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Gene: Stx1a (syntaxin 1A (brain)) Mus musculus
Symbol: Stx1a
Name: syntaxin 1A (brain)
Description: Exhibits SNARE binding activity and calcium channel inhibitor activity. Involved in modulation of chemical synaptic transmission; secretion by cell; and vesicle docking. Localizes to several cellular components, including nuclear membrane; secretory vesicle; and synaptobrevin 2-SNAP-25-syntaxin-1a complex. Predicted to colocalize with voltage-gated potassium channel complex. Is expressed in several structures, including adrenal gland; diaphragm; intercostal muscle; nervous system; and retina. Used to study disease of mental health. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HPC-1; neuron-specific antigen HPC-1; syntaxin 1 a; syntaxin-1A
Homo sapiens (human) : STX1A (syntaxin 1A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Stx1a (syntaxin 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Stx1a (syntaxin 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : STX1A (syntaxin 1A)
Canis lupus familiaris (dog) : STX1A (syntaxin 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Stx1a (syntaxin 1A)
Chlorocebus sabaeus (African green monkey) : STX1A (syntaxin 1A)
Heterocephalus glaber (naked mole-rat) : Stx1a (syntaxin 1A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5135,023,482 - 135,051,100 (+)EnsemblGRCm38mm10GRCm38
GRCm385135,023,482 - 135,051,100 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375135,499,442 - 135,526,969 (+)NCBIGRCm37mm9NCBIm37
MGSCv365135,308,199 - 135,335,726 (+)NCBImm8
Celera5132,033,901 - 132,061,428 (+)NCBICelera
Cytogenetic Map5G2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Stx1a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69486
Created: 2001-11-27
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.