Ndufa4 (Ndufa4, mitochondrial complex associated) - Rat Genome Database

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Gene: Ndufa4 (Ndufa4, mitochondrial complex associated) Rattus norvegicus
Analyze
Symbol: Ndufa4
Name: Ndufa4, mitochondrial complex associated
RGD ID: 1584719
Description: Part of respiratory chain complex I and respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 21. Orthologous to human NDUFA4 (NDUFA4 mitochondrial complex associated); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome c oxidase subunit NDUFA4; LOC681024; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4; NADH:ubiquinone oxidoreductase subunit A4; similar to NADH-ubiquinone oxidoreductase MLRQ subunit (Complex I-MLRQ) (CI-MLRQ)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Gluco61 Niddm71
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8440,968,391 - 40,975,559 (-)NCBIGRCr8
mRatBN7.2440,002,216 - 40,009,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl440,002,216 - 40,023,920 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx444,975,238 - 44,982,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0440,901,442 - 40,908,606 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0439,304,957 - 39,312,121 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0438,233,680 - 38,240,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl438,233,680 - 38,240,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0438,070,978 - 38,078,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4437,125,782 - 37,133,055 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera435,414,376 - 35,421,532 (-)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
picoxystrobin  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model. Yagil C, etal., Dis Model Mech. 2018 Nov 20;11(11). pii: dmm.036699. doi: 10.1242/dmm.036699.
Additional References at PubMed
PMID:12477932   PMID:12611891   PMID:12865426   PMID:14651853   PMID:16729965   PMID:18614015   PMID:20530722   PMID:22902835   PMID:23209302   PMID:23376485   PMID:30030519   PMID:31536960  
PMID:33994501   PMID:35352799  


Genomics

Comparative Map Data
Ndufa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8440,968,391 - 40,975,559 (-)NCBIGRCr8
mRatBN7.2440,002,216 - 40,009,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl440,002,216 - 40,023,920 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx444,975,238 - 44,982,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0440,901,442 - 40,908,606 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0439,304,957 - 39,312,121 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0438,233,680 - 38,240,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl438,233,680 - 38,240,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0438,070,978 - 38,078,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4437,125,782 - 37,133,055 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera435,414,376 - 35,421,532 (-)NCBICelera
Cytogenetic Map4q21NCBI
NDUFA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38710,931,943 - 10,940,153 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl710,931,943 - 10,940,153 (-)EnsemblGRCh38hg38GRCh38
GRCh37710,971,570 - 10,979,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36710,939,340 - 10,946,338 (-)NCBINCBI36Build 36hg18NCBI36
Build 34710,746,054 - 10,753,053NCBI
Celera710,947,593 - 10,954,592 (-)NCBICelera
Cytogenetic Map7p21.3NCBI
HuRef710,829,724 - 10,838,039 (-)NCBIHuRef
CHM1_1710,972,141 - 10,980,374 (-)NCBICHM1_1
T2T-CHM13v2.0711,062,535 - 11,070,743 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2711,025,124 - 11,033,358 (-)NCBI
Ndufa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39611,900,371 - 11,907,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl611,900,291 - 11,907,496 (-)EnsemblGRCm39 Ensembl
GRCm38611,900,372 - 11,907,450 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl611,900,292 - 11,907,497 (-)EnsemblGRCm38mm10GRCm38
MGSCv37611,850,373 - 11,857,446 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36611,850,373 - 11,857,446 (-)NCBIMGSCv36mm8
Celera611,992,912 - 11,999,985 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map65.01NCBI
Ndufa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543217,502,272 - 17,509,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543217,502,272 - 17,509,517 (-)NCBIChiLan1.0ChiLan1.0
NDUFA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2615,760,949 - 15,767,672 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1764,085,666 - 64,092,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0711,585,054 - 11,591,775 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1710,932,727 - 10,939,949 (-)NCBIpanpan1.1PanPan1.1panPan2
NDUFA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11425,887,204 - 25,893,746 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1425,468,815 - 25,475,355 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01425,696,535 - 25,703,079 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11425,864,709 - 25,871,252 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01425,594,037 - 25,600,585 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01425,847,856 - 25,854,404 (-)NCBIUU_Cfam_GSD_1.0
Ndufa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511839,433,348 - 39,440,232 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936761554,028 - 560,901 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936761554,025 - 560,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl980,636,929 - 80,644,315 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1980,637,005 - 80,644,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2988,555,979 - 88,563,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12147,245,396 - 47,252,145 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2147,245,170 - 47,252,730 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604257,188,514 - 57,195,774 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248278,366,027 - 8,375,881 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248278,366,597 - 8,373,881 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufa4
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:252
Count of miRNA genes:166
Interacting mature miRNAs:190
Transcripts:ENSRNOT00000007567
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
2290374Gluco32Glucose level QTL 326.27blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43717795044463908Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
4889511Gluco61Glucose level QTL 614.70.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43717795040869000Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat

Markers in Region
RH127505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,120,397 - 1,120,573 (+)MAPPERmRatBN7.2
Rnor_6.0181,279,266 - 1,279,441NCBIRnor6.0
Rnor_5.0181,321,700 - 1,321,875UniSTSRnor5.0
RGSC_v3.4181,396,306 - 1,396,481UniSTSRGSC3.4
Celera181,006,194 - 1,006,369UniSTS
RH 3.4 Map1832.2UniSTS
Cytogenetic Map18p13UniSTS
Cytogenetic Map4q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000007567   ⟹   ENSRNOP00000007567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl440,002,216 - 40,008,418 (-)Ensembl
Rnor_6.0 Ensembl438,233,680 - 38,240,848 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108269   ⟹   ENSRNOP00000093714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl440,005,645 - 40,023,920 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112879   ⟹   ENSRNOP00000096418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl440,002,392 - 40,023,920 (-)Ensembl
RefSeq Acc Id: NM_001127684   ⟹   NP_001121156
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8440,968,391 - 40,975,559 (-)NCBI
mRatBN7.2440,002,216 - 40,009,384 (-)NCBI
Rnor_6.0438,233,680 - 38,240,848 (-)NCBI
Rnor_5.0438,070,978 - 38,078,251 (-)NCBI
RGSC_v3.4437,125,782 - 37,133,055 (-)RGD
Celera435,414,376 - 35,421,532 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001121156 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI67115 (Get FASTA)   NCBI Sequence Viewer  
  EDM15076 (Get FASTA)   NCBI Sequence Viewer  
  EDM15077 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007567.4
  ENSRNOP00000093714.1
  ENSRNOP00000096418.1
RefSeq Acc Id: NP_001121156   ⟸   NM_001127684
- UniProtKB: B2RZD6 (UniProtKB/TrEMBL),   A6IDY9 (UniProtKB/TrEMBL),   F7FN80 (UniProtKB/TrEMBL),   A0A8I6AQR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007567   ⟸   ENSRNOT00000007567
Ensembl Acc Id: ENSRNOP00000093714   ⟸   ENSRNOT00000108269
Ensembl Acc Id: ENSRNOP00000096418   ⟸   ENSRNOT00000112879

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZD6-F1-model_v2 AlphaFold B2RZD6 1-82 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692878
Promoter ID:EPDNEW_R3403
Type:initiation region
Name:Ndufa4_1
Description:NDUFA4, mitochondrial complex associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0438,240,814 - 38,240,874EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584719 AgrOrtholog
BioCyc Gene G2FUF-45634 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000005512 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007567.5 UniProtKB/TrEMBL
  ENSRNOT00000108269.1 UniProtKB/TrEMBL
  ENSRNOT00000112879.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922256 IMAGE-MGC_LOAD
InterPro B12D UniProtKB/TrEMBL
KEGG Report rno:681024 UniProtKB/TrEMBL
MGC_CLONE MGC:189583 IMAGE-MGC_LOAD
NCBI Gene 681024 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT NDUFA4 UniProtKB/TrEMBL
  PTHR14256 UniProtKB/TrEMBL
Pfam B12D UniProtKB/TrEMBL
PhenoGen Ndufa4 PhenoGen
RatGTEx ENSRNOG00000005512 RatGTEx
UniProt A0A8I6AQR1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AXF3_RAT UniProtKB/TrEMBL
  A6IDY9 ENTREZGENE, UniProtKB/TrEMBL
  B2RZD6 ENTREZGENE
  F7FN80 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2RZD6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-28 Ndufa4  Ndufa4, mitochondrial complex associated  Ndufa4  NDUFA4, mitochondrial complex associated  Name changed 629549 APPROVED
2017-03-29 Ndufa4  NDUFA4, mitochondrial complex associated  Ndufa4  NADH:ubiquinone oxidoreductase subunit A4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-17 Ndufa4  NADH:ubiquinone oxidoreductase subunit A4  Ndufa4  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ndufa4  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4  LOC681024  similar to NADH-ubiquinone oxidoreductase MLRQ subunit (Complex I-MLRQ) (CI-MLRQ)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC681024  similar to NADH-ubiquinone oxidoreductase MLRQ subunit (Complex I-MLRQ) (CI-MLRQ)  LOC679503  similar to NADH-ubiquinone oxidoreductase MLRQ subunit (Complex I-MLRQ) (CI-MLRQ)  Data merged from RGD:1587180 1643240 APPROVED
2006-11-19 LOC681024  similar to NADH-ubiquinone oxidoreductase MLRQ subunit (Complex I-MLRQ) (CI-MLRQ)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679503  similar to NADH-ubiquinone oxidoreductase MLRQ subunit (Complex I-MLRQ) (CI-MLRQ)      Symbol and Name status set to provisional 70820 PROVISIONAL