CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: EC 3.1.26.13 (retroviral ribonuclease H) inhibitor
Accession: CHEBI:52629
browse the term
Definition: An inhibitor of ribonuclease H (EC 3.1.26.13), an enzyme required for specific hydrolysis of the RNA strand of an RNA/DNA hybrid.
Synonyms: related_synonym: EC 3.1.26.13 (retroviral ribonuclease H) inhibitors; EC 3.1.26.13 inhibitor; EC 3.1.26.13 inhibitors; HIV RNase H inhibitor; HIV RNase H inhibitors; HIV-1 RNase H inhibitor; HIV-1 RNase H inhibitors; HIV-1 ribonuclease H inhibitor; HIV-1 ribonuclease H inhibitors; RT/RNase H inhibitor; RT/RNase H inhibitors; retroviral reverse transcriptase RNaseH inhibitor; retroviral reverse transcriptase RNaseH inhibitors; retroviral ribonuclease H inhibitor
xref: Wikipedia:Retroviral_ribonuclease_H
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions increases export decreases export
ISO
[Estradiol results in decreased activity of ABCG2 protein] which results in increased uptake of abacavir; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCG2 protein] which results in increased uptake of abacavir 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of abacavir]; Elacridar inhibits the reaction [ABCG2 protein results in decreased export of abacavir]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of abacavir]; Nelfinavir inhibits the reaction [ABCG2 protein results in increased export of abacavir]; pluronic block copolymer p85 inhibits the reaction [ABCG2 protein results in increased export of abacavir]
CTD
PMID:17437964 PMID:19056916 PMID:25844889
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Alb
albumin
affects binding multiple interactions
ISO
abacavir binds to ALB protein abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a2
aldehyde dehydrogenase 1 family, member A2
decreases expression
ISO
abacavir results in decreased expression of ALDH1A2 mRNA
CTD
PMID:31711903
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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Crp
C-reactive protein
increases expression
ISO
abacavir results in increased expression of CRP protein
CTD
PMID:19891054
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
abacavir results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
abacavir results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Eya1
EYA transcriptional coactivator and phosphatase 1
decreases expression
ISO
abacavir results in decreased expression of EYA1 mRNA
CTD
PMID:31711903
NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
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Fgf8
fibroblast growth factor 8
increases expression
ISO
abacavir results in increased expression of FGF8 mRNA
CTD
PMID:31711903
NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
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Foxc2
forkhead box C2
decreases expression
ISO
abacavir results in decreased expression of FOXC2 mRNA
CTD
PMID:31711903
NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737
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Gfap
glial fibrillary acidic protein
increases expression
ISO
abacavir results in increased expression of GFAP protein
CTD
PMID:19358275
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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Hoxb7
homeo box B7
increases expression
ISO
abacavir results in increased expression of HOXB7 mRNA
CTD
PMID:31711903
NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
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Hoxb9
homeo box B9
increases expression
ISO
abacavir results in increased expression of HOXB9 mRNA
CTD
PMID:31711903
NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
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Ifng
interferon gamma
multiple interactions
ISO
[HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IFNG protein
CTD
PMID:23541086
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il13
interleukin 13
multiple interactions
ISO
[HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IL13 protein
CTD
PMID:23541086
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il4
interleukin 4
affects response to substance
ISO
IL4 protein affects the susceptibility to abacavir
CTD
PMID:15867870
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Meox1
mesenchyme homeobox 1
decreases expression
ISO
abacavir results in decreased expression of MEOX1 mRNA
CTD
PMID:31711903
NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
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Mesp2
mesoderm posterior bHLH transcription factor 2
decreases expression
ISO
abacavir results in decreased expression of MESP2 mRNA
CTD
PMID:31711903
NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198
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Mmp9
matrix metallopeptidase 9
increases expression
ISO
abacavir results in increased expression of MMP9 protein
CTD
PMID:19891054
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
increases expression
ISO
abacavir results in increased expression of MPO protein
CTD
PMID:19891054
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Neurog2
neurogenin 2
increases expression
ISO
abacavir results in increased expression of NEUROG2 mRNA
CTD
PMID:31711903
NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154
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Olig3
oligodendrocyte transcription factor 3
increases expression
ISO
abacavir results in increased expression of OLIG3 mRNA
CTD
PMID:31711903
NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149
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Pax3
paired box 3
decreases expression
ISO
abacavir results in decreased expression of PAX3 mRNA
CTD
PMID:31711903
NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
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Pax6
paired box 6
increases expression
ISO
abacavir results in increased expression of PAX6 mRNA
CTD
PMID:31711903
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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Pdcd1
programmed cell death 1
multiple interactions
ISO
[HLA-B protein alternative form results in increased susceptibility to abacavir] which results in increased expression of PDCD1
CTD
PMID:34606953
NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
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Slc22a1
solute carrier family 22 member 1
multiple interactions
ISO
[Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir
CTD
PMID:25844889
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Syp
synaptophysin
increases expression
ISO
abacavir results in increased expression of SYP protein
CTD
PMID:19358275
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Tcf15
transcription factor 15
decreases expression
ISO
abacavir results in decreased expression of TCF15 mRNA
CTD
PMID:31711903
NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
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Tert
telomerase reverse transcriptase
decreases activity
ISO
abacavir results in decreased activity of TERT protein
CTD
PMID:19358275
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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Tnf
tumor necrosis factor
multiple interactions
ISO
[HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of TNF protein
CTD
PMID:23541086
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ucp1
uncoupling protein 1
increases expression
ISO
abacavir results in increased expression of UCP1 mRNA
CTD
PMID:14518702
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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Uncx
UNC homeobox
decreases expression
ISO
abacavir results in decreased expression of UNCX mRNA
CTD
PMID:31711903
NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
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Abcb4
ATP binding cassette subfamily B member 4
multiple interactions affects transport
EXP
Calcitriol promotes the reaction [ABCB4 protein affects the transport of adefovir]
CTD
PMID:21240898 PMID:21341280
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc4
ATP binding cassette subfamily C member 4
affects abundance multiple interactions decreases expression increases export
ISO EXP
ABCC4 protein affects the abundance of adefovir [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid] results in decreased expression of ABCC4 protein adefovir results in decreased expression of ABCC4 protein ABCC4 protein results in increased export of adefovir
CTD
PMID:18364470 PMID:35114312
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Acta2
actin alpha 2, smooth muscle
increases expression multiple interactions
EXP
adefovir results in increased expression of ACTA2 protein [adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]
CTD
PMID:35114312
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Agt
angiotensinogen
multiple interactions
EXP
[Probenecid co-treated with adefovir] results in increased expression of AGT protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]
CTD
PMID:35114312
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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B2m
beta-2 microglobulin
increases secretion
EXP
adefovir results in increased secretion of B2M protein
CTD
PMID:27742868
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Calb1
calbindin 1
increases secretion
EXP
adefovir results in increased secretion of CALB1 protein
CTD
PMID:27742868
NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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Cma1
chymase 1
increases secretion
EXP
adefovir results in increased secretion of CMA1 protein
CTD
PMID:35114312
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
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Cst3
cystatin C
multiple interactions increases expression
EXP
[adefovir co-treated with Probenecid] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan] inhibits the reaction [adefovir results in increased expression of CST3 protein]; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein]
CTD
PMID:35114312
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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Havcr1
hepatitis A virus cellular receptor 1
increases secretion
EXP
adefovir results in increased secretion of HAVCR1 protein
CTD
PMID:27742868
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Lcn2
lipocalin 2
increases secretion
EXP
adefovir results in increased secretion of LCN2 protein
CTD
PMID:27742868
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Mmut
methylmalonyl-CoA mutase
affects expression increases expression
ISO
adefovir affects the expression of MMUT mRNA mutant form; adefovir affects the expression of MMUT protein mutant form adefovir results in increased expression of MMUT mRNA; adefovir results in increased expression of MMUT protein
CTD
PMID:19199343 PMID:19427250
NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
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Slc22a6
solute carrier family 22 member 6
increases uptake multiple interactions decreases expression affects response to substance increases response to substance
EXP ISO
SLC22A6 protein results in increased uptake of adefovir [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein] adefovir results in decreased expression of SLC22A6 protein SLC22A6 protein affects the susceptibility to adefovir adefovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]; quercetin 3'-sulfate inhibits the reaction [SLC22A6 protein affects the susceptibility to adefovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to adefovir
CTD
PMID:16857889 PMID:21244849 PMID:23856525 PMID:25448811 PMID:35114312
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
increases response to substance multiple interactions decreases expression
ISO EXP
SLC22A8 protein results in increased susceptibility to adefovir [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein] adefovir results in decreased expression of SLC22A8 protein
CTD
PMID:25448811 PMID:35114312
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Spp1
secreted phosphoprotein 1
increases secretion
EXP
adefovir results in increased secretion of SPP1 protein
CTD
PMID:27742868
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Tgfb1
transforming growth factor, beta 1
increases expression multiple interactions
EXP
adefovir results in increased expression of TGFB1 protein [adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]
CTD
PMID:35114312
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Ahr
aryl hydrocarbon receptor
affects activity
ISO
adefovir dipivoxil affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ak4
adenylate kinase 4
increases expression
ISO
adefovir dipivoxil results in increased expression of AK4 mRNA
CTD
PMID:25596134
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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Akr1c2
aldo-keto reductase family 1, member C2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of AKR1C2 mRNA
CTD
PMID:25596134
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
ISO
adefovir dipivoxil results in increased expression of ALDH1A3 mRNA
CTD
PMID:25596134
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Als2cl
ALS2 C-terminal like
increases expression
ISO
adefovir dipivoxil results in increased expression of ALS2CL mRNA
CTD
PMID:25596134
NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419
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Angptl4
angiopoietin-like 4
increases expression
ISO
adefovir dipivoxil results in increased expression of ANGPTL4 mRNA
CTD
PMID:25596134
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ASNS mRNA
CTD
PMID:25596134
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Atad2
ATPase family, AAA domain containing 2
increases expression
ISO
adefovir dipivoxil results in increased expression of ATAD2 mRNA
CTD
PMID:25596134
NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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Atf3
activating transcription factor 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ATF3 mRNA
CTD
PMID:25596134
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Aurkb
aurora kinase B
increases expression
ISO
adefovir dipivoxil results in increased expression of AURKB mRNA
CTD
PMID:25596134
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Axl
Axl receptor tyrosine kinase
increases expression
ISO
adefovir dipivoxil results in increased expression of AXL mRNA
CTD
PMID:25596134
NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
adefovir dipivoxil results in increased expression of BAX mRNA
CTD
PMID:25596134
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcar3
BCAR3 adaptor protein, NSP family member
increases expression
ISO
adefovir dipivoxil results in increased expression of BCAR3 mRNA
CTD
PMID:25596134
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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Bend5
BEN domain containing 5
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BEND5 mRNA
CTD
PMID:25596134
NCBI chr 5:126,290,648...126,336,662
Ensembl chr 5:125,254,956...126,534,367
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Bmf
Bcl2 modifying factor
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BMF mRNA
CTD
PMID:25596134
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
adefovir dipivoxil results in increased expression of BTG2 mRNA
CTD
PMID:25596134
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Ccne2
cyclin E2
increases expression
ISO
adefovir dipivoxil results in increased expression of CCNE2 mRNA
CTD
PMID:25596134
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cdk6
cyclin-dependent kinase 6
increases expression
ISO
adefovir dipivoxil results in increased expression of CDK6 mRNA
CTD
PMID:25596134
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
adefovir dipivoxil results in increased expression of CDKN1A mRNA
CTD
PMID:25596134
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cmbl
carboxymethylenebutenolidase homolog
increases expression
ISO
adefovir dipivoxil results in increased expression of CMBL mRNA
CTD
PMID:25596134
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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Coch
cochlin
increases expression
ISO
adefovir dipivoxil results in increased expression of COCH mRNA
CTD
PMID:25596134
NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109
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Col4a1
collagen type IV alpha 1 chain
decreases expression
ISO
adefovir dipivoxil results in decreased expression of COL4A1 mRNA
CTD
PMID:25596134
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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Cth
cystathionine gamma-lyase
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Ctsc
cathepsin C
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTSC mRNA
CTD
PMID:25596134
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
adefovir dipivoxil results in increased expression of CYP1B1 mRNA
CTD
PMID:25596134
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
adefovir dipivoxil results in decreased activity of CYP3A4 protein
CTD
PMID:17162464
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Ddb2
damage specific DNA binding protein 2
increases expression
ISO
adefovir dipivoxil results in increased expression of DDB2 mRNA
CTD
PMID:25596134
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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Dgka
diacylglycerol kinase, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of DGKA mRNA
CTD
PMID:25596134
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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Dlgap5
DLG associated protein 5
increases expression
ISO
adefovir dipivoxil results in increased expression of DLGAP5 mRNA
CTD
PMID:25596134
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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Dlx1
distal-less homeobox 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of DLX1 mRNA
CTD
PMID:25596134
NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780
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Dnai3
dynein axonemal intermediate chain 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DNAI3 mRNA
CTD
PMID:25596134
NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173
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Dpysl3
dihydropyrimidinase-like 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DPYSL3 mRNA
CTD
PMID:25596134
NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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Efna1
ephrin A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of EFNA1 mRNA
CTD
PMID:25596134
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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Fas
Fas cell surface death receptor
increases expression
ISO
adefovir dipivoxil results in increased expression of FAS mRNA
CTD
PMID:25596134
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fbxo22
F-box protein 22
increases expression
ISO
adefovir dipivoxil results in increased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
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Gabarapl1
GABA type A receptor associated protein like 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA
CTD
PMID:25596134
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of GADD45A mRNA
CTD
PMID:25596134
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Galnt16
polypeptide N-acetylgalactosaminyltransferase 16
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GALNT16 mRNA
CTD
PMID:25596134
NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
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Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
ISO
adefovir dipivoxil results in increased expression of GCNT3 mRNA
CTD
PMID:25596134
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
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Gdf15
growth differentiation factor 15
increases expression
ISO
adefovir dipivoxil results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Got1
glutamic-oxaloacetic transaminase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GOT1 mRNA
CTD
PMID:25596134
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpr87
G protein-coupled receptor 87
increases expression
ISO
adefovir dipivoxil results in increased expression of GPR87 mRNA
CTD
PMID:25596134
NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190
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H1f2
H1.2 linker histone, cluster member
increases expression
ISO
adefovir dipivoxil results in increased expression of H1-2 mRNA
CTD
PMID:25596134
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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Hmox1
heme oxygenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HMOX1 mRNA
CTD
PMID:25596134
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa1b
heat shock protein family A (Hsp70) member 1B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HSPA1B mRNA
CTD
PMID:25596134
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Ifng
interferon gamma
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il19
interleukin 19
increases secretion
ISO
adefovir dipivoxil results in increased secretion of IL19 protein
CTD
PMID:24714768
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
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Kat6b
lysine acetyltransferase 6B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KAT6B mRNA
CTD
PMID:25596134
NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
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Kdm3a
lysine demethylase 3A
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KDM3A mRNA
CTD
PMID:25596134
NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
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Krt15
keratin 15
increases expression
ISO
adefovir dipivoxil results in increased expression of KRT15 mRNA
CTD
PMID:25596134
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
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Lama3
laminin subunit alpha 3
increases expression
ISO
adefovir dipivoxil results in increased expression of LAMA3 mRNA
CTD
PMID:25596134
NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
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Lcn2
lipocalin 2
increases secretion
ISO
adefovir dipivoxil results in increased secretion of LCN2 protein
CTD
PMID:24714768
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Map3k8
mitogen-activated protein kinase kinase kinase 8
increases expression
ISO
adefovir dipivoxil results in increased expression of MAP3K8 mRNA
CTD
PMID:25596134
NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
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Mdm2
MDM2 proto-oncogene
increases expression
ISO
adefovir dipivoxil results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mxi1
MAX interactor 1, dimerization protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of MXI1 mRNA
CTD
PMID:25596134
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
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Ncapd2
non-SMC condensin I complex, subunit D2
increases expression
ISO
adefovir dipivoxil results in increased expression of NCAPD2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
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Ninj1
ninjurin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NQO1 mRNA
CTD
PMID:25596134
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nrep
neuronal regeneration related protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NREP mRNA
CTD
PMID:25596134
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
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Ntpcr
nucleoside-triphosphatase, cancer-related
increases expression
ISO
adefovir dipivoxil results in increased expression of NTPCR mRNA
CTD
PMID:25596134
NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of P4HA1 mRNA
CTD
PMID:25596134
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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Pank1
pantothenate kinase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PANK1 mRNA
CTD
PMID:25596134
NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
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Pdia5
protein disulfide isomerase family A, member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
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Pdlim1
PDZ and LIM domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PDLIM1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
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Pgr
progesterone receptor
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phlda3
pleckstrin homology-like domain, family A, member 3
increases expression
ISO
adefovir dipivoxil results in increased expression of PHLDA3 mRNA
CTD
PMID:25596134
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Pidd1
p53-induced death domain protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PIDD1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Pir
pirin
increases expression
ISO
adefovir dipivoxil results in increased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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Plec
plectin
increases expression
ISO
adefovir dipivoxil results in increased expression of PLEC mRNA
CTD
PMID:25596134
NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PMAIP1 mRNA
CTD
PMID:25596134
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Pparg
peroxisome proliferator-activated receptor gamma
affects activity
ISO
adefovir dipivoxil affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
increases expression
ISO
adefovir dipivoxil results in increased expression of PPM1D mRNA
CTD
PMID:25596134
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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Prc1
protein regulator of cytokinesis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRC1 mRNA
CTD
PMID:25596134
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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Prdm1
PR/SET domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRDM1 mRNA
CTD
PMID:25596134
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Prkab2
protein kinase AMP-activated non-catalytic subunit beta 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PRKAB2 mRNA
CTD
PMID:25596134
NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
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Psat1
phosphoserine aminotransferase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PSAT1 mRNA
CTD
PMID:25596134
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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Rara
retinoic acid receptor, alpha
decreases expression
ISO
adefovir dipivoxil results in decreased expression of RARA mRNA
CTD
PMID:25596134
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rps27l
ribosomal protein S27-like
increases expression
ISO
adefovir dipivoxil results in increased expression of RPS27L mRNA
CTD
PMID:25596134
NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
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Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
ISO
adefovir dipivoxil results in increased expression of RRM2B mRNA
CTD
PMID:25596134
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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Serpinb5
serpin family B member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of SERPINB5 mRNA
CTD
PMID:25596134
NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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Sesn1
sestrin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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Sfn
stratifin
increases expression
ISO
adefovir dipivoxil results in increased expression of SFN mRNA
CTD
PMID:25596134
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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Sh3tc1
SH3 domain and tetratricopeptide repeats 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SH3TC1 mRNA
CTD
PMID:25596134
NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995
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Slc27a2
solute carrier family 27 member 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC27A2 mRNA
CTD
PMID:25596134
NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
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Slc6a9
solute carrier family 6 member 9
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC6A9 mRNA
CTD
PMID:25596134
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
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Slco2b1
solute carrier organic anion transporter family, member 2b1
increases expression
ISO
adefovir dipivoxil results in increased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Smap1
small ArfGAP 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SMAP1 mRNA
CTD
PMID:25596134
NCBI chr 9:26,250,178...26,342,151
Ensembl chr 9:26,249,978...26,342,170
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Sulf2
sulfatase 2
increases expression
ISO
adefovir dipivoxil results in increased expression of SULF2 mRNA
CTD
PMID:25596134
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Tigar
TP53 induced glycolysis regulatory phosphatase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIGAR mRNA
CTD
PMID:25596134
NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tnfsf9
TNF superfamily member 9
increases expression
ISO
adefovir dipivoxil results in increased expression of TNFSF9 mRNA
CTD
PMID:25596134
NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
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Tp53
tumor protein p53
affects activity
ISO
adefovir dipivoxil affects the activity of TP53 protein
CTD
PMID:25596134 PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TP53INP1 mRNA
CTD
PMID:25596134
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Trafd1
TRAF type zinc finger domain containing 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
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Triap1
TP53 regulated inhibitor of apoptosis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TRIAP1 mRNA
CTD
PMID:25596134
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
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Ube2o
ubiquitin-conjugating enzyme E2O
decreases expression
ISO
adefovir dipivoxil results in decreased expression of UBE2O mRNA
CTD
PMID:25596134
NCBI chr10:101,765,572...101,812,736
Ensembl chr10:101,766,005...101,812,899
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Yars1
tyrosyl-tRNA synthetase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of YARS1 mRNA
CTD
PMID:25596134
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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Zmat3
zinc finger, matrin type 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ZMAT3 mRNA
CTD
PMID:25596134
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
Delavirdine results in decreased activity of CYP2C19 protein
CTD
PMID:11225565
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Alb
albumin
affects binding
ISO
Didanosine binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Hfe
homeostatic iron regulator
multiple interactions
ISO
HFE gene SNP affects the susceptibility to [Didanosine co-treated with Stavudine]
CTD
PMID:16847405
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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Il24
interleukin 24
decreases expression
ISO
Didanosine results in decreased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
decreases expression multiple interactions
ISO
Didanosine results in decreased expression of COX2 mRNA tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]
CTD
PMID:16940060
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Slc29a3
solute carrier family 29 member 3
affects transport
ISO
SLC29A3 protein affects the transport of Didanosine
CTD
PMID:19164483
NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Didanosine results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
ISO
efavirenz inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] efavirenz results in decreased activity of ABCB11 protein
CTD
PMID:24014644
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression decreases secretion
ISO
efavirenz results in decreased expression of ADIPOQ mRNA efavirenz results in decreased secretion of ADIPOQ protein
CTD
PMID:21619898
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Alb
albumin
affects binding
ISO
efavirenz binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Bcl2l11
Bcl2-like 11
increases response to substance increases expression
ISO
BCL2L11 protein results in increased susceptibility to efavirenz metabolite efavirenz metabolite results in increased expression of BCL2L11 mRNA; efavirenz metabolite results in increased expression of BCL2L11 protein; efavirenz results in increased expression of BCL2L11 mRNA; efavirenz results in increased expression of BCL2L11 protein
CTD
PMID:21958719
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Canx
calnexin
affects localization
ISO
efavirenz affects the localization of CANX protein
CTD
PMID:28940366
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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Casp3
caspase 3
multiple interactions
ISO EXP
efavirenz metabolite results in increased cleavage of and results in increased activity of CASP3 protein; efavirenz results in increased cleavage of and results in increased activity of CASP3 protein [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein]
CTD
PMID:21958719 PMID:36309141
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in decreased activity of CAT protein
CTD
PMID:34118364
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
increases secretion
ISO
efavirenz results in increased secretion of CCL2 protein
CTD
PMID:21619898
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cebpa
CCAAT/enhancer binding protein alpha
decreases expression
ISO
efavirenz results in decreased expression of CEBPA mRNA
CTD
PMID:21619898
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
affects metabolic processing decreases activity multiple interactions increases metabolic processing
ISO
CYP2B6 gene polymorphism affects the metabolism of efavirenz; CYP2B6 protein affects the metabolism of efavirenz efavirenz results in decreased activity of CYP2B6 protein [efavirenz results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion; [efavirenz results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [efavirenz results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA CYP2B6 protein results in increased metabolism of efavirenz
CTD
PMID:15622315 PMID:15769884 PMID:17041008 PMID:17559344 PMID:26599973
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
efavirenz results in decreased activity of CYP2C19 protein
CTD
PMID:11225565
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity increases expression increases activity
ISO
efavirenz results in decreased activity of CYP3A4 protein efavirenz results in increased expression of CYP3A4 mRNA efavirenz results in increased activity of CYP3A4 protein
CTD
PMID:15980690 PMID:16837568
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
efavirenz results in increased expression of DDIT3 protein
CTD
PMID:28940366
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dnm1l
dynamin 1-like
affects localization
ISO
efavirenz affects the localization of DNM1L protein modified form
CTD
PMID:28940366
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases expression
ISO
efavirenz results in increased expression of EIF2AK3 protein modified form
CTD
PMID:28940366
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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Fis1
fission, mitochondrial 1
increases expression
ISO
efavirenz results in increased expression of FIS1 mRNA
CTD
PMID:28940366
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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Hgf
hepatocyte growth factor
increases secretion
ISO
efavirenz results in increased secretion of HGF protein
CTD
PMID:21619898
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Hspa9
heat shock protein family A (Hsp70) member 9
multiple interactions
ISO
efavirenz promotes the reaction [VDAC1 protein binds to HSPA9 protein]
CTD
PMID:28940366
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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Il1b
interleukin 1 beta
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein]
CTD
PMID:36309141
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
increases secretion
ISO
efavirenz results in increased secretion of IL6 protein
CTD
PMID:21619898
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation
ISO
efavirenz metabolite results in increased phosphorylation of JUN protein; efavirenz results in increased phosphorylation of JUN protein
CTD
PMID:21958719
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Lep
leptin
decreases expression
ISO
efavirenz results in decreased expression of LEP mRNA
CTD
PMID:21619898
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lonp1
lon peptidase 1, mitochondrial
multiple interactions increases expression increases response to substance
ISO
efavirenz results in increased expression of and affects the localization of LONP1 protein; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [efavirenz results in increased expression of LONP1 mRNA] LONP1 protein results in increased susceptibility to efavirenz
CTD
PMID:28940366
NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
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Lpl
lipoprotein lipase
decreases expression
ISO
efavirenz results in decreased expression of LPL mRNA
CTD
PMID:21619898
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Map3k5
mitogen-activated protein kinase kinase kinase 5
increases phosphorylation
ISO
efavirenz metabolite results in increased phosphorylation of MAP3K5 protein; efavirenz results in increased phosphorylation of MAP3K5 protein
CTD
PMID:21958719
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Mapk8
mitogen-activated protein kinase 8
multiple interactions increases phosphorylation
ISO
Acetylcysteine inhibits the reaction [efavirenz metabolite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [efavirenz results in increased phosphorylation of MAPK8 protein] efavirenz metabolite results in increased phosphorylation of MAPK8 protein; efavirenz results in increased phosphorylation of MAPK8 protein
CTD
PMID:21958719
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mfn2
mitofusin 2
increases expression
ISO
efavirenz results in increased expression of MFN2 mRNA
CTD
PMID:28940366
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mpo
myeloperoxidase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of MPO protein
CTD
PMID:34118364
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
EXP
efavirenz results in increased activity of NR1I2 protein
CTD
PMID:27732639
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions increases activity
ISO EXP
[efavirenz results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [efavirenz results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CTD
PMID:17041008 PMID:27732639
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Opa1
OPA1, mitochondrial dynamin like GTPase
increases expression
ISO
efavirenz results in increased expression of OPA1 mRNA
CTD
PMID:28940366
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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Pparg
peroxisome proliferator-activated receptor gamma
decreases expression
ISO
efavirenz results in decreased expression of PPARG mRNA
CTD
PMID:21619898
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Rmdn3
regulator of microtubule dynamics 3
increases expression
ISO
efavirenz results in increased expression of RMDN3 protein
CTD
PMID:28940366
NCBI chr 3:106,125,961...106,146,568
Ensembl chr 3:106,125,951...106,146,586
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Serpine1
serpin family E member 1
increases secretion
ISO
efavirenz results in increased secretion of SERPINE1 protein
CTD
PMID:21619898
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc5a5
solute carrier family 5 member 5
multiple interactions
ISO
[efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 protein
CTD
PMID:16030158
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
efavirenz results in decreased expression of SREBF1 mRNA
CTD
PMID:21619898
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Tg
thyroglobulin
increases expression
ISO
efavirenz results in increased expression of TG mRNA; efavirenz results in increased expression of TG protein
CTD
PMID:16030158
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
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Tnf
tumor necrosis factor
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein]
CTD
PMID:36309141
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tpo
thyroid peroxidase
increases expression
ISO
efavirenz results in increased expression of TPO mRNA; efavirenz results in increased expression of TPO protein
CTD
PMID:16030158
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
[efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 protein; efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]
CTD
PMID:16030158
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Tshr
thyroid stimulating hormone receptor
increases expression
ISO
efavirenz results in increased expression of TSHR mRNA
CTD
PMID:16030158
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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Vdac1
voltage-dependent anion channel 1
multiple interactions
ISO
efavirenz promotes the reaction [VDAC1 protein binds to HSPA9 protein]
CTD
PMID:28940366
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Alb
albumin
affects binding
ISO
Emtricitabine binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[Emtricitabine co-treated with Tenofovir] results in increased expression of CDKN1A protein
CTD
PMID:31545371
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Dck
deoxycytidine kinase
multiple interactions affects binding
ISO
DCK protein results in increased phosphorylation of and results in increased activity of Emtricitabine Emtricitabine binds to DCK protein
CTD
PMID:17530837
NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247
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Prkn
parkin RBR E3 ubiquitin protein ligase
decreases expression multiple interactions
ISO
Emtricitabine results in decreased expression of PRKN protein [Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein
CTD
PMID:31545371
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Tp53
tumor protein p53
multiple interactions
ISO
[Emtricitabine co-treated with Tenofovir] results in increased expression of TP53 protein
CTD
PMID:31545371
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Acadsb
acyl-CoA dehydrogenase, short/branched chain
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA
CTD
PMID:18313992
NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379
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Acsl6
acyl-CoA synthetase long-chain family member 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA
CTD
PMID:18313992
NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
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Acta2
actin alpha 2, smooth muscle
decreases expression
ISO
Lamivudine results in decreased expression of ACTA2 protein
CTD
PMID:11738102
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA
CTD
PMID:16931933
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Aebp1
AE binding protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of AEBP1 mRNA
CTD
PMID:16931933
NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877
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Afap1
actin filament associated protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA
CTD
PMID:15784690
NCBI chr14:74,743,322...74,856,300
Ensembl chr14:74,743,320...74,856,263
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Alb
albumin
affects binding
ISO
Lamivudine binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alox5ap
arachidonate 5-lipoxygenase activating protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA
CTD
PMID:16931933
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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Aqp9
aquaporin 9
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA
CTD
PMID:18313992
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Arpp21
cAMP regulated phosphoprotein 21
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNA
CTD
PMID:16931933
NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
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Asic2
acid sensing ion channel subunit 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA
CTD
PMID:16931933
NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
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Asns
asparagine synthetase (glutamine-hydrolyzing)
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ASNS mRNA
CTD
PMID:15784690
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Ass1
argininosuccinate synthase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA
CTD
PMID:15784690
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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Atf3
activating transcription factor 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATF3 mRNA
CTD
PMID:15784690
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA
CTD
PMID:11706060
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Atp5f1c
ATP synthase F1 subunit gamma
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5F1C mRNA
CTD
PMID:18313992
NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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Atp5mc3
ATP synthase membrane subunit c locus 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5MC3 mRNA
CTD
PMID:18313992
NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
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Atp5mf
ATP synthase membrane subunit f
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5MF mRNA
CTD
PMID:18313992
NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
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Atp5pd
ATP synthase peripheral stalk subunit d
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PD mRNA
CTD
PMID:18313992
NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
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Atp5pf
ATP synthase peripheral stalk subunit F6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PF mRNA
CTD
PMID:18313992
NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
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Atp5po
ATP synthase peripheral stalk subunit OSCP
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5PO mRNA
CTD
PMID:18313992
NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of BCL2 mRNA
CTD
PMID:18313992
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bnip3l
BCL2 interacting protein 3 like
increases expression
ISO
Lamivudine results in increased expression of BNIP3L protein
CTD
PMID:23640862
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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C1r
complement C1r
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA
CTD
PMID:16931933
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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C3ar1
complement C3a receptor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of C3AR1 mRNA
CTD
PMID:16931933
NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
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Cars1
cysteinyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CARS1 mRNA
CTD
PMID:15784690
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
G
Casp3
caspase 3
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein]
CTD
PMID:36309141
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in decreased activity of CAT protein
CTD
PMID:34118364
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccna2
cyclin A2
multiple interactions decreases expression
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNA2 mRNA Lamivudine results in decreased expression of CCNA2 mRNA
CTD
PMID:15784690
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ccnc
cyclin C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNC mRNA
CTD
PMID:15784690
NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
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Ccnd1
cyclin D1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CCND1 mRNA
CTD
PMID:15784690
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
decreases expression multiple interactions
ISO
Lamivudine results in decreased expression of CCND2 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA
CTD
PMID:15784690
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ccne2
cyclin E2
multiple interactions decreases expression
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNE2 mRNA Lamivudine results in decreased expression of CCNE2 mRNA
CTD
PMID:15784690
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cd36
CD36 molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA
CTD
PMID:16931933
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd44
CD44 molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA
CTD
PMID:15784690
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd83
CD83 molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CD83 mRNA
CTD
PMID:15784690
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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Cdk7
cyclin-dependent kinase 7
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA
CTD
PMID:15784690
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression multiple interactions
ISO
Lamivudine results in decreased expression of CDKN1A mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1A mRNA
CTD
PMID:15784690
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA
CTD
PMID:15784690
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
G
Cdkn1c
cyclin-dependent kinase inhibitor 1C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA
CTD
PMID:15784690
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
G
Cdkn2c
cyclin-dependent kinase inhibitor 2C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN2C mRNA
CTD
PMID:15784690
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
G
Cfd
complement factor D
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA
CTD
PMID:16931933
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
G
Cidec
cell death-inducing DFFA-like effector c
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA
CTD
PMID:16931933
NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
G
Clcn3
chloride voltage-gated channel 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CLCN3 mRNA
CTD
PMID:16931933
NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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Col3a1
collagen type III alpha 1 chain
decreases expression
ISO
Lamivudine results in decreased expression of COL3A1 protein
CTD
PMID:11738102
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Comt
catechol-O-methyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA
CTD
PMID:15784690
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cox5a
cytochrome c oxidase subunit 5A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX5A mRNA
CTD
PMID:18313992
NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
G
Cox5b
cytochrome c oxidase subunit 5B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNA
CTD
PMID:18313992
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
G
Cox6a1
cytochrome c oxidase subunit 6A1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COX6A1 mRNA
CTD
PMID:18313992
NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041
G
Cox6c
cytochrome c oxidase subunit 6C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COX6C mRNA
CTD
PMID:18313992
NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
G
Cox7c
cytochrome c oxidase subunit 7C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COX7C mRNA
CTD
PMID:18313992
NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
G
Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNA
CTD
PMID:18313992
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Crat
carnitine O-acetyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CRAT mRNA
CTD
PMID:18313992
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
G
Cul7
cullin 7
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNA
CTD
PMID:18313992
NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741
G
Cyb5a
cytochrome b5 type A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA
CTD
PMID:18313992
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA
CTD
PMID:18313992
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Dck
deoxycytidine kinase
multiple interactions
ISO
DCK protein results in increased phosphorylation of and results in increased activity of Lamivudine
CTD
PMID:17530837
NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247
G
Dcn
decorin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA
CTD
PMID:16931933
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
G
Ddit3
DNA-damage inducible transcript 3
increases expression multiple interactions
ISO
Lamivudine results in increased expression of DDIT3 mRNA [Zidovudine co-treated with Lamivudine] results in increased expression of DDIT3 mRNA
CTD
PMID:15784690
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Dhfr
dihydrofolate reductase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA
CTD
PMID:15784690
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
G
Diablo
diablo, IAP-binding mitochondrial protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA
CTD
PMID:18313992
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
G
Dlst
dihydrolipoamide S-succinyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA
CTD
PMID:18313992
NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
G
Dnaja3
DnaJ heat shock protein family (Hsp40) member A3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNA
CTD
PMID:18313992
NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
G
Dusp3
dual specificity phosphatase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNA
CTD
PMID:16931933
NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
G
Echs1
enoyl-CoA hydratase, short chain 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA
CTD
PMID:18313992
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
G
Eci1
enoyl-CoA delta isomerase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNA
CTD
PMID:18313992
NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
G
Edn1
endothelin 1
multiple interactions increases secretion
ISO
coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]
CTD
PMID:23640862
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of EIF4EBP1 mRNA
CTD
PMID:15784690
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
G
Elovl3
ELOVL fatty acid elongase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of ELOVL3 mRNA
CTD
PMID:16931933
NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115
G
Esr2
estrogen receptor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA
CTD
PMID:16931933
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Etv6
ETS variant transcription factor 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA
CTD
PMID:16931933
NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
G
Fads2
fatty acid desaturase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA
CTD
PMID:16931933
NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
G
Faim
Fas apoptotic inhibitory molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNA
CTD
PMID:16931933
NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562
G
Fasn
fatty acid synthase
multiple interactions
ISO
[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNA
CTD
PMID:11741158
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
G
Fdxr
ferredoxin reductase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA
CTD
PMID:18313992
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
G
Fh
fumarate hydratase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of FH1 mRNA
CTD
PMID:18313992
NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
G
G0s2
G0/G1switch 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA
CTD
PMID:16931933
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of G6PC1 mRNA
CTD
PMID:16931933
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
Ganc
glucosidase, alpha; neutral C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNA
CTD
PMID:16931933
NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241
G
Gars1
glycyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of GARS1 mRNA
CTD
PMID:15784690
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
G
Gas1
growth arrest-specific 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of GAS1 mRNA
CTD
PMID:15784690
NCBI chr17:4,482,168...4,485,153
G
Grhl2
grainyhead-like transcription factor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA
CTD
PMID:16931933
NCBI chr 7:68,400,287...68,530,269
Ensembl chr 7:68,400,477...68,530,258
G
Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of GUCY1B1 mRNA
CTD
PMID:16931933
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
G
Gypa
glycophorin A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA gene
CTD
PMID:17358027
NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
G
Hadh
hydroxyacyl-CoA dehydrogenase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of HADH mRNA
CTD
PMID:16931933
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNA
CTD
PMID:18313992
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
G
Hax1
HCLS1 associated protein X-1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA
CTD
PMID:15784690
NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
G
Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA
CTD
PMID:16931933
NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774
G
Hist1h4b
histone cluster 1 H4 family member B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA
CTD
PMID:16931933
NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA
CTD
PMID:18313992
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
G
Hrk
harakiri, BCL2 interacting protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA
CTD
PMID:16931933
NCBI chr12:38,387,484...38,409,652
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA
CTD
PMID:18313992
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hsd3b3
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B3 mRNA
CTD
PMID:18313992
NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA
CTD
PMID:18313992
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
G
Idh3a
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA
CTD
PMID:18313992
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
G
Idh3g
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of IDH3G mRNA
CTD
PMID:18313992
NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171
G
Ifng
interferon gamma
increases expression
ISO
Lamivudine results in increased expression of IFNG protein
CTD
PMID:16250037
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Ikzf4
IKAROS family zinc finger 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of IKZF4 mRNA
CTD
PMID:16931933
NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341
G
Il1b
interleukin 1 beta
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein]
CTD
PMID:36309141
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il27ra
interleukin 27 receptor subunit alpha
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA
CTD
PMID:15784690
NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938
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Inpp5e
inositol polyphosphate-5-phosphatase E
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of INPP5E mRNA
CTD
PMID:18313992
NCBI chr 3:9,216,776...9,229,539
Ensembl chr 3:9,216,776...9,229,450
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Kcng1
potassium voltage-gated channel modifier subfamily G member 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KCNG1 mRNA
CTD
PMID:15784690
NCBI chr 3:156,960,717...156,992,877
Ensembl chr 3:156,973,156...156,992,635
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Kifc2
kinesin family member C2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of KIFC2 mRNA
CTD
PMID:16931933
NCBI chr 7:108,380,634...108,388,364
Ensembl chr 7:108,376,011...108,388,484
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Klf4
KLF transcription factor 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KLF4 mRNA
CTD
PMID:15784690
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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Klhl28
kelch-like family member 28
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of KLHL28 mRNA
CTD
PMID:16931933
NCBI chr 6:82,987,360...83,018,971
Ensembl chr 6:82,990,945...83,016,164
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Krt7
keratin 7
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KRT7 mRNA
CTD
PMID:15784690
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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Kynu
kynureninase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KYNU mRNA
CTD
PMID:15784690
NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
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Lamb3
laminin subunit beta 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of LAMB3 mRNA
CTD
PMID:15784690
NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
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Lamc2
laminin subunit gamma 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of LAMC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of LAMC2 mRNA
CTD
PMID:16931933
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
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Lef1
lymphoid enhancer binding factor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA
CTD
PMID:16931933
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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Lep
leptin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA
CTD
PMID:16931933
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lpl
lipoprotein lipase
decreases expression multiple interactions
ISO
Lamivudine results in decreased expression of LPL mRNA [Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNA; [Stavudine co-treated with Lamivudine] affects the expression of LPL mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNA
CTD
PMID:11741158
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Mars1
methionyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MARS1 mRNA
CTD
PMID:15784690
NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
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Me1
malic enzyme 1
multiple interactions increases expression
ISO
[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNA Lamivudine results in increased expression of ME1 mRNA
CTD
PMID:11741158
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Mfn1
mitofusin 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNA
CTD
PMID:18313992
NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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Mfn2
mitofusin 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MFN2 mRNA
CTD
PMID:18313992
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mgat4c
MGAT4 family, member C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MGAT4C mRNA
CTD
PMID:16931933
NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571
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Mmp1
matrix metallopeptidase 1
increases expression
ISO
Lamivudine results in increased expression of MMP1 protein
CTD
PMID:15309715
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mpo
myeloperoxidase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of MPO protein
CTD
PMID:34118364
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mrap
melanocortin 2 receptor accessory protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNA
CTD
PMID:16931933
NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA
CTD
PMID:17526437 PMID:18313992
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX2 mRNA
CTD
PMID:18313992
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Mt-co3
mitochondrially encoded cytochrome c oxidase III
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COX3 mRNA
CTD
PMID:17526437 PMID:18313992
NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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Mt-nd2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ND2 mRNA
CTD
PMID:18313992
NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
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Mt-nd5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ND5 mRNA
CTD
PMID:17526437 PMID:18313992
NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MTHFD2 mRNA
CTD
PMID:15784690
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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Myod1
myogenic differentiation 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MYOD1 mRNA
CTD
PMID:16931933
NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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Nap1l5
nucleosome assembly protein 1-like 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NAP1L5 mRNA
CTD
PMID:16931933
NCBI chr 4:88,022,670...88,024,988
Ensembl chr 4:88,022,569...88,024,654
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Ndufa4
Ndufa4, mitochondrial complex associated
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFA4 mRNA
CTD
PMID:18313992
NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920
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Ndufab1
NADH:ubiquinone oxidoreductase subunit AB1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAB1 mRNA
CTD
PMID:18313992
NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
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Ndufaf1
NADH:ubiquinone oxidoreductase complex assembly factor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAF1 mRNA
CTD
PMID:18313992
NCBI chr 3:106,639,025...106,650,549
Ensembl chr 3:106,639,851...106,650,212
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Ndufb3
NADH:ubiquinone oxidoreductase subunit B3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB3 mRNA
CTD
PMID:18313992
NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446
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Ndufb5
NADH:ubiquinone oxidoreductase subunit B5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB5 mRNA
CTD
PMID:18313992
NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589
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Ndufb9
NADH:ubiquinone oxidoreductase subunit B9
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFB9 mRNA
CTD
PMID:18313992
NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009
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Ndufc1
NADH:ubiquinone oxidoreductase subunit C1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFC1 mRNA
CTD
PMID:18313992
NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874
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Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFS1 mRNA
CTD
PMID:18313992
NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
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Niban1
niban apoptosis regulator 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NIBAN1 mRNA
CTD
PMID:15784690
NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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Noct
nocturnin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of NOCT mRNA
CTD
PMID:16931933
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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Nos3
nitric oxide synthase 3
multiple interactions decreases phosphorylation
ISO
coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]
CTD
PMID:23640862
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nppa
natriuretic peptide A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA
CTD
PMID:11706060
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Nup210
nucleoporin 210
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NUP210 mRNA
CTD
PMID:16931933
NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874
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Nxnl2
nucleoredoxin-like 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NXNL2 mRNA
CTD
PMID:16931933
NCBI chr17:14,031,151...14,035,897
Ensembl chr17:14,031,153...14,036,189
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Oaz3
ornithine decarboxylase antizyme 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of OAZ3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of OAZ3 mRNA
CTD
PMID:16931933
NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399
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Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of OGT mRNA
CTD
PMID:15784690
NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146
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Opa1
OPA1, mitochondrial dynamin like GTPase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA
CTD
PMID:18313992
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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Oprl1
opioid related nociceptin receptor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNA
CTD
PMID:16931933
NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
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Pcdh15
protocadherin related 15
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PCDH15 mRNA
CTD
PMID:16931933
NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNA
CTD
PMID:15784690
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA
CTD
PMID:16931933
NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
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Pgap6
post-GPI attachment to proteins 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of PGAP6 mRNA
CTD
PMID:16931933
NCBI chr10:15,138,918...15,148,431
Ensembl chr10:15,138,959...15,148,431
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Phf6
PHD finger protein 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of PHF6 mRNA
CTD
PMID:16931933
NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127
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Pidd1
p53-induced death domain protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIDD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIDD1 mRNA
CTD
PMID:16931933
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Piwil2
piwi-like RNA-mediated gene silencing 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PIWIL2 mRNA
CTD
PMID:16931933
NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702
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Porcn
porcupine O-acyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PPN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PPN mRNA
CTD
PMID:16931933
NCBI chr X:14,285,864...14,298,481
Ensembl chr X:14,285,871...14,298,481
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Pou5f1
POU class 5 homeobox 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of POU5F1 mRNA
CTD
PMID:16931933
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Prdm1
PR/SET domain 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA
CTD
PMID:16931933
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Psat1
phosphoserine aminotransferase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of PSAT1 mRNA
CTD
PMID:15784690
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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Rabepk
Rab9 effector protein with kelch motifs
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of RABEPK mRNA
CTD
PMID:15784690
NCBI chr 3:18,061,299...18,083,191
Ensembl chr 3:18,061,574...18,083,191
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Rbl1
RB transcriptional corepressor like 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL1 mRNA
CTD
PMID:15784690
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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Rbl2
RB transcriptional corepressor like 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL2 mRNA
CTD
PMID:15784690
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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Reep6
receptor accessory protein 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of REEP6 mRNA
CTD
PMID:16931933
NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
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Ripk2
receptor-interacting serine-threonine kinase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of RIPK2 mRNA
CTD
PMID:15784690
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Rnf151
ring finger protein 151
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of RNF151 mRNA
CTD
PMID:16931933
NCBI chr10:13,742,682...13,747,192
Ensembl chr10:13,742,682...13,745,000
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Rpain
RPA interacting protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of RPAIN mRNA
CTD
PMID:16931933
NCBI chr10:55,692,410...55,699,910
Ensembl chr10:55,692,417...55,699,933
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S100a8
S100 calcium binding protein A8
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA
CTD
PMID:16931933
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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Sdhb
succinate dehydrogenase complex iron sulfur subunit B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA
CTD
PMID:18313992
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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Serinc1
serine incorporator 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SERINC1 mRNA
CTD
PMID:16931933
NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691
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Sfxn1
sideroflexin 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN1 mRNA
CTD
PMID:18313992
NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
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Sfxn2
sideroflexin 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN2 mRNA
CTD
PMID:18313992
NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411 Ensembl chr 1:245,447,015...245,468,411
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Sfxn4
sideroflexin 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN4 mRNA
CTD
PMID:18313992
NCBI chr 1:259,976,480...259,998,778
Ensembl chr 1:259,976,481...259,998,754
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Sgpp1
sphingosine-1-phosphate phosphatase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SGPP1 mRNA
CTD
PMID:18313992
NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534
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Slc1a4
solute carrier family 1 member 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A4 mRNA
CTD
PMID:15784690
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
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Slc1a5
solute carrier family 1 member 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A5 mRNA
CTD
PMID:15784690
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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Slc22a1
solute carrier family 22 member 1
increases uptake
ISO
SLC22A1 protein results in increased uptake of Lamivudine
CTD
PMID:19141712
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
increases uptake
ISO
SLC22A2 protein results in increased uptake of Lamivudine
CTD
PMID:19141712
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a3
solute carrier family 22 member 3
increases uptake
ISO
SLC22A3 protein results in increased uptake of Lamivudine
CTD
PMID:19141712
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc25a12
solute carrier family 25 member 12
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A12 mRNA
CTD
PMID:18313992
NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100
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Slc25a15
solute carrier family 25 member 15
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A15 mRNA
CTD
PMID:18313992
NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010
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Slc25a19
solute carrier family 25 member 19
multiple interactions
ISO
SLC25A19 protein affects the susceptibility to [Stavudine co-treated with Lamivudine co-treated with Indinavir]; SLC25A19 protein affects the susceptibility to [Zidovudine co-treated with Lamivudine co-treated with Indinavir] [Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A19 mRNA
CTD
PMID:15951836 PMID:18313992
NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
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Slc25a2
solute carrier family 25 member 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A2 mRNA
CTD
PMID:18313992
NCBI chr18:29,452,943...29,456,324
Ensembl chr18:29,453,582...29,460,383
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Slc25a20
solute carrier family 25 member 20
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A20 mRNA
CTD
PMID:18313992
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
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Slc25a29
solute carrier family 25 member 29
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A29 mRNA
CTD
PMID:18313992
NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940
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Slc25a3
solute carrier family 25 member 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A3 mRNA
CTD
PMID:18313992
NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727
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Slc25a4
solute carrier family 25 member 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A4 mRNA
CTD
PMID:18313992
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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Slc28a1
solute carrier family 28 member 1
multiple interactions
ISO
Lamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]
CTD
PMID:10772724
NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
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Slc31a1
solute carrier family 31 member 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC31A1 mRNA
CTD
PMID:15784690
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
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Slc3a2
solute carrier family 3 member 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC3A2 mRNA
CTD
PMID:15784690
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc40a1
solute carrier family 40 member 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC40A1 mRNA
CTD
PMID:18313992
NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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Slc6a4
solute carrier family 6 member 4
multiple interactions increases expression
ISO
[Lamivudine co-treated with IFNA2 protein] results in increased expression of SLC6A4 mRNA; Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Lamivudine results in increased expression of and results in increased activity of SLC6A4 protein Lamivudine results in increased expression of SLC6A4 mRNA
CTD
PMID:16476009
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Spink5
serine peptidase inhibitor, Kazal type 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of SPINK5 mRNA
CTD
PMID:16931933
NCBI chr18:36,264,452...36,333,143
Ensembl chr18:36,264,452...36,332,185
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Star
steroidogenic acute regulatory protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of STAR mRNA
CTD
PMID:18313992
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stc2
stanniocalcin 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of STC2 mRNA
CTD
PMID:15784690
NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
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Sub1
SUB1 regulator of transcription
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNA
CTD
PMID:16931933
NCBI chr 2:61,005,646...61,020,486
Ensembl chr 2:61,005,666...61,020,436 Ensembl chr 2:61,005,666...61,020,436
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Tcea1
transcription elongation factor A1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TCEA1 mRNA
CTD
PMID:15784690
NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745 Ensembl chr15:14,631,454...14,668,745
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Tgfb1
transforming growth factor, beta 1
decreases expression
ISO
Lamivudine results in decreased expression of TGFB1 protein
CTD
PMID:15309715
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Timm17b
translocase of inner mitochondrial membrane 17b
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM17B mRNA
CTD
PMID:18313992
NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416
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Timm23
translocase of inner mitochondrial membrane 23
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM23 mRNA
CTD
PMID:18313992
NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379
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Timp1
TIMP metallopeptidase inhibitor 1
decreases expression
ISO
Lamivudine results in decreased expression of TIMP1 protein
CTD
PMID:15309715
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Timp2
TIMP metallopeptidase inhibitor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA
CTD
PMID:16931933
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tk2
thymidine kinase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TK2 mRNA
CTD
PMID:18313992
NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
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Tnf
tumor necrosis factor
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein]
CTD
PMID:36309141
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trib3
tribbles pseudokinase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TRIB3 mRNA
CTD
PMID:15784690
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Trim42
tripartite motif-containing 42
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TRIM42 mRNA
CTD
PMID:16931933
NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268
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Twnk
twinkle mtDNA helicase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of TWNK mRNA
CTD
PMID:18313992
NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802
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Tyms
thymidylate synthetase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA
CTD
PMID:15784690
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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Tyrp1
tyrosinase-related protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of TYRP1 mRNA
CTD
PMID:15784690
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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Uqcrb
ubiquinol-cytochrome c reductase binding protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRB mRNA
CTD
PMID:18313992
NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
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Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA
CTD
PMID:17526437 PMID:18313992
NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
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Uqcrc2
ubiquinol cytochrome c reductase core protein 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of UQCRC2 mRNA
CTD
PMID:18313992
NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
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Vdac1
voltage-dependent anion channel 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of VDAC1 mRNA
CTD
PMID:18313992
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vdr
vitamin D receptor
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of VDR mRNA
CTD
PMID:11741158
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vps4b
vacuolar protein sorting 4 homolog B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of VPS4B mRNA
CTD
PMID:16931933
NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229
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Wars1
tryptophanyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of WARS1 mRNA
CTD
PMID:15784690
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Wnt10a
Wnt family member 10A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of WNT10A mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of WNT10A mRNA
CTD
PMID:16931933
NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
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Yars1
tyrosyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of YARS1 mRNA
CTD
PMID:15784690
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
EXP
Nevirapine results in increased expression of ABCB1A mRNA
CTD
PMID:23947594
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Adamts9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
decreases expression
EXP
Nevirapine metabolite results in decreased expression of ADAMTS9 mRNA; Nevirapine results in decreased expression of ADAMTS9 mRNA
CTD
PMID:23947594
NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929
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Adgrf5
adhesion G protein-coupled receptor F5
increases expression
EXP
Nevirapine metabolite results in increased expression of ADGRF5 mRNA
CTD
PMID:23947594
NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968
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Adipoq
adiponectin, C1Q and collagen domain containing
increases expression increases secretion
ISO
Nevirapine results in increased expression of ADIPOQ mRNA Nevirapine results in increased secretion of ADIPOQ protein
CTD
PMID:21619898
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Aif1
allograft inflammatory factor 1
decreases expression
EXP
Nevirapine metabolite results in decreased expression of AIF1 mRNA
CTD
PMID:23947594
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Alb
albumin
affects binding
ISO
Nevirapine binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Apoa1
apolipoprotein A1
increases expression
ISO
Nevirapine results in increased expression of APOA1 protein
CTD
PMID:19667106
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Ar
androgen receptor
increases expression
ISO
Nevirapine results in increased expression of AR mRNA; Nevirapine results in increased expression of AR protein
CTD
PMID:19152342
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Armcx2
armadillo repeat containing, X-linked 2
decreases expression
EXP
Nevirapine metabolite results in decreased expression of ARMCX2 mRNA; Nevirapine results in decreased expression of ARMCX2 mRNA
CTD
PMID:23947594
NCBI chr X:97,980,662...97,985,523
Ensembl chr X:97,980,660...97,985,552
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Arnt
aryl hydrocarbon receptor nuclear translocator
increases expression
EXP
Nevirapine metabolite results in increased expression of ARNT mRNA
CTD
PMID:23947594
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Bmp6
bone morphogenetic protein 6
increases expression
ISO
Nevirapine results in increased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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Cd36
CD36 molecule
increases expression
EXP
Nevirapine metabolite results in increased expression of CD36 mRNA
CTD
PMID:23947594
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cebpa
CCAAT/enhancer binding protein alpha
increases expression
ISO
Nevirapine results in increased expression of CEBPA mRNA
CTD
PMID:21619898
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Ces2h
carboxylesterase 2H
increases expression
EXP
Nevirapine results in increased expression of CES2 mRNA
CTD
PMID:23947594
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Ciita
class II, major histocompatibility complex, transactivator
increases expression
ISO
Nevirapine results in increased expression of CIITA
CTD
PMID:26626330
NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
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Clec4a1
C-type lectin domain family 4, member A1
decreases expression
EXP
Nevirapine results in decreased expression of CLEC4A1 mRNA
CTD
PMID:23947594
NCBI chr 4:156,173,894...156,186,009
Ensembl chr 4:156,173,894...156,186,008
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Clec4a3
C-type lectin domain family 4, member A3
decreases expression
EXP
Nevirapine results in decreased expression of CLEC4A3 mRNA
CTD
PMID:23947594
NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817
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Clec4m
C-type lectin domain family 4 member M
increases expression
EXP
Nevirapine metabolite results in increased expression of CD209B mRNA
CTD
PMID:23947594
NCBI chr12:1,915,902...1,924,529
Ensembl chr12:1,915,919...1,924,539
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Cotl1
coactosin-like F-actin binding protein 1
decreases expression
EXP
Nevirapine results in decreased expression of COTL1 mRNA
CTD
PMID:23947594
NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
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Cux2
cut-like homeobox 2
decreases expression
EXP
Nevirapine metabolite results in decreased expression of CUX2 mRNA
CTD
PMID:23947594
NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Nevirapine metabolite results in increased expression of CYP2B1 mRNA; Nevirapine results in increased expression of CYP2B1 mRNA
CTD
PMID:23947594
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
[Nevirapine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Nevirapine results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CTD
PMID:17041008
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
affects binding
EXP
Nevirapine binds to CYP2C11 protein
CTD
PMID:22793666
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects binding
ISO
Nevirapine binds to CYP3A4 protein
CTD
PMID:22793666
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
affects binding increases expression
EXP
Nevirapine binds to CYP3A23-3A1 protein Nevirapine results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:22793666 PMID:23947594
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
EXP
Nevirapine results in increased expression of CYP3A9 mRNA
CTD
PMID:23947594
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
increases expression
EXP
Nevirapine metabolite results in increased expression of CYP4B1 mRNA
CTD
PMID:23947594
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
G
Dapk1
death associated protein kinase 1
increases expression
EXP
Nevirapine metabolite results in increased expression of DAPK1 mRNA
CTD
PMID:23947594
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
G
Dbp
D-box binding PAR bZIP transcription factor
decreases expression
EXP
Nevirapine metabolite results in decreased expression of DBP mRNA
CTD
PMID:23947594
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
G
Ddhd1
DDHD domain containing 1
decreases expression
EXP
Nevirapine results in decreased expression of DDHD1 mRNA
CTD
PMID:23947594
NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
G
Dip2a
disco-interacting protein 2 homolog A
increases expression
EXP
Nevirapine results in increased expression of DIP2A mRNA
CTD
PMID:23947594
NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217
G
Dnajb5
DnaJ heat shock protein family (Hsp40) member B5
increases expression
EXP
Nevirapine metabolite results in increased expression of DNAJB5 mRNA
CTD
PMID:23947594
NCBI chr 5:57,176,840...57,186,067
Ensembl chr 5:57,176,845...57,185,490
G
Edem1
ER degradation enhancing alpha-mannosidase like protein 1
increases expression
EXP
Nevirapine results in increased expression of EDEM1 mRNA
CTD
PMID:23947594
NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
G
Egf
epidermal growth factor
decreases expression
ISO
Nevirapine results in decreased expression of EGF mRNA
CTD
PMID:19152342
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Egfr
epidermal growth factor receptor
decreases expression
ISO
Nevirapine results in decreased expression of EGFR mRNA
CTD
PMID:19152342
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Epb41l3
erythrocyte membrane protein band 4.1-like 3
decreases expression
EXP
Nevirapine results in decreased expression of EPB41L3 mRNA
CTD
PMID:23947594
NCBI chr 9:109,056,178...109,260,607
Ensembl chr 9:109,016,113...109,260,607
G
Ereg
epiregulin
increases expression
ISO
Nevirapine results in increased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
G
Esm1
endothelial cell-specific molecule 1
increases expression
EXP
Nevirapine metabolite results in increased expression of ESM1 mRNA; Nevirapine results in increased expression of ESM1 mRNA
CTD
PMID:23947594
NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
G
Fam107a
family with sequence similarity 107, member A
increases expression
EXP
Nevirapine results in increased expression of FAM107A mRNA
CTD
PMID:23947594
NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
G
Fibin
fin bud initiation factor homolog
increases expression
EXP
Nevirapine results in increased expression of FIBIN mRNA
CTD
PMID:23947594
NCBI chr 3:96,942,405...96,944,676
Ensembl chr 3:96,942,406...96,944,676
G
Fkbp5
FKBP prolyl isomerase 5
increases expression
EXP
Nevirapine metabolite results in increased expression of FKBP5 mRNA; Nevirapine results in increased expression of FKBP5 mRNA
CTD
PMID:23947594
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
EXP
Nevirapine metabolite results in decreased expression of FMO1 mRNA
CTD
PMID:23947594
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
G
Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
EXP
Nevirapine results in increased expression of GADD45B mRNA
CTD
PMID:23947594
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
G
Glul
glutamate-ammonia ligase
decreases expression
EXP
Nevirapine metabolite results in decreased expression of GLUL mRNA
CTD
PMID:23947594
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
G
Gsta1
glutathione S-transferase alpha 1
increases glutathionylation
ISO
GSTA1 protein results in increased glutathionylation of Nevirapine metabolite
CTD
PMID:27989146
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gstm1
glutathione S-transferase mu 1
increases glutathionylation
ISO
GSTM1 protein results in increased glutathionylation of Nevirapine metabolite
CTD
PMID:27989146
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstp1
glutathione S-transferase pi 1
increases glutathionylation
ISO
GSTP1 protein results in increased glutathionylation of Nevirapine metabolite
CTD
PMID:27989146
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gzma
granzyme A
decreases expression
EXP
Nevirapine metabolite results in decreased expression of GZMA mRNA
CTD
PMID:23947594
NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
G
Gzmf
granzyme F
decreases expression
EXP
Nevirapine metabolite results in decreased expression of GZMF mRNA
CTD
PMID:23947594
NCBI chr15:30,005,361...30,018,649
Ensembl chr15:30,007,267...30,018,649
G
Hao2
hydroxyacid oxidase 2
decreases expression
EXP
Nevirapine metabolite results in decreased expression of HAO2 mRNA; Nevirapine results in decreased expression of HAO2 mRNA
CTD
PMID:23947594
NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
G
Hdc
histidine decarboxylase
decreases expression
EXP
Nevirapine metabolite results in decreased expression of HDC mRNA
CTD
PMID:23947594
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
G
Hgf
hepatocyte growth factor
decreases secretion
ISO
Nevirapine results in decreased secretion of HGF protein
CTD
PMID:21619898
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
increases expression
EXP
Nevirapine metabolite results in increased expression of HMGCS2 mRNA; Nevirapine results in increased expression of HMGCS2 mRNA
CTD
PMID:23947594
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
G
Hpgd
15-hydroxyprostaglandin dehydrogenase
increases expression
EXP
Nevirapine metabolite results in increased expression of HPGD mRNA
CTD
PMID:23947594
NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
decreases expression
EXP
Nevirapine metabolite results in decreased expression of HSD17B2 mRNA
CTD
PMID:23947594
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
G
Ifng
interferon gamma
increases expression
ISO EXP
Nevirapine results in increased expression of IFNG protein
CTD
PMID:23947594
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igh-6
immunoglobulin heavy chain 6
increases expression
EXP
Nevirapine results in increased expression of IGH-6 mRNA
CTD
PMID:23947594
G
Il1b
interleukin 1 beta
increases expression
ISO
Nevirapine results in increased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il22ra2
interleukin 22 receptor subunit alpha 2
increases expression
EXP
Nevirapine metabolite results in increased expression of IL22RA2 mRNA
CTD
PMID:23947594
NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:14,364,489...14,377,844
G
Il24
interleukin 24
increases expression
ISO
Nevirapine results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
G
Il6
interleukin 6
decreases secretion
ISO
Nevirapine results in decreased secretion of IL6 protein
CTD
PMID:21619898
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Inhbe
inhibin subunit beta E
decreases expression
EXP
Nevirapine metabolite results in decreased expression of INHBE mRNA
CTD
PMID:23947594
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Inmt
indolethylamine N-methyltransferase
increases expression
EXP
Nevirapine results in increased expression of INMT mRNA
CTD
PMID:23947594
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
G
Insig2
insulin induced gene 2
increases expression
EXP
Nevirapine results in increased expression of INSIG2 mRNA
CTD
PMID:23947594
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
G
Irgm
immunity-related GTPase M
decreases expression
EXP
Nevirapine results in decreased expression of IRGM mRNA
CTD
PMID:23947594
NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
increases expression
EXP
Nevirapine results in increased expression of ITPR1 mRNA
CTD
PMID:23947594
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
G
Klf15
KLF transcription factor 15
increases expression
EXP
Nevirapine metabolite results in increased expression of KLF15 mRNA
CTD
PMID:23947594
NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
G
Klk1c10
kallikrein 1-related peptidase C10
increases expression
ISO
Nevirapine results in increased expression of KLK3 mRNA; Nevirapine results in increased expression of KLK3 protein
CTD
PMID:19152342
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
G
Krt18
keratin 18
increases expression
ISO
Nevirapine results in increased expression of KRT18 protein
CTD
PMID:19152342
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
G
Krt23
keratin 23
increases expression
EXP
Nevirapine metabolite results in increased expression of KRT23 mRNA
CTD
PMID:23947594
NCBI chr10:84,434,445...84,450,773
Ensembl chr10:84,434,380...84,450,983
G
Lcat
lecithin cholesterol acyltransferase
increases expression
ISO
Nevirapine results in increased expression of LCAT protein
CTD
PMID:19667106
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
G
Ldaf1
lipid droplet assembly factor 1
decreases expression
EXP
Nevirapine results in decreased expression of LDAF1 mRNA
CTD
PMID:23947594
NCBI chr 1:174,484,438...174,503,037
Ensembl chr 1:174,484,447...174,503,036
G
Lep
leptin
increases expression
ISO
Nevirapine results in increased expression of LEP mRNA
CTD
PMID:21619898
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lifr
LIF receptor subunit alpha
increases expression
EXP
Nevirapine metabolite results in increased expression of LIFR mRNA
CTD
PMID:23947594
NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
G
Lipg
lipase G, endothelial type
decreases expression
EXP
Nevirapine metabolite results in decreased expression of LIPG mRNA; Nevirapine results in decreased expression of LIPG mRNA
CTD
PMID:23947594
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
G
Lpin1
lipin 1
increases expression
EXP
Nevirapine metabolite results in increased expression of LPIN1 mRNA
CTD
PMID:23947594
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
G
Lpl
lipoprotein lipase
increases expression
ISO
Nevirapine results in increased expression of LPL mRNA
CTD
PMID:21619898
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
G
Lrg1
leucine-rich alpha-2-glycoprotein 1
increases expression
EXP
Nevirapine metabolite results in increased expression of LRG1 mRNA
CTD
PMID:23947594
NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813
G
Ly86
lymphocyte antigen 86
decreases expression
EXP
Nevirapine results in decreased expression of LY86 mRNA
CTD
PMID:23947594
NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260
G
Meox2
mesenchyme homeobox 2
increases expression
EXP
Nevirapine results in increased expression of MEOX2 mRNA
CTD
PMID:23947594
NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467
G
Met
MET proto-oncogene, receptor tyrosine kinase
increases expression
ISO
Nevirapine results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Mgp
matrix Gla protein
increases expression
EXP
Nevirapine results in increased expression of MGP mRNA
CTD
PMID:23947594
NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
G
Mrc1
mannose receptor, C type 1
increases expression
EXP
Nevirapine metabolite results in increased expression of MRC1 mRNA
CTD
PMID:23947594
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
G
Ms4a7
membrane spanning 4-domains A7
decreases expression
EXP
Nevirapine results in decreased expression of MS4A7 mRNA
CTD
PMID:23947594
NCBI chr 1:207,969,117...207,984,743
Ensembl chr 1:207,968,761...207,983,260
G
Nampt
nicotinamide phosphoribosyltransferase
increases expression
EXP
Nevirapine metabolite results in increased expression of NAMPT mRNA
CTD
PMID:23947594
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
G
Ndufaf4
NADH:ubiquinone oxidoreductase complex assembly factor 4
increases expression
EXP
Nevirapine results in increased expression of NDUFAF4 mRNA
CTD
PMID:23947594
NCBI chr 5:38,605,169...38,610,341
Ensembl chr 5:38,605,153...38,610,336
G
Nlrc5
NLR family, CARD domain containing 5
increases expression
ISO
Nevirapine results in increased expression of NLRC5
CTD
PMID:26626330
NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121
G
Npas2
neuronal PAS domain protein 2
decreases expression
EXP
Nevirapine metabolite results in decreased expression of NPAS2 mRNA; Nevirapine results in decreased expression of NPAS2 mRNA
CTD
PMID:23947594
NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
G
Nptx2
neuronal pentraxin 2
increases expression
EXP
Nevirapine results in increased expression of NPTX2 mRNA
CTD
PMID:23947594
NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
decreases expression
EXP
Nevirapine metabolite results in decreased expression of NR1D1 mRNA
CTD
PMID:23947594
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
[Nevirapine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Nevirapine results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CTD
PMID:17041008
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Nrep
neuronal regeneration related protein
decreases expression
EXP
Nevirapine metabolite results in decreased expression of NREP mRNA; Nevirapine results in decreased expression of NREP mRNA
CTD
PMID:23947594
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
G
P2rx7
purinergic receptor P2X 7
decreases expression
EXP
Nevirapine results in decreased expression of P2RX7 mRNA
CTD
PMID:23947594
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
G
Pcp4l1
Purkinje cell protein 4-like 1
decreases expression
EXP
Nevirapine results in decreased expression of PCP4L1 mRNA
CTD
PMID:23947594
NCBI chr13:83,588,992...83,612,631
Ensembl chr13:83,588,992...83,609,966
G
Pdk4
pyruvate dehydrogenase kinase 4
increases expression
EXP
Nevirapine metabolite results in increased expression of PDK4 mRNA
CTD
PMID:23947594
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
G
Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Nevirapine results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
G
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
increases expression
EXP
Nevirapine results in increased expression of PIK3IP1 mRNA
CTD
PMID:23947594
NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608
G
Pir
pirin
increases expression
EXP
Nevirapine metabolite results in increased expression of PIR mRNA
CTD
PMID:23947594
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
G
Pira2
paired-Ig-like receptor A2
decreases expression
EXP
Nevirapine results in decreased expression of PIRA2 mRNA
CTD
PMID:23947594
NCBI chr 1:65,352,125...65,422,842
Ensembl chr 1:65,415,946...65,422,853
G
Pnpla2
patatin-like phospholipase domain containing 2
increases expression
EXP
Nevirapine metabolite results in increased expression of PNPLA2 mRNA
CTD
PMID:23947594
NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
G
Por
cytochrome p450 oxidoreductase
increases expression
EXP
Nevirapine metabolite results in increased expression of POR mRNA; Nevirapine results in increased expression of POR mRNA
CTD
PMID:23947594
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
Nevirapine results in increased expression of PPARG mRNA
CTD
PMID:21619898
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
decreases expression
EXP
Nevirapine metabolite results in decreased expression of PPP2R2B mRNA; Nevirapine results in decreased expression of PPP2R2B mRNA
CTD
PMID:23947594
NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
G
Prf1
perforin 1
decreases expression
EXP
Nevirapine metabolite results in decreased expression of PRF1 mRNA
CTD
PMID:23947594
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
G
Pycr1
pyrroline-5-carboxylate reductase 1
decreases expression
EXP
Nevirapine metabolite results in decreased expression of PYCR1 mRNA
CTD
PMID:23947594
NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
G
Rbm3
RNA binding motif protein 3
increases expression
EXP
Nevirapine results in increased expression of RBM3 mRNA
CTD
PMID:23947594
NCBI chr X:14,348,909...14,352,387
Ensembl chr X:14,348,910...14,353,580
G
Retreg1
reticulophagy regulator 1
increases expression
EXP
Nevirapine metabolite results in increased expression of RETREG1 mRNA; Nevirapine results in increased expression of RETREG1 mRNA
CTD
PMID:23947594
NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898
G
Rhbdd2
rhomboid domain containing 2
increases expression
EXP
Nevirapine results in increased expression of RHBDD2 mRNA
CTD
PMID:23947594
NCBI chr12:21,043,605...21,054,305
Ensembl chr12:21,043,608...21,054,289
G
Rprm
reprimo, TP53 dependent G2 arrest mediator homolog
decreases expression
EXP
Nevirapine metabolite results in decreased expression of RPRM mRNA
CTD
PMID:23947594
NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998
G
S100a7a
S100 calcium binding protein A7A
increases expression
EXP
Nevirapine metabolite results in increased expression of S100A7A mRNA
CTD
PMID:23947594
NCBI chr 2:176,151,405...176,155,846
Ensembl chr 2:176,151,288...176,156,441
G
Scp2
sterol carrier protein 2
increases expression
ISO
Nevirapine results in increased expression of SCP2
CTD
PMID:26626330
NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
G
Slamf9
SLAM family member 9
decreases expression
EXP
Nevirapine results in decreased expression of SLAMF9 mRNA
CTD
PMID:23947594
NCBI chr13:84,941,896...84,944,749
Ensembl chr13:84,941,982...84,944,748
G
Slc34a2
solute carrier family 34 member 2
decreases expression
EXP
Nevirapine metabolite results in decreased expression of SLC34A2 mRNA
CTD
PMID:23947594
NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
G
Slc5a5
solute carrier family 5 member 5
multiple interactions
ISO
[Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 protein
CTD
PMID:16030158
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Nevirapine results in increased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Srebf1
sterol regulatory element binding transcription factor 1
increases expression decreases expression
ISO EXP
Nevirapine results in increased expression of SREBF1 mRNA Nevirapine metabolite results in decreased expression of SREBF1 mRNA
CTD
PMID:21619898 PMID:23947594
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Sult1a1
sulfotransferase family 1A member 1
increases activity
EXP
Nevirapine metabolite results in increased activity of SULT1A1 protein; Nevirapine results in increased activity of SULT1A1 protein
CTD
PMID:27417440
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Tg
thyroglobulin
increases expression
ISO
Nevirapine results in increased expression of TG mRNA; Nevirapine results in increased expression of TG protein
CTD
PMID:16030158
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
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Tmem64
transmembrane protein 64
increases expression
EXP
Nevirapine metabolite results in increased expression of TMEM64 mRNA; Nevirapine results in increased expression of TMEM64 mRNA
CTD
PMID:23947594
NCBI chr 5:28,698,947...28,745,384
Ensembl chr 5:28,698,918...28,745,330
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Tnfaip6
TNF alpha induced protein 6
increases expression
ISO
Nevirapine results in increased expression of TNFAIP6 mRNA
CTD
PMID:32816093
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Tox3
TOX high mobility group box family member 3
increases expression
EXP
Nevirapine results in increased expression of TOX3 mRNA
CTD
PMID:23947594
NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148
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Tpo
thyroid peroxidase
increases expression
ISO
Nevirapine results in increased expression of TPO mRNA; Nevirapine results in increased expression of TPO protein
CTD
PMID:16030158
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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Trim24
tripartite motif-containing 24
decreases expression
EXP
Nevirapine results in decreased expression of TRIM24 mRNA
CTD
PMID:23947594
NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241
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Trim63
tripartite motif containing 63
increases expression
EXP
Nevirapine metabolite results in increased expression of TRIM63 mRNA
CTD
PMID:23947594
NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
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Tsc22d3
TSC22 domain family, member 3
increases expression
EXP
Nevirapine results in increased expression of TSC22D3 mRNA
CTD
PMID:23947594
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
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Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
[Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 protein; Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]
CTD
PMID:16030158
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Tshr
thyroid stimulating hormone receptor
increases expression
ISO
Nevirapine results in increased expression of TSHR mRNA
CTD
PMID:16030158
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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Tsku
tsukushi, small leucine rich proteoglycan
increases expression
EXP
Nevirapine results in increased expression of TSKU mRNA
CTD
PMID:23947594
NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
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Ucp1
uncoupling protein 1
increases expression
ISO
Nevirapine results in increased expression of UCP1
CTD
PMID:16038477
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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Ucp3
uncoupling protein 3
increases expression
EXP
Nevirapine metabolite results in increased expression of UCP3 mRNA
CTD
PMID:23947594
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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Vcam1
vascular cell adhesion molecule 1
increases expression
EXP
Nevirapine metabolite results in increased expression of VCAM1 mRNA
CTD
PMID:23947594
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Nevirapine results in decreased expression of VEGFA mRNA
CTD
PMID:19152342
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vsnl1
visinin-like 1
decreases expression
EXP
Nevirapine metabolite results in decreased expression of VSNL1 mRNA; Nevirapine results in decreased expression of VSNL1 mRNA
CTD
PMID:23947594
NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
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Zap70
zeta chain of T cell receptor associated protein kinase 70
increases expression
EXP
Nevirapine results in increased expression of ZAP70 mRNA
CTD
PMID:23947594
NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
Foscarnet inhibits the reaction [Phosphates results in decreased expression of AKT1 mRNA]
CTD
PMID:23308213
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Dmp1
dentin matrix acidic phosphoprotein 1
multiple interactions
ISO
Foscarnet inhibits the reaction [Phosphates results in increased expression of DMP1 mRNA]
CTD
PMID:20185895
NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323
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Phex
phosphate regulating endopeptidase X-linked
multiple interactions
ISO
Foscarnet inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA]
CTD
PMID:18500657
NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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Slc16a1
solute carrier family 16 member 1
multiple interactions increases import
EXP
Foscarnet inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid] SLC16A1 protein results in increased import of Foscarnet
CTD
PMID:10579682 PMID:10714609
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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Slc20a1
solute carrier family 20 member 1
decreases activity multiple interactions increases expression
ISO EXP
Foscarnet results in decreased activity of SLC20A1 protein Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A1 mRNA] Foscarnet results in increased expression of SLC20A1 mRNA
CTD
PMID:15641067 PMID:17438129 PMID:23308213
NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
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Slc20a2
solute carrier family 20 member 2
multiple interactions
ISO
Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A2 mRNA]
CTD
PMID:23308213
NCBI chr16:69,460,850...69,551,418
Ensembl chr16:69,460,462...69,521,711
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Slc23a2
solute carrier family 23 member 2
multiple interactions
ISO
Foscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]
CTD
PMID:12788230
NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
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Spp1
secreted phosphoprotein 1
multiple interactions
ISO
Foscarnet inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 protein]
CTD
PMID:12788230 PMID:17383965 PMID:18412142
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Stc1
stanniocalcin 1
increases expression
EXP
Foscarnet results in increased expression of STC1 mRNA
CTD
PMID:17438129
NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
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Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
Tenofovir results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Acacb
acetyl-CoA carboxylase beta
affects expression
ISO
Tenofovir affects the expression of ACACB mRNA
CTD
PMID:20032539
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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Bnip3l
BCL2 interacting protein 3 like
increases expression
ISO
Tenofovir results in increased expression of BNIP3L protein
CTD
PMID:23640862
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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Casp3
caspase 3
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein]
CTD
PMID:36309141
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in decreased activity of CAT protein
CTD
PMID:34118364
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl20
C-C motif chemokine ligand 20
increases expression multiple interactions
ISO
Tenofovir results in increased expression of CCL20 mRNA Tenofovir results in increased expression of and results in increased secretion of CCL20 protein
CTD
PMID:24205323
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
[Emtricitabine co-treated with Tenofovir] results in increased expression of CDKN1A protein Tenofovir results in increased expression of CDKN1A protein
CTD
PMID:31545371
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Tenofovir results in decreased activity of CYP2E1 protein
CTD
PMID:17162464
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Ddx3y
DEAD box helicase 3, Y-linked
increases expression
EXP
Tenofovir results in increased expression of DDX3Y mRNA
CTD
PMID:37852574
NCBI chr Y:1,115,095...1,135,754
Ensembl chr Y:1,116,309...1,135,706
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Edn1
endothelin 1
increases secretion multiple interactions
ISO
Tenofovir results in increased secretion of EDN1 protein coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]
CTD
PMID:23640862
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
affects phosphorylation
ISO
Tenofovir affects the phosphorylation of EIF2S1 protein
CTD
PMID:27041070
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Fgb
fibrinogen beta chain
decreases expression
EXP
Tenofovir results in decreased expression of FGB mRNA
CTD
PMID:37852574
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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Gjc2
gap junction protein, gamma 2
increases expression
EXP
Tenofovir results in increased expression of GJC2 mRNA
CTD
PMID:37852574
NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467
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Havcr1
hepatitis A virus cellular receptor 1
increases secretion multiple interactions
ISO
Tenofovir results in increased secretion of HAVCR1 protein Tenofovir inhibits the reaction [cidofovir results in increased secretion of HAVCR1 protein]
CTD
PMID:29738843
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
affects expression
ISO
Tenofovir affects the expression of HSD11B1 mRNA
CTD
PMID:20032539
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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Hspd1
heat shock protein family D (Hsp60) member 1
affects expression
ISO
Tenofovir affects the expression of HSPD1 protein
CTD
PMID:27041070
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Il1b
interleukin 1 beta
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein]
CTD
PMID:36309141
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Irf4
interferon regulatory factor 4
decreases expression
EXP
Tenofovir results in decreased expression of IRF4 mRNA
CTD
PMID:37852574
NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
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Kdm5d
lysine demethylase 5D
increases expression
EXP
Tenofovir results in increased expression of KDM5D mRNA
CTD
PMID:37852574
NCBI chr Y:527,069...624,019
Ensembl chr Y:530,401...624,018
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Klf15
KLF transcription factor 15
decreases expression
EXP
Tenofovir results in decreased expression of KLF15 mRNA
CTD
PMID:37852574
NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
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Lipe
lipase E, hormone sensitive type
affects expression
ISO
Tenofovir affects the expression of LIPE mRNA
CTD
PMID:20032539
NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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Lonp1
lon peptidase 1, mitochondrial
affects expression
ISO
Tenofovir affects the expression of LONP1 protein
CTD
PMID:27041070
NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
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Lpin1
lipin 1
decreases expression
EXP
Tenofovir results in decreased expression of LPIN1 mRNA
CTD
PMID:37852574
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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Mapk8
mitogen-activated protein kinase 8
affects phosphorylation
ISO
Tenofovir affects the phosphorylation of MAPK8 protein
CTD
PMID:27041070
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mpo
myeloperoxidase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of MPO protein
CTD
PMID:34118364
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
multiple interactions
ISO
Tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]
CTD
PMID:16940060
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Nfkbia
NFKB inhibitor alpha
decreases expression
EXP
Tenofovir results in decreased expression of NFKBIA protein
CTD
PMID:27899301
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
increases expression
EXP
Tenofovir results in increased expression of NOS2 mRNA; Tenofovir results in increased expression of NOS2 protein
CTD
PMID:27899301
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
multiple interactions decreases phosphorylation
ISO
coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]
CTD
PMID:23640862
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects expression
ISO
Tenofovir affects the expression of NR3C1 mRNA
CTD
PMID:20032539
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nt5e
5' nucleotidase, ecto
increases expression
ISO
Tenofovir results in increased expression of NT5E mRNA
CTD
PMID:24205323
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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Nt5m
5',3'-nucleotidase, mitochondrial
decreases expression
ISO
Tenofovir results in decreased expression of NT5M mRNA
CTD
PMID:24205323
NCBI chr10:44,652,845...44,680,549
Ensembl chr10:44,652,975...44,679,150
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Pparg
peroxisome proliferator-activated receptor gamma
affects expression
ISO
Tenofovir affects the expression of PPARG mRNA
CTD
PMID:20032539
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Prkn
parkin RBR E3 ubiquitin protein ligase
multiple interactions
ISO
[Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein
CTD
PMID:31545371
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
EXP
Tenofovir results in increased expression of PTGS2 mRNA; Tenofovir results in increased expression of PTGS2 protein
CTD
PMID:27899301
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression affects localization
EXP
Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]; Tenofovir results in increased expression of and results in increased activity of RELA protein
CTD
PMID:27899301
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Sirt3
sirtuin 3
increases expression
ISO
Tenofovir results in increased expression of SIRT3 protein
CTD
PMID:27041070
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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Slc22a6
solute carrier family 22 member 6
increases response to substance multiple interactions increases import
ISO
SLC22A6 protein results in increased susceptibility to Tenofovir Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to Tenofovir; Tenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] SLC22A6 protein results in increased import of Tenofovir
CTD
PMID:23856525 PMID:25448811 PMID:29738843
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
increases response to substance increases import
ISO
SLC22A8 protein results in increased susceptibility to Tenofovir SLC22A8 protein results in increased import of Tenofovir
CTD
PMID:25448811 PMID:29738843
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Tnf
tumor necrosis factor
decreases expression increases expression multiple interactions
ISO EXP
Tenofovir results in decreased expression of TNF mRNA Tenofovir results in increased expression of TNF mRNA; Tenofovir results in increased expression of TNF protein [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein]
CTD
PMID:24205323 PMID:27899301 PMID:36309141
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Emtricitabine co-treated with Tenofovir] results in increased expression of TP53 protein Tenofovir results in increased expression of TP53 protein
CTD
PMID:31545371
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Usp18
ubiquitin specific peptidase 18
increases expression
EXP
Tenofovir results in increased expression of USP18 mRNA
CTD
PMID:37852574
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
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Akt1
AKT serine/threonine kinase 1
affects phosphorylation
EXP
Zalcitabine affects the phosphorylation of AKT1 protein
CTD
PMID:19781600
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
affects binding
ISO
Zalcitabine binds to ALB protein
CTD
PMID:15814459
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Ano3
anoctamin 3
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ANO3 mRNA
CTD
PMID:18606552
NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
increases response to substance
ISO
APEX1 protein mutant form results in increased susceptibility to Zalcitabine
CTD
PMID:17259346
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Arnt2
aryl hydrocarbon receptor nuclear translocator 2
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ARNT2 mRNA
CTD
PMID:18606552
NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
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Atp2b4
ATPase plasma membrane Ca2+ transporting 4
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ATP2B4 mRNA
CTD
PMID:18606552
NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
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Bptf
bromodomain PHD finger transcription factor
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of BPTF mRNA
CTD
PMID:18606552
NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769
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C10h17orf75
similar to human chromosome 17 open reading frame 75
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of C10H17ORF75 mRNA
CTD
PMID:18606552
NCBI chr10:65,360,924...65,373,864
Ensembl chr10:65,360,924...65,373,864
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Ccl2
C-C motif chemokine ligand 2
increases expression
EXP
Zalcitabine results in increased expression of CCL2 protein
CTD
PMID:17761732
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cxcl12
C-X-C motif chemokine ligand 12
increases expression
EXP
Zalcitabine results in increased expression of CXCL12 mRNA
CTD
PMID:17292584
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcr4
C-X-C motif chemokine receptor 4
increases expression
EXP
Zalcitabine results in increased expression of CXCR4 mRNA
CTD
PMID:17292584
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Dck
deoxycytidine kinase
affects response to substance
ISO
DCK protein affects the susceptibility to Zalcitabine
CTD
PMID:11952160
NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247
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Depdc1b
DEP domain containing 1B
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of DEPDC1B mRNA
CTD
PMID:18606552
NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
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Dlg5
discs large MAGUK scaffold protein 5
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNA
CTD
PMID:18606552
NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837
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Esrrg
estrogen-related receptor gamma
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNA
CTD
PMID:18606552
NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
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Fam81a
family with sequence similarity 81, member A
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FAM81A mRNA
CTD
PMID:18606552
NCBI chr 8:70,762,852...70,821,898
Ensembl chr 8:70,763,614...70,821,875
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Fpgt
fucose-1-phosphate guanylyltransferase
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FPGT mRNA
CTD
PMID:18606552
NCBI chr 2:244,099,031...244,119,967
Ensembl chr 2:244,099,076...244,119,899
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Gla
galactosidase, alpha
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of GLA mRNA
CTD
PMID:18606552
NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664
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Htr2a
5-hydroxytryptamine receptor 2A
increases response to substance increases expression multiple interactions
ISO EXP
HTR2A gene results in increased susceptibility to Zalcitabine Zalcitabine results in increased expression of HTR2A protein [alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Zalcitabine
CTD
PMID:17888573
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Il2ra
interleukin 2 receptor subunit alpha
decreases expression multiple interactions
ISO
Zalcitabine results in decreased expression of IL2RA mRNA; Zalcitabine results in decreased expression of IL2RA protein Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]
CTD
PMID:7606800
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Irf7
interferon regulatory factor 7
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of IRF7 mRNA
CTD
PMID:18606552
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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Kif5a
kinesin family member 5A
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNA
CTD
PMID:18606552
NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858
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Lama5
laminin subunit alpha 5
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNA
CTD
PMID:18606552
NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451
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Luzp2
leucine zipper protein 2
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of LUZP2 mRNA
CTD
PMID:18606552
NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183
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Midn
midnolin
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of MIDN mRNA
CTD
PMID:18606552
NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
decreases expression multiple interactions
ISO
Zalcitabine results in decreased expression of COX1 protein Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein]
CTD
PMID:17187420 PMID:18823003 PMID:20032772
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
decreases expression
EXP
Zalcitabine results in decreased expression of COX2 mRNA
CTD
PMID:19781600
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Mt-co3
mitochondrially encoded cytochrome c oxidase III
decreases expression
ISO
Zalcitabine results in decreased expression of COX3 protein
CTD
PMID:17508937
NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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Ndufb11
NADH:ubiquinone oxidoreductase subunit B11
multiple interactions
ISO
Zalcitabine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]
CTD
PMID:17904600
NCBI chr X:1,572,805...1,575,063
Ensembl chr X:1,572,785...1,575,062
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Necab1
N-terminal EF-hand calcium binding protein 1
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NECAB1 mRNA
CTD
PMID:18606552
NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642 Ensembl chr 5:28,357,859...28,578,642
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Nkiras1
NFKB inhibitor interacting Ras-like 1
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NKIRAS1 mRNA
CTD
PMID:18606552
NCBI chr15:7,493,531...7,503,758
Ensembl chr15:7,493,531...7,503,854
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Notch1
notch receptor 1
increases mutagenesis
ISO
Zalcitabine results in increased mutagenesis of NOTCH1 gene
CTD
PMID:18798262
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Npy
neuropeptide Y
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNA
CTD
PMID:18606552
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative form
CTD
PMID:18606552
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Per2
period circadian regulator 2
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of PER2 mRNA
CTD
PMID:18606552
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Rab27b
RAB27B, member RAS oncogene family
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of RAB27B mRNA
CTD
PMID:18606552
NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
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Reg3b
regenerating family member 3 beta
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B mRNA; [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B protein
CTD
PMID:18606552
NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
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Robo2
roundabout guidance receptor 2
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNA
CTD
PMID:18606552
NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536
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Sanbr
SANT and BTB domain regulator of CSR
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SANBR mRNA
CTD
PMID:18606552
NCBI chr14:97,516,652...97,585,955
Ensembl chr14:97,516,413...97,581,346
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Scube1
signal peptide, CUB domain and EGF like domain containing 1
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SCUBE1 mRNA
CTD
PMID:18606552
NCBI chr 7:114,759,016...114,880,995
Ensembl chr 7:114,759,010...114,880,940
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Senp5
SUMO specific peptidase 5
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SENP5 mRNA
CTD
PMID:18606552
NCBI chr11:68,784,699...68,819,569
Ensembl chr11:68,784,957...68,819,562
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Slc28a1
solute carrier family 28 member 1
multiple interactions increases uptake
EXP
Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine] SLC28A1 protein results in increased uptake of Zalcitabine
CTD
PMID:8027026 PMID:8700147 PMID:8713072
NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
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Slc29a3
solute carrier family 29 member 3
affects transport
ISO
SLC29A3 protein affects the transport of Zalcitabine
CTD
PMID:19164483
NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388
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Slc35g2
solute carrier family 35, member G2
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SLC35G2 mRNA
CTD
PMID:18606552
NCBI chr 8:101,085,579...101,113,339
Ensembl chr 8:101,085,545...101,113,349
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Slc4a8
solute carrier family 4 member 8
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SLC4A8 mRNA
CTD
PMID:18606552
NCBI chr 7:131,861,284...131,939,295
Ensembl chr 7:131,864,102...131,931,051
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St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ST8SIA3 mRNA
CTD
PMID:18606552
NCBI chr18:57,754,349...57,760,839
Ensembl chr18:57,754,347...57,760,839
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Sv2b
synaptic vesicle glycoprotein 2b
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SV2B mRNA
CTD
PMID:18606552
NCBI chr 1:128,978,471...129,152,479
Ensembl chr 1:128,978,473...129,152,479
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Tfam
transcription factor A, mitochondrial
affects expression
ISO
Zalcitabine affects the expression of TFAM protein
CTD
PMID:7849699
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Tk1
thymidine kinase 1
decreases expression
ISO
Zalcitabine results in decreased expression of TK1 mRNA; Zalcitabine results in decreased expression of TK1 protein
CTD
PMID:14659972
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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Tk2
thymidine kinase 2
decreases expression
ISO
Zalcitabine results in decreased expression of TK2 mRNA
CTD
PMID:14659972
NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
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Trpv4
transient receptor potential cation channel, subfamily V, member 4
increases response to substance
EXP
TRPV4 protein results in increased susceptibility to Zalcitabine
CTD
PMID:18234883
NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
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Tymp
thymidine phosphorylase
increases expression
ISO
Zalcitabine results in increased expression of TYMP protein
CTD
PMID:16457948
NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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Vgf
VGF nerve growth factor inducible
multiple interactions
EXP
[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of VGF mRNA
CTD
PMID:18606552
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Abca3
ATP binding cassette subfamily A member 3
increases expression
ISO
Zidovudine results in increased expression of ABCA3 mRNA
CTD
PMID:24292225
NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
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Abca7
ATP binding cassette subfamily A member 7
decreases expression increases expression
ISO
Zidovudine results in decreased expression of ABCA7 mRNA Zidovudine results in increased expression of ABCA7 mRNA
CTD
PMID:24292225
NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression
EXP
Zidovudine results in decreased expression of ABCB11 mRNA
CTD
PMID:27765674
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
Zidovudine results in increased expression of ABCB1 mRNA; Zidovudine results in increased expression of ABCB1 protein
CTD
PMID:9148857 PMID:15456083 PMID:18310046 PMID:24292225
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb9
ATP binding cassette subfamily B member 9
increases expression
ISO
Zidovudine results in increased expression of ABCB9 mRNA
CTD
PMID:24292225
NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
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Abcc1
ATP binding cassette subfamily C member 1
increases expression
ISO
Zidovudine results in increased expression of ABCC1 mRNA
CTD
PMID:24292225
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc10
ATP binding cassette subfamily C member 10
increases expression
ISO
Zidovudine results in increased expression of ABCC10 mRNA
CTD
PMID:24292225
NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178
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Abcc3
ATP binding cassette subfamily C member 3
increases expression decreases expression
ISO EXP
Zidovudine results in increased expression of ABCC3 mRNA Zidovudine results in decreased expression of ABCC3 mRNA
CTD
PMID:24292225 PMID:27765674
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4
ATP binding cassette subfamily C member 4
affects abundance increases expression increases export
ISO
ABCC4 protein affects the abundance of Zidovudine Zidovudine results in increased expression of ABCC4 mRNA ABCC4 protein results in increased export of Zidovudine
CTD
PMID:15456083 PMID:18364470 PMID:18535159
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abcc5
ATP binding cassette subfamily C member 5
increases export increases expression
ISO
ABCC5 protein results in increased export of Zidovudine Zidovudine results in increased expression of ABCC5 mRNA
CTD
PMID:15456083 PMID:18535159 PMID:24292225
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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Abcc6
ATP binding cassette subfamily C member 6
increases expression
ISO
Zidovudine results in increased expression of ABCC6 mRNA
CTD
PMID:24292225
NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Abcd1
ATP binding cassette subfamily D member 1
increases expression
ISO
Zidovudine results in increased expression of ABCD1 mRNA
CTD
PMID:24292225
NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115
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Abcf2
ATP binding cassette subfamily F member 2
increases expression
ISO
Zidovudine results in increased expression of ABCF2 mRNA
CTD
PMID:24292225
NCBI chr 4:10,594,802...10,607,620
Ensembl chr 4:10,594,907...10,607,606
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Abcf3
ATP binding cassette subfamily F member 3
increases expression
ISO
Zidovudine results in increased expression of ABCF3 mRNA
CTD
PMID:24292225
NCBI chr11:80,340,476...80,352,211
Ensembl chr11:80,339,977...80,352,211
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions increases expression decreases expression increases export decreases export
ISO EXP
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Nelfinavir inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; pluronic block copolymer p85 inhibits the reaction [ABCG2 protein results in increased export of Zidovudine] Zidovudine results in increased expression of ABCG2 protein Zidovudine results in decreased expression of ABCG2 mRNA Zidovudine results in increased expression of ABCG2 mRNA
CTD
PMID:17437964 PMID:19056916 PMID:24292225 PMID:27765674 PMID:28705594 PMID:35843342 More...
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abcg8
ATP binding cassette subfamily G member 8
decreases expression
EXP
Zidovudine results in decreased expression of ABCG8 mRNA
CTD
PMID:27765674
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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Acaca
acetyl-CoA carboxylase alpha
affects expression
ISO
Zidovudine affects the expression of ACACA mRNA
CTD
PMID:20032539
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acacb
acetyl-CoA carboxylase beta
affects expression
ISO
Zidovudine affects the expression of ACACB mRNA
CTD
PMID:20032539
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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Acadsb
acyl-CoA dehydrogenase, short/branched chain
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA
CTD
PMID:18313992
NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379
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Acsl6
acyl-CoA synthetase long-chain family member 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA
CTD
PMID:18313992
NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
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Ada
adenosine deaminase
increases expression
ISO
Zidovudine results in increased expression of ADA protein
CTD
PMID:2261134
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression multiple interactions
ISO
Zidovudine results in decreased expression of ADIPOQ protein Zidovudine results in decreased expression of ADIPOQ mRNA; Zidovudine results in decreased expression of ADIPOQ protein [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA
CTD
PMID:15865214 PMID:16931933 PMID:17503663 PMID:17668557
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Aebp1
AE binding protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of AEBP1 mRNA
CTD
PMID:16931933
NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877
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Afap1
actin filament associated protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA
CTD
PMID:15784690
NCBI chr14:74,743,322...74,856,300
Ensembl chr14:74,743,320...74,856,263
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Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
multiple interactions increases expression
EXP
[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA] Zidovudine results in increased expression of AGPAT3 mRNA
CTD
PMID:28619387
NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation
EXP
Zidovudine results in increased phosphorylation of AKT1 protein
CTD
PMID:29594326
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
affects binding
ISO
Zidovudine binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alox5ap
arachidonate 5-lipoxygenase activating protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA
CTD
PMID:16931933
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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Apoa5
apolipoprotein A5
decreases expression multiple interactions
EXP
Zidovudine results in decreased expression of APOA5 mRNA [Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]
CTD
PMID:28619387
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
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Aprt
adenine phosphoribosyl transferase
increases mutagenesis
ISO
Zidovudine results in increased mutagenesis of APRT gene
CTD
PMID:10970446
NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431
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Aqp9
aquaporin 9
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA [Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA
CTD
PMID:18313992 PMID:20370541
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Arpp21
cAMP regulated phosphoprotein 21
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNA
CTD
PMID:16931933
NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
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Asic2
acid sensing ion channel subunit 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA
CTD
PMID:16931933
NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
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Asl
argininosuccinate lyase
multiple interactions increases activity
EXP
[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein] Zidovudine results in increased activity of ASL protein
CTD
PMID:28619387
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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Asns
asparagine synthetase (glutamine-hydrolyzing)
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ASNS mRNA
CTD
PMID:15784690
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Ass1
argininosuccinate synthase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA
CTD
PMID:15784690
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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Atf3
activating transcription factor 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATF3 mRNA
CTD
PMID:15784690
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA
CTD
PMID:11706060
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Atp5f1c
ATP synthase F1 subunit gamma
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5F1C mRNA
CTD
PMID:18313992
NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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Atp5f1d
ATP synthase F1 subunit delta
decreases expression
ISO
Zidovudine results in decreased expression of ATP5F1D mRNA
CTD
PMID:16894629
NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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Atp5mc3
ATP synthase membrane subunit c locus 3
increases expression multiple interactions
ISO
Zidovudine results in increased expression of ATP5MC3 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5MC3 mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
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Atp5me
ATP synthase membrane subunit e
increases expression
ISO
Zidovudine results in increased expression of ATP5ME mRNA
CTD
PMID:16894629
NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
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Atp5mf
ATP synthase membrane subunit f
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5MF mRNA
CTD
PMID:18313992
NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
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Atp5mg
ATP synthase membrane subunit G
increases expression
ISO
Zidovudine results in increased expression of ATP5MG mRNA
CTD
PMID:16894629
NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559
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Atp5pb
ATP synthase peripheral stalk-membrane subunit b
increases expression
ISO
Zidovudine results in increased expression of ATP5PB mRNA
CTD
PMID:16894629
NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
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Atp5pd
ATP synthase peripheral stalk subunit d
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PD mRNA
CTD
PMID:18313992
NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
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Atp5pf
ATP synthase peripheral stalk subunit F6
increases expression multiple interactions
ISO
Zidovudine results in increased expression of ATP5PF mRNA [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PF mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
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Atp5po
ATP synthase peripheral stalk subunit OSCP
increases expression multiple interactions
ISO
Zidovudine results in increased expression of ATP5PO mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5PO mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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Atp8b1
ATPase phospholipid transporting 8B1
decreases expression
ISO
Zidovudine results in decreased expression of ATP8B1 mRNA
CTD
PMID:16894629
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Bcl2
BCL2, apoptosis regulator
affects response to substance increases expression multiple interactions decreases expression
ISO EXP
BCL2 protein affects the susceptibility to Zidovudine Zidovudine results in increased expression of BCL2 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of BCL2 mRNA Drugs, Chinese Herbal promotes the reaction [Zidovudine results in decreased expression of BCL2 mRNA]
CTD
PMID:9850737 PMID:17696246 PMID:18313992 PMID:29594326
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bnip3l
BCL2 interacting protein 3 like
increases expression
ISO
Zidovudine results in increased expression of BNIP3L protein
CTD
PMID:23640862
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
G
Bst2
bone marrow stromal cell antigen 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNA
CTD
PMID:20370541
NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
G
Btg2
BTG anti-proliferation factor 2
increases expression
ISO
Zidovudine results in increased expression of BTG2 mRNA
CTD
PMID:23675285
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
G
C1r
complement C1r
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA
CTD
PMID:16931933
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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C3ar1
complement C3a receptor 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of C3AR1 mRNA
CTD
PMID:16931933 PMID:20370541
NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
G
Cars1
cysteinyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CARS1 mRNA
CTD
PMID:15784690
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
G
Casp3
caspase 3
multiple interactions increases cleavage increases expression increases activity
ISO
[Acrolein co-treated with Zidovudine] results in increased cleavage of CASP3 protein; Drugs, Chinese Herbal promotes the reaction [Zidovudine results in increased expression of CASP3 mRNA] Zidovudine results in increased cleavage of CASP3 protein Zidovudine results in increased expression of CASP3 protein Zidovudine results in increased activity of CASP3 protein 2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; glutapyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; tauropyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]
CTD
PMID:16601281 PMID:17696246 PMID:17943461 PMID:18801031 PMID:27238871
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases cleavage multiple interactions
ISO
Zidovudine results in increased cleavage of CASP8 protein Acrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein]; Zidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein]
CTD
PMID:27238871
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Cat
catalase
decreases response to substance multiple interactions decreases activity
ISO EXP
CAT protein results in decreased susceptibility to Zidovudine Silybin inhibits the reaction [Zidovudine results in decreased activity of CAT protein]
CTD
PMID:19398959 PMID:25586000
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
Zidovudine results in increased expression of CCL2 protein
CTD
PMID:17668557
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccna2
cyclin A2
multiple interactions decreases expression
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNA2 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CCNA2 mRNA Zidovudine results in decreased expression of CCNA2 mRNA
CTD
PMID:15784690 PMID:20370541
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA
CTD
PMID:20370541
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Ccnc
cyclin C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNC mRNA
CTD
PMID:15784690
NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
G
Ccnd1
cyclin D1
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CCND1 mRNA Zidovudine results in increased expression of CCND1 mRNA
CTD
PMID:15784690
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Ccnd2
cyclin D2
multiple interactions decreases expression
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA Zidovudine results in decreased expression of CCND2 mRNA
CTD
PMID:15784690
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
G
Ccne2
cyclin E2
decreases expression multiple interactions
ISO
Zidovudine results in decreased expression of CCNE2 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of CCNE2 mRNA
CTD
PMID:15784690
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
G
Ccnl2
cyclin L2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA
CTD
PMID:20370541
NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882
G
Ccr5
C-C motif chemokine receptor 5
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA
CTD
PMID:20370541
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Cd36
CD36 molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA
CTD
PMID:16931933
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
G
Cd44
CD44 molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA
CTD
PMID:15784690
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
G
Cd83
CD83 molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CD83 mRNA
CTD
PMID:15784690
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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Cdc25a
cell division cycle 25A
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA
CTD
PMID:20370541
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
G
Cdca8
cell division cycle associated 8
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA
CTD
PMID:20370541
NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
G
Cdk1
cyclin-dependent kinase 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA
CTD
PMID:20370541
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
G
Cdk4
cyclin-dependent kinase 4
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA
CTD
PMID:20370541
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
G
Cdk6
cyclin-dependent kinase 6
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA
CTD
PMID:20370541
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdk7
cyclin-dependent kinase 7
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA
CTD
PMID:15784690
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions affects expression decreases expression
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1A mRNA Zidovudine affects the expression of CDKN1A protein Zidovudine results in decreased expression of CDKN1A mRNA
CTD
PMID:15784690 PMID:18389896
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA
CTD
PMID:15784690
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
G
Cdkn1c
cyclin-dependent kinase inhibitor 1C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA
CTD
PMID:15784690
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
affects expression increases expression
ISO
Zidovudine affects the expression of CDKN2A protein Zidovudine results in increased expression of CDKN2A mRNA; Zidovudine results in increased expression of CDKN2A protein
CTD
PMID:16797627 PMID:18389896
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
G
Cdkn2c
cyclin-dependent kinase inhibitor 2C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN2C mRNA
CTD
PMID:15784690
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
G
Cebpa
CCAAT/enhancer binding protein alpha
decreases expression
ISO
Zidovudine results in decreased expression of CEBPA protein
CTD
PMID:15722030
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
G
Cfd
complement factor D
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA
CTD
PMID:16931933
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
G
Chek1
checkpoint kinase 1
increases phosphorylation decreases expression
ISO
Zidovudine results in increased phosphorylation of CHEK1 protein Zidovudine results in decreased expression of CHEK1 protein
CTD
PMID:19541796
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
G
Chek2
checkpoint kinase 2
decreases expression increases phosphorylation
ISO
Zidovudine results in decreased expression of CHEK2 protein Zidovudine results in increased phosphorylation of CHEK2 protein
CTD
PMID:19541796
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Chn1
chimerin 1
decreases expression
ISO
Zidovudine results in decreased expression of CHN1 mRNA
CTD
PMID:16894629
NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490
G
Cidec
cell death-inducing DFFA-like effector c
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA
CTD
PMID:16931933
NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
G
Clcn3
chloride voltage-gated channel 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CLCN3 mRNA
CTD
PMID:16931933
NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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Comt
catechol-O-methyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA
CTD
PMID:15784690
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cox11
cytochrome c oxidase copper chaperone COX11
decreases expression
ISO
Zidovudine results in decreased expression of COX11 mRNA
CTD
PMID:16894629
NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
G
Cox15
cytochrome c oxidase assembly homolog COX15
decreases expression
ISO
Zidovudine results in decreased expression of COX15 mRNA
CTD
PMID:16894629
NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
G
Cox5a
cytochrome c oxidase subunit 5A
decreases expression multiple interactions
ISO
Zidovudine results in decreased expression of COX5A protein [Zidovudine co-treated with Lamivudine] results in decreased expression of COX5A mRNA
CTD
PMID:7807166 PMID:18313992
NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
G
Cox5b
cytochrome c oxidase subunit 5B
multiple interactions decreases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNA Zidovudine results in decreased expression of COX5B protein
CTD
PMID:7807166 PMID:18313992
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
G
Cox6a1
cytochrome c oxidase subunit 6A1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of COX6A1 mRNA
CTD
PMID:18313992
NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041
G
Cox6c
cytochrome c oxidase subunit 6C
decreases expression multiple interactions
ISO
Zidovudine results in decreased expression of COX6C protein [Zidovudine co-treated with Lamivudine] results in increased expression of COX6C mRNA
CTD
PMID:7807166 PMID:18313992
NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
G
Cox7a1
cytochrome c oxidase subunit 7A1
decreases expression
ISO
Zidovudine results in decreased expression of COX7A1 protein
CTD
PMID:7807166
NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151
G
Cox7a2
cytochrome c oxidase subunit 7A2
increases expression
ISO
Zidovudine results in increased expression of COX7A2 mRNA
CTD
PMID:16894629
NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633 Ensembl chr 8:51,301,168...51,301,633
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Cox7b
cytochrome c oxidase subunit 7B
increases expression decreases expression
ISO
Zidovudine results in increased expression of COX7B mRNA Zidovudine results in decreased expression of COX7B protein
CTD
PMID:7807166 PMID:16894629
NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732
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Cox7c
cytochrome c oxidase subunit 7C
decreases expression multiple interactions
ISO
Zidovudine results in decreased expression of COX7C protein [Zidovudine co-treated with Lamivudine] results in increased expression of COX7C mRNA
CTD
PMID:7807166 PMID:18313992
NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
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Cpne5
copine 5
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA
CTD
PMID:20370541
NCBI chr20:7,206,742...7,289,309
Ensembl chr20:7,206,742...7,288,883
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Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNA Zidovudine results in increased expression of CPT1A mRNA
CTD
PMID:14576092 PMID:18313992
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Crat
carnitine O-acetyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of CRAT mRNA
CTD
PMID:18313992
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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Cs
citrate synthase
affects expression decreases expression
ISO
Zidovudine affects the expression of CS mRNA Zidovudine results in decreased expression of CS protein
CTD
PMID:1892364 PMID:20032539
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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Csf2
colony stimulating factor 2
multiple interactions
ISO
[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]; [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]
CTD
PMID:12084393
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Csf2ra
colony stimulating factor 2 receptor subunit alpha
multiple interactions decreases expression
ISO
[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]
CTD
PMID:12084393
NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128
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Csgalnact1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNA
CTD
PMID:20370541
NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
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Cul7
cullin 7
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNA
CTD
PMID:18313992
NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741
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Cyb5a
cytochrome b5 type A
multiple interactions decreases expression
ISO EXP
[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA Zidovudine results in decreased expression of CYB5A mRNA [Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]
CTD
PMID:18313992 PMID:28619387
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA
CTD
PMID:18313992
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CYP1B1 mRNA
CTD
PMID:20370541
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
EXP
[SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine
CTD
PMID:19501153
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Dcn
decorin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA
CTD
PMID:16931933
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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Ddit3
DNA-damage inducible transcript 3
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of DDIT3 mRNA Zidovudine results in increased expression of DDIT3 mRNA
CTD
PMID:15784690
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ddr2
discoidin domain receptor tyrosine kinase 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA
CTD
PMID:20370541
NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
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Dhfr
dihydrofolate reductase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA
CTD
PMID:15784690
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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Diablo
diablo, IAP-binding mitochondrial protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA
CTD
PMID:18313992
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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Dlst
dihydrolipoamide S-succinyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA
CTD
PMID:18313992
NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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Dmd
dystrophin
affects localization
ISO
Zidovudine affects the localization of DMD protein
CTD
PMID:17943461
NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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Dnaja3
DnaJ heat shock protein family (Hsp40) member A3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNA
CTD
PMID:18313992
NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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Dnm1l
dynamin 1-like
multiple interactions affects localization
ISO EXP
[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein Zidovudine affects the localization of DNM1L protein
CTD
PMID:28683400
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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Dtx3l
deltex E3 ubiquitin ligase 3L
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of DTX3L mRNA
CTD
PMID:20370541
NCBI chr11:64,814,926...64,824,539
Ensembl chr11:64,814,926...64,824,538
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Dtymk
deoxythymidylate kinase
multiple interactions affects response to substance
ISO
[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein; DTYMK gene mutant form results in increased phosphorylation of and results in increased susceptibility to Zidovudine
CTD
PMID:17375075 PMID:28683400
NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
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Dusp3
dual specificity phosphatase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNA
CTD
PMID:16931933
NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
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Echs1
enoyl-CoA hydratase, short chain 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA
CTD
PMID:18313992
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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Eci1
enoyl-CoA delta isomerase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNA
CTD
PMID:18313992
NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
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Edn1
endothelin 1
multiple interactions increases secretion
ISO
coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]
CTD
PMID:23640862
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Egr1
early growth response 1
multiple interactions
ISO
[Zidovudine co-treated with Arsenic Trioxide] results in increased expression of EGR1 mRNA
CTD
PMID:29910624
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Ehf
ets homologous factor
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA
CTD
PMID:20370541
NCBI chr 3:89,639,845...89,680,061
Ensembl chr 3:89,641,833...89,679,997
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
Zidovudine results in increased phosphorylation of EIF2S1 protein
CTD
PMID:27041070
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of EIF4EBP1 mRNA
CTD
PMID:15784690
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Elovl3
ELOVL fatty acid elongase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of ELOVL3 mRNA
CTD
PMID:16931933
NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115
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Epo
erythropoietin
increases expression multiple interactions
ISO
Zidovudine results in increased expression of EPO protein EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]; Zidovudine promotes the reaction [Staphylococcal Protein A results in increased expression of EPO protein]
CTD
PMID:1549625 PMID:1889487 PMID:3422548 PMID:7646543 PMID:9735323
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Epor
erythropoietin receptor
multiple interactions decreases expression
ISO
EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein] Zidovudine results in decreased expression of EPOR mRNA; Zidovudine results in decreased expression of EPOR protein
CTD
PMID:1417927 PMID:7646543
NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
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Epsti1
epithelial stromal interaction 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of EPSTI1 mRNA
CTD
PMID:20370541
NCBI chr15:53,283,964...53,382,192
Ensembl chr15:53,284,216...53,382,191
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Esr1
estrogen receptor 1
affects localization
EXP
Zidovudine affects the localization of ESR1 protein
CTD
PMID:15531092
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA
CTD
PMID:16931933
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Etv6
ETS variant transcription factor 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA
CTD
PMID:16931933
NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
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Fabp4
fatty acid binding protein 4
affects expression
ISO
Zidovudine affects the expression of FABP4 mRNA
CTD
PMID:20032539
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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Fads2
fatty acid desaturase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA
CTD
PMID:16931933
NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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Faim
Fas apoptotic inhibitory molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNA
CTD
PMID:16931933
NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562
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Fas
Fas cell surface death receptor
increases expression
ISO
Zidovudine results in increased expression of FAS protein
CTD
PMID:17943461
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression multiple interactions
ISO EXP
Zidovudine results in increased expression of FASLG protein Zidovudine results in increased expression of FASLG mRNA Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA] [Acrolein co-treated with Zidovudine] results in increased expression of FASLG protein; Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]
CTD
PMID:17943461 PMID:27238871
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fasn
fatty acid synthase
affects expression decreases expression multiple interactions
ISO
Zidovudine affects the expression of FASN mRNA Zidovudine results in decreased expression of FASN protein [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNA
CTD
PMID:11741158 PMID:15722030 PMID:20032539
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fcgr1a
Fc gamma receptor 1A
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of FCGR1A mRNA
CTD
PMID:20370541
NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
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Fdxr
ferredoxin reductase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA
CTD
PMID:18313992
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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Fgl2
fibrinogen-like 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of FGL2 mRNA
CTD
PMID:20370541
NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207
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Fh
fumarate hydratase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of FH1 mRNA
CTD
PMID:18313992
NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression
ISO
EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]
CTD
PMID:7646543
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Foxp3
forkhead box P3
multiple interactions
ISO
[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA
CTD
PMID:23962110
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G0s2
G0/G1switch 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA
CTD
PMID:16931933
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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G6pc1
glucose-6-phosphatase catalytic subunit 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of G6PC1 mRNA
CTD
PMID:16931933
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Ganc
glucosidase, alpha; neutral C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNA
CTD
PMID:16931933
NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241
G
Gars1
glycyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of GARS1 mRNA
CTD
PMID:15784690
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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Gas1
growth arrest-specific 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of GAS1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GAS1 mRNA
CTD
PMID:15784690 PMID:20370541
NCBI chr17:4,482,168...4,485,153
G
Gata1
GATA binding protein 1
decreases activity decreases expression
ISO
Zidovudine results in decreased activity of GATA1 protein Zidovudine results in decreased expression of GATA1 mRNA
CTD
PMID:8599995 PMID:10651068
NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530
G
Gbp1
guanylate binding protein 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNA
CTD
PMID:20370541
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
G
Gbp4
guanylate binding protein 4
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNA
CTD
PMID:20370541
NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
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Gpt
glutamic--pyruvic transaminase
multiple interactions affects activity increases activity
EXP
Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; Silybin affects the reaction [Zidovudine affects the activity of GPT protein]; Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]
CTD
PMID:25586000 PMID:28619387
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Grb7
growth factor receptor bound protein 7
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of GRB7 mRNA
CTD
PMID:20370541
NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
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Grhl2
grainyhead-like transcription factor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA
CTD
PMID:16931933
NCBI chr 7:68,400,287...68,530,269
Ensembl chr 7:68,400,477...68,530,258
G
Gtf2h1
general transcription factor IIH subunit 1
increases expression
ISO
Zidovudine results in increased expression of GTF2H1 mRNA; Zidovudine results in increased expression of GTF2H1 protein
CTD
PMID:21192964
NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455
G
Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of GUCY1B1 mRNA
CTD
PMID:16931933
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
G
Gypa
glycophorin A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA gene
CTD
PMID:17358027
NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
G
H2ax
H2A.X variant histone
increases phosphorylation
ISO
Zidovudine results in increased phosphorylation of H2AX protein
CTD
PMID:34510228
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
affects expression
ISO
Zidovudine affects the expression of H6PD mRNA
CTD
PMID:20032539
NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
G
Hadh
hydroxyacyl-CoA dehydrogenase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of HADH mRNA
CTD
PMID:16931933
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNA
CTD
PMID:18313992
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
G
Hax1
HCLS1 associated protein X-1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA
CTD
PMID:15784690
NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
G
Hbb
hemoglobin subunit beta
decreases expression
ISO
Zidovudine results in decreased expression of HBB mRNA
CTD
PMID:10651068
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
G
Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA
CTD
PMID:16931933
NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774
G
Hdlbp
high density lipoprotein binding protein
decreases expression
ISO
Zidovudine results in decreased expression of HDLBP mRNA
CTD
PMID:16894629
NCBI chr 9:93,948,099...94,018,040
Ensembl chr 9:93,949,913...94,018,048
G
Herc6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNA
CTD
PMID:20370541
NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
G
Hist1h4b
histone cluster 1 H4 family member B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA
CTD
PMID:16931933
NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA
CTD
PMID:18313992
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
G
Hmox1
heme oxygenase 1
increases expression
EXP
Zidovudine results in increased expression of HMOX1 mRNA
CTD
PMID:29594326
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
increases mutagenesis
ISO
Zidovudine results in increased mutagenesis of HPRT1 exon
CTD
PMID:10526209
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
G
Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
[Zidovudine co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene
CTD
PMID:9766437
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Hrk
harakiri, BCL2 interacting protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA
CTD
PMID:16931933
NCBI chr12:38,387,484...38,409,652
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
affects expression
ISO
Zidovudine affects the expression of HSD11B1 mRNA
CTD
PMID:20032539
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA
CTD
PMID:18313992
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hsd3b3
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B3 mRNA
CTD
PMID:18313992
NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033
G
Hspd1
heat shock protein family D (Hsp60) member 1
affects expression
ISO
Zidovudine affects the expression of HSPD1 protein
CTD
PMID:27041070
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA
CTD
PMID:18313992
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
G
Idh3a
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA
CTD
PMID:18313992
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
G
Idh3g
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of IDH3G mRNA
CTD
PMID:18313992
NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171
G
Ifi27
interferon, alpha-inducible protein 27
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI27 mRNA
CTD
PMID:20370541
NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
G
Ifi35
interferon-induced protein 35
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI35 mRNA
CTD
PMID:20370541
NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
G
Ifi44l
interferon-induced protein 44-like
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA
CTD
PMID:20370541
NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
G
Ifih1
interferon induced with helicase C domain 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIH1 mRNA
CTD
PMID:20370541
NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
G
Ifit2
interferon-induced protein with tetratricopeptide repeats 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT2 mRNA
CTD
PMID:20370541
NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
G
Ifitm1
interferon induced transmembrane protein 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFITM1 mRNA
CTD
PMID:20370541
NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
G
Ifna1
interferon, alpha 1
multiple interactions affects expression
ISO
[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 protein; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL4 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in increased expression of IL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CD1C mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CYP1B1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GAS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GRB7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of H4C3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of LGALS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of MVD mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PGR mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PIERCE1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB17 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB3B mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RASSF7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of SAPCD2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRIQK mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of WDR62 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNA2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DDX60L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DNA2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DTX3L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of EPSTI1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ERV3-2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of FCGR1A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of FGL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI27 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI35 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIH1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFITM1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ISG15 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of JAK2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LAMP3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LAP3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LGALS9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRA1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LY6E mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MNDA mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MOV10 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MT1G mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MT2A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MX1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MX2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NEXN mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NT5C3A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NUB1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NUF2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PARP9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PCNA mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PF4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PIK3AP1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PLSCR1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RGS6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RNF213 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RPT4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RSAD2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SAMD9L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SCIMP mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SERPING1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SHFL mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC24A4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC7A7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF10 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF13B mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNNI2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TRIM22 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TRMT44 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TTC21A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TXLNGY mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ZNF629 mRNA; IRF4 protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]; REL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein] Zidovudine affects the expression of IFNA1 protein
CTD
PMID:9612607 PMID:17138822 PMID:20370541 PMID:23962110
NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
G
Ifng
interferon gamma
affects expression multiple interactions
ISO
Zidovudine affects the expression of IFNG protein [Arsenic co-treated with Zidovudine co-treated with IFNG protein] results in increased expression of IL2 mRNA
CTD
PMID:9612607 PMID:23962110
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Ikzf4
IKAROS family zinc finger 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of IKZF4 mRNA
CTD
PMID:16931933
NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341
G
Il10
interleukin 10
multiple interactions
ISO
[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 protein
CTD
PMID:23962110
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1a
interleukin 1 alpha
increases expression
ISO
Zidovudine results in increased expression of IL1A protein
CTD
PMID:7979221
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
increases expression
ISO
Zidovudine results in increased expression of IL1B mRNA; Zidovudine results in increased expression of IL1B protein
CTD
PMID:9184656 PMID:17668557
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
multiple interactions
ISO
[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in increased expression of IL2 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNG protein] results in increased expression of IL2 mRNA
CTD
PMID:23962110
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il27ra
interleukin 27 receptor subunit alpha
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA
CTD
PMID:15784690
NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938
G
Il2ra
interleukin 2 receptor subunit alpha
multiple interactions decreases expression
ISO
Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein] Zidovudine results in decreased expression of IL2RA mRNA; Zidovudine results in decreased expression of IL2RA protein
CTD
PMID:7606800
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Il3
interleukin 3
multiple interactions
ISO
[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]; [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]
CTD
PMID:7646543 PMID:12084393
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
G
Il3ra
interleukin 3 receptor subunit alpha
multiple interactions decreases expression
ISO
[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]
CTD
PMID:12084393
NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484
G
Il4
interleukin 4
multiple interactions
ISO
[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL4 mRNA
CTD
PMID:23962110
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il6
interleukin 6
increases expression
ISO
Zidovudine results in increased expression of IL6 protein
CTD
PMID:17668557
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Inpp5e
inositol polyphosphate-5-phosphatase E
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of INPP5E mRNA
CTD
PMID:18313992
NCBI chr 3:9,216,776...9,229,539
Ensembl chr 3:9,216,776...9,229,450
G
Irf2
interferon regulatory factor 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNA
CTD
PMID:20370541
NCBI chr16:45,439,215...45,550,054
Ensembl chr16:45,439,225...45,550,024
G
Irf4
interferon regulatory factor 4
multiple interactions
ISO
IRF4 protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]
CTD
PMID:17138822
NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
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Irf7
interferon regulatory factor 7
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF7 mRNA
CTD
PMID:20370541
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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Isg15
ISG15 ubiquitin-like modifier
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of ISG15 mRNA
CTD
PMID:20370541
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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Itih4
inter-alpha-trypsin inhibitor heavy chain 4
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNA
CTD
PMID:20370541
NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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Jak2
Janus kinase 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of JAK2 mRNA
CTD
PMID:20370541
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Kcng1
potassium voltage-gated channel modifier subfamily G member 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KCNG1 mRNA
CTD
PMID:15784690
NCBI chr 3:156,960,717...156,992,877
Ensembl chr 3:156,973,156...156,992,635
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Kifc2
kinesin family member C2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of KIFC2 mRNA
CTD
PMID:16931933
NCBI chr 7:108,380,634...108,388,364
Ensembl chr 7:108,376,011...108,388,484
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Klf4
KLF transcription factor 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KLF4 mRNA
CTD
PMID:15784690
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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Klhl28
kelch-like family member 28
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of KLHL28 mRNA
CTD
PMID:16931933
NCBI chr 6:82,987,360...83,018,971
Ensembl chr 6:82,990,945...83,016,164
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Kras
KRAS proto-oncogene, GTPase
increases mutagenesis
ISO
Zidovudine results in increased mutagenesis of KRAS gene
CTD
PMID:18800350
NCBI chr 4:178,185,418...178,218,484
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Krt7
keratin 7
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KRT7 mRNA
CTD
PMID:15784690
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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Kynu
kynureninase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of KYNU mRNA
CTD
PMID:15784690
NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
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Lamb3
laminin subunit beta 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of LAMB3 mRNA
CTD
PMID:15784690
NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
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Lamc2
laminin subunit gamma 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of LAMC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of LAMC2 mRNA
CTD
PMID:16931933
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
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Lamp2
lysosomal-associated membrane protein 2
decreases expression
EXP
Zidovudine results in decreased expression of LAMP2 protein
CTD
PMID:29594326
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
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Lamp3
lysosomal-associated membrane protein 3
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of LAMP3 mRNA
CTD
PMID:20370541
NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784
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Lap3
leucine aminopeptidase 3
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of LAP3 mRNA
CTD
PMID:20370541
NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359
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Lef1
lymphoid enhancer binding factor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA
CTD
PMID:16931933
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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Lep
leptin
decreases expression multiple interactions
ISO
Zidovudine results in decreased expression of LEP protein [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA
CTD
PMID:16931933 PMID:17668557
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lgals1
galectin 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of LGALS1 mRNA
CTD
PMID:20370541
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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Lgals9
galectin 9
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of LGALS9 mRNA
CTD
PMID:20370541
NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
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Lilrb4
leukocyte immunoglobulin like receptor B4
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB4 mRNA
CTD
PMID:20370541
NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
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Lipe
lipase E, hormone sensitive type
affects expression
ISO
Zidovudine affects the expression of LIPE mRNA
CTD
PMID:20032539
NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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Lonp1
lon peptidase 1, mitochondrial
affects expression
ISO
Zidovudine affects the expression of LONP1 protein
CTD
PMID:27041070
NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
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Lpl
lipoprotein lipase
decreases expression multiple interactions affects expression
ISO
Zidovudine results in decreased expression of LPL mRNA [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNA Zidovudine affects the expression of LPL mRNA
CTD
PMID:11741158 PMID:16894629 PMID:20032539
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Ly6e
lymphocyte antigen 6 family member E
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of LY6E mRNA
CTD
PMID:20370541
NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
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Mapk8
mitogen-activated protein kinase 8
increases phosphorylation
ISO
Zidovudine results in increased phosphorylation of MAPK8 protein
CTD
PMID:27041070
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mars1
methionyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MARS1 mRNA
CTD
PMID:15784690
NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
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Mdm2
MDM2 proto-oncogene
increases expression
ISO
Zidovudine results in increased expression of MDM2 protein
CTD
PMID:16797627
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Me1
malic enzyme 1
multiple interactions decreases expression
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNA Zidovudine results in decreased expression of ME1 mRNA
CTD
PMID:11741158
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Mff
mitochondrial fission factor
multiple interactions
ISO
[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein
CTD
PMID:28683400
NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039
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Mfn1
mitofusin 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNA
CTD
PMID:18313992
NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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Mfn2
mitofusin 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MFN2 mRNA
CTD
PMID:18313992
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mgat4c
MGAT4 family, member C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MGAT4C mRNA
CTD
PMID:16931933
NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571
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Mmp2
matrix metallopeptidase 2
multiple interactions
EXP
Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]
CTD
PMID:14662518
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
multiple interactions
EXP
Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]
CTD
PMID:14662518
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mmut
methylmalonyl-CoA mutase
affects expression increases expression
ISO
Zidovudine affects the expression of MMUT mRNA mutant form; Zidovudine affects the expression of MMUT protein mutant form Zidovudine results in increased expression of MMUT mRNA; Zidovudine results in increased expression of MMUT protein
CTD
PMID:19199343 PMID:19427250
NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
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Mnda
myeloid cell nuclear differentiation antigen
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of MNDA mRNA
CTD
PMID:20370541
NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201
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Mov10
Mov10 RNA helicase
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of MOV10 mRNA
CTD
PMID:20370541
NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083
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Mr1
major histocompatibility complex, class I-related
affects expression
ISO
Zidovudine affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
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Mrap
melanocortin 2 receptor accessory protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNA
CTD
PMID:16931933
NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024
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Mt-atp6
mitochondrially encoded ATP synthase membrane subunit 6
increases expression
ISO
Zidovudine results in increased expression of ATP6 mRNA
CTD
PMID:16894629
NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
increases expression decreases expression multiple interactions
ISO EXP
Zidovudine results in increased expression of COX1 mRNA Zidovudine results in decreased expression of COX1 protein [Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA; Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein]
CTD
PMID:7528833 PMID:17526437 PMID:18163507 PMID:18313992 PMID:20032772 PMID:29594326 More...
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
decreases expression multiple interactions increases expression
ISO
Zidovudine results in decreased expression of COX2 protein [Zidovudine co-treated with Lamivudine] results in decreased expression of COX2 mRNA Zidovudine results in increased expression of COX2 mRNA
CTD
PMID:7807166 PMID:10912924 PMID:16894629 PMID:18313992
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Mt-co3
mitochondrially encoded cytochrome c oxidase III
affects expression multiple interactions decreases expression increases expression
ISO EXP
Zidovudine affects the expression of COX3 mRNA [Zidovudine co-treated with Lamivudine] results in increased expression of COX3 mRNA Zidovudine results in decreased expression of COX3 mRNA Zidovudine results in increased expression of COX3 mRNA
CTD
PMID:8828681 PMID:9799652 PMID:16894629 PMID:17526437 PMID:18313992 PMID:20032539 More...
NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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Mt-cyb
mitochondrially encoded cytochrome b
affects expression decreases expression increases expression
ISO EXP
Zidovudine affects the expression of CYTB mRNA Zidovudine results in decreased expression of CYTB mRNA Zidovudine results in increased expression of CYTB mRNA
CTD
PMID:1715447 PMID:7528833 PMID:20032539
NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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Mt-nd1
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
increases expression
ISO
Zidovudine results in increased expression of ND1 mRNA
CTD
PMID:16894629
NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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Mt-nd2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
increases expression multiple interactions
ISO
Zidovudine results in increased expression of ND2 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of ND2 mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
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Mt-nd4
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
increases expression affects expression
ISO
Zidovudine results in increased expression of ND4 mRNA Zidovudine affects the expression of ND4 mRNA
CTD
PMID:16894629 PMID:20032539
NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
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Mt-nd5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
increases expression multiple interactions
ISO
Zidovudine results in increased expression of ND5 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of ND5 mRNA
CTD
PMID:16894629 PMID:17526437 PMID:18313992
NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
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Mt2A
metallothionein 2A
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of MT2A mRNA
CTD
PMID:20370541
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of MTHFD2 mRNA
CTD
PMID:15784690
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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Mtor
mechanistic target of rapamycin kinase
increases phosphorylation
EXP
Zidovudine results in increased phosphorylation of MTOR protein
CTD
PMID:29594326
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Mvd
mevalonate diphosphate decarboxylase
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of MVD mRNA
CTD
PMID:20370541
NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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Mx1
MX dynamin like GTPase 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX1 mRNA
CTD
PMID:20370541
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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Mx2
MX dynamin like GTPase 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX2 mRNA
CTD
PMID:20370541
NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
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Myh7
myosin heavy chain 7
increases expression
EXP
Zidovudine results in increased expression of MYH7 mRNA; Zidovudine results in increased expression of MYH7 protein
CTD
PMID:9799652
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Myod1
myogenic differentiation 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MYOD1 mRNA
CTD
PMID:16931933
NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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Nap1l5
nucleosome assembly protein 1-like 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NAP1L5 mRNA
CTD
PMID:16931933
NCBI chr 4:88,022,670...88,024,988
Ensembl chr 4:88,022,569...88,024,654
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Nat2
N-acetyltransferase 2
decreases expression multiple interactions
EXP
Zidovudine results in decreased expression of NAT2 mRNA [Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]
CTD
PMID:28619387
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Ndufa4
Ndufa4, mitochondrial complex associated
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFA4 mRNA
CTD
PMID:18313992
NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920
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Ndufa6
NADH:ubiquinone oxidoreductase subunit A6
increases expression
ISO
Zidovudine results in increased expression of NDUFA6 mRNA
CTD
PMID:16894629
NCBI chr 7:113,866,382...113,870,239
Ensembl chr 7:113,866,382...113,870,239
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Ndufa9
NADH:ubiquinone oxidoreductase subunit A9
increases expression
ISO
Zidovudine results in increased expression of NDUFA9 mRNA
CTD
PMID:16894629
NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
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Ndufab1
NADH:ubiquinone oxidoreductase subunit AB1
increases expression multiple interactions
ISO
Zidovudine results in increased expression of NDUFAB1 mRNA [Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAB1 mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
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Ndufaf1
NADH:ubiquinone oxidoreductase complex assembly factor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAF1 mRNA
CTD
PMID:18313992
NCBI chr 3:106,639,025...106,650,549
Ensembl chr 3:106,639,851...106,650,212
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Ndufb11
NADH:ubiquinone oxidoreductase subunit B11
multiple interactions
ISO
Zidovudine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]
CTD
PMID:17904600
NCBI chr X:1,572,805...1,575,063
Ensembl chr X:1,572,785...1,575,062
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Ndufb3
NADH:ubiquinone oxidoreductase subunit B3
increases expression multiple interactions
ISO
Zidovudine results in increased expression of NDUFB3 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB3 mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446
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Ndufb5
NADH:ubiquinone oxidoreductase subunit B5
increases expression multiple interactions
ISO
Zidovudine results in increased expression of NDUFB5 mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB5 mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589
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Ndufb6
NADH:ubiquinone oxidoreductase subunit B6
increases expression
ISO
Zidovudine results in increased expression of NDUFB6 mRNA
CTD
PMID:16894629
NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
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Ndufb9
NADH:ubiquinone oxidoreductase subunit B9
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFB9 mRNA
CTD
PMID:18313992
NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009
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Ndufc1
NADH:ubiquinone oxidoreductase subunit C1
increases expression multiple interactions
ISO
Zidovudine results in increased expression of NDUFC1 mRNA [Zidovudine co-treated with Lamivudine] results in increased expression of NDUFC1 mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874
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Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
increases expression multiple interactions
ISO
Zidovudine results in increased expression of NDUFS1 mRNA [Zidovudine co-treated with Lamivudine] results in increased expression of NDUFS1 mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
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Ndufs2
NADH:ubiquinone oxidoreductase core subunit S2
decreases expression
ISO
Zidovudine results in decreased expression of NDUFS2 mRNA
CTD
PMID:16894629
NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
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Ndufs5
NADH:ubiquinone oxidoreductase subunit S5
increases expression
ISO
Zidovudine results in increased expression of NDUFS5 mRNA
CTD
PMID:16894629
NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603 Ensembl chr14:135,974,034...135,979,603 Ensembl chr 2:135,974,034...135,979,603
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Ndufs6
NADH:ubiquinone oxidoreductase subunit S6
increases expression
ISO
Zidovudine results in increased expression of NDUFS6 mRNA
CTD
PMID:16894629
NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467
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Ndufv1
NADH:ubiquinone oxidoreductase core subunit V1
decreases expression
ISO
Zidovudine results in decreased expression of NDUFV1 mRNA
CTD
PMID:16894629
NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
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Nexn
nexilin (F actin binding protein)
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of NEXN mRNA
CTD
PMID:20370541
NCBI chr 2:241,186,783...241,218,315
Ensembl chr 2:241,186,790...241,218,342
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Nfe2
nuclear factor, erythroid 2
decreases activity decreases expression
ISO
Zidovudine results in decreased activity of NFE2 protein Zidovudine results in decreased expression of NFE2 mRNA
CTD
PMID:8599995
NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
EXP
Zidovudine results in increased expression of NFE2L2 protein
CTD
PMID:29594326
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Niban1
niban apoptosis regulator 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NIBAN1 mRNA
CTD
PMID:15784690
NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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Noct
nocturnin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of NOCT mRNA
CTD
PMID:16931933
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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Nos3
nitric oxide synthase 3
multiple interactions decreases phosphorylation
ISO
coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein]
CTD
PMID:23640862
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nppa
natriuretic peptide A
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA Zidovudine results in increased expression of NPPA mRNA
CTD
PMID:10701688 PMID:11706060
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
Zidovudine results in increased expression of NQO1 mRNA
CTD
PMID:29594326
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects expression
ISO
Zidovudine affects the expression of NR3C1 mRNA
CTD
PMID:20032539
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nrf1
nuclear respiratory factor 1
increases expression
ISO
Zidovudine results in increased expression of NRF1 mRNA
CTD
PMID:17926646
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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Nt5c3a
5'-nucleotidase, cytosolic IIIA
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of NT5C3A mRNA
CTD
PMID:20370541
NCBI chr 4:86,161,642...86,204,656
Ensembl chr 4:86,161,643...86,204,628
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Nub1
negative regulator of ubiquitin-like proteins 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of NUB1 mRNA
CTD
PMID:20370541
NCBI chr 4:10,442,917...10,473,689
Ensembl chr 4:10,442,917...10,473,694
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Nuf2
NUF2 component of NDC80 kinetochore complex
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of NUF2 mRNA
CTD
PMID:20370541
NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
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Nup210
nucleoporin 210
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NUP210 mRNA
CTD
PMID:16931933
NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874
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Nxnl2
nucleoredoxin-like 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of NXNL2 mRNA
CTD
PMID:16931933
NCBI chr17:14,031,151...14,035,897
Ensembl chr17:14,031,153...14,036,189
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Oas1a
2'-5' oligoadenylate synthetase 1A
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS1 mRNA
CTD
PMID:20370541
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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Oas2
2'-5' oligoadenylate synthetase 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS2 mRNA
CTD
PMID:20370541
NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
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Oas3
2'-5'-oligoadenylate synthetase 3
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNA
CTD
PMID:20370541
NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
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Oaz3
ornithine decarboxylase antizyme 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of OAZ3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of OAZ3 mRNA
CTD
PMID:16931933
NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399
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Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of OGT mRNA
CTD
PMID:15784690
NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146
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Opa1
OPA1, mitochondrial dynamin like GTPase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein
CTD
PMID:18313992 PMID:28683400
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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Oprl1
opioid related nociceptin receptor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNA
CTD
PMID:16931933
NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
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Parp9
poly (ADP-ribose) polymerase family, member 9
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of PARP9 mRNA
CTD
PMID:20370541
NCBI chr11:64,780,977...64,814,995
Ensembl chr11:64,780,981...64,815,455
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Pcbp4
poly(rC) binding protein 4
increases expression
ISO
Zidovudine results in increased expression of PCBP4 mRNA
CTD
PMID:23675285
NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276
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Pcdh15
protocadherin related 15
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PCDH15 mRNA
CTD
PMID:16931933
NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNA
CTD
PMID:15784690
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of PCNA mRNA
CTD
PMID:20370541
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pebp1
phosphatidylethanolamine binding protein 1
decreases expression
ISO
Zidovudine results in decreased expression of PEBP1 mRNA
CTD
PMID:16894629
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
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Pf4
platelet factor 4
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of PF4 mRNA
CTD
PMID:20370541
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA
CTD
PMID:16931933
NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
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Pgap6
post-GPI attachment to proteins 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of PGAP6 mRNA
CTD
PMID:16931933
NCBI chr10:15,138,918...15,148,431
Ensembl chr10:15,138,959...15,148,431
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Pgr
progesterone receptor
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PGR mRNA
CTD
PMID:20370541
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phf6
PHD finger protein 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of PHF6 mRNA
CTD
PMID:16931933
NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127
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Pidd1
p53-induced death domain protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIDD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIDD1 mRNA
CTD
PMID:16931933
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Pierce1
piercer of microtubule wall 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PIERCE1 mRNA
CTD
PMID:20370541
NCBI chr 3:11,797,031...11,801,568
Ensembl chr 3:11,797,031...11,801,568
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Pik3ap1
phosphoinositide-3-kinase adaptor protein 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of PIK3AP1 mRNA
CTD
PMID:20370541
NCBI chr 1:240,090,854...240,245,007
Ensembl chr 1:240,093,065...240,204,828
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Pirb
paired Ig-like receptor B
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB3 mRNA
CTD
PMID:20370541
NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666
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Piwil2
piwi-like RNA-mediated gene silencing 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PIWIL2 mRNA
CTD
PMID:16931933
NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702
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Pkmyt1
protein kinase, membrane associated tyrosine/threonine 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNA
CTD
PMID:20370541
NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
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Plscr1
phospholipid scramblase 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of PLSCR1 mRNA
CTD
PMID:20370541
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
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Pnkp
polynucleotide kinase 3'-phosphatase
increases expression
ISO
Zidovudine results in increased expression of PNKP mRNA
CTD
PMID:23675285
NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920
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Por
cytochrome p450 oxidoreductase
decreases expression multiple interactions
EXP
Zidovudine results in decreased expression of POR mRNA [Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]
CTD
PMID:28619387
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Porcn
porcupine O-acyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PPN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PPN mRNA
CTD
PMID:16931933
NCBI chr X:14,285,864...14,298,481
Ensembl chr X:14,285,871...14,298,481
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Pou5f1
POU class 5 homeobox 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of POU5F1 mRNA
CTD
PMID:16931933
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Pparg
peroxisome proliferator-activated receptor gamma
decreases expression
ISO
Zidovudine results in decreased expression of PPARG mRNA; Zidovudine results in decreased expression of PPARG protein
CTD
PMID:15722030 PMID:17926646
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Prdm1
PR/SET domain 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA
CTD
PMID:16931933
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Psat1
phosphoserine aminotransferase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of PSAT1 mRNA
CTD
PMID:15784690
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Zidovudine results in decreased expression of PTGS2 protein
CTD
PMID:18389896
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rab17
RAB17, member RAS oncogene family
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB17 mRNA
CTD
PMID:20370541
NCBI chr 9:91,552,924...91,566,759
Ensembl chr 9:91,553,464...91,566,451
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Rab3b
RAB3B, member RAS oncogene family
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB3B mRNA
CTD
PMID:20370541
NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
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Rabepk
Rab9 effector protein with kelch motifs
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of RABEPK mRNA
CTD
PMID:15784690
NCBI chr 3:18,061,299...18,083,191
Ensembl chr 3:18,061,574...18,083,191
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Rassf7
Ras association domain family member 7
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RASSF7 mRNA
CTD
PMID:20370541
NCBI chr 1:196,319,600...196,323,787
Ensembl chr 1:196,320,902...196,323,770
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Rbl1
RB transcriptional corepressor like 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL1 mRNA
CTD
PMID:15784690
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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Rbl2
RB transcriptional corepressor like 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL2 mRNA
CTD
PMID:15784690
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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Reep6
receptor accessory protein 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of REEP6 mRNA
CTD
PMID:16931933
NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
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Rel
REL proto-oncogene, NF-kB subunit
multiple interactions
ISO
REL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]
CTD
PMID:17138822
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression
ISO
2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of RELA protein]; glutapyrone inhibits the reaction [Zidovudine results in increased expression of RELA protein]; tauropyrone inhibits the reaction [Zidovudine results in increased expression of RELA protein] Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]
CTD
PMID:18801031 PMID:27238871
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rgs6
regulator of G-protein signaling 6
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of RGS6 mRNA
CTD
PMID:20370541
NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753
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Ripk2
receptor-interacting serine-threonine kinase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of RIPK2 mRNA
CTD
PMID:15784690
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Rnf151
ring finger protein 151
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of RNF151 mRNA
CTD
PMID:16931933
NCBI chr10:13,742,682...13,747,192
Ensembl chr10:13,742,682...13,745,000
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Rnf213
ring finger protein 213
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of RNF213 mRNA
CTD
PMID:20370541
NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918
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Rpa1
replication protein A1
increases expression
ISO
Zidovudine results in increased expression of RPA1 mRNA
CTD
PMID:21192964
NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
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Rpain
RPA interacting protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of RPAIN mRNA
CTD
PMID:16931933
NCBI chr10:55,692,410...55,699,910
Ensembl chr10:55,692,417...55,699,933
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Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
ISO
Zidovudine results in increased expression of RRM2B mRNA
CTD
PMID:21704725
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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Rsad2
radical S-adenosyl methionine domain containing 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of RSAD2 mRNA
CTD
PMID:20370541
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
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RT1-CE16
RT1 class I, locus CE16
affects expression
ISO
Zidovudine affects the expression of HLA-A mRNA
CTD
PMID:25811541
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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S100a8
S100 calcium binding protein A8
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA
CTD
PMID:16931933
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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Samd9l
sterile alpha motif domain containing 9 like
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SAMD9L mRNA
CTD
PMID:20370541
NCBI chr 4:31,362,054...31,376,412
Ensembl chr 4:31,361,669...31,376,415
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Sapcd2
suppressor APC domain containing 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of SAPCD2 mRNA
CTD
PMID:20370541
NCBI chr 3:8,186,089...8,195,119
Ensembl chr 3:8,187,266...8,192,546
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Scimp
SLP adaptor and CSK interacting membrane protein
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SCIMP mRNA
CTD
PMID:20370541
NCBI chr10:55,507,646...55,527,764
Ensembl chr10:55,507,519...55,528,171
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Sdhb
succinate dehydrogenase complex iron sulfur subunit B
decreases expression multiple interactions
ISO
Zidovudine results in decreased expression of SDHB mRNA [Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA
CTD
PMID:16894629 PMID:18313992
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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Sdhd
succinate dehydrogenase complex subunit D
increases expression
ISO
Zidovudine results in increased expression of SDHD mRNA
CTD
PMID:16894629
NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238
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Serinc1
serine incorporator 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SERINC1 mRNA
CTD
PMID:16931933
NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691
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Serping1
serpin family G member 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SERPING1 mRNA
CTD
PMID:20370541
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Sfxn1
sideroflexin 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN1 mRNA
CTD
PMID:18313992
NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
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Sfxn2
sideroflexin 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN2 mRNA
CTD
PMID:18313992
NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411 Ensembl chr 1:245,447,015...245,468,411
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Sfxn4
sideroflexin 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN4 mRNA
CTD
PMID:18313992
NCBI chr 1:259,976,480...259,998,778
Ensembl chr 1:259,976,481...259,998,754
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Sgpp1
sphingosine-1-phosphate phosphatase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SGPP1 mRNA
CTD
PMID:18313992
NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534
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Shfl
shiftless antiviral inhibitor of ribosomal frameshifting
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SHFL mRNA
CTD
PMID:20370541
NCBI chr 8:19,408,298...19,414,084
Ensembl chr 8:19,408,333...19,413,971
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Siglec1
sialic acid binding Ig like lectin 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA
CTD
PMID:20370541
NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850
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Sirt3
sirtuin 3
increases expression
ISO
Zidovudine results in increased expression of SIRT3 protein
CTD
PMID:27041070
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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Slc10a3
solute carrier family 10, member 3
increases expression
ISO
Zidovudine results in increased expression of SLC10A3 mRNA
CTD
PMID:24292225
NCBI chr X:152,154,757...152,158,563
Ensembl chr X:152,151,076...152,162,958
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Slc12a3
solute carrier family 12 member 3
decreases expression
ISO
Zidovudine results in decreased expression of SLC12A3 mRNA
CTD
PMID:24292225
NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091
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Slc12a4
solute carrier family 12 member 4
increases expression
ISO
Zidovudine results in increased expression of SLC12A4 mRNA
CTD
PMID:24292225
NCBI chr19:33,838,418...33,860,369
Ensembl chr19:33,838,419...33,860,331
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Slc12a9
solute carrier family 12, member 9
increases expression
ISO
Zidovudine results in increased expression of SLC12A9 mRNA
CTD
PMID:24292225
NCBI chr12:19,368,990...19,385,881
Ensembl chr12:19,369,004...19,385,877
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Slc13a3
solute carrier family 13 member 3
increases expression decreases expression
ISO
Zidovudine results in increased expression of SLC13A3 mRNA Zidovudine results in decreased expression of SLC13A3 mRNA
CTD
PMID:24292225
NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
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Slc13a5
solute carrier family 13 member 5
decreases expression increases expression
ISO
Zidovudine results in decreased expression of SLC13A5 mRNA Zidovudine results in increased expression of SLC13A5 mRNA
CTD
PMID:24292225
NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945
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Slc16a1
solute carrier family 16 member 1
decreases expression
ISO
Zidovudine results in decreased expression of SLC16A1 mRNA
CTD
PMID:24292225
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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Slc16a2
solute carrier family 16 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC16A2 mRNA
CTD
PMID:24292225
NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771
G
Slc16a3
solute carrier family 16 member 3
decreases expression
ISO
Zidovudine results in decreased expression of SLC16A3 mRNA
CTD
PMID:24292225
NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562
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Slc16a4
solute carrier family 16, member 4
increases expression
ISO
Zidovudine results in increased expression of SLC16A4 mRNA
CTD
PMID:24292225
NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
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Slc16a6
solute carrier family 16, member 6
decreases expression increases expression
ISO
Zidovudine results in decreased expression of SLC16A6 mRNA Zidovudine results in increased expression of SLC16A6 mRNA
CTD
PMID:24292225
NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
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Slc17a2
solute carrier family 17, member 2
decreases expression
ISO
Zidovudine results in decreased expression of SLC17A2 mRNA
CTD
PMID:24292225
NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325
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Slc17a8
solute carrier family 17 member 8
increases expression
ISO
Zidovudine results in increased expression of SLC17A8 mRNA
CTD
PMID:24292225
NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079
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Slc19a2
solute carrier family 19 member 2
decreases expression
ISO
Zidovudine results in decreased expression of SLC19A2 mRNA
CTD
PMID:24292225
NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
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Slc19a3
solute carrier family 19 member 3
decreases expression
ISO
Zidovudine results in decreased expression of SLC19A3 mRNA
CTD
PMID:24292225
NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
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Slc1a1
solute carrier family 1 member 1
increases expression
ISO
Zidovudine results in increased expression of SLC1A1 mRNA
CTD
PMID:24292225
NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
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Slc1a4
solute carrier family 1 member 4
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A4 mRNA Zidovudine results in increased expression of SLC1A4 mRNA
CTD
PMID:15784690 PMID:24292225
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
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Slc1a5
solute carrier family 1 member 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A5 mRNA
CTD
PMID:15784690
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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Slc20a1
solute carrier family 20 member 1
decreases expression
ISO
Zidovudine results in decreased expression of SLC20A1 mRNA
CTD
PMID:24292225
NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
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Slc20a2
solute carrier family 20 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC20A2 mRNA
CTD
PMID:24292225
NCBI chr16:69,460,850...69,551,418
Ensembl chr16:69,460,462...69,521,711
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Slc22a15
solute carrier family 22, member 15
decreases expression
ISO
Zidovudine results in decreased expression of SLC22A15 mRNA
CTD
PMID:24292225
NCBI chr 2:189,298,836...189,359,902
Ensembl chr 2:189,298,832...189,358,792
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Slc22a17
solute carrier family 22, member 17
increases expression
ISO
Zidovudine results in increased expression of SLC22A17 mRNA
CTD
PMID:24292225
NCBI chr15:28,382,285...28,389,435
Ensembl chr15:28,382,292...28,388,799
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Slc22a18
solute carrier family 22, member 18
increases expression
ISO
Zidovudine results in increased expression of SLC22A18 mRNA
CTD
PMID:24292225
NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975
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Slc22a23
solute carrier family 22, member 23
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNA
CTD
PMID:20370541
NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790
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Slc22a25
solute carrier family 22, member 25
decreases expression
ISO
Zidovudine results in decreased expression of SLC22A9 mRNA
CTD
PMID:24292225
NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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Slc22a4
solute carrier family 22 member 4
increases expression
ISO
Zidovudine results in increased expression of SLC22A4 mRNA
CTD
PMID:24292225
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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Slc22a5
solute carrier family 22 member 5
increases expression
ISO
Zidovudine results in increased expression of SLC22A5 mRNA
CTD
PMID:24292225
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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Slc22a7
solute carrier family 22 member 7
increases uptake increases expression
ISO
SLC22A7 protein results in increased uptake of Zidovudine Zidovudine results in increased expression of SLC22A7 mRNA
CTD
PMID:15901346 PMID:24292225
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc23a2
solute carrier family 23 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC23A2 mRNA
CTD
PMID:24292225
NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
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Slc24a4
solute carrier family 24 member 4
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC24A4 mRNA
CTD
PMID:20370541
NCBI chr 6:121,279,590...121,419,811
Ensembl chr 6:121,280,031...121,414,949
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Slc25a1
solute carrier family 25 member 1
increases expression
ISO
Zidovudine results in increased expression of SLC25A1 mRNA
CTD
PMID:24292225
NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781
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Slc25a10
solute carrier family 25 member 10
increases expression
ISO
Zidovudine results in increased expression of SLC25A10 mRNA
CTD
PMID:24292225
NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556
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Slc25a11
solute carrier family 25 member 11
increases expression
ISO
Zidovudine results in increased expression of SLC25A11 mRNA
CTD
PMID:24292225
NCBI chr10:55,357,590...55,360,441
Ensembl chr10:55,357,597...55,360,410
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Slc25a12
solute carrier family 25 member 12
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A12 mRNA
CTD
PMID:18313992
NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100
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Slc25a15
solute carrier family 25 member 15
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A15 mRNA
CTD
PMID:18313992
NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010
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Slc25a16
solute carrier family 25 member 16
increases expression
ISO
Zidovudine results in increased expression of SLC25A16 mRNA
CTD
PMID:24292225
NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319
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Slc25a19
solute carrier family 25 member 19
multiple interactions
ISO
SLC25A19 protein affects the susceptibility to [Zidovudine co-treated with Lamivudine co-treated with Indinavir] [Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A19 mRNA
CTD
PMID:15951836 PMID:18313992
NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
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Slc25a2
solute carrier family 25 member 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A2 mRNA
CTD
PMID:18313992
NCBI chr18:29,452,943...29,456,324
Ensembl chr18:29,453,582...29,460,383
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Slc25a20
solute carrier family 25 member 20
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A20 mRNA Zidovudine results in increased expression of SLC25A20 mRNA
CTD
PMID:18313992 PMID:24292225
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
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Slc25a21
solute carrier family 25 member 21
increases expression
ISO
Zidovudine results in increased expression of SLC25A21 mRNA
CTD
PMID:24292225
NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680
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Slc25a29
solute carrier family 25 member 29
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A29 mRNA
CTD
PMID:18313992
NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940
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Slc25a3
solute carrier family 25 member 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A3 mRNA
CTD
PMID:18313992
NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727
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Slc25a4
solute carrier family 25 member 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A4 mRNA
CTD
PMID:18313992
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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Slc26a1
solute carrier family 26 member 1
increases expression
ISO
Zidovudine results in increased expression of SLC26A1 mRNA
CTD
PMID:24292225
NCBI chr14:1,040,565...1,045,851
Ensembl chr14:1,040,243...1,045,849
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Slc26a11
solute carrier family 26 member 11
increases expression
ISO
Zidovudine results in increased expression of SLC26A11 mRNA
CTD
PMID:24292225
NCBI chr10:104,613,498...104,635,873
Ensembl chr10:104,613,564...104,635,970
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Slc26a2
solute carrier family 26 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC26A2 mRNA
CTD
PMID:24292225
NCBI chr18:54,648,276...54,666,627
Ensembl chr18:54,652,951...54,666,626
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Slc26a3
solute carrier family 26 member 3
decreases expression
ISO
Zidovudine results in decreased expression of SLC26A3 mRNA
CTD
PMID:24292225
NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
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Slc26a9
solute carrier family 26 member 9
increases expression
ISO
Zidovudine results in increased expression of SLC26A9 mRNA
CTD
PMID:24292225
NCBI chr13:43,177,806...43,205,450
Ensembl chr13:43,177,867...43,204,330
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Slc27a2
solute carrier family 27 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC27A2 mRNA
CTD
PMID:24292225
NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
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Slc28a1
solute carrier family 28 member 1
affects transport multiple interactions increases uptake
ISO EXP
SLC28A1 protein affects the transport of Zidovudine Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine] SLC28A1 protein results in increased uptake of Zidovudine
CTD
PMID:8027026 PMID:8700147 PMID:8713072 PMID:9124315
NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
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Slc28a3
solute carrier family 28 member 3
increases expression
ISO
Zidovudine results in increased expression of SLC28A3 mRNA
CTD
PMID:24292225
NCBI chr17:6,062,563...6,112,965
Ensembl chr17:6,062,549...6,114,038
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Slc29a1
solute carrier family 29 member 1
increases expression
ISO
Zidovudine results in increased expression of SLC29A1 mRNA
CTD
PMID:24292225
NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
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Slc29a3
solute carrier family 29 member 3
affects transport increases expression
ISO
SLC29A3 protein affects the transport of Zidovudine Zidovudine results in increased expression of SLC29A3 mRNA
CTD
PMID:19164483 PMID:24292225
NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388
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Slc2a1
solute carrier family 2 member 1
decreases expression
ISO
Zidovudine results in decreased expression of SLC2A1 mRNA
CTD
PMID:24292225
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a10
solute carrier family 2 member 10
decreases expression
ISO
Zidovudine results in decreased expression of SLC2A10 mRNA
CTD
PMID:24292225
NCBI chr 3:154,240,395...154,252,690
Ensembl chr 3:154,240,391...154,252,690
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Zidovudine results in decreased expression of SLC2A3 mRNA
CTD
PMID:24292225
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc2a4
solute carrier family 2 member 4
affects expression
ISO
Zidovudine affects the expression of SLC2A4 mRNA
CTD
PMID:20032539
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slc2a6
solute carrier family 2 member 6
increases expression
ISO
Zidovudine results in increased expression of SLC2A6 mRNA
CTD
PMID:24292225
NCBI chr 3:10,348,395...10,355,208
Ensembl chr 3:10,348,395...10,355,208
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Slc2a8
solute carrier family 2 member 8
increases expression
ISO
Zidovudine results in increased expression of SLC2A8 mRNA
CTD
PMID:24292225
NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464
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Slc30a1
solute carrier family 30 member 1
increases expression
ISO
Zidovudine results in increased expression of SLC30A1 mRNA
CTD
PMID:24292225
NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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Slc30a3
solute carrier family 30 member 3
increases expression
ISO
Zidovudine results in increased expression of SLC30A3 mRNA
CTD
PMID:24292225
NCBI chr 6:25,264,310...25,284,720
Ensembl chr 6:25,275,528...25,284,720
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Slc30a7
solute carrier family 30 member 7
increases expression
ISO
Zidovudine results in increased expression of SLC30A7 mRNA
CTD
PMID:24292225
NCBI chr 2:203,855,484...203,922,155
Ensembl chr 2:203,859,175...203,922,132
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Slc30a9
solute carrier family 30 member 9
increases expression
ISO
Zidovudine results in increased expression of SLC30A9 mRNA
CTD
PMID:24292225
NCBI chr14:40,816,284...40,870,992
Ensembl chr14:40,816,290...40,870,929
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Slc31a1
solute carrier family 31 member 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC31A1 mRNA
CTD
PMID:15784690
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
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Slc31a2
solute carrier family 31 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC31A2 mRNA
CTD
PMID:24292225
NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
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Slc35a4
solute carrier family 35, member A4
increases expression
ISO
Zidovudine results in increased expression of SLC35A4 mRNA
CTD
PMID:24292225
NCBI chr18:28,280,483...28,284,610
Ensembl chr18:28,279,750...28,284,725
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Slc35b3
solute carrier family 35 member B3
increases expression
ISO
Zidovudine results in increased expression of SLC35B3 mRNA
CTD
PMID:24292225
NCBI chr17:25,846,590...25,873,115
Ensembl chr17:25,846,748...25,872,557
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Slc35b4
solute carrier family 35 member B4
increases expression
ISO
Zidovudine results in increased expression of SLC35B4 mRNA
CTD
PMID:24292225
NCBI chr 4:62,776,993...62,799,013
Ensembl chr 4:62,776,993...62,799,003
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Slc35d1
solute carrier family 35 member D1
increases expression
ISO
Zidovudine results in increased expression of SLC35D1 mRNA
CTD
PMID:24292225
NCBI chr 5:117,928,628...117,981,289
Ensembl chr 5:117,934,352...117,981,311
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Slc35f2
solute carrier family 35, member F2
increases expression
ISO
Zidovudine results in increased expression of SLC35F2 mRNA
CTD
PMID:24292225
NCBI chr 8:54,159,970...54,203,614
Ensembl chr 8:54,159,970...54,203,612
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Slc37a1
solute carrier family 37 member 1
increases expression
ISO
Zidovudine results in increased expression of SLC37A1 mRNA
CTD
PMID:24292225
NCBI chr20:9,360,501...9,433,895
Ensembl chr20:9,378,836...9,433,892
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Slc37a2
solute carrier family 37 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC37A2 mRNA
CTD
PMID:24292225
NCBI chr 8:36,945,787...36,971,748
Ensembl chr 8:36,946,930...36,971,482
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Slc38a2
solute carrier family 38, member 2
decreases expression
ISO
Zidovudine results in decreased expression of SLC38A2 mRNA
CTD
PMID:24292225
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
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Slc38a3
solute carrier family 38, member 3
increases expression
ISO
Zidovudine results in increased expression of SLC38A3 mRNA
CTD
PMID:24292225
NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988
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Slc38a4
solute carrier family 38, member 4
decreases expression
ISO
Zidovudine results in decreased expression of SLC38A4 mRNA
CTD
PMID:24292225
NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
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Slc38a5
solute carrier family 38, member 5
decreases expression
ISO
Zidovudine results in decreased expression of SLC38A5 mRNA
CTD
PMID:24292225
NCBI chr X:14,213,727...14,222,498
Ensembl chr X:14,213,729...14,222,498
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Slc38a6
solute carrier family 38, member 6
increases expression
ISO
Zidovudine results in increased expression of SLC38A6 mRNA
CTD
PMID:24292225
NCBI chr 6:91,987,652...92,076,416
Ensembl chr 6:91,987,672...92,049,935
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Slc39a10
solute carrier family 39 member 10
decreases expression
ISO
Zidovudine results in decreased expression of SLC39A10 mRNA
CTD
PMID:24292225
NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325
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Slc39a14
solute carrier family 39 member 14
decreases expression
ISO
Zidovudine results in decreased expression of SLC39A14 mRNA
CTD
PMID:24292225
NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
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Slc39a9
solute carrier family 39, member 9
increases expression
ISO
Zidovudine results in increased expression of SLC39A9 mRNA
CTD
PMID:24292225
NCBI chr 6:100,291,537...100,330,419
Ensembl chr 6:100,291,573...100,330,408
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Slc3a2
solute carrier family 3 member 2
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC3A2 mRNA Zidovudine results in increased expression of SLC3A2 mRNA
CTD
PMID:15784690 PMID:24292225
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc40a1
solute carrier family 40 member 1
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SLC40A1 mRNA Zidovudine results in increased expression of SLC40A1 mRNA
CTD
PMID:18313992 PMID:24292225
NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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Slc4a2
solute carrier family 4 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC4A2 mRNA
CTD
PMID:24292225
NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
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Slc5a3
solute carrier family 5 member 3
decreases expression
ISO
Zidovudine results in decreased expression of SLC5A3 mRNA
CTD
PMID:24292225
NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
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Slc6a11
solute carrier family 6 member 11
increases expression
ISO
Zidovudine results in increased expression of SLC6A11 mRNA
CTD
PMID:24292225
NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443
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Slc6a12
solute carrier family 6 member 12
increases expression
ISO
Zidovudine results in increased expression of SLC6A12 mRNA
CTD
PMID:24292225
NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
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Slc6a2
solute carrier family 6 member 2
increases expression
ISO
Zidovudine results in increased expression of SLC6A2 mRNA
CTD
PMID:24292225
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
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Slc6a8
solute carrier family 6 member 8
decreases expression
ISO
Zidovudine results in decreased expression of SLC6A8 mRNA
CTD
PMID:24292225
NCBI chr X:151,384,675...151,393,979
Ensembl chr X:151,384,675...151,393,979
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Slc7a10
solute carrier family 7 member 10
decreases expression increases expression
ISO
Zidovudine results in decreased expression of SLC7A10 mRNA Zidovudine results in increased expression of SLC7A10 mRNA
CTD
PMID:24292225
NCBI chr 1:87,829,084...87,845,073
Ensembl chr 1:87,829,175...87,845,071
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Slc7a2
solute carrier family 7 member 2
decreases expression
ISO
Zidovudine results in decreased expression of SLC7A2 mRNA
CTD
PMID:24292225
NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
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Slc7a5
solute carrier family 7 member 5
increases expression
ISO
Zidovudine results in increased expression of SLC7A5 mRNA
CTD
PMID:24292225
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
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Slc7a7
solute carrier family 7 member 7
multiple interactions increases expression
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC7A7 mRNA Zidovudine results in increased expression of SLC7A7 mRNA
CTD
PMID:20370541 PMID:24292225
NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648
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Slc7a8
solute carrier family 7 member 8
increases expression
ISO
Zidovudine results in increased expression of SLC7A8 mRNA
CTD
PMID:24292225
NCBI chr15:28,183,013...28,242,717
Ensembl chr15:28,183,015...28,242,717
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Slc7a9
solute carrier family 7 member 9
increases expression
ISO
Zidovudine results in increased expression of SLC7A9 mRNA
CTD
PMID:24292225
NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641
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Slc9a1
solute carrier family 9 member A1
increases expression
ISO
Zidovudine results in increased expression of SLC9A1 mRNA
CTD
PMID:24292225
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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Slco2a1
solute carrier organic anion transporter family, member 2a1
decreases expression
ISO
Zidovudine results in decreased expression of SLCO2A1 mRNA
CTD
PMID:24292225
NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
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Slco2b1
solute carrier organic anion transporter family, member 2b1
increases expression decreases expression
ISO
Zidovudine results in increased expression of SLCO2B1 mRNA Zidovudine results in decreased expression of SLCO2B1 mRNA
CTD
PMID:24292225
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Slco4a1
solute carrier organic anion transporter family, member 4a1
decreases expression
ISO
Zidovudine results in decreased expression of SLCO4A1 mRNA
CTD
PMID:24292225
NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
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Sod2
superoxide dismutase 2
decreases response to substance multiple interactions
ISO EXP
SOD2 protein results in decreased susceptibility to Zidovudine [SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine
CTD
PMID:19398959 PMID:19501153
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spink5
serine peptidase inhibitor, Kazal type 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of SPINK5 mRNA
CTD
PMID:16931933
NCBI chr18:36,264,452...36,333,143
Ensembl chr18:36,264,452...36,332,185
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Sqstm1
sequestosome 1
increases expression
EXP
Zidovudine results in increased expression of SQSTM1 protein
CTD
PMID:29594326
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Star
steroidogenic acute regulatory protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of STAR mRNA
CTD
PMID:18313992
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT1 mRNA
CTD
PMID:20370541
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat2
signal transducer and activator of transcription 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNA
CTD
PMID:20370541
NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
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Stc2
stanniocalcin 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of STC2 mRNA
CTD
PMID:15784690
NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
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Sub1
SUB1 regulator of transcription
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNA
CTD
PMID:16931933
NCBI chr 2:61,005,646...61,020,486
Ensembl chr 2:61,005,666...61,020,436 Ensembl chr 2:61,005,666...61,020,436
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Tcea1
transcription elongation factor A1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TCEA1 mRNA
CTD
PMID:15784690
NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745 Ensembl chr15:14,631,454...14,668,745
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Tcn2
transcobalamin 2
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNA
CTD
PMID:20370541
NCBI chr14:78,813,343...78,828,549
Ensembl chr14:78,813,343...78,828,489
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Tert
telomerase reverse transcriptase
decreases activity
ISO
Zidovudine results in decreased activity of TERT protein
CTD
PMID:16601281 PMID:18097608
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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Tfam
transcription factor A, mitochondrial
increases expression
EXP
Zidovudine results in increased expression of TFAM mRNA
CTD
PMID:10535663
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Tfap2a
transcription factor AP-2 alpha
decreases expression
ISO
Zidovudine results in decreased expression of TFAP2A mRNA
CTD
PMID:17926646
NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507
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Tfeb
transcription factor EB
decreases expression
EXP
Zidovudine results in decreased expression of TFEB protein
CTD
PMID:29594326
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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Timm17b
translocase of inner mitochondrial membrane 17b
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM17B mRNA
CTD
PMID:18313992
NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416
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Timm23
translocase of inner mitochondrial membrane 23
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM23 mRNA
CTD
PMID:18313992
NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379
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Timp2
TIMP metallopeptidase inhibitor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA
CTD
PMID:16931933
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tk1
thymidine kinase 1
decreases response to substance increases expression decreases expression increases mutagenesis increases response to substance increases metabolic processing increases activity increases methylation decreases activity affects transport multiple interactions
ISO
TK1 gene modified form results in decreased susceptibility to Zidovudine Zidovudine results in increased expression of TK1 mRNA; Zidovudine results in increased expression of TK1 protein Zidovudine results in decreased expression of TK1 mRNA; Zidovudine results in decreased expression of TK1 protein Zidovudine results in increased mutagenesis of TK1 gene TK1 protein results in increased susceptibility to Zidovudine TK1 protein results in increased metabolism of Zidovudine Zidovudine results in increased activity of TK1 protein Zidovudine results in increased methylation of TK1 exon Zidovudine results in decreased activity of TK1 protein TK1 protein affects the transport of Zidovudine Ethanol inhibits the reaction [Zidovudine results in increased activity of TK1 protein]; Zidovudine inhibits the reaction [Ethanol results in decreased activity of TK1 protein]
CTD
PMID:8915012 PMID:8941356 PMID:11923581 PMID:15013700 PMID:15708581 PMID:17067265 PMID:19237551 PMID:20106944 PMID:24292225 More...
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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Tk2
thymidine kinase 2
multiple interactions increases expression
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TK2 mRNA Zidovudine results in increased expression of TK2 mRNA
CTD
PMID:18313992 PMID:24292225
NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
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Tlr7
toll-like receptor 7
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNA
CTD
PMID:20370541
NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
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Tmem97
transmembrane protein 97
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNA
CTD
PMID:20370541
NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730
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Tnc
tenascin C
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA
CTD
PMID:20370541
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Tnf
tumor necrosis factor
decreases expression multiple interactions increases expression
ISO EXP
Zidovudine analog results in decreased expression of TNF protein [Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein] Zidovudine results in increased expression of TNF protein
CTD
PMID:12729831 PMID:17668557 PMID:28619387
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf10
TNF superfamily member 10
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF10 mRNA
CTD
PMID:20370541
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tnfsf13b
TNF superfamily member 13b
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF13B mRNA
CTD
PMID:20370541
NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693
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Tnni2
troponin I2, fast skeletal type
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNNI2 mRNA
CTD
PMID:20370541
NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560
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Tnni3
troponin I3, cardiac type
affects localization
ISO
Zidovudine affects the localization of TNNI3 protein
CTD
PMID:17943461
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Tp53
tumor protein p53
increases expression
ISO
Zidovudine results in increased expression of TP53 protein
CTD
PMID:16797627
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trdmt1
tRNA aspartic acid methyltransferase 1
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA
CTD
PMID:20370541
NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
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Trib3
tribbles pseudokinase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of TRIB3 mRNA
CTD
PMID:15784690
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Trim42
tripartite motif-containing 42
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TRIM42 mRNA
CTD
PMID:16931933
NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268
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Triqk
triple QxxK/R motif containing
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRIQK mRNA
CTD
PMID:20370541
NCBI chr 5:26,391,511...26,464,422
Ensembl chr 5:26,391,552...26,464,421
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Trmt44
tRNA methyltransferase 44
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of TRMT44 mRNA
CTD
PMID:20370541
NCBI chr14:75,175,331...75,204,291
Ensembl chr14:75,182,029...75,200,147
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Ttc21a
tetratricopeptide repeat domain 21A
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of TTC21A mRNA
CTD
PMID:20370541
NCBI chr 8:119,667,044...119,702,028
Ensembl chr 8:119,666,933...119,702,456
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Twnk
twinkle mtDNA helicase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of TWNK mRNA
CTD
PMID:18313992
NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802
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Tymp
thymidine phosphorylase
multiple interactions increases expression increases activity
ISO
[5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]; [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridine Zidovudine results in increased expression of TYMP mRNA; Zidovudine results in increased expression of TYMP protein
CTD
PMID:16457948
NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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Tyms
thymidylate synthetase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA
CTD
PMID:15784690
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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Tyrp1
tyrosinase-related protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of TYRP1 mRNA
CTD
PMID:15784690
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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Ucp1
uncoupling protein 1
increases expression decreases expression
ISO
Zidovudine results in increased expression of UCP1 mRNA Zidovudine results in decreased expression of UCP1 mRNA
CTD
PMID:14518702 PMID:17926646
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases glucuronidation
EXP
UGT2B1 protein results in increased glucuronidation of Zidovudine
CTD
PMID:8302279
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
increases glucuronidation multiple interactions decreases expression increases expression
ISO
UGT2B7 protein results in increased glucuronidation of Zidovudine 10-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; 4'-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; 7-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; shikonin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] Zidovudine results in decreased expression of UGT2B7 mRNA; Zidovudine results in decreased expression of UGT2B7 protein Zidovudine results in increased expression of UGT2B7 mRNA; Zidovudine results in increased expression of UGT2B7 protein
CTD
PMID:10772627 PMID:17898154 PMID:24292225 PMID:25393417 PMID:31128210
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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Ulk1
unc-51 like autophagy activating kinase 1
decreases phosphorylation
EXP
Zidovudine results in decreased phosphorylation of ULK1 protein
CTD
PMID:29594326
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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Uqcrb
ubiquinol-cytochrome c reductase binding protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRB mRNA
CTD
PMID:18313992
NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
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Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA
CTD
PMID:17526437 PMID:18313992
NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
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Uqcrc2
ubiquinol cytochrome c reductase core protein 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of UQCRC2 mRNA
CTD
PMID:18313992
NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
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Usp18
ubiquitin specific peptidase 18
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNA
CTD
PMID:20370541
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
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Vdac1
voltage-dependent anion channel 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of VDAC1 mRNA
CTD
PMID:18313992
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vdr
vitamin D receptor
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of VDR mRNA
CTD
PMID:11741158
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vps4b
vacuolar protein sorting 4 homolog B
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in decreased expression of VPS4B mRNA
CTD
PMID:16931933
NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229
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Wars1
tryptophanyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of WARS1 mRNA
CTD
PMID:15784690
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Wdr62
WD repeat domain 62
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in decreased expression of WDR62 mRNA
CTD
PMID:20370541
NCBI chr 1:85,491,531...85,530,643
Ensembl chr 1:85,491,533...85,530,637
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Wnt10a
Wnt family member 10A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of WNT10A mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of WNT10A mRNA
CTD
PMID:16931933
NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
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Xpa
XPA, DNA damage recognition and repair factor
increases expression
ISO
Zidovudine results in increased expression of XPA mRNA; Zidovudine results in increased expression of XPA protein
CTD
PMID:21192964 PMID:23675285
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases response to substance increases expression
ISO
XPC protein results in decreased susceptibility to Zidovudine Zidovudine results in increased expression of XPC mRNA; Zidovudine results in increased expression of XPC protein
CTD
PMID:21192964 PMID:23675285
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Yars1
tyrosyl-tRNA synthetase 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine] results in increased expression of YARS1 mRNA
CTD
PMID:15784690
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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Zfp629
zinc finger protein 629
multiple interactions
ISO
[Zidovudine co-treated with IFNA1 protein] results in increased expression of ZNF629 mRNA
CTD
PMID:20370541
NCBI chr 1:182,217,499...182,258,585
Ensembl chr 1:182,210,935...182,230,016
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