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Gene: Stx1a (syntaxin 1A (brain)) Mus musculus
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Symbol: Stx1a
Name: syntaxin 1A (brain)
Description: Exhibits SNARE binding activity and calcium channel inhibitor activity. Involved in modulation of chemical synaptic transmission; secretion by cell; and vesicle docking. Localizes to several cellular components, including nuclear membrane; secretory vesicle; and synaptobrevin 2-SNAP-25-syntaxin-1a complex. Predicted to colocalize with voltage-gated potassium channel complex. Is expressed in several structures, including adrenal gland; diaphragm; intercostal muscle; nervous system; and retina. Used to study disease of mental health. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HPC-1; neuron-specific antigen HPC-1; syntaxin 1 a; syntaxin-1A
Orthologs:
Homo sapiens (human) : STX1A (syntaxin 1A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Stx1a (syntaxin 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Stx1a (syntaxin 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : STX1A (syntaxin 1A)
Canis lupus familiaris (dog) : STX1A (syntaxin 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Stx1a (syntaxin 1A)
Chlorocebus sabaeus (African green monkey) : STX1A (syntaxin 1A)
Heterocephalus glaber (naked mole-rat) : Stx1a (syntaxin 1A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl5135,023,482 - 135,051,100 (+)EnsemblGRCm38mm10GRCm38
GRCm385135,023,482 - 135,051,100 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375135,499,442 - 135,526,969 (+)NCBIGRCm37mm9NCBIm37
MGSCv365135,308,199 - 135,335,726 (+)NCBImm8
Celera5132,033,901 - 132,061,428 (+)NCBICelera
Cytogenetic Map5G2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Stx1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69486
Created: 2001-11-27
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.