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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pramipexole
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Accession:CHEBI:8356 term browser browse the term
Definition:A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.
Synonyms:exact_synonym: (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
 related_synonym: 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-;   Formula=C10H17N3S;   InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1;   InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N;   SMILES=CCCN[C@H]1CCc2nc(N)sc2C1;   pramipexol;   pramipexolum
 xref: Beilstein:6479326;   CAS:104632-26-0;   DrugBank:DB00413;   Drug_Central:2233;   KEGG:D00559;   KEGG:D05575;   LINCS:LSM-5243
 xref_mesh: MESH:C061333
 xref: Patent:EP186087;   Patent:US4886812;   Wikipedia:Pramipexole
 cyclic_relationship: is_conjugate_base_of CHEBI:63218


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pramipexole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] CTD PMID:16362428 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP
ISO		 pramipexole binds to and results in increased activity of DRD2 protein CTD PMID:10728880 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO pramipexole binds to and results in increased activity of DRD3 protein CTD PMID:10728880 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:16362428 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] CTD PMID:16362428 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      chemical role 19316
        antioxidant 14437
          radical scavenger 6242
            pramipexole 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            inorganic hydride 17688
                              pnictogen hydride 17668
                                nitrogen hydride 17540
                                  azane 17273
                                    ammonia 17272
                                      organic amino compound 17272
                                        polyamine 8277
                                          diamine 8205
                                            pramipexole 5
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