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Gene: ABCE1 (ATP binding cassette subfamily E member 1) Homo sapiens
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Symbol: ABCE1
Name: ATP binding cassette subfamily E member 1
Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2'-5'-oligoadenylate-binding protein; ABC38; ATP-binding cassette sub-family E member 1; ATP-binding cassette, sub-family E (OABP), member 1; huHP68; OABP; ribonuclease 4 inhibitor; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; RLI; RLI1; RNase L inhibitor; RNase L inhibitor 1; RNASEL1; RNASELI; RNS4I
Orthologs:
Mus musculus (house mouse) : Abce1 (ATP-binding cassette, sub-family E (OABP), member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Abce1 (ATP binding cassette subfamily E member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abce1 (ATP binding cassette subfamily E member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCE1 (ATP binding cassette subfamily E member 1)
Canis lupus familiaris (dog) : ABCE1 (ATP binding cassette subfamily E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abce1 (ATP binding cassette subfamily E member 1)
Sus scrofa (pig) : ABCE1 (ATP binding cassette subfamily E member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384145,098,004 - 145,129,524 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374146,019,156 - 146,050,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,238,606 - 146,270,126 (+)NCBINCBI36hg18NCBI36
Build 344146,377,090 - 146,407,936NCBI
Celera4143,346,498 - 143,378,018 (+)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4141,750,477 - 141,781,999 (+)NCBIHuRef
CHM1_14145,995,426 - 146,026,945 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ABCE1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313249
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.