Gluco61 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Gluco61 (Glucose level QTL 61) Rattus norvegicus

Symbol: Gluco61
Name: Glucose level QTL 61
RGD ID: 4889511
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level area under curve (AUC)   (CMO:0000350)    
LOD Score: 4.7
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2437,177,950 - 40,869,000RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0435,138,860 - 39,073,276RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0434,996,009 - 38,909,359RGDRnor5.0
RGSC_v3.4434,206,019 - 38,029,988RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: CDR/Ygl CDS/Ygl 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Ica1 is a candidate Gene for Gluco61
Ndufa4 is a candidate Gene for Gluco61

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Measurement Method

Vertebrate Trait

Rat Strain
CDR/Ygl  (IEA)
CDS/Ygl  (IEA)

References

References - curated
# Reference Title Reference Citation
1. GENDER-SPECIFIC GENETIC DISSECTION OF DIABETES IN A RODENT MODEL IDENTIFIES ICA1 AND NDUFA4 AS MAJOR CANDIDATE GENES. Barkalifa R, etal., Physiol Genomics. 2010 Jun 8.
Related QTLs

Related QTL Description Reference
Gluco32 maps to same region RGD:2326163


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3218Nxph1neurexophilin 143699806837311135Rat
3600Rps4x-ps9ribosomal protein S4, X-linked, pseudogene 943775837337759289Rat
1560448LOC500028hypothetical protein LOC50002843791783737918511Rat
1565400Actc1-ps1actin, alpha, cardiac muscle 1, pseudogene 143762082037622087Rat
1563764Phf14PHD finger protein 1444000969140195870Rat
1566201Thsd7athrombospondin type 1 domain containing 7A44046112440899345Rat
1584730Stmnl-ps2stathmin like, pseudogene 243976968439770132Rat
1585861Nsa2-ps9NSA2 ribosome biogenesis factor, pseudogene 943756118837561974Rat
1584719Ndufa4Ndufa4, mitochondrial complex associated44000221640009384Rat
1585825LOC680964similar to high mobility group nucleosomal binding domain 143860485638606026Rat
1562387Gtpbp4-ps3GTP binding protein 4, pseudogene 343939107939425066Rat
2322154Psma6-ps3proteasome 20S subunit alpha 6, pseudogene 343919157039192321Rat
2322347Tomm20-ps2translocase of outer mitochondrial membrane 20, pseudogene 243801322738013802Rat
7641224Rps2-ps40ribosomal protein S2, pseudogene 4044068219240683121Rat
7596691LOC102547989uncharacterized LOC10254798943959860439678420Rat
9330178LOC10369207460 kDa heat shock protein, mitochondrial pseudogene44072136940732042Rat
11516558LOC10835085540S ribosomal protein S23 pseudogene43826319438263628Rat
41140158LOC120102687small nucleolar RNA SNORA1744030905740309173Rat
41122445LOC120102236uncharacterized LOC12010223644016991540171995Rat
40971411LOC120102154uncharacterized LOC12010215443864163538646263Rat
40982246LOC120102694small nucleolar RNA SNORA1743973394139734060Rat
41002968LOC120102235uncharacterized LOC12010223544011938740123944Rat
41248065LOC120102234uncharacterized LOC12010223443890194838907419Rat
41319059LOC120102653small nucleolar RNA SNORA4843748469037484833Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
34238D4Mgh225043952426439524530Ratregion
34716D4Mgh1413343950527539505420Ratregion
35847D4Rat1214643846577438465927Ratregion
39688D4Rat21110644019349640193597Ratregion
38628D4Rat13022243865742738657645Ratregion
39194D4Rat11524043717795037178180Ratregion
42158D4Arb2613043950527539505418Ratregion
41202D4Rat15219744078009840780283Ratregion
42691D4Rat22321243884718238847397Ratregion
42691D4Rat22321243884718238847569Ratregion
41888D4Rat28224544086875240869000Ratregion
43782D4Got2017943854696138547140Ratregion
43783D4Got2116643723314237233308Ratregion
43784D4Got15714743773361237733759Ratregion
43786D4Got2423943831722238317461Ratregion
43787D4Got2517643896180238961978Ratregion
60436D4Got2629844019331240193610Ratregion
625773D4Got2317343854696938547140Ratregion
67352D4Arb1717443775307137753245Ratregion
1627175D4Uia1043928891439289215Ratregion
5035282BF38772015244042285340423004Ratregion
5054585RH14330929444045571040456004Ratregion
5071908RH13535419144015848840158679Ratregion
5068462AU04713019644085057940850773Ratregion
5064052BE12056815144076225440762405Ratregion
5064674BF39954820044063049440630695Ratregion
5503766STS_ADH227543762119337621465Ratregion
5506354UniSTS:47894812943762091737621046Ratregion
5500336GDB:19474862143775860837759229Ratregion
5500340GDB:19474713143775909837759229Ratregion
Position Markers

Flank 1: (D4Rat115)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2437,177,950 - 37,178,180 (+)MAPPER
Rnor_6.0435,138,860 - 35,139,089NCBI
Rnor_5.0434,996,009 - 34,996,238UniSTS
RGSC_v3.4434,206,020 - 34,206,249UniSTS
RGSC_v3.4434,206,019 - 34,206,249RGD
RGSC_v3.1434,324,560 - 34,324,789RGD
Celera432,661,853 - 32,662,082UniSTS
RH 3.4 Map4191.8RGD
RH 3.4 Map4191.8UniSTS
RH 2.0 Map4255.1RGD
SHRSP x BN Map419.87RGD
FHH x ACI Map423.1799RGD
Cytogenetic Map4q21UniSTS
Peak: (D4Got15)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,675,789 - 10,675,932 (+)MAPPER
Rnor_6.047,204,056 - 7,204,196NCBI
Rnor_5.047,215,423 - 7,215,563UniSTS
RGSC_v3.446,040,004 - 6,040,145RGD
RGSC_v3.446,040,005 - 6,040,145UniSTS
RGSC_v3.146,040,004 - 6,040,145RGD
Celera46,290,539 - 6,290,683UniSTS
RH 2.0 Map40.0RGD
Cytogenetic Map4q11UniSTS
Flank 2: (D4Rat282)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2440,868,752 - 40,869,000 (+)MAPPER
Rnor_6.0439,073,031 - 39,073,276NCBI
Rnor_5.0438,909,114 - 38,909,359UniSTS
RGSC_v3.4438,029,742 - 38,029,988RGD
RGSC_v3.4438,029,743 - 38,029,988UniSTS
RGSC_v3.1438,148,282 - 38,148,528RGD
Celera436,254,630 - 36,254,875UniSTS
FHH x ACI Map423.1799RGD
FHH x ACI Map423.1799UniSTS
Cytogenetic Map4q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
4889511Gluco61Glucose level QTL 614.70.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43717795040869000Rat
2290374Gluco32Glucose level QTL 326.27blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43717795044463908Rat
1300156Bp179Blood pressure QTL 1792.85arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43846577439524530Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general this region incorporates 6 known genes and spans 2.6 cM 2326163
qtl_general number of animals used: 159 F2 females 2326163
qtl_general the SS allele from CDS was responsible for the phenotypes mentioned including lower glucose to insulin ratio 2326163
qtl_general measurement method: 1 month old animals were weaned and fed the diabetogenic diet (DD) after 4 weeks on DD diet glucose level and plasma insulin level were measured; pancreas was weighed after OGTT when the animals were sacrificed 2326163
qtl_general software package used: one-way ANOVA and MultiQTL version 2.5 2326163
qtl_general combining the data of this QTL and Gluco32 for both the sexes gave a composite dataset used for genetic linkage 2326163