CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pramipexole
Accession: CHEBI:8356
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Definition: A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.
Synonyms: exact_synonym: (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
related_synonym: 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-; Formula=C10H17N3S; InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1; InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N; SMILES=CCCN[C@H]1CCc2nc(N)sc2C1; pramipexol; pramipexolum
xref: Beilstein:6479326; CAS:104632-26-0; DrugBank:DB00413; Drug_Central:2233; KEGG:D00559; KEGG:D05575; LINCS:LSM-5243
xref_mesh: MESH:C061333
xref: Patent:EP186087; Patent:US4886812; Wikipedia:Pramipexole
cyclic_relationship: is_conjugate_base_of CHEBI:63218
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Casp3
caspase 3
multiple interactions
EXP
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
CTD
PMID:16362428
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Drd2
dopamine receptor D2
multiple interactions
EXP ISO
pramipexole binds to and results in increased activity of DRD2 protein
CTD
PMID:10728880
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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Drd3
dopamine receptor D3
multiple interactions
ISO
pramipexole binds to and results in increased activity of DRD3 protein
CTD
PMID:10728880
NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
CTD
PMID:16362428
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
EXP
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]
CTD
PMID:16362428
NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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