Adrb2 (adrenergic receptor, beta 2) - Rat Genome Database

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Gene: Adrb2 (adrenergic receptor, beta 2) Mus musculus
Analyze
Symbol: Adrb2
Name: adrenergic receptor, beta 2
RGD ID: 10109
MGI Page MGI
Description: Enables adenylate cyclase binding activity and beta2-adrenergic receptor activity. Involved in cellular response to amyloid-beta; positive regulation of cold-induced thermogenesis; and positive regulation of signal transduction. Acts upstream of or within several processes, including bone resorption; brown fat cell differentiation; and diet induced thermogenesis. Located in apical plasma membrane and nucleus. Is active in neuronal dense core vesicle. Is expressed in several structures, including central nervous system; early conceptus; heart; liver; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Adrb; Adrb-2; Bad; Badm; beta 2-adrenoceptor; beta 2-AR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; Gpc; Gpcr7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1862,310,887 - 62,313,030 (-)EnsemblGRCm39 Ensembl
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBIMGSCv36mm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
AIDS Dementia Complex  (ISO)
Angina Pectoris  (ISO)
asthma  (IMP,ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
dermatitis  (ISO)
dilated cardiomyopathy  (ISO)
disease of metabolism  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial hyperlipidemia  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypokalemia  (ISO)
hypothyroidism  (ISO)
Insulin Resistance  (ISO)
interstitial cystitis  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
lung disease  (ISO)
Metabolic Syndrome  (ISO)
myasthenia gravis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
nervous system disease  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IGI,ISO)
open-angle glaucoma  (ISO)
Paroxysmal Dyspnea  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Tremor  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Ventricular Dysfunction, Left  (ISO)
Vestibulocochlear Nerve Injuries  (ISO)
viral encephalitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(5-hydroxyindol-3-yl)acetic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(R)-octopamine  (ISO)
(S)-nicotine  (ISO)
(S)-timolol (anhydrous)  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-nitropyrene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-imidazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(tert-butylamino)-1-(2-chlorophenyl)ethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acebutolol  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
albuterol  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alprenolol  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
asbestos  (ISO)
atenolol  (ISO)
bambuterol  (ISO)
beclomethasone  (ISO)
befunolol  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
betaxolol  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bitolterol  (ISO)
bosentan  (ISO)
budesonide  (EXP)
busulfan  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
carteolol  (ISO)
carvedilol  (EXP,ISO)
CGP 12177  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
cisplatin  (ISO)
clenbuterol  (EXP,ISO)
clobenpropit  (ISO)
clofibrate  (EXP)
clorgyline  (ISO)
clorprenaline  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dichlorine  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenamidone  (EXP)
fenoterol  (ISO)
fipronil  (ISO)
folic acid  (EXP)
fonofos  (ISO)
formoterol fumarate  (EXP,ISO)
FR900359  (ISO)
furan  (ISO)
glucose  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hexane  (ISO)
histamine  (EXP,ISO)
ICI 118551  (EXP,ISO)
imipramine  (ISO)
Immepip  (ISO)
indacaterol  (ISO)
iodocyanopindolol  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (ISO)
ketotifen  (ISO)
L-methionine  (EXP)
labetalol  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
metaproterenol  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
metoprolol  (EXP,ISO)
mifepristone  (ISO)
miquelianin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nadolol  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
octopamine  (ISO)
olodaterol  (ISO)
orciprenaline  (ISO)
orphenadrine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (ISO)
pindolol  (ISO)
Pirbuterol  (ISO)
pirinixic acid  (EXP)
potassium atom  (ISO)
potassium chromate  (ISO)
practolol  (ISO)
progesterone  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
propranolol hydrochloride  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
putrescine  (ISO)
rac-lactic acid  (ISO)
ractopamine  (ISO)
reproterol  (ISO)
reserpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium atom  (ISO)
sodium dodecyl sulfate  (ISO)
sotalol  (ISO)
sotorasib  (ISO)
spermidine  (ISO)
spermine  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
synephrine  (ISO)
tamoxifen  (EXP)
terbufos  (ISO)
terbutaline  (EXP,ISO)
tetrachloroethene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
vilanterol  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
Zilpaterol  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IMP,ISO)
adrenergic receptor signaling pathway  (ISO)
associative learning  (ISO)
blood vessel diameter maintenance  (IEA)
bone resorption  (IMP)
brown fat cell differentiation  (IGI)
cellular response to amyloid-beta  (IGI,ISO)
cellular response to hypoxia  (ISO)
diaphragm contraction  (ISO)
diet induced thermogenesis  (IGI)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
heat generation  (IGI)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of interleukin-6 production  (IMP)
negative regulation of multicellular organism growth  (IGI)
negative regulation of ossification  (ISO)
negative regulation of smooth muscle contraction  (IGI)
negative regulation of tumor necrosis factor production  (IMP)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,IGI,IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP-dependent activity  (ISO)
positive regulation of autophagosome maturation  (ISO)
positive regulation of bone mineralization  (IMP)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IGI)
positive regulation of lipophagy  (ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of mini excitatory postsynaptic potential  (IGI)
positive regulation of potassium ion transport  (ISO)
positive regulation of protein kinase A signaling  (IGI,ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of the force of heart contraction by epinephrine  (ISO)
positive regulation of transcription by RNA polymerase II  (IGI)
presynaptic modulation of chemical synaptic transmission  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of calcium ion transport  (ISO)
regulation of smooth muscle contraction  (IEA)
regulation of sodium ion transport  (IMP)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine  (IMP)
regulation of vein smooth muscle contraction  (ISO)
response to catecholamine  (ISO)
response to cold  (IGI)
response to dexamethasone  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to monoamine  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
signal transduction  (IEA)
smooth muscle contraction  (IGI)
synaptic transmission, glutamatergic  (ISO)
transcription by RNA polymerase II  (IGI)
vasodilation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction. Ahmet I, etal., J Pharmacol Exp Ther. 2008 May;325(2):491-9. Epub 2008 Feb 20.
2. Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor. Ahmet I, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):178-85. Epub 2009 Jul 8.
3. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
4. Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol. Basu K, etal., J Allergy Clin Immunol. 2009 Dec;124(6):1188-94.e3. Epub .
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. beta1, beta2, and beta3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
7. Argl6gly polymorphism of the beta2-adrenoceptor gene (ADRBeta2) as a susceptibility factor for nasal polyposis. Bussu F, etal., Am J Rhinol. 2007 May-Jun;21(3):378-82.
8. Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations. Carroll CL, etal., Chest. 2009 May;135(5):1186-92. Epub 2008 Nov 24.
9. Attenuation of insulin resistance by chronic beta2-adrenergic agonist treatment possible muscle specific contributions. Castle A, etal., Life Sci. 2001 Jun 22;69(5):599-611.
10. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Chen Y, etal., Am J Nephrol. 2010;32(1):23-30. Epub 2010 May 19.
11. Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment. Choucair-Jaafar N, etal., Br J Pharmacol. 2009 Dec;158(7):1683-94. doi: 10.1111/j.1476-5381.2009.00510.x. Epub .
12. Targeted disruption of the beta2 adrenergic receptor gene. Chruscinski AJ, etal., J Biol Chem. 1999 Jun 11;274(24):16694-700.
13. Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. Communal C, etal., Circulation. 1999 Nov 30;100(22):2210-2.
14. The Gly16-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. Dallongeville J, etal., J Clin Endocrinol Metab. 2003 Oct;88(10):4862-6.
15. Different genes and polymorphisms affecting high-density lipoprotein cholesterol levels in greek familial hypercholesterolemia patients. Dedoussis GV, etal., Genet Test. 2006 Fall;10(3):192-9.
16. Safety and efficacy of beta agonists. Donohue JF Respir Care. 2008 May;53(5):618-22; discussion 623-4.
17. Long-term treatment of angina pectoris with bisoprolol or atenolol in patients with chronic obstructive bronchitis: a randomized, double-blind crossover study. Dorow P, etal., J Cardiovasc Pharmacol. 1990;16 Suppl 5:S36-44.
18. Beta-adrenergic stimulation and myocardial function in the failing heart. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
19. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Elefteriou F, etal., Nature. 2005 Mar 24;434(7032):514-20. Epub 2005 Feb 20.
20. Role of beta2-adrenoceptor-beta-arrestin2-nuclear factor-kappaB signal transduction pathway and intervention effects of oxymatrine in ulcerative colitis. Fan H, etal., Chin J Integr Med. 2012 Jul;18(7):514-21. Epub 2012 Jul 7.
21. Efficacy and safety of indacaterol 150 microg once-daily in COPD: a double-blind, randomised, 12-week study. Feldman G, etal., BMC Pulm Med. 2010 Mar 8;10:11.
22. Effects of uremic plasma on alpha- and beta-adrenoceptor subtypes. Ferchland A, etal., Nephron. 1998 Sep;80(1):46-50.
23. beta-Adrenergic blockers: a 50-year historical perspective. Frishman WH Am J Ther. 2008 Nov-Dec;15(6):565-76.
24. Inhaled corticosteroids and long-acting beta 2-agonists in treatment of patients with chronic bronchiolitis following exposure to sulfur mustard. Ghanei M, etal., Inhal Toxicol. 2007 Aug;19(10):889-94.
25. Studies of the associations between functional beta(2)-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects. Gjesing AP, etal., Diabetologia. 2007 Mar;50(3):563-8. Epub 2007 Jan 13.
26. Hypertension genes are genetic markers for insulin sensitivity and resistance. Guo X, etal., Hypertension. 2005 Apr;45(4):799-803. Epub 2005 Feb 7.
27. Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly. Heckbert SR, etal., Circulation. 2003 Apr 22;107(15):2021-4. Epub 2003 Apr 7.
28. Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model. Hewitt M, etal., Am J Respir Cell Mol Biol. 2010 Feb;42(2):243-9. Epub 2009 May 7.
29. Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension. Iaccarino G, etal., Clin Pharmacol Ther. 2006 Dec;80(6):633-45.
30. Polymorphism of beta-adrenergic receptors and susceptibility to open-angle glaucoma. Inagaki Y, etal., Mol Vis. 2006 Jun 12;12:673-80.
31. Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population. Isaza C, etal., Methods Find Exp Clin Pharmacol. 2005 May;27(4):237-44.
32. A selective beta2-adrenergic agonist, terbutaline, improves sepsis-induced diaphragmatic dysfunction in the rat. Ito T, etal., Life Sci. 2006 Jul 24;79(9):905-12. Epub 2006 Apr 17.
33. Gln27Glu beta2-adrenergic receptor variant is associated with hypertriglyceridemia and the development of fatty liver. Iwamoto N, etal., Clin Chim Acta. 2001 Dec;314(1-2):85-91.
34. beta-2-adrenergic receptor gene polymorphism confers susceptibility to Graves disease. Jazdzewski K, etal., Int J Mol Med. 2007 Jan;19(1):181-6.
35. DNA elements and protein factors involved in the transcription of the beta 2-adrenergic receptor gene in rat liver. The negative regulatory role of C/EBP alpha. Jiang L, etal., Biochemistry. 1996 Oct 8;35(40):13136-46.
36. Synthesis, beta-adrenergic blocking activity and beta-receptor binding affinities of 1-substituted-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalates. Jindal DP, etal., Farmaco. 2003 Aug;58(8):557-62.
37. Alpha1-and beta2-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C. Kassahun WT, etal., Naunyn Schmiedebergs Arch Pharmacol. 2005 Nov;372(3):171-81. Epub 2005 Nov 15.
38. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
39. Association of beta 2-adrenergic receptor polymorphism with the phenotype of aspirin-intolerant acute urticaria. Kim HA, etal., Yonsei Med J. 2007 Dec 31;48(6):1079-81.
40. Association of COPD candidate genes with CT emphysema and airway phenotypes in severe COPD. Kim WJ, etal., Eur Respir J. 2010 Jun 4.
41. CT scanning-based phenotypes vary with ADRB2 polymorphisms in chronic obstructive pulmonary disease. Kim WJ, etal., Respir Med. 2009 Jan;103(1):98-103. Epub 2008 Sep 11.
42. Changes in beta-2 adrenergic receptor and AMP-activated protein kinase alpha-2 subunit in the rat vestibular nerve after labyrinthectomy. Kitahara T, etal., Neurosci Res. 2012 Mar;72(3):221-6. doi: 10.1016/j.neures.2011.11.007. Epub 2011 Dec 8.
43. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
44. [Dynamic changes of alpha-AR, beta1-AR and beta2-AR expression during hepatic fibrogenesis]. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
45. A46G and C79G polymorphisms in the beta2-adrenergic receptor gene (ADRB2) and essential hypertension risk: a meta-analysis. Lou Y, etal., Hypertens Res. 2010 Aug 26.
46. Combined therapy of pentastarch, dexamethasone, and dibutyryl-cAMP or beta 2-agonist attenuates ischaemia/reperfusion injury of rat lung. Lu HL and Chiang CH, Injury. 2008 Sep;39(9):1062-70. Epub 2008 Mar 11.
47. Increased reabsorption of alveolar edema fluid in the obese Zucker rat. Ma G, etal., Tohoku J Exp Med. 2008 Nov;216(3):223-30.
48. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
49. Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma. Martin AC, etal., J Asthma. 2008 Jun;45(5):383-8.
50. Beta2-adrenoceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation. Masuo K, etal., Am J Hypertens. 2006 Oct;19(10):1084-91.
51. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
52. MGDs mouse GO annotations MGD data from the GO Consortium
53. MGD IEA MGD IEA
54. Alpha and beta-adrenoceptors in hypertension. I. Cardiac and renal alpha 1-, beta 1-, and beta 2-adrenoceptors in rat models of acquired hypertension. Michel MC, etal., J Cardiovasc Pharmacol. 1989 Mar;13(3):421-31.
55. Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction. Mieno S, etal., Ann Thorac Surg. 2002 Oct;74(4):1213-8.
56. Activation of beta2-adrenergic receptor plays a pivotal role in generating the protective effect of ischemic preconditioning in rat hearts. Mieno S, etal., Scand Cardiovasc J. 2005 Oct;39(5):313-9.
57. Beta2-adrenergic receptor haplotype and bronchodilator response to salbutamol in patients with acute exacerbations of COPD. Mokry M, etal., Med Sci Monit. 2008 Aug;14(8):CR392-8.
58. beta(2)-adrenergic receptor promoter haplotype influences spirometric response during an acute asthma exacerbation. Moore PE, etal., Clin Transl Sci. 2008 Sep;1(2):155-61.
59. beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock. Nakada TA, etal., Am J Respir Crit Care Med. 2010 Jan 15;181(2):143-9. doi: 10.1164/rccm.200903-0332OC. Epub 2009 Oct 22.
60. Adenoviral delivery of the beta2-adrenoceptor gene in sepsis: a subcutaneous approach in rat for kidney protection. Nakamura A, etal., Clin Sci (Lond). 2005 Dec;109(6):503-11.
61. Renal beta(2)-adrenoceptor modulates the lipopolysaccharide transport system in sepsis-induced acute renal failure. Nakamura A, etal., Inflammation. 2009 Feb;32(1):12-9.
62. beta(2)-Adrenoceptor activation attenuates endotoxin-induced acute renal failure. Nakamura A, etal., J Am Soc Nephrol. 2004 Feb;15(2):316-25.
63. Renal beta2-adrenoceptor blockade worsens the outcome of an induced Escherichia coli renal infection. Nakamura A, etal., J Nephrol. 2010 May-Jun;23(3):341-9.
64. beta(2)-adrenoceptor agonist suppresses renal tumour necrosis factor and enhances interleukin-6 gene expression induced by endotoxin. Nakamura A, etal., Nephrol Dial Transplant. 2000 Dec;15(12):1928-34.
65. Protection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of beta2-adrenoceptor. Nakamura A, etal., Nephrol Dial Transplant. 2010 Mar;25(3):730-7. Epub 2009 Nov 3.
66. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Nikolaev VO, etal., Science. 2010 Mar 26;327(5973):1653-7. Epub 2010 Feb 25.
67. Beta2-Adrenergic agonists suppress rat autoimmune myocarditis: potential role of beta2-adrenergic stimulants as new therapeutic agents for myocarditis. Nishii M, etal., Circulation. 2006 Aug 29;114(9):936-44. Epub 2006 Aug 14.
68. Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma. O'Byrne PM, etal., J Allergy Clin Immunol. 2009 Dec;124(6):1217-21.
69. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
70. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
71. Association of the Arg16Gly polymorphism of the beta-2-adrenergic receptor with psoriasis. Ozkur M, etal., J Dermatol Sci. 2004 Aug;35(2):162-4.
72. Development of novel microarray methodology for the study of mutations in the SERPINA1 and ADRB2 genes--their association with Obstructive Pulmonary Disease and Disseminated Bronchiectasis in Greek patients. Papatheodorou A, etal., Clin Biochem. 2010 Jan;43(1-2):43-50. Epub 2009 Sep 10.
73. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
74. [Association between beta2-adrenergic receptor haplotype/polymorphisms and asthma phenotype] Qiu YY and Yin KS, Zhonghua Jie He He Hu Xi Za Zhi. 2008 Mar;31(3):201-5.
75. beta2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia. Rami A, etal., Neurosci Res. 2003 Dec;47(4):373-82.
76. Changes in beta 1- and beta 2-adrenergic receptor mRNA levels in brown adipose tissue and heart of hypothyroid rats. Revelli JP, etal., Biochem J. 1991 Aug 1;277 ( Pt 3):625-9.
77. Mouse MP Annotation Import Pipeline RGD automated import pipeline
78. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
79. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
80. Intrinsic atopic dermatitis is associated with a beta-2 adrenergic receptor polymorphism. Roguedas AM, etal., Acta Derm Venereol. 2006;86(5):447-8.
81. Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors. Rohrer DK, etal., J Biol Chem. 1999 Jun 11;274(24):16701-8.
82. 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study. Sethi AA, etal., Pharmacogenet Genomics. 2005 Sep;15(9):633-45.
83. Beta-2-adrenergic receptor polymorphisms in cystic fibrosis. Steagall WK, etal., Pharmacogenet Genomics. 2007 Jun;17(6):425-30.
84. Probable role of beta2-adrenergic receptor gene haplotype in high-altitude pulmonary oedema. Stobdan T, etal., Respirology. 2010 May;15(4):651-8.
85. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. Sugaya K, etal., J Urol. 2002 Dec;168(6):2668-71.
86. Role of ADRB2 gene polymorphism in asthma and response to beta(2)-agonists in Polish children. Szczepankiewicz A, etal., J Appl Genet. 2009;50(3):275-81.
87. Decreased beta 2-adrenergic receptor-mRNA and loricrin-mRNA, and increased involucrin-mRNA transcripts in psoriatic epidermis: analysis by reverse transcription-polymerase chain reaction. Takahashi H, etal., Br J Dermatol. 1996 Jun;134(6):1065-9.
88. Polymorphisms of the beta2 adrenoreceptor gene in chronic obstructive pulmonary disease. Vacca G, etal., Ther Adv Respir Dis. 2009 Feb;3(1):3-10.
89. Autoantibodies to beta 2-adrenergic receptors with antiadrenergic activity from patients with allergic asthma. Wallukat G and Wollenberger A, J Allergy Clin Immunol. 1991 Oct;88(4):581-7.
90. Association of the beta2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population. Wu H, etal., J Hypertens. 2006 Jun;24(6):1041-7.
91. beta2-adrenergic receptor gene polymorphisms in myasthenia gravis (MG). Xu BY, etal., Clin Exp Immunol. 2000 Jan;119(1):156-60.
92. Transcriptional and posttranscriptional regulation of beta(2)-adrenergic receptor gene in rat liver during sepsis. Yang J, etal., Am J Physiol. 1999 Jul;277(1 Pt 2):R132-9.
93. Haplotype analysis of the beta2 adrenergic receptor gene and risk of myocardial infarction in humans. Zee RY, etal., Genetics. 2005 Mar;169(3):1583-7. Epub 2004 Nov 1.
94. Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats. Zhang W, etal., Eur J Pharmacol. 2010 Feb 25;628(1-3):171-8. Epub 2009 Nov 24.
95. Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure. Zhang ZS, etal., J Pharmacol Exp Ther. 2001 Jul;298(1):188-96.
96. [Expression and significance of beta(2)-adrenoreceptor in inflammatory cells of patients with chronic obstructive pulmonary disease] Zhu WJ, etal., Zhonghua Yi Xue Za Zhi. 2008 Aug 5;88(30):2099-102.
Additional References at PubMed
PMID:1354640   PMID:1628813   PMID:1676978   PMID:1686018   PMID:2154750   PMID:2549959   PMID:2569767   PMID:2834198   PMID:3141418   PMID:6321299   PMID:7651355   PMID:7738011  
PMID:7873877   PMID:7949735   PMID:8094989   PMID:8099512   PMID:8160017   PMID:8288218   PMID:8308019   PMID:8396717   PMID:8597598   PMID:8693001   PMID:8770105   PMID:9139936  
PMID:9235896   PMID:9305915   PMID:9506519   PMID:9826121   PMID:10066919   PMID:10349636   PMID:10725249   PMID:10878340   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11214319  
PMID:11448841   PMID:11502890   PMID:11557593   PMID:11641423   PMID:11679434   PMID:11737201   PMID:11748583   PMID:11782469   PMID:12055247   PMID:12097322   PMID:12297500   PMID:12352327  
PMID:12387862   PMID:12477932   PMID:12509508   PMID:12615050   PMID:12734361   PMID:12925702   PMID:12933684   PMID:12954981   PMID:14500986   PMID:14625387   PMID:14966518   PMID:14990578  
PMID:15016730   PMID:15066901   PMID:15336560   PMID:15474034   PMID:15585594   PMID:15791602   PMID:15802488   PMID:15939797   PMID:16001069   PMID:16002745   PMID:16040722   PMID:16113068  
PMID:16141072   PMID:16141073   PMID:16171811   PMID:16458323   PMID:16602821   PMID:16645459   PMID:16648270   PMID:16670773   PMID:16767221   PMID:16790355   PMID:16876797   PMID:16920928  
PMID:16996249   PMID:17043217   PMID:17115048   PMID:17170700   PMID:17296797   PMID:17404268   PMID:17435077   PMID:17442405   PMID:17446185   PMID:17498818   PMID:17510209   PMID:17515456  
PMID:17543594   PMID:17873881   PMID:17885689   PMID:17996646   PMID:18006484   PMID:18056263   PMID:18188154   PMID:18193078   PMID:18194271   PMID:18245567   PMID:18256599   PMID:18305025  
PMID:18421015   PMID:18436820   PMID:18511502   PMID:18694395   PMID:18761104   PMID:18801900   PMID:18814142   PMID:18820136   PMID:18851973   PMID:19047375   PMID:19059194   PMID:19084064  
PMID:19095863   PMID:19103808   PMID:19167076   PMID:19171883   PMID:19213958   PMID:19333138   PMID:19364979   PMID:19420258   PMID:19596833   PMID:19633206   PMID:19706446   PMID:19706594  
PMID:19801680   PMID:19837877   PMID:19855129   PMID:19865483   PMID:19926878   PMID:20059989   PMID:20138019   PMID:20197056   PMID:20335229   PMID:20363288   PMID:20395378   PMID:20395454  
PMID:20406048   PMID:20413718   PMID:20443853   PMID:20613718   PMID:20705779   PMID:20805681   PMID:20836991   PMID:20864554   PMID:21130738   PMID:21131397   PMID:21138422   PMID:21148315  
PMID:21177286   PMID:21209093   PMID:21224388   PMID:21266510   PMID:21267068   PMID:21282381   PMID:21321602   PMID:21335487   PMID:21366703   PMID:21368050   PMID:21389089   PMID:21419339  
PMID:21444660   PMID:21614075   PMID:21680711   PMID:21705675   PMID:21833475   PMID:21857681   PMID:21873635   PMID:21878527   PMID:21976502   PMID:21990347   PMID:22028912   PMID:22227600  
PMID:22315324   PMID:22323706   PMID:22381067   PMID:22407956   PMID:22442147   PMID:22457517   PMID:22495178   PMID:22500016   PMID:22538810   PMID:22593095   PMID:22683571   PMID:22863835  
PMID:22867428   PMID:22912718   PMID:22913394   PMID:23090606   PMID:23093370   PMID:23129275   PMID:23133676   PMID:23219791   PMID:23243208   PMID:23287463   PMID:23312282   PMID:23382219  
PMID:23418295   PMID:23420884   PMID:23430246   PMID:23436577   PMID:23473322   PMID:23644514   PMID:23684624   PMID:23708524   PMID:23745588   PMID:23846904   PMID:23894672   PMID:23920331  
PMID:23978467   PMID:23984976   PMID:24011077   PMID:24058627   PMID:24121404   PMID:24140643   PMID:24170934   PMID:24215978   PMID:24312457   PMID:24333561   PMID:24389135   PMID:24465481  
PMID:24562381   PMID:24622771   PMID:24626633   PMID:24629015   PMID:24642449   PMID:24677713   PMID:24831005   PMID:24865431   PMID:24868110   PMID:24938737   PMID:24947582   PMID:24950230  
PMID:24966659   PMID:25000590   PMID:25008179   PMID:25063231   PMID:25138272   PMID:25193472   PMID:25260754   PMID:25348166   PMID:25401477   PMID:25422496   PMID:25491117   PMID:25503457  
PMID:25658948   PMID:25683697   PMID:25756236   PMID:25852085   PMID:25853667   PMID:26058426   PMID:26132918   PMID:26193120   PMID:26391182   PMID:26410627   PMID:26527381   PMID:26566631  
PMID:26612203   PMID:26777404   PMID:26952573   PMID:26972746   PMID:27103070   PMID:27150455   PMID:27194135   PMID:27206969   PMID:27222010   PMID:27330078   PMID:27342779   PMID:27354517  
PMID:27364164   PMID:27541735   PMID:27776147   PMID:27799619   PMID:27815373   PMID:27838449   PMID:27956622   PMID:27978539   PMID:27983752   PMID:27989802   PMID:28041995   PMID:28119465  
PMID:28219977   PMID:28283550   PMID:28348522   PMID:28394333   PMID:28416795   PMID:28487987   PMID:28684080   PMID:28724789   PMID:28752049   PMID:28814453   PMID:28819022   PMID:28877454  
PMID:28918935   PMID:28939592   PMID:28950943   PMID:29073113   PMID:29123236   PMID:29167435   PMID:29249692   PMID:29445008   PMID:29452585   PMID:29496881   PMID:29514069   PMID:29535304  
PMID:29627294   PMID:29642004   PMID:29688375   PMID:29715048   PMID:29914852   PMID:30093491   PMID:30174297   PMID:30195028   PMID:30229289   PMID:30249798   PMID:30303066   PMID:30361261  
PMID:30415995   PMID:30483153   PMID:30538132   PMID:30683314   PMID:30770098   PMID:31107911   PMID:31230416   PMID:31242414   PMID:31264512   PMID:31473062   PMID:31533035   PMID:31534216  
PMID:31566578   PMID:31636451   PMID:31838908   PMID:31923400   PMID:31926929   PMID:32029230   PMID:32045471   PMID:32045472   PMID:32238715   PMID:32286326   PMID:32426489   PMID:32532293  
PMID:32610084   PMID:32755608   PMID:33484195   PMID:33505018   PMID:33540675   PMID:33568757   PMID:33667431   PMID:33774223   PMID:33915109   PMID:34415184   PMID:34459015   PMID:34483955  
PMID:34551310   PMID:34555226   PMID:34706232   PMID:34733286   PMID:34830474   PMID:34836959   PMID:34883278   PMID:35095883   PMID:35244862   PMID:35636458   PMID:35714603   PMID:35931084  
PMID:35944008   PMID:36208707   PMID:36631664   PMID:36875113   PMID:37151872   PMID:37369341   PMID:37380764   PMID:37473755   PMID:37597516   PMID:37633515   PMID:37680481   PMID:38331165  


Genomics

Comparative Map Data
Adrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1862,310,887 - 62,313,030 (-)EnsemblGRCm39 Ensembl
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBIMGSCv36mm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
ADRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5148,826,611 - 148,828,623 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,206,174 - 148,208,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36Build 36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
T2T-CHM13v2.05149,361,444 - 149,363,456 (+)NCBIT2T-CHM13v2.0
Adrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,912,760 - 57,914,802 (-)NCBIGRCr8
mRatBN7.21855,642,459 - 55,644,501 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,502,903 - 55,644,512 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,735,062 - 57,737,132 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01858,450,067 - 58,452,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01856,266,287 - 56,268,329 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01857,513,792 - 57,515,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,513,793 - 57,515,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,739,990 - 56,742,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41858,174,958 - 58,177,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11858,247,190 - 58,249,232 (-)NCBI
Celera1853,789,848 - 53,791,890 (-)NCBICelera
RH 3.4 Map18542.9RGD
Cytogenetic Map18q12.1NCBI
Adrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554155,515,697 - 5,516,980 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,515,157 - 5,517,198 (-)NCBIChiLan1.0ChiLan1.0
ADRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,063,792 - 144,193,838 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15142,203,567 - 142,333,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
ADRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1460,048,502 - 60,050,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,941,517 - 60,050,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,812,943 - 59,814,888 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0460,537,283 - 60,539,228 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1460,317,278 - 60,319,223 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0460,444,286 - 60,446,231 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,962,485 - 60,964,430 (-)NCBIUU_Cfam_GSD_1.0
Adrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213144,411,444 - 144,414,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,985,960 - 5,987,210 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365045,985,407 - 5,987,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,033,579 - 150,040,731 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,445,920 - 51,447,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2351,446,154 - 51,447,401 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603426,307,284 - 26,309,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247748,211,984 - 8,213,240 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247748,211,723 - 8,215,962 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adrb2
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:153
Interacting mature miRNAs:162
Transcripts:ENSMUST00000053640
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
27226720Tibw5_mtibia width 5, proximal, 10 week (mouse)185043306762633071Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse

Markers in Region
Adrb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,051 - 62,178,217UniSTSGRCm38
MGSCv371862,338,103 - 62,338,217UniSTSGRCm37
MGSCv371862,338,098 - 62,338,478UniSTSGRCm37
Celera1863,463,029 - 63,463,195UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
cM Map1834.0UniSTS
X15643  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,177,613 - 62,177,737UniSTSGRCm38
MGSCv371862,337,267 - 62,337,391UniSTSGRCm37
Celera1863,462,601 - 63,462,725UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
Whitehead/MRC_RH18797.32UniSTS
UniSTS:237819  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,032 - 62,178,243UniSTSGRCm38
MGSCv371862,337,686 - 62,337,897UniSTSGRCm37
Celera1863,463,010 - 63,463,233UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
ADRB2sts1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,882 - 62,179,336UniSTSGRCm38
MGSCv371862,338,536 - 62,338,990UniSTSGRCm37
Celera1863,463,872 - 63,464,326UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
Adrb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,449 - 62,178,563UniSTSGRCm38
MGSCv371862,338,103 - 62,338,217UniSTSGRCm37
Celera1863,463,439 - 63,463,553UniSTS
Cytogenetic Map18E1UniSTS
Adrb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,444 - 62,178,824UniSTSGRCm38
MGSCv371862,338,098 - 62,338,478UniSTSGRCm37
Celera1863,463,434 - 63,463,814UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000053640   ⟹   ENSMUSP00000062256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1862,310,887 - 62,313,030 (-)Ensembl
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)Ensembl
RefSeq Acc Id: NM_007420   ⟹   NP_031446
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391862,310,784 - 62,313,052 (-)NCBI
GRCm381862,177,713 - 62,179,981 (-)NCBI
MGSCv371862,337,470 - 62,339,613 (-)RGD
Celera1863,462,701 - 63,464,971 (-)NCBI
cM Map18 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031446   ⟸   NM_007420
- UniProtKB: Q8BH38 (UniProtKB/Swiss-Prot),   P18762 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000062256   ⟸   ENSMUST00000053640
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18762-F1-model_v2 AlphaFold P18762 1-418 view protein structure

Promoters
RGD ID:6850206
Promoter ID:EP29017
Type:single initiation site
Name:MM_B2AR
Description:beta 2-Adrenergic receptor, ADRB2 or ADRB2R gene
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 159; Mammalian beta 2-adrenergic receptor
Experiment Methods:Nuclease protection; Nuclease protection; transfected or transformed cells
Regulation:various tissues; (induced by or strongly expressed in) butyrate, (induced by or strongly expressed in) glucc
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36Un2,000 - 2,060EPD
RGD ID:13677974
Promoter ID:EPDNEW_M23136
Type:multiple initiation site
Name:Adrb2_1
Description:Mus musculus adrenergic receptor, beta 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381862,179,978 - 62,180,038EPDNEW
RGD ID:6829042
Promoter ID:MM_KWN:25447
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000067743,   NM_007420
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361862,336,986 - 62,340,312 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87938 AgrOrtholog
Ensembl Genes ENSMUSG00000045730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053640 ENTREZGENE
  ENSMUST00000053640.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11555 UniProtKB/Swiss-Prot
MGD MGI:87938 ENTREZGENE
NCBI Gene 11555 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24248:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADRB2 RGD
PhenoGen Adrb2 PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCB2AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADRB2_MOUSE UniProtKB/Swiss-Prot
  F8UX47_MOUSE UniProtKB/TrEMBL
  P18762 ENTREZGENE
  Q8BH38 ENTREZGENE
  Q8K0V0_MOUSE UniProtKB/TrEMBL
  Q99P03_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8BH38 UniProtKB/Swiss-Prot