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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621703
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxc2
Name: forkhead box C2
Acc ID: CHEBI:421707
Term: abacavir
Definition: A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
Chemical ID: MESH:C106538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxc2decreases expressionISOFOXC2 (Homo sapiens)6480464CTDabacavir results in decreased expression of FOXC2 mRNAPMID:31711903
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