA | CTD | PMID:21427059 | valproic acid | affects expression | ISO | SREK1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SREK1 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | SREK1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREK1 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SREK1 mRNA | CTD | PMID:22083351 more ... | vincristine | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of SREK1 mRNA | CTD | PMID:23649840 | vorinostat | decreases expression | ISO | SREK1 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of SREK1 mRNA | CTD | PMID:22083351 | | 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Gene Ontology Annotations Click to see Annotation Detail View
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Molecular Function
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Mammalian Phenotype
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 2. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:7671812 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:15033168 | PMID:15489334 | PMID:16033648 |
| PMID:16141072 | PMID:16141073 | PMID:21267068 | PMID:21873635 | PMID:26206133 | PMID:31162944 |
Genomics
Comparative Map Data
| Srek1 (Mus musculus - house mouse) |
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| SREK1 (Homo sapiens - human) |
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| Srek1 (Rattus norvegicus - Norway rat) |
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| Srek1 (Chinchilla lanigera - long-tailed chinchilla) |
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| SREK1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| SREK1 (Canis lupus familiaris - dog) |
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| Srek1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| SREK1 (Sus scrofa - pig) |
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| SREK1 (Chlorocebus sabaeus - green monkey) |
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| Srek1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Srek1
1182 total Variants 
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