Per2 (period circadian clock 2) - Rat Genome Database

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Gene: Per2 (period circadian clock 2) Mus musculus
Analyze
Symbol: Per2
Name: period circadian clock 2
RGD ID: 62238
MGI Page MGI
Description: Enables several functions, including enzyme binding activity; nucleic acid binding activity; and transcription corepressor binding activity. Involved in several processes, including gluconeogenesis; monocarboxylic acid metabolic process; and regulation of gene expression. Acts upstream of or within circadian rhythm and negative regulation of transcription by RNA polymerase II. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study advanced sleep phase syndrome 1. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and advanced sleep phase syndrome 1. Orthologous to human PER2 (period circadian regulator 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: circadian clock protein PERIOD 2; mKIAA0347; mPe; mPer2; period 2; period circadian protein homolog 2; period homolog 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,343,699 - 91,387,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,343,704 - 91,387,046 (-)EnsemblGRCm39 Ensembl
GRCm38191,415,977 - 91,459,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,312,559 - 93,355,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,246,388 - 93,289,702 (-)NCBIMGSCv36mm8
Celera194,353,350 - 94,396,834 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acamprosate  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chloroprene  (EXP,ISO)
choline  (EXP)
chrysene  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
Erionite  (EXP)
ethanol  (EXP,ISO)
ferric oxide  (EXP)
flavonoids  (ISO)
fluoranthene  (EXP)
fluoxetine  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glycine betaine  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
linsidomine  (EXP)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
milrinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morphine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
orphenadrine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
plumbagin  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
styrene  (EXP)
sulforaphane  (EXP)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
torcetrapib  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP,ISO)
zalcitabine  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (ISO,TAS)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,IPI,ISO)
perinuclear region of cytoplasm  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal basal metabolism  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal body weight  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone mineralization  (IEA)
abnormal brain wave pattern  (IAGP)
abnormal circadian behavior  (IEA)
abnormal circadian behavior period  (IAGP)
abnormal circadian behavior phase  (IAGP)
abnormal circadian sleep/wake cycle  (IAGP)
abnormal circadian temperature homeostasis  (IAGP)
abnormal circardian behavior entrainment  (IAGP)
abnormal coat/hair pigmentation  (IEA)
abnormal eye physiology  (IAGP)
abnormal fibroblast physiology  (IAGP)
abnormal food intake  (IAGP)
abnormal food preference  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hypothalamus physiology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor circadian rhythm  (IAGP)
abnormal male preputial gland morphology  (IAGP)
abnormal maternal behavior  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal pregnancy  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal urine catecholamine level  (IAGP)
absent estrous cycle  (IAGP)
arrhythmic circadian behavior persistence  (IAGP)
decreased bone ossification  (IAGP)
decreased cellular sensitivity to gamma-irradiation  (IAGP)
decreased hematopoietic stem cell proliferation  (IAGP)
decreased litter size  (IAGP)
decreased osteoblast cell number  (IAGP)
delayed circadian behavior phase  (IEA)
early reproductive senescence  (IAGP)
enhanced behavioral response to cocaine  (IAGP)
enhanced conditioned place preference behavior  (IAGP)
impaired wound healing  (IAGP)
improved glucose tolerance  (IAGP)
increased body weight  (IAGP)
increased bone mass  (IAGP)
increased bone ossification  (IAGP)
increased bone volume  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating leptin level  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased lymphoma incidence  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoblast proliferation  (IAGP)
increased salivary gland tumor incidence  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
prolonged circadian behavior period  (IAGP)
prolonged estrous cycle  (IAGP)
pup cannibalization  (IAGP)
reduced female fertility  (IAGP)
salivary gland epithelial hyperplasia  (IAGP)
shortened circadian behavior period  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Reduced expression of circadian clock genes in male alcoholic patients. Huang MC, etal., Alcohol Clin Exp Res. 2010 Nov;34(11):1899-904. doi: 10.1111/j.1530-0277.2010.01278.x. Epub 2010 Aug 24.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2. Perreau-Lenz S, etal., Eur Neuropsychopharmacol. 2010 Jul;20(7):509-17. doi: 10.1016/j.euroneuro.2010.03.006.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. Shumay E, etal., Transl Psychiatry. 2012 Mar 6;2(3):e86. doi: 10.1038/tp.2012.11.
11. A light-independent oscillatory gene mPer3 in mouse SCN and OVLT. Takumi T, etal., EMBO J 1998 Aug 17;17(16):4753-9.
12. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Toh KL, etal., Science. 2001 Feb 9;291(5506):1040-3.
Additional References at PubMed
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PMID:12084940   PMID:12150932   PMID:12372028   PMID:12372299   PMID:12374857   PMID:12381662   PMID:12383239   PMID:12466851   PMID:12477932   PMID:12531511   PMID:12622829   PMID:12693553  
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PMID:20030538   PMID:20043880   PMID:20053965   PMID:20059953   PMID:20061537   PMID:20072700   PMID:20075296   PMID:20159955   PMID:20180860   PMID:20211142   PMID:20236181   PMID:20300063  
PMID:20352049   PMID:20370466   PMID:20404168   PMID:20421981   PMID:20450826   PMID:20539819   PMID:20543573   PMID:20560710   PMID:20562852   PMID:20634945   PMID:20668203   PMID:20696890  
PMID:20826680   PMID:20829506   PMID:20832105   PMID:20840750   PMID:20887817   PMID:20932939   PMID:20944004   PMID:20947768   PMID:20967239   PMID:21035761   PMID:21113167   PMID:21151601  
PMID:21156215   PMID:21179498   PMID:21186050   PMID:21267068   PMID:21285316   PMID:21324900   PMID:21366728   PMID:21382453   PMID:21392557   PMID:21458659   PMID:21488990   PMID:21549097  
PMID:21559484   PMID:21613214   PMID:21624349   PMID:21628550   PMID:21655193   PMID:21680841   PMID:21703244   PMID:21768648   PMID:21773940   PMID:21793695   PMID:21818120   PMID:21873635  
PMID:21901130   PMID:21915348   PMID:21929298   PMID:21969583   PMID:22039518   PMID:22043319   PMID:22069332   PMID:22080784   PMID:22140039   PMID:22154820   PMID:22158133   PMID:22159024  
PMID:22170608   PMID:22184247   PMID:22208286   PMID:22210883   PMID:22236088   PMID:22238756   PMID:22261359   PMID:22274616   PMID:22331899   PMID:22341446   PMID:22342842   PMID:22362755  
PMID:22405069   PMID:22460952   PMID:22504074   PMID:22504483   PMID:22558277   PMID:22723262   PMID:22734566   PMID:22745491   PMID:22764243   PMID:22767893   PMID:22823489   PMID:22833565  
PMID:22891330   PMID:22905719   PMID:22934083   PMID:22936566   PMID:22966205   PMID:22988135   PMID:22988430   PMID:23024437   PMID:23039899   PMID:23079727   PMID:23110090   PMID:23193187  
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PMID:24767996   PMID:24770415   PMID:24797626   PMID:24829500   PMID:24842115   PMID:24843129   PMID:24845399   PMID:24855952   PMID:24897937   PMID:24933288   PMID:24952961   PMID:24997189  
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PMID:25525750   PMID:25573753   PMID:25581923   PMID:25660546   PMID:25689298   PMID:25741729   PMID:25741730   PMID:25756610   PMID:25779967   PMID:25821984   PMID:25846207   PMID:25888034  
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PMID:29447160   PMID:29463694   PMID:29463714   PMID:29478834   PMID:29481323   PMID:29490985   PMID:29491349   PMID:29518531   PMID:29533925   PMID:29540683   PMID:29555746   PMID:29561690  
PMID:29610316   PMID:29626648   PMID:29688375   PMID:29750810   PMID:29760192   PMID:29784789   PMID:29899468   PMID:29931690   PMID:29937374   PMID:29965797   PMID:29982483   PMID:30017392  
PMID:30031683   PMID:30242505   PMID:30283092   PMID:30287844   PMID:30321360   PMID:30321586   PMID:30429219   PMID:30452546   PMID:30487216   PMID:30527742   PMID:30612576   PMID:30630934  
PMID:30710088   PMID:30744968   PMID:30773466   PMID:30782483   PMID:30794439   PMID:30822304   PMID:30884411   PMID:31006590   PMID:31136603   PMID:31138685   PMID:31189119   PMID:31189882  
PMID:31211910   PMID:31260634   PMID:31263776   PMID:31296902   PMID:31308426   PMID:31358797   PMID:31390562   PMID:31398249   PMID:31420455   PMID:31428688   PMID:31522764   PMID:31607531  
PMID:31687929   PMID:31746738   PMID:31797953   PMID:31822134   PMID:31847374   PMID:31848250   PMID:31875550   PMID:31879343   PMID:31907414   PMID:31914667   PMID:31919902   PMID:31930968  
PMID:32245954   PMID:32325033   PMID:32348614   PMID:32354999   PMID:32369735   PMID:32385329   PMID:32433970   PMID:32455427   PMID:32543667   PMID:32555162   PMID:32555251   PMID:32613762  
PMID:32615095   PMID:32644041   PMID:32681096   PMID:32768389   PMID:32796949   PMID:32888430   PMID:32896721   PMID:32968200   PMID:33053337   PMID:33086741   PMID:33123539   PMID:33135952  
PMID:33202247   PMID:33207207   PMID:33234609   PMID:33382840   PMID:33443219   PMID:33491228   PMID:33526663   PMID:33554778   PMID:33606281   PMID:33621249   PMID:33913482   PMID:34009269  
PMID:34011974   PMID:34048425   PMID:34112905   PMID:34160105   PMID:34426495   PMID:34529765   PMID:34584158   PMID:34632336   PMID:34661529   PMID:34695438   PMID:34702951   PMID:34705514  
PMID:34732735   PMID:34741086   PMID:34851661   PMID:34887762   PMID:34895464   PMID:34968386   PMID:34974160   PMID:35023384   PMID:35046033   PMID:35172136   PMID:35272486   PMID:35386071  
PMID:35401134   PMID:35418126   PMID:35443162   PMID:35460695   PMID:35486444   PMID:35584682   PMID:35606517   PMID:35755440   PMID:35806403   PMID:35810166   PMID:35902736   PMID:35910841  
PMID:35933488   PMID:36194579   PMID:36213234   PMID:36285301   PMID:36350921   PMID:36361751   PMID:36450499   PMID:36465103   PMID:36638184   PMID:36724252   PMID:36764158   PMID:36871756  
PMID:36882059   PMID:37092429   PMID:37141987   PMID:37162693   PMID:37215573   PMID:37349305   PMID:37621713   PMID:37643163   PMID:37657440   PMID:37769257   PMID:37951213   PMID:37951214  
PMID:38221535   PMID:38229522  


Genomics

Comparative Map Data
Per2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,343,699 - 91,387,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,343,704 - 91,387,046 (-)EnsemblGRCm39 Ensembl
GRCm38191,415,977 - 91,459,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,312,559 - 93,355,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,246,388 - 93,289,702 (-)NCBIMGSCv36mm8
Celera194,353,350 - 94,396,834 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.13NCBI
PER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,244,044 - 238,300,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,244,044 - 238,290,102 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,152,685 - 239,197,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,817,418 - 238,861,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 342238,934,685 - 238,979,092NCBI
Celera2232,865,233 - 232,909,762 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,943,837 - 230,988,232 (-)NCBIHuRef
CHM1_12239,158,528 - 239,203,056 (-)NCBICHM1_1
T2T-CHM13v2.02238,733,782 - 238,779,869 (-)NCBIT2T-CHM13v2.0
Per2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,454,828 - 99,497,069 (-)NCBIGRCr8
mRatBN7.2992,007,289 - 92,049,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,434,053 - 100,476,216 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,569,813 - 105,611,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,933,398 - 103,975,592 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,555,154 - 98,597,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,231,202 - 98,273,371 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,645,342 - 90,687,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,850,110 - 90,892,278 (-)NCBI
Celera989,548,336 - 89,590,505 (-)NCBICelera
Cytogenetic Map9q36NCBI
Per2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,338,099 - 2,371,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555422,331,547 - 2,369,011 (+)NCBIChiLan1.0ChiLan1.0
PER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,876,886 - 140,921,469 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,891,847 - 140,936,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,477,021 - 125,521,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,328,122 - 244,371,040 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B244,328,122 - 244,371,040 (-)Ensemblpanpan1.1panPan2
PER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,716,499 - 48,761,617 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,717,173 - 48,758,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,211,912 - 49,257,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,102,140 - 49,147,315 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,102,151 - 49,143,375 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,977,242 - 49,022,398 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,765,877 - 48,806,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,998,242 - 49,043,270 (-)NCBIUU_Cfam_GSD_1.0
Per2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,676,406 - 190,718,243 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525221,510 - 263,295 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936525221,601 - 263,284 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,793,422 - 137,837,070 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,793,419 - 137,837,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,264,819 - 152,284,153 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,270,917 - 124,316,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,269,543 - 124,315,904 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,104,175 - 75,149,164 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Per2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,361,170 - 3,390,405 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,359,174 - 3,399,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Per2
1288 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:775
Count of miRNA genes:470
Interacting mature miRNAs:559
Transcripts:ENSMUST00000069620
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse

Markers in Region
PMC124275P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38191,417,344 - 91,417,845UniSTSGRCm38
MGSCv37193,313,921 - 93,314,422UniSTSGRCm37
Celera194,354,712 - 94,355,213UniSTS
Cytogenetic Map1C5UniSTS
Per2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C5UniSTS
cM Map146.13UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000069620   ⟹   ENSMUSP00000066620
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,343,704 - 91,387,046 (-)Ensembl
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185298
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,375,444 - 91,377,587 (-)Ensembl
GRCm38.p6 Ensembl191,447,722 - 91,449,865 (-)Ensembl
RefSeq Acc Id: NM_001420881   ⟹   NP_001407810
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,704 - 91,387,028 (-)NCBI
RefSeq Acc Id: NM_011066   ⟹   NP_035196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,704 - 91,387,028 (-)NCBI
GRCm38191,415,982 - 91,459,328 (-)NCBI
MGSCv37193,312,559 - 93,355,905 (-)RGD
Celera194,353,350 - 94,396,834 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_185210
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,704 - 91,387,028 (-)NCBI
RefSeq Acc Id: XM_006529250   ⟹   XP_006529313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,343,699 - 91,373,833 (-)NCBI
GRCm38191,415,977 - 91,446,017 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035196   ⟸   NM_011066
- Peptide Label: isoform 1
- UniProtKB: A0A0R4J0U3 (UniProtKB/TrEMBL),   Q3TN36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006529313   ⟸   XM_006529250
- Peptide Label: isoform X2
- UniProtKB: Q3TN36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000066620   ⟸   ENSMUST00000069620
RefSeq Acc Id: NP_001407810   ⟸   NM_001420881
- Peptide Label: isoform 2
- UniProtKB: Q3TN36 (UniProtKB/TrEMBL)
Protein Domains
PAC   PAS   Period circadian-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54943-F1-model_v2 AlphaFold O54943 1-1257 view protein structure

Promoters
RGD ID:6874488
Promoter ID:EPDNEW_M695
Type:initiation region
Name:Per2_1
Description:Mus musculus period circadian clock 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38191,459,306 - 91,459,366EPDNEW
RGD ID:6846632
Promoter ID:MM_ACW:1727
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:PER2.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,320,491 - 93,320,991 (-)MPROMDB
RGD ID:6818226
Promoter ID:MM_KWN:1632
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000069620,   UC007CAW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,355,631 - 93,356,131 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1195265 AgrOrtholog
Ensembl Genes ENSMUSG00000055866 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069620 ENTREZGENE
  ENSMUST00000069620.10 UniProtKB/TrEMBL
Gene3D-CATH PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Per1-3_PAS-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Period_circadian-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1195265 ENTREZGENE
NCBI Gene 18627 ENTREZGENE
PANTHER PERIOD CIRCADIAN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PERIOD CIRCADIAN PROTEIN HOMOLOG 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAS_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Per3-like_PAS-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Period_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Per2 PhenoGen
PROSITE PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0U3 ENTREZGENE, UniProtKB/TrEMBL
  O54943 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TN36 ENTREZGENE, UniProtKB/TrEMBL
  Q3TW41_MOUSE UniProtKB/TrEMBL
  Q7TMG5_MOUSE UniProtKB/TrEMBL
  Q8C8R0_MOUSE UniProtKB/TrEMBL
UniProt Secondary O54954 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-08 Per2  period circadian clock 2    period homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED