Adrb2 (adrenergic receptor, beta 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Adrb2 (adrenergic receptor, beta 2) Mus musculus
Symbol: Adrb2
Name: adrenergic receptor, beta 2
RGD ID: 10109
Description: Exhibits adenylate cyclase binding activity and beta2-adrenergic receptor activity. Involved in several processes, including bone resorption; brown fat cell differentiation; and positive regulation of signal transduction. Localizes to apical plasma membrane and nucleus. Is expressed in several structures, including central nervous system; early conceptus; heart; liver; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Adrb; Adrb-2; Bad; Badm; beta 2-adrenoceptor; beta 2-AR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; Gpc; Gpcr7
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39mm39
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBImm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
AIDS Dementia Complex  (ISO)
Angina Pectoris  (ISO)
asthma  (IMP,ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
dermatitis  (ISO)
dilated cardiomyopathy  (ISO)
disease of metabolism  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Graves' disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypokalemia  (ISO)
hypothyroidism  (ISO)
Insulin Resistance  (ISO)
interstitial cystitis  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
lung disease  (ISO)
Metabolic Syndrome  (ISO)
myasthenia gravis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
nervous system disease  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IGI,ISO)
open-angle glaucoma  (ISO)
Paroxysmal Dyspnea  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (ISO)
Stomach Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Tremor  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Ventricular Dysfunction, Left  (ISO)
Vestibulocochlear Nerve Injuries  (ISO)
viral encephalitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(5-hydroxyindol-3-yl)acetic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(R)-octopamine  (ISO)
(S)-nicotine  (ISO)
(S)-timolol (anhydrous)  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-nitropyrene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-imidazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(tert-butylamino)-1-(2-chlorophenyl)ethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP,ISO)
acebutolol  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
albuterol  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alprenolol  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atenolol  (ISO)
beclomethasone  (ISO)
befunolol  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
betaxolol  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisoprolol  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
budesonide  (EXP)
busulfan  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
carteolol  (ISO)
carvedilol  (EXP,ISO)
CGP 12177  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
cisplatin  (ISO)
clenbuterol  (EXP,ISO)
clobenpropit  (ISO)
clofibrate  (EXP)
clorgyline  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dichlorine  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenamidone  (EXP)
fenoterol  (ISO)
fipronil  (ISO)
folic acid  (EXP)
fonofos  (ISO)
formoterol fumarate  (EXP,ISO)
furan  (ISO)
glucose  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hexane  (ISO)
histamine  (EXP,ISO)
ICI 118551  (EXP,ISO)
imipramine  (ISO)
Immepip  (ISO)
iodocyanopindolol  (ISO)
isoprenaline  (EXP,ISO)
ketotifen  (ISO)
L-methionine  (EXP)
labetalol  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
metaproterenol  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
metoprolol  (EXP,ISO)
mifepristone  (ISO)
miquelianin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nadolol  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
octopamine  (ISO)
olodaterol  (ISO)
orciprenaline  (ISO)
orphenadrine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (ISO)
pindolol  (ISO)
pirinixic acid  (EXP)
potassium atom  (ISO)
potassium chromate  (ISO)
practolol  (ISO)
progesterone  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
putrescine  (ISO)
rac-lactic acid  (ISO)
reserpine  (ISO)
Salmeterol xinafoate  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium atom  (ISO)
sodium dodecyl sulfate  (ISO)
sotalol  (ISO)
spermidine  (ISO)
spermine  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
synephrine  (ISO)
tamoxifen  (EXP)
terbufos  (ISO)
terbutaline  (EXP,ISO)
tetrachloroethene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IMP,ISO)
adrenergic receptor signaling pathway  (ISO)
aging  (ISO)
associative learning  (ISO)
blood vessel diameter maintenance  (IEA)
bone resorption  (IMP)
brown fat cell differentiation  (IGI)
cellular response to amyloid-beta  (IGI,ISO)
cellular response to hypoxia  (ISO)
desensitization of G protein-coupled receptor signaling pathway by arrestin  (ISO)
diaphragm contraction  (ISO)
diet induced thermogenesis  (IGI)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
heat generation  (IGI)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-6 production  (IMP)
negative regulation of multicellular organism growth  (IGI)
negative regulation of ossification  (ISO)
negative regulation of platelet aggregation  (ISO)
negative regulation of smooth muscle contraction  (IBA,IGI)
negative regulation of tumor necrosis factor production  (IMP)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,IGI,IMP)
obsolete positive regulation of blood vessel diameter  (ISO)
positive regulation of AMPA receptor activity  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATPase activity  (ISO)
positive regulation of autophagosome maturation  (ISO)
positive regulation of bone mineralization  (IMP)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IGI)
positive regulation of heart contraction  (ISO)
positive regulation of lipophagy  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mini excitatory postsynaptic potential  (IGI)
positive regulation of potassium ion transport  (ISO)
positive regulation of protein kinase A signaling  (IGI,ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of the force of heart contraction by epinephrine  (ISO)
positive regulation of transcription by RNA polymerase II  (IGI)
receptor-mediated endocytosis  (ISO)
regulation of calcium ion transport  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of smooth muscle contraction  (IEA)
regulation of sodium ion transport  (IMP)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine  (IMP)
response to cold  (IGI)
response to dexamethasone  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to monoamine  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
signal transduction  (IEA)
synaptic transmission, glutamatergic  (ISO)
wound healing  (ISO)

Cellular Component


References - curated
1. Ahmet I, etal., J Pharmacol Exp Ther. 2008 May;325(2):491-9. Epub 2008 Feb 20.
2. Ahmet I, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):178-85. Epub 2009 Jul 8.
3. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
4. Basu K, etal., J Allergy Clin Immunol. 2009 Dec;124(6):1188-94.e3. Epub .
5. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
7. Bussu F, etal., Am J Rhinol. 2007 May-Jun;21(3):378-82.
8. Carroll CL, etal., Chest. 2009 May;135(5):1186-92. Epub 2008 Nov 24.
9. Castle A, etal., Life Sci. 2001 Jun 22;69(5):599-611.
10. Chen Y, etal., Am J Nephrol. 2010;32(1):23-30. Epub 2010 May 19.
11. Choucair-Jaafar N, etal., Br J Pharmacol. 2009 Dec;158(7):1683-94. doi: 10.1111/j.1476-5381.2009.00510.x. Epub .
12. Chruscinski AJ, etal., J Biol Chem. 1999 Jun 11;274(24):16694-700.
13. Communal C, etal., Circulation. 1999 Nov 30;100(22):2210-2.
14. Dallongeville J, etal., J Clin Endocrinol Metab. 2003 Oct;88(10):4862-6.
15. Dedoussis GV, etal., Genet Test. 2006 Fall;10(3):192-9.
16. Donohue JF Respir Care. 2008 May;53(5):618-22; discussion 623-4.
17. Dorow P, etal., J Cardiovasc Pharmacol. 1990;16 Suppl 5:S36-44.
18. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
19. Elefteriou F, etal., Nature. 2005 Mar 24;434(7032):514-20. Epub 2005 Feb 20.
20. Fan H, etal., Chin J Integr Med. 2012 Jul;18(7):514-21. Epub 2012 Jul 7.
21. Feldman G, etal., BMC Pulm Med. 2010 Mar 8;10:11.
22. Ferchland A, etal., Nephron. 1998 Sep;80(1):46-50.
23. Frishman WH Am J Ther. 2008 Nov-Dec;15(6):565-76.
24. Ghanei M, etal., Inhal Toxicol. 2007 Aug;19(10):889-94.
25. Gjesing AP, etal., Diabetologia. 2007 Mar;50(3):563-8. Epub 2007 Jan 13.
26. Guo X, etal., Hypertension. 2005 Apr;45(4):799-803. Epub 2005 Feb 7.
27. Heckbert SR, etal., Circulation. 2003 Apr 22;107(15):2021-4. Epub 2003 Apr 7.
28. Hewitt M, etal., Am J Respir Cell Mol Biol. 2010 Feb;42(2):243-9. Epub 2009 May 7.
29. Iaccarino G, etal., Clin Pharmacol Ther. 2006 Dec;80(6):633-45.
30. Inagaki Y, etal., Mol Vis. 2006 Jun 12;12:673-80.
31. Isaza C, etal., Methods Find Exp Clin Pharmacol. 2005 May;27(4):237-44.
32. Ito T, etal., Life Sci. 2006 Jul 24;79(9):905-12. Epub 2006 Apr 17.
33. Iwamoto N, etal., Clin Chim Acta. 2001 Dec;314(1-2):85-91.
34. Jazdzewski K, etal., Int J Mol Med. 2007 Jan;19(1):181-6.
35. Jiang L, etal., Biochemistry. 1996 Oct 8;35(40):13136-46.
36. Kassahun WT, etal., Naunyn Schmiedebergs Arch Pharmacol. 2005 Nov;372(3):171-81. Epub 2005 Nov 15.
37. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
38. Kim HA, etal., Yonsei Med J. 2007 Dec 31;48(6):1079-81.
39. Kim WJ, etal., Eur Respir J. 2010 Jun 4.
40. Kim WJ, etal., Respir Med. 2009 Jan;103(1):98-103. Epub 2008 Sep 11.
41. Kitahara T, etal., Neurosci Res. 2012 Mar;72(3):221-6. doi: 10.1016/j.neures.2011.11.007. Epub 2011 Dec 8.
42. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
43. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
44. Lou Y, etal., Hypertens Res. 2010 Aug 26.
45. Lu HL and Chiang CH, Injury. 2008 Sep;39(9):1062-70. Epub 2008 Mar 11.
46. Ma G, etal., Tohoku J Exp Med. 2008 Nov;216(3):223-30.
47. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
48. Martin AC, etal., J Asthma. 2008 Jun;45(5):383-8.
49. Masuo K, etal., Am J Hypertens. 2006 Oct;19(10):1084-91.
50. MGD and Homologene mouse data transfer
51. MGD data from the GO Consortium
53. Michel MC, etal., J Cardiovasc Pharmacol. 1989 Mar;13(3):421-31.
54. Mieno S, etal., Ann Thorac Surg. 2002 Oct;74(4):1213-8.
55. Mieno S, etal., Scand Cardiovasc J. 2005 Oct;39(5):313-9.
56. Mokry M, etal., Med Sci Monit. 2008 Aug;14(8):CR392-8.
57. Moore PE, etal., Clin Transl Sci. 2008 Sep;1(2):155-61.
58. Nakada TA, etal., Am J Respir Crit Care Med. 2010 Jan 15;181(2):143-9. doi: 10.1164/rccm.200903-0332OC. Epub 2009 Oct 22.
59. Nakamura A, etal., Clin Sci (Lond). 2005 Dec;109(6):503-11.
60. Nakamura A, etal., Inflammation. 2009 Feb;32(1):12-9.
61. Nakamura A, etal., J Am Soc Nephrol. 2004 Feb;15(2):316-25.
62. Nakamura A, etal., J Nephrol. 2010 May-Jun;23(3):341-9.
63. Nakamura A, etal., Nephrol Dial Transplant. 2000 Dec;15(12):1928-34.
64. Nakamura A, etal., Nephrol Dial Transplant. 2010 Mar;25(3):730-7. Epub 2009 Nov 3.
65. Nikolaev VO, etal., Science. 2010 Mar 26;327(5973):1653-7. Epub 2010 Feb 25.
66. Nishii M, etal., Circulation. 2006 Aug 29;114(9):936-44. Epub 2006 Aug 14.
67. O'Byrne PM, etal., J Allergy Clin Immunol. 2009 Dec;124(6):1217-21.
68. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
69. OMIM Disease Annotation Pipeline
70. Ozkur M, etal., J Dermatol Sci. 2004 Aug;35(2):162-4.
71. Papatheodorou A, etal., Clin Biochem. 2010 Jan;43(1-2):43-50. Epub 2009 Sep 10.
72. Pipeline to import KEGG annotations from KEGG into RGD
73. Qiu YY and Yin KS, Zhonghua Jie He He Hu Xi Za Zhi. 2008 Mar;31(3):201-5.
74. Rami A, etal., Neurosci Res. 2003 Dec;47(4):373-82.
75. Revelli JP, etal., Biochem J. 1991 Aug 1;277 ( Pt 3):625-9.
76. RGD automated import pipeline
77. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
78. RGD automated import pipeline for gene-chemical interactions
79. Roguedas AM, etal., Acta Derm Venereol. 2006;86(5):447-8.
80. Rohrer DK, etal., J Biol Chem. 1999 Jun 11;274(24):16701-8.
81. Sethi AA, etal., Pharmacogenet Genomics. 2005 Sep;15(9):633-45.
82. Steagall WK, etal., Pharmacogenet Genomics. 2007 Jun;17(6):425-30.
83. Stobdan T, etal., Respirology. 2010 May;15(4):651-8.
84. Sugaya K, etal., J Urol. 2002 Dec;168(6):2668-71.
85. Szczepankiewicz A, etal., J Appl Genet. 2009;50(3):275-81.
86. Takahashi H, etal., Br J Dermatol. 1996 Jun;134(6):1065-9.
87. Vacca G, etal., Ther Adv Respir Dis. 2009 Feb;3(1):3-10.
88. Wallukat G and Wollenberger A, J Allergy Clin Immunol. 1991 Oct;88(4):581-7.
89. Wu H, etal., J Hypertens. 2006 Jun;24(6):1041-7.
90. Xu BY, etal., Clin Exp Immunol. 2000 Jan;119(1):156-60.
91. Yang J, etal., Am J Physiol. 1999 Jul;277(1 Pt 2):R132-9.
92. Zee RY, etal., Genetics. 2005 Mar;169(3):1583-7. Epub 2004 Nov 1.
93. Zhang W, etal., Eur J Pharmacol. 2010 Feb 25;628(1-3):171-8. Epub 2009 Nov 24.
94. Zhang ZS, etal., J Pharmacol Exp Ther. 2001 Jul;298(1):188-96.
95. Zhu WJ, etal., Zhonghua Yi Xue Za Zhi. 2008 Aug 5;88(30):2099-102.
Additional References at PubMed
PMID:1354640   PMID:1628813   PMID:1676978   PMID:1686018   PMID:2154750   PMID:2549959   PMID:2569767   PMID:2834198   PMID:3141418   PMID:6321299   PMID:7651355   PMID:7738011  
PMID:7873877   PMID:7949735   PMID:8094989   PMID:8099512   PMID:8160017   PMID:8288218   PMID:8308019   PMID:8396717   PMID:8597598   PMID:8693001   PMID:8770105   PMID:9139936  
PMID:9235896   PMID:9305915   PMID:9506519   PMID:9826121   PMID:10066919   PMID:10349636   PMID:10725249   PMID:10878340   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11214319  
PMID:11448841   PMID:11502890   PMID:11557593   PMID:11641423   PMID:11679434   PMID:11737201   PMID:11748583   PMID:11782469   PMID:12055247   PMID:12097322   PMID:12297500   PMID:12352327  
PMID:12387862   PMID:12477932   PMID:12509508   PMID:12615050   PMID:12734361   PMID:12925702   PMID:12933684   PMID:12954981   PMID:14500986   PMID:14625387   PMID:14966518   PMID:14990578  
PMID:15016730   PMID:15066901   PMID:15336560   PMID:15474034   PMID:15585594   PMID:15791602   PMID:15802488   PMID:15939797   PMID:16001069   PMID:16002745   PMID:16040722   PMID:16113068  
PMID:16141072   PMID:16141073   PMID:16171811   PMID:16458323   PMID:16602821   PMID:16645459   PMID:16648270   PMID:16670773   PMID:16767221   PMID:16790355   PMID:16876797   PMID:16920928  
PMID:16996249   PMID:17043217   PMID:17115048   PMID:17170700   PMID:17296797   PMID:17404268   PMID:17435077   PMID:17442405   PMID:17446185   PMID:17498818   PMID:17510209   PMID:17515456  
PMID:17543594   PMID:17873881   PMID:17885689   PMID:17996646   PMID:18006484   PMID:18056263   PMID:18188154   PMID:18193078   PMID:18194271   PMID:18245567   PMID:18256599   PMID:18305025  
PMID:18421015   PMID:18436820   PMID:18511502   PMID:18694395   PMID:18761104   PMID:18801900   PMID:18814142   PMID:18820136   PMID:18851973   PMID:19047375   PMID:19059194   PMID:19084064  
PMID:19095863   PMID:19103808   PMID:19167076   PMID:19171883   PMID:19213958   PMID:19333138   PMID:19364979   PMID:19420258   PMID:19596833   PMID:19633206   PMID:19706446   PMID:19706594  
PMID:19801680   PMID:19837877   PMID:19855129   PMID:19865483   PMID:19926878   PMID:20059989   PMID:20138019   PMID:20197056   PMID:20335229   PMID:20363288   PMID:20395378   PMID:20395454  
PMID:20406048   PMID:20413718   PMID:20443853   PMID:20613718   PMID:20705779   PMID:20805681   PMID:20836991   PMID:20864554   PMID:21130738   PMID:21131397   PMID:21138422   PMID:21148315  
PMID:21177286   PMID:21209093   PMID:21224388   PMID:21266510   PMID:21267068   PMID:21282381   PMID:21335487   PMID:21366703   PMID:21368050   PMID:21389089   PMID:21419339   PMID:21444660  
PMID:21614075   PMID:21680711   PMID:21705675   PMID:21833475   PMID:21857681   PMID:21873635   PMID:21878527   PMID:21976502   PMID:21990347   PMID:22028912   PMID:22227600   PMID:22315324  
PMID:22323706   PMID:22407956   PMID:22442147   PMID:22457517   PMID:22495178   PMID:22500016   PMID:22538810   PMID:22593095   PMID:22683571   PMID:22863835   PMID:22867428   PMID:22912718  
PMID:22913394   PMID:23090606   PMID:23093370   PMID:23129275   PMID:23133676   PMID:23219791   PMID:23243208   PMID:23287463   PMID:23312282   PMID:23382219   PMID:23418295   PMID:23420884  
PMID:23430246   PMID:23436577   PMID:23473322   PMID:23644514   PMID:23684624   PMID:23708524   PMID:23745588   PMID:23846904   PMID:23894672   PMID:23920331   PMID:23978467   PMID:23984976  
PMID:24011077   PMID:24058627   PMID:24121404   PMID:24140643   PMID:24170934   PMID:24215978   PMID:24312457   PMID:24333561   PMID:24389135   PMID:24465481   PMID:24562381   PMID:24622771  
PMID:24626633   PMID:24629015   PMID:24642449   PMID:24677713   PMID:24831005   PMID:24865431   PMID:24868110   PMID:24938737   PMID:24947582   PMID:24950230   PMID:24966659   PMID:25000590  
PMID:25008179   PMID:25063231   PMID:25138272   PMID:25193472   PMID:25260754   PMID:25348166   PMID:25401477   PMID:25422496   PMID:25491117   PMID:25503457   PMID:25658948   PMID:25756236  
PMID:25852085   PMID:25853667   PMID:26058426   PMID:26132918   PMID:26193120   PMID:26391182   PMID:26410627   PMID:26527381   PMID:26566631   PMID:26612203   PMID:26777404   PMID:26952573  
PMID:26972746   PMID:27103070   PMID:27150455   PMID:27194135   PMID:27222010   PMID:27330078   PMID:27342779   PMID:27354517   PMID:27364164   PMID:27776147   PMID:27799619   PMID:27815373  
PMID:27838449   PMID:27956622   PMID:27978539   PMID:27983752   PMID:27989802   PMID:28041995   PMID:28119465   PMID:28219977   PMID:28283550   PMID:28348522   PMID:28394333   PMID:28416795  
PMID:28487987   PMID:28684080   PMID:28724789   PMID:28752049   PMID:28814453   PMID:28819022   PMID:28877454   PMID:28918935   PMID:28939592   PMID:28950943   PMID:29073113   PMID:29123236  
PMID:29167435   PMID:29249692   PMID:29445008   PMID:29452585   PMID:29496881   PMID:29514069   PMID:29535304   PMID:29627294   PMID:29688375   PMID:29715048   PMID:29914852   PMID:30093491  
PMID:30174297   PMID:30195028   PMID:30229289   PMID:30249798   PMID:30303066   PMID:30361261   PMID:30415995   PMID:30483153   PMID:30538132   PMID:30770098   PMID:31107911   PMID:31230416  
PMID:31242414   PMID:31264512   PMID:31533035   PMID:31534216   PMID:31566578   PMID:31636451   PMID:31838908   PMID:31923400   PMID:31926929   PMID:32045471   PMID:32238715   PMID:32286326  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39mm39
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBImm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5148,826,611 - 148,828,623 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5148,825,245 - 148,828,687 (+)EnsemblGRCh38hg38GRCh38
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375148,206,156 - 148,254,628 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh375148,206,174 - 148,208,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBI
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21855,642,459 - 55,644,501 (-)NCBI
Rnor_6.0 Ensembl1857,513,793 - 57,515,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01857,513,792 - 57,515,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01856,739,990 - 56,742,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41858,174,958 - 58,177,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11858,247,190 - 58,249,232 (-)NCBI
Celera1853,789,848 - 53,791,890 (-)NCBICelera
RH 3.4 Map18542.9RGD
Cytogenetic Map18q12.1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554155,515,697 - 5,516,980 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,515,157 - 5,517,198 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1 Ensembl459,941,517 - 60,050,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1460,048,502 - 60,050,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
SpeTri2.0NW_0049365045,985,407 - 5,987,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2150,032,782 - 150,035,591 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12351,445,920 - 51,447,942 (+)NCBI
ChlSab1.1 Ensembl2351,446,154 - 51,447,401 (+)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247748,211,723 - 8,215,962 (+)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,051 - 62,178,217UniSTSGRCm38
MGSCv371862,338,103 - 62,338,217UniSTSGRCm37
MGSCv371862,338,098 - 62,338,478UniSTSGRCm37
Celera1863,463,029 - 63,463,195UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
cM Map1834.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,177,613 - 62,177,737UniSTSGRCm38
MGSCv371862,337,267 - 62,337,391UniSTSGRCm37
Celera1863,462,601 - 63,462,725UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,032 - 62,178,243UniSTSGRCm38
MGSCv371862,337,686 - 62,337,897UniSTSGRCm37
Celera1863,463,010 - 63,463,233UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,882 - 62,179,336UniSTSGRCm38
MGSCv371862,338,536 - 62,338,990UniSTSGRCm37
Celera1863,463,872 - 63,464,326UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,449 - 62,178,563UniSTSGRCm38
MGSCv371862,338,103 - 62,338,217UniSTSGRCm37
Celera1863,463,439 - 63,463,553UniSTS
Cytogenetic Map18E1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381862,178,444 - 62,178,824UniSTSGRCm38
MGSCv371862,338,098 - 62,338,478UniSTSGRCm37
Celera1863,463,434 - 63,463,814UniSTS
Cytogenetic Map18E1UniSTS
cM Map1834.0UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181389696666965891Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182953484763534993Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183010000064100000Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183185541365855562Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183295797666958154Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183552556069525779Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183615795070158108Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183807349772073497Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183807349772073497Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183807349772073497Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183807349772073497Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183897060572970721Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183948686184620653Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184317804877178271Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184499753768645706Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184629021680290216Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184674183280741971Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184674183280741971Mouse
27226720Tibw5_mtibia width 5, proximal, 10 week (mouse)185030000062500000Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185091908584919240Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185091908584919240Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185153522985535397Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185153522985535397Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185267220586672345Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185283308468645706Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185315795076826598Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185484280185496018Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185630000090300000Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185630000090300000Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185666155866819414Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185730000090702639Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185742926790702639Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5745748782586603Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5785721090702639Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185788832769216071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185904702190702639Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185904702190702639Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185904702190702639Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185982648990702639Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185984762690702639Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186000000080000000Mouse
10412265Par7_mpulmonary adenoma resistance 7 (mouse)Not determined186113937667919240Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186113937674429343Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186113937681448616Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186113937682586603Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:153
Interacting mature miRNAs:162
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000053640   ⟹   ENSMUSP00000062256
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)Ensembl
RefSeq Acc Id: NM_007420   ⟹   NP_031446
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391862,310,784 - 62,313,052 (-)NCBI
GRCm381862,177,713 - 62,179,981 (-)NCBI
MGSCv371862,337,470 - 62,339,613 (-)RGD
Celera1863,462,701 - 63,464,971 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_031446   ⟸   NM_007420
- UniProtKB: P18762 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000062256   ⟸   ENSMUST00000053640
Protein Domains

RGD ID:6850206
Promoter ID:EP29017
Type:single initiation site
Description:beta 2-Adrenergic receptor, ADRB2 or ADRB2R gene
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database,
Notes:homology_group=Homology group 159; Mammalian beta 2-adrenergic receptor
Experiment Methods:Nuclease protection; Nuclease protection; transfected or transformed cells
Regulation:various tissues; (induced by or strongly expressed in) butyrate, (induced by or strongly expressed in) glucc
Mouse AssemblyChrPosition (strand)Source
MGSCv36Un2,000 - 2,060EPD
RGD ID:13677974
Promoter ID:EPDNEW_M23136
Type:multiple initiation site
Description:Mus musculus adrenergic receptor, beta 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381862,179,978 - 62,180,038EPDNEW
RGD ID:6829042
Promoter ID:MM_KWN:25447
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000067743,   NM_007420
Mouse AssemblyChrPosition (strand)Source
MGSCv361862,336,986 - 62,340,312 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87938 AgrOrtholog
Ensembl Genes ENSMUSG00000045730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000062256 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053640 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11555 UniProtKB/Swiss-Prot
PANTHER PTHR24248:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adrb2 PhenoGen
  ADRENRGCB2AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADRB2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8BH38 UniProtKB/Swiss-Prot