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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pramipexole
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Accession:CHEBI:8356 term browser browse the term
Definition:A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.
Synonyms:exact_synonym: (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
 related_synonym: 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-;   Formula=C10H17N3S;   InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1;   InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N;   SMILES=CCCN[C@H]1CCc2nc(N)sc2C1;   pramipexol;   pramipexolum
 xref: Beilstein:6479326;   CAS:104632-26-0;   DrugBank:DB00413;   Drug_Central:2233;   KEGG:D00559;   KEGG:D05575;   LINCS:LSM-5243
 xref_mesh: MESH:C061333
 xref: Patent:EP186087;   Patent:US4886812;   Wikipedia:Pramipexole
 cyclic_relationship: is_conjugate_base_of CHEBI:63218

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pramipexole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] CTD PMID:16362428 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP
ISO		 pramipexole binds to and results in increased activity of DRD2 protein CTD PMID:10728880 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO pramipexole binds to and results in increased activity of DRD3 protein CTD PMID:10728880 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:16362428 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] CTD PMID:16362428 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      chemical role 19309
        antioxidant 14234
          radical scavenger 5211
            pramipexole 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            inorganic hydride 17483
                              pnictogen hydride 17456
                                nitrogen hydride 17300
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        polyamine 8224
                                          diamine 8152
                                            pramipexole 5
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