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Gene: Uqcrc1 (ubiquinol-cytochrome c reductase core protein 1) Rattus norvegicus

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Symbol:

Uqcrc1

Name:

ubiquinol-cytochrome c reductase core protein 1

RGD ID:

1303314

Description:

Predicted to enable ubiquitin protein ligase binding activity. Involved in response to activity and response to alkaloid. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1); PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

complex III subunit 1; core protein I; cytochrome b-c1 complex subunit 1, mitochondrial; MGC93712; ubiquinol-cytochrome c reductase core protein I; ubiquinol-cytochrome-c reductase complex core protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,468,223 - 118,479,968 (+)	NCBI		GRCr8
mRatBN7.2	8	109,589,735 - 109,601,481 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,589,706 - 109,601,480 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	115,207,272 - 115,219,022 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,406,459 - 113,418,209 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,249,253 - 111,261,004 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,679,328 - 117,691,073 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,679,278 - 117,691,071 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	117,030,932 - 117,042,820 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,955,930 - 113,967,675 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,975,384 - 113,987,128 (+)	NCBI
Celera	8	108,883,471 - 108,895,222 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	Alzheimer's disease		ISO	RGD:1342599	13831335	protein:decreased expression:temporal cortex	RGD
Uqcrc1	Rat	Alzheimer's disease		ISO	RGD:1342599	11572212	DNA:hypermethylation:promoter:	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	Aicardi-Goutieres Syndrome 1		ISO	RGD:1342599	8554872	ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 1	ClinVar	PMID:16845398\|PMID:28492532
Uqcrc1	Rat	hypertrophic cardiomyopathy		ISO	RGD:1342599	8554872	ClinVar Annotator: match by term: Hypertrophic cardiomyopathy	ClinVar
Uqcrc1	Rat	PARKINSONISM WITH POLYNEUROPATHY		ISO	RGD:1342599	8554872	ClinVar Annotator: match by term: Parkinsonism with polyneuropathy	ClinVar	PMID:25741868\|PMID:33141179
Uqcrc1	Rat	Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy		ISO	RGD:1342599	8554872	ClinVar Annotator: match by term: Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy	ClinVar	PMID:28492532

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	PARKINSONISM WITH POLYNEUROPATHY		ISO	RGD:1342599	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	(-)-epigallocatechin 3-gallate	decreases expression	ISO	RGD:1551847	6480464	epigallocatechin gallate results in decreased expression of UQCRC1 mRNA	CTD	PMID:29175576
Uqcrc1	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:1551847	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of UQCRC1 mRNA	CTD	PMID:36331819
Uqcrc1	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1551847	6480464	1,2-Dimethylhydrazine results in decreased expression of UQCRC1 mRNA	CTD	PMID:22206623
Uqcrc1	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1551847	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of UQCRC1 mRNA	CTD	PMID:22206623
Uqcrc1	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:1551847	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRC1 mRNA	CTD	PMID:17942748
Uqcrc1	Rat	17alpha-ethynylestradiol	affects expression	ISO	RGD:1551847	6480464	Ethinyl Estradiol affects the expression of UQCRC1 mRNA	CTD	PMID:17555576
Uqcrc1	Rat	17alpha-ethynylestradiol	increases expression	ISO	RGD:1551847	6480464	Ethinyl Estradiol results in increased expression of UQCRC1 mRNA	CTD	PMID:17942748
Uqcrc1	Rat	1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one	multiple interactions	ISO	RGD:1342599	6480464	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of UQCRC1 protein]	CTD	PMID:24041027
Uqcrc1	Rat	2,2,2-tetramine	multiple interactions	EXP		6480464	Trientine inhibits the reaction [Streptozocin results in increased expression of UQCRC1 protein]	CTD	PMID:19634143\|PMID:21136691
Uqcrc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1551847	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRC1 mRNA	CTD	PMID:17942748
Uqcrc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of UQCRC1 mRNA	CTD	PMID:33387578
Uqcrc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of UQCRC1 mRNA	CTD	PMID:34747641
Uqcrc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1551847	6480464	Tetrachlorodibenzodioxin affects the expression of UQCRC1 mRNA	CTD	PMID:21570461
Uqcrc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1551847	6480464	Tetrachlorodibenzodioxin results in increased expression of UQCRC1 mRNA	CTD	PMID:20399798
Uqcrc1	Rat	2-amino-14,16-dimethyloctadecan-3-ol	decreases expression	ISO	RGD:1342599	6480464	2-amino-14,16-dimethyloctadecan-3-ol results in decreased expression of UQCRC1 protein	CTD	PMID:32044396
Uqcrc1	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1551847	6480464	bisphenol S results in increased expression of UQCRC1 mRNA	CTD	PMID:39298647
Uqcrc1	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...	CTD	PMID:36041667
Uqcrc1	Rat	8-bromo-3',5'-cyclic GMP	multiple interactions	ISO	RGD:1342599	6480464	tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of UQCRC1 protein]	CTD	PMID:24041027
Uqcrc1	Rat	8-bromo-3',5'-cyclic GMP	increases expression	ISO	RGD:1342599	6480464	8-bromocyclic GMP results in increased expression of UQCRC1 protein	CTD	PMID:24041027
Uqcrc1	Rat	acrolein	multiple interactions	ISO	RGD:1342599	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Uqcrc1	Rat	acrylamide	decreases expression	ISO	RGD:1342599	6480464	Acrylamide results in decreased expression of UQCRC1 mRNA	CTD	PMID:32763439
Uqcrc1	Rat	aflatoxin B1	increases methylation	ISO	RGD:1342599	6480464	Aflatoxin B1 results in increased methylation of UQCRC1 gene	CTD	PMID:27153756
Uqcrc1	Rat	alpha-pinene	multiple interactions	ISO	RGD:1342599	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Uqcrc1	Rat	ampicillin	multiple interactions	EXP		6480464	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in more ...	CTD	PMID:30545405
Uqcrc1	Rat	arsane	increases expression	ISO	RGD:1342599	6480464	Arsenic results in increased expression of UQCRC1 protein	CTD	PMID:21514422
Uqcrc1	Rat	arsane	multiple interactions	ISO	RGD:1342599	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:35809665\|PMID:39836092
Uqcrc1	Rat	arsenic atom	increases expression	ISO	RGD:1342599	6480464	Arsenic results in increased expression of UQCRC1 protein	CTD	PMID:21514422
Uqcrc1	Rat	arsenic atom	multiple interactions	ISO	RGD:1342599	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:35809665\|PMID:39836092
Uqcrc1	Rat	arsenic trichloride	multiple interactions	ISO	RGD:1342599	6480464	[arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of UQCRC1 more ...	CTD	PMID:35809665
Uqcrc1	Rat	arsenite(3-)	multiple interactions	ISO	RGD:1342599	6480464	arsenite promotes the reaction [G3BP1 protein binds to UQCRC1 mRNA]	CTD	PMID:32406909
Uqcrc1	Rat	atrazine	decreases expression	EXP		6480464	Atrazine results in decreased expression of UQCRC1 mRNA	CTD	PMID:27114639
Uqcrc1	Rat	atrazine	decreases expression	ISO	RGD:1342599	6480464	Atrazine results in decreased expression of UQCRC1 mRNA	CTD	PMID:22378314\|PMID:27114639
Uqcrc1	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1342599	6480464	Benzo(a)pyrene results in decreased methylation of UQCRC1 3' UTR; Benzo(a)pyrene results in decreased methylation of more ...	CTD	PMID:27901495
Uqcrc1	Rat	bilirubin IXalpha	decreases expression	ISO	RGD:1342599	6480464	Bilirubin results in decreased expression of UQCRC1 mRNA	CTD	PMID:20196124
Uqcrc1	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1551847	6480464	Diethylhexyl Phthalate results in increased expression of UQCRC1 mRNA	CTD	PMID:33754040
Uqcrc1	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of UQCRC1 mRNA	CTD	PMID:25181051
Uqcrc1	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...	CTD	PMID:36041667
Uqcrc1	Rat	bisphenol A	increases expression	ISO	RGD:1551847	6480464	bisphenol A results in increased expression of UQCRC1 mRNA	CTD	PMID:32156529\|PMID:33221593
Uqcrc1	Rat	bisphenol A	increases expression	ISO	RGD:1342599	6480464	bisphenol A results in increased expression of UQCRC1 protein	CTD	PMID:37567409
Uqcrc1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of UQCRC1 mRNA	CTD	PMID:33296240
Uqcrc1	Rat	bisphenol A	decreases expression	ISO	RGD:1342599	6480464	bisphenol A results in decreased expression of UQCRC1 mRNA; bisphenol A results in decreased expression more ...	CTD	PMID:30099677\|PMID:34186270
Uqcrc1	Rat	bisphenol A	decreases expression	ISO	RGD:1551847	6480464	bisphenol A results in decreased expression of UQCRC1 protein	CTD	PMID:24909818
Uqcrc1	Rat	bisphenol AF	increases expression	ISO	RGD:1342599	6480464	bisphenol AF results in increased expression of UQCRC1 protein	CTD	PMID:34186270
Uqcrc1	Rat	Bisphenol B	increases expression	ISO	RGD:1342599	6480464	bisphenol B results in increased expression of UQCRC1 protein	CTD	PMID:34186270
Uqcrc1	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...	CTD	PMID:36041667
Uqcrc1	Rat	bisphenol F	increases expression	ISO	RGD:1342599	6480464	bisphenol F results in increased expression of UQCRC1 protein	CTD	PMID:34186270
Uqcrc1	Rat	bleomycin A2	decreases expression	EXP		6480464	Bleomycin results in decreased expression of UQCRC1 protein	CTD	PMID:25933445
Uqcrc1	Rat	cadmium atom	multiple interactions	ISO	RGD:1551847	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of UQCRC1 more ...	CTD	PMID:33038468
Uqcrc1	Rat	cadmium atom	multiple interactions	ISO	RGD:1342599	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of UQCRC1 more ...	CTD	PMID:35301059
Uqcrc1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1551847	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of UQCRC1 more ...	CTD	PMID:33038468
Uqcrc1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1342599	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of UQCRC1 more ...	CTD	PMID:35301059
Uqcrc1	Rat	carbon nanotube	increases expression	ISO	RGD:1551847	6480464	Nanotubes, Carbon analog results in increased expression of UQCRC1 mRNA	CTD	PMID:25554681
Uqcrc1	Rat	chromium trinitrate	decreases expression	ISO	RGD:1551847	6480464	chromium nitrate results in decreased expression of UQCRC1 protein	CTD	PMID:22144121
Uqcrc1	Rat	cisplatin	increases expression	EXP		6480464	Cisplatin results in increased expression of UQCRC1 protein	CTD	PMID:22023808
Uqcrc1	Rat	cisplatin	decreases expression	ISO	RGD:1342599	6480464	Cisplatin results in decreased expression of UQCRC1 protein	CTD	PMID:25450742
Uqcrc1	Rat	clobetasol	increases expression	ISO	RGD:1551847	6480464	Clobetasol results in increased expression of UQCRC1 mRNA	CTD	PMID:27462272
Uqcrc1	Rat	clofibrate	increases expression	EXP		6480464	Clofibrate results in increased expression of UQCRC1 protein	CTD	PMID:16470657
Uqcrc1	Rat	clofibrate	decreases expression	ISO	RGD:1551847	6480464	Clofibrate results in decreased expression of UQCRC1 mRNA	CTD	PMID:17585979
Uqcrc1	Rat	cobalt dichloride	decreases expression	ISO	RGD:1342599	6480464	cobaltous chloride results in decreased expression of UQCRC1 mRNA	CTD	PMID:19376846
Uqcrc1	Rat	copper atom	increases expression	ISO	RGD:1551847	6480464	Copper analog results in increased expression of UQCRC1 protein	CTD	PMID:23882024
Uqcrc1	Rat	copper(0)	increases expression	ISO	RGD:1551847	6480464	Copper analog results in increased expression of UQCRC1 protein	CTD	PMID:23882024
Uqcrc1	Rat	copper(II) chloride	increases expression	ISO	RGD:1551847	6480464	cupric chloride results in increased expression of UQCRC1 protein	CTD	PMID:29617964
Uqcrc1	Rat	CU-O LINKAGE	increases expression	ISO	RGD:1551847	6480464	cupric oxide analog results in increased expression of UQCRC1 protein	CTD	PMID:23882024
Uqcrc1	Rat	cyclosporin A	decreases expression	ISO	RGD:1342599	6480464	Cyclosporine results in decreased expression of UQCRC1 mRNA	CTD	PMID:20106945
Uqcrc1	Rat	deoxynivalenol	decreases expression	ISO	RGD:1342599	6480464	deoxynivalenol results in decreased expression of UQCRC1 protein	CTD	PMID:33890134
Uqcrc1	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1342599	6480464	di-n-butylphosphoric acid affects the expression of UQCRC1 mRNA	CTD	PMID:37042841
Uqcrc1	Rat	disodium selenite	increases expression	ISO	RGD:1342599	6480464	Sodium Selenite results in increased expression of UQCRC1 mRNA	CTD	PMID:18175754
Uqcrc1	Rat	doxorubicin	increases expression	ISO	RGD:1551847	6480464	Doxorubicin results in increased expression of UQCRC1 protein	CTD	PMID:21251210
Uqcrc1	Rat	doxorubicin	increases expression	ISO	RGD:1342599	6480464	Doxorubicin results in increased expression of UQCRC1 mRNA	CTD	PMID:29803840
Uqcrc1	Rat	doxorubicin	decreases expression	EXP		6480464	Doxorubicin results in decreased expression of UQCRC1 mRNA	CTD	PMID:28865727
Uqcrc1	Rat	doxorubicin	decreases expression	ISO	RGD:1551847	6480464	Doxorubicin results in decreased expression of UQCRC1 mRNA	CTD	PMID:26873546
Uqcrc1	Rat	doxorubicin	multiple interactions	ISO	RGD:1551847	6480464	sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of UQCRC1 protein]	CTD	PMID:21251210
Uqcrc1	Rat	elemental selenium	increases expression	ISO	RGD:1342599	6480464	Selenium results in increased expression of UQCRC1 mRNA	CTD	PMID:19244175
Uqcrc1	Rat	epoxiconazole	decreases expression	ISO	RGD:1551847	6480464	epoxiconazole results in decreased expression of UQCRC1 mRNA	CTD	PMID:35436446
Uqcrc1	Rat	fipronil	decreases expression	EXP		6480464	fipronil results in decreased expression of UQCRC1 mRNA	CTD	PMID:23962444
Uqcrc1	Rat	flutamide	increases expression	EXP		6480464	Flutamide results in increased expression of UQCRC1 mRNA	CTD	PMID:24136188
Uqcrc1	Rat	folic acid	multiple interactions	ISO	RGD:1551847	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of UQCRC1 mRNA	CTD	PMID:22206623
Uqcrc1	Rat	FR900359	increases phosphorylation	ISO	RGD:1342599	6480464	FR900359 results in increased phosphorylation of UQCRC1 protein	CTD	PMID:37730182
Uqcrc1	Rat	furan	increases methylation	EXP		6480464	furan results in increased methylation of UQCRC1 gene	CTD	PMID:22079235
Uqcrc1	Rat	furfural	multiple interactions	ISO	RGD:1342599	6480464	[Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ...	CTD	PMID:38598786
Uqcrc1	Rat	gentamycin	multiple interactions	EXP		6480464	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in more ...	CTD	PMID:30545405
Uqcrc1	Rat	isotretinoin	decreases expression	ISO	RGD:1342599	6480464	Isotretinoin results in decreased expression of UQCRC1 mRNA	CTD	PMID:20436886
Uqcrc1	Rat	ivermectin	decreases expression	ISO	RGD:1342599	6480464	Ivermectin results in decreased expression of UQCRC1 protein	CTD	PMID:32959892
Uqcrc1	Rat	lamivudine	multiple interactions	ISO	RGD:1551847	6480464	[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA	CTD	PMID:17526437\|PMID:18313992
Uqcrc1	Rat	lead diacetate	increases expression	ISO	RGD:1551847	6480464	lead acetate results in increased expression of UQCRC1 protein	CTD	PMID:20797405
Uqcrc1	Rat	lead(0)	decreases expression	ISO	RGD:1342599	6480464	Lead results in decreased expression of UQCRC1 mRNA	CTD	PMID:19921347
Uqcrc1	Rat	LY294002	multiple interactions	ISO	RGD:1342599	6480464	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of UQCRC1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the more ...	CTD	PMID:24041027
Uqcrc1	Rat	maneb	multiple interactions	ISO	RGD:1551847	6480464	[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein; Levodopa inhibits the reaction more ...	CTD	PMID:23562983
Uqcrc1	Rat	manganese atom	multiple interactions	ISO	RGD:1342599	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Uqcrc1	Rat	manganese(0)	multiple interactions	ISO	RGD:1342599	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Uqcrc1	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:1342599	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Uqcrc1	Rat	metronidazole	multiple interactions	EXP		6480464	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in more ...	CTD	PMID:30545405
Uqcrc1	Rat	molybdenum atom	multiple interactions	ISO	RGD:1551847	6480464	[molybdenum trioxide results in increased abundance of Molybdenum] which results in decreased expression of UQCRC1 more ...	CTD	PMID:33038468
Uqcrc1	Rat	molybdenum trioxide	multiple interactions	ISO	RGD:1551847	6480464	[molybdenum trioxide results in increased abundance of Molybdenum] which results in decreased expression of UQCRC1 more ...	CTD	PMID:33038468
Uqcrc1	Rat	N,N-diethyl-m-toluamide	multiple interactions	EXP		6480464	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UQCRC1 mRNA	CTD	PMID:28659758
Uqcrc1	Rat	nefazodone	increases expression	EXP		6480464	nefazodone results in increased expression of UQCRC1 mRNA	CTD	PMID:24136188
Uqcrc1	Rat	neomycin	multiple interactions	EXP		6480464	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in more ...	CTD	PMID:30545405
Uqcrc1	Rat	oxybenzone	increases expression	EXP		6480464	oxybenzone results in increased expression of UQCRC1 mRNA	CTD	PMID:30316929
Uqcrc1	Rat	ozone	multiple interactions	ISO	RGD:1342599	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Uqcrc1	Rat	paracetamol	increases expression	ISO	RGD:1551847	6480464	Acetaminophen results in increased expression of UQCRC1 protein	CTD	PMID:21329376
Uqcrc1	Rat	paraquat	multiple interactions	ISO	RGD:1551847	6480464	[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein; Levodopa inhibits the reaction more ...	CTD	PMID:23562983
Uqcrc1	Rat	PCB138	decreases expression	EXP		6480464	2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of UQCRC1 protein	CTD	PMID:21673325
Uqcrc1	Rat	perfluorododecanoic acid	increases expression	EXP		6480464	perfluorododecanoic acid results in increased expression of UQCRC1 protein	CTD	PMID:26168851
Uqcrc1	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1551847	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of UQCRC1 mRNA	CTD	PMID:36331819
Uqcrc1	Rat	permethrin	multiple interactions	EXP		6480464	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UQCRC1 mRNA	CTD	PMID:28659758
Uqcrc1	Rat	potassium chromate	decreases expression	ISO	RGD:1551847	6480464	potassium chromate(VI) results in decreased expression of UQCRC1 protein	CTD	PMID:22144121
Uqcrc1	Rat	propiconazole	increases metabolic processing	ISO	RGD:1551847	6480464	propiconazole results in increased metabolism of UQCRC1 protein	CTD	PMID:19714882
Uqcrc1	Rat	Pseudolaric acid B	decreases expression	ISO	RGD:1551847	6480464	pseudolaric acid B results in decreased expression of UQCRC1 mRNA	CTD	PMID:37244295
Uqcrc1	Rat	Pyridostigmine bromide	multiple interactions	EXP		6480464	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UQCRC1 mRNA	CTD	PMID:28659758
Uqcrc1	Rat	resveratrol	increases expression	ISO	RGD:1551847	6480464	Resveratrol results in increased expression of UQCRC1 mRNA; Resveratrol results in increased expression of UQCRC1 more ...	CTD	PMID:24041027\|PMID:34216621
Uqcrc1	Rat	resveratrol	increases expression	ISO	RGD:1342599	6480464	resveratrol results in increased expression of UQCRC1 protein	CTD	PMID:24365713
Uqcrc1	Rat	resveratrol	multiple interactions	ISO	RGD:1342599	6480464	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of UQCRC1 protein]; HMOX1 mutant form more ...	CTD	PMID:24041027
Uqcrc1	Rat	resveratrol	multiple interactions	ISO	RGD:1551847	6480464	Resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of UQCRC1 protein]; more ...	CTD	PMID:24041027\|PMID:34216621
Uqcrc1	Rat	rotenone	increases expression	ISO	RGD:1342599	6480464	Rotenone results in increased expression of UQCRC1 mRNA	CTD	PMID:18191903
Uqcrc1	Rat	rotenone	decreases expression	ISO	RGD:1551847	6480464	Rotenone results in decreased expression of UQCRC1 mRNA	CTD	PMID:23186747
Uqcrc1	Rat	selenium atom	increases expression	ISO	RGD:1342599	6480464	Selenium results in increased expression of UQCRC1 mRNA	CTD	PMID:19244175
Uqcrc1	Rat	sodium arsenate	increases expression	ISO	RGD:1551847	6480464	sodium arsenate results in increased expression of UQCRC1 mRNA	CTD	PMID:30953684
Uqcrc1	Rat	sodium arsenite	decreases expression	ISO	RGD:1342599	6480464	sodium arsenite results in decreased expression of UQCRC1 mRNA; sodium arsenite results in decreased expression more ...	CTD	PMID:15725613\|PMID:38568856
Uqcrc1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1342599	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:25879800\|PMID:39836092
Uqcrc1	Rat	sodium chloride	multiple interactions	ISO	RGD:1342599	6480464	[Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ...	CTD	PMID:38598786
Uqcrc1	Rat	sodium nitrate	multiple interactions	ISO	RGD:1551847	6480464	sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of UQCRC1 protein]	CTD	PMID:21251210
Uqcrc1	Rat	streptozocin	increases expression	EXP		6480464	Streptozocin results in increased expression of UQCRC1 protein	CTD	PMID:19634143\|PMID:21136691
Uqcrc1	Rat	streptozocin	multiple interactions	EXP		6480464	Trientine inhibits the reaction [Streptozocin results in increased expression of UQCRC1 protein]	CTD	PMID:19634143\|PMID:21136691
Uqcrc1	Rat	sulforaphane	increases expression	ISO	RGD:1551847	6480464	sulforaphane results in increased expression of UQCRC1 mRNA	CTD	PMID:30529165
Uqcrc1	Rat	sunitinib	decreases expression	ISO	RGD:1342599	6480464	Sunitinib results in decreased expression of UQCRC1 mRNA	CTD	PMID:31533062
Uqcrc1	Rat	tamoxifen	affects expression	ISO	RGD:1551847	6480464	Tamoxifen affects the expression of UQCRC1 mRNA	CTD	PMID:17555576
Uqcrc1	Rat	tert-butyl ethyl ether	increases expression	EXP		6480464	ethyl tert-butyl ether results in increased expression of UQCRC1 protein	CTD	PMID:24090815
Uqcrc1	Rat	thapsigargin	decreases expression	ISO	RGD:1342599	6480464	Thapsigargin results in decreased expression of UQCRC1 mRNA	CTD	PMID:22378314
Uqcrc1	Rat	thapsigargin	decreases expression	EXP		6480464	Thapsigargin results in decreased expression of UQCRC1 protein	CTD	PMID:35544339
Uqcrc1	Rat	thiram	decreases expression	ISO	RGD:1342599	6480464	Thiram results in decreased expression of UQCRC1 mRNA	CTD	PMID:38568856
Uqcrc1	Rat	titanium dioxide	decreases methylation	ISO	RGD:1551847	6480464	titanium dioxide results in decreased methylation of UQCRC1 gene	CTD	PMID:35295148
Uqcrc1	Rat	titanium dioxide	increases methylation	ISO	RGD:1551847	6480464	titanium dioxide results in increased methylation of UQCRC1 gene	CTD	PMID:35295148
Uqcrc1	Rat	triphenyl phosphate	affects expression	ISO	RGD:1342599	6480464	triphenyl phosphate affects the expression of UQCRC1 mRNA	CTD	PMID:37042841
Uqcrc1	Rat	Triptolide	decreases expression	ISO	RGD:1551847	6480464	triptolide results in decreased expression of UQCRC1 mRNA	CTD	PMID:29723566
Uqcrc1	Rat	troglitazone	increases expression	ISO	RGD:1551847	6480464	troglitazone results in increased expression of UQCRC1 protein	CTD	PMID:18495193
Uqcrc1	Rat	tunicamycin	decreases expression	ISO	RGD:1342599	6480464	Tunicamycin results in decreased expression of UQCRC1 mRNA	CTD	PMID:22378314
Uqcrc1	Rat	valproic acid	increases methylation	ISO	RGD:1342599	6480464	Valproic Acid results in increased methylation of UQCRC1 gene	CTD	PMID:29154799
Uqcrc1	Rat	valproic acid	affects expression	ISO	RGD:1342599	6480464	Valproic Acid affects the expression of UQCRC1 mRNA	CTD	PMID:25979313
Uqcrc1	Rat	vancomycin	multiple interactions	EXP		6480464	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in more ...	CTD	PMID:30545405
Uqcrc1	Rat	vitamin E	increases expression	ISO	RGD:1342599	6480464	Vitamin E results in increased expression of UQCRC1 mRNA	CTD	PMID:19244175
Uqcrc1	Rat	zidovudine	multiple interactions	ISO	RGD:1551847	6480464	[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA	CTD	PMID:17526437\|PMID:18313992
Uqcrc1	Rat	zoledronic acid	decreases expression	ISO	RGD:1342599	6480464	zoledronic acid results in decreased expression of UQCRC1 protein	CTD	PMID:28871336

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	mitochondrial electron transport, ubiquinol to cytochrome c	acts_upstream_of_or_within	IEA	UniProtKB:Q9CZ13\|ensembl:ENSMUSP00000026743	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Uqcrc1	Rat	mitochondrial electron transport, ubiquinol to cytochrome c	acts_upstream_of_or_within	ISO	RGD:1551847	1624291	PMID:16782889	RGD	PMID:16782889
Uqcrc1	Rat	response to activity		IEP		2303193		RGD
Uqcrc1	Rat	response to alkaloid		IEP		2303353		RGD

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Uqcrc1	Rat	mitochondrial inner membrane	is_active_in	ISO	RGD:1551847	1624291	PMID:34616041, PMID:38575788	RGD	PMID:34616041\|PMID:38575788
Uqcrc1	Rat	mitochondrial inner membrane	located_in	IEA	UniProtKB-SubCell:SL-0168	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Uqcrc1	Rat	mitochondrial inner membrane	located_in	ISO	RGD:1342599	1624291	PMID:28844695	RGD	PMID:28844695
Uqcrc1	Rat	mitochondrial inner membrane	located_in	IEA	UniProtKB-KW:KW-0999	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Uqcrc1	Rat	mitochondrial inner membrane	is_active_in	IEA	UniProtKB:Q9CZ13\|ensembl:ENSMUSP00000026743	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Uqcrc1	Rat	mitochondrial inner membrane	located_in	IEA	UniProtKB:P31930\|ensembl:ENSP00000203407	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Uqcrc1	Rat	mitochondrion	is_active_in	IBA	CGD:CAL0000178676\|CGD:CAL0000195289\|MGI:107876\|MGI:1914253\|PANTHER:PTN000220169\|RGD:621297\|SGD:S000000141\|SGD:S000001066\|SGD:S000004153\|SGD:S000006395\|TAIR:locus:2088309\|UniProtKB:O75439\|UniProtKB:P22695\|UniProtKB:P31930\|UniProtKB:Q10713\|UniProtKB:Q57W51\|UniProtKB:Q586V8\|WB:WBGene00013880\|WB:WBGene00022159\|dictyBase:DDB_G0274809\|dictyBase:DDB_G0288777	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Uqcrc1	Rat	mitochondrion	located_in	IEA	UniProtKB:Q9CZ13\|ensembl:ENSMUSP00000026743	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Uqcrc1	Rat	mitochondrion	located_in	IEA	UniProtKB:P31930\|ensembl:ENSP00000203407	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Uqcrc1	Rat	mitochondrion	located_in	IEA	UniProtKB-KW:KW-0496	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Uqcrc1	Rat	mitochondrion	located_in	ISO	RGD:1551847	1624291	PMID:16120479	RGD	PMID:16120479
Uqcrc1	Rat	mitochondrion	located_in	ISO	RGD:1342599	1624291		RGD	GO_REF:0000052
Uqcrc1	Rat	respiratory chain complex III		IDA		1299349	Uqcrc1 is subunit I	RGD
Uqcrc1	Rat	respiratory chain complex III	part_of	IEA	UniProtKB:Q9CZ13\|ensembl:ENSMUSP00000026743	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Uqcrc1	Rat	respiratory chain complex III	part_of	ISO	RGD:1551847	1624291	PMID:34616041, PMID:38575788	RGD	PMID:34616041\|PMID:38575788

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	metal ion binding	enables	IEA	InterPro:IPR011249	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Uqcrc1	Rat	protein binding	enables	ISO	RGD:1342599	1624291	UniProtKB:C9J082\|UniProtKB:O14744\|UniProtKB:O43704\|UniProtKB:O95416\|UniProtKB:O95947\|UniProtKB:P0DP99\|UniProtKB:P26641\|UniProtKB:P52566\|UniProtKB:Q00169\|UniProtKB:Q06547-2\|UniProtKB:Q14457\|UniProtKB:Q69YU5\|UniProtKB:Q6ZMY6-2\|UniProtKB:Q8IV13\|UniProtKB:Q8N108-16\|UniProtKB:Q8N5Z5\|UniProtKB:Q8N8E2\|UniProtKB:Q8WTV1\|UniProtKB:Q8WU43\|UniProtKB:Q96JM7-2\|UniProtKB:Q96MN9-2\|UniProtKB:Q9BRT8\|UniProtKB:Q9BUA3\|UniProtKB:Q9BZM4\|UniProtKB:Q9HC44\|UniProtKB:Q9P0T4\|UniProtKB:Q9UFG5\|UniProtKB:Q9UHV9\|UniProtKB:Q9UI10\|UniProtKB:Q9UNY5\|UniProtKB:Q9Y6G5 PMID:32161263, PMID:32814053, PMID:35101990	RGD	PMID:32161263\|PMID:32814053\|PMID:35101990
Uqcrc1	Rat	protein binding	enables	ISO	RGD:1551847	1624291	PR:Q5Y5T5\|UniProtKB:Q8BTC1\|UniProtKB:Q8CC21 PMID:18775783, PMID:21278747, PMID:32161263	RGD	PMID:18775783\|PMID:21278747\|PMID:32161263
Uqcrc1	Rat	protein-containing complex binding		IDA		1299349		RGD
Uqcrc1	Rat	ubiquitin protein ligase binding	enables	ISO	RGD:1342599	1624291	UniProtKB:O60260 PMID:19725078	RGD	PMID:19725078
Uqcrc1	Rat	ubiquitin protein ligase binding	enables	IEA	UniProtKB:P31930\|ensembl:ENSP00000203407	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Pathway Annotations Click to see Annotation Detail View

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	electron transport chain pathway		ISO	RGD:1342599	10402751		SMPDB	SMP:00355

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uqcrc1	Rat	Alzheimer's disease pathway		IEA		6907045		KEGG	rno:05010
Uqcrc1	Rat	Huntington's disease pathway		IEA		6907045		KEGG	rno:05016
Uqcrc1	Rat	oxidative phosphorylation pathway		IEA		6907045		KEGG	rno:00190
Uqcrc1	Rat	Parkinson's disease pathway		IEA		6907045		KEGG	rno:05012

BioCyc Pathways

aerobic respiration I (cytochrome c)	aerobic respiration II (cytochrome c) (yeast)

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 1 (ISO)

Alzheimer's disease (ISO)

hypertrophic cardiomyopathy (ISO)

PARKINSONISM WITH POLYNEUROPATHY (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ISO)

2,2,2-tetramine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

8-bromo-3',5'-cyclic GMP (ISO)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

ampicillin (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenic trichloride (ISO)

arsenite(3-) (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

bilirubin IXalpha (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

bleomycin A2 (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chromium trinitrate (ISO)

cisplatin (EXP,ISO)

clobetasol (ISO)

clofibrate (EXP,ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

Dibutyl phosphate (ISO)

disodium selenite (ISO)

doxorubicin (EXP,ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

furfural (ISO)

gentamycin (EXP)

isotretinoin (ISO)

ivermectin (ISO)

lamivudine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

LY294002 (ISO)

maneb (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

metronidazole (EXP)

molybdenum atom (ISO)

molybdenum trioxide (ISO)

N,N-diethyl-m-toluamide (EXP)

nefazodone (EXP)

neomycin (EXP)

oxybenzone (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

PCB138 (EXP)

perfluorododecanoic acid (EXP)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

potassium chromate (ISO)

propiconazole (ISO)

Pseudolaric acid B (ISO)

Pyridostigmine bromide (EXP)

resveratrol (ISO)

rotenone (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium nitrate (ISO)

streptozocin (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl ethyl ether (EXP)

thapsigargin (EXP,ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

Triptolide (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vancomycin (EXP)

vitamin E (ISO)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial electron transport, ubiquinol to cytochrome c (IEA,ISO)

response to activity (IEP)

response to alkaloid (IEP)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (IEA,ISO)

mitochondrion (IBA,IEA,ISO)

respiratory chain complex III (IDA,IEA,ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

protein-containing complex binding (IDA)

ubiquitin protein ligase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Alzheimer's disease pathway (IEA)

electron transport chain pathway (ISO)

Huntington's disease pathway (IEA)

oxidative phosphorylation pathway (IEA)

Parkinson's disease pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase.	Hoffman GG, etal., J Biol Chem 1993 Oct 5;268(28):21113-9.
3.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
4.	Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome.	Kim SH, etal., Cell Mol Life Sci. 2000 Nov;57(12):1810-6.
5.	Hippocampal metabolic proteins are modulated in voluntary and treadmill exercise rats.	Kirchner L, etal., Exp Neurol. 2008 Jul;212(1):145-51. Epub 2008 Mar 27.
6.	Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population.	Ma SL, etal., J Psychiatr Res. 2016 May;76:143-7. doi: 10.1016/j.jpsychires.2016.02.010. Epub 2016 Feb 18.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Pressure overload and neurohumoral activation differentially affect the myocardial proteome.	Schott P, etal., Proteomics. 2005 Apr;5(5):1372-81.
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Mass spectrometric characterization of mitochondrial electron transport complexes: subunits of the rat heart ubiquinol-cytochrome c reductase.	Sun G, etal., J Mass Spectrom 2003 May;38(5):531-9.

Additional References at PubMed

PMID:12865426	PMID:14651853	PMID:15489334	PMID:16120479	PMID:16782889	PMID:17634366	PMID:18614015	PMID:19041937	PMID:19725078	PMID:20833797	PMID:26316108	PMID:28676853
PMID:28750029	PMID:28844695	PMID:32357304	PMID:32819597

Genomics

Comparative Map Data

Uqcrc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,468,223 - 118,479,968 (+)	NCBI		GRCr8
mRatBN7.2	8	109,589,735 - 109,601,481 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,589,706 - 109,601,480 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	115,207,272 - 115,219,022 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,406,459 - 113,418,209 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,249,253 - 111,261,004 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,679,328 - 117,691,073 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,679,278 - 117,691,071 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	117,030,932 - 117,042,820 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,955,930 - 113,967,675 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,975,384 - 113,987,128 (+)	NCBI
Celera	8	108,883,471 - 108,895,222 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

UQCRC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	48,599,002 - 48,609,646 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	48,599,002 - 48,610,976 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	48,636,435 - 48,647,079 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	48,611,436 - 48,622,102 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	48,611,435 - 48,622,102	NCBI
Celera	3	48,592,174 - 48,602,839 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	48,694,682 - 48,705,348 (-)	NCBI		HuRef
CHM1_1	3	48,588,742 - 48,599,408 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	48,627,962 - 48,639,898 (-)	NCBI		T2T-CHM13v2.0

Uqcrc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,765,716 - 108,778,709 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	108,765,701 - 108,778,691 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	108,936,648 - 108,949,641 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,936,633 - 108,949,623 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	108,838,661 - 108,851,686 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	108,793,553 - 108,806,578 (+)	NCBI		MGSCv36	mm8
Celera	9	108,494,681 - 108,507,601 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.63	NCBI

LOC102005965
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	685,395 - 696,554 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	685,315 - 691,286 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100977575
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	48,573,688 - 48,584,412 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	48,578,456 - 48,589,180 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	48,520,870 - 48,531,947 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	49,602,770 - 49,613,717 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	49,602,770 - 49,613,717 (-)	Ensembl	panpan1.1		panPan2

UQCRC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	40,507,767 - 40,515,854 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	40,506,907 - 40,520,110 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	40,424,996 - 40,433,095 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	40,993,125 - 41,001,225 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	40,992,686 - 41,001,240 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	40,230,564 - 40,238,664 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	40,635,079 - 40,643,433 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	40,916,265 - 40,924,365 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101956274
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	63,625,445 - 63,635,735 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	385,851 - 396,230 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	385,942 - 396,196 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UQCRC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	31,298,449 - 31,309,516 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	31,298,449 - 31,308,719 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	34,542,911 - 34,553,174 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UQCRC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	10,000,432 - 10,012,524 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	10,000,864 - 10,012,202 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	157,073,473 - 157,085,359 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101719627
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	2,603,089 - 2,613,828 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	2,603,301 - 2,613,105 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Uqcrc1
30 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	116
Count of miRNA genes:	98
Interacting mature miRNAs:	106
Transcripts:	ENSRNOT00000042114
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Markers in Region

AA819271

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,477,381 - 118,477,709 (+)	Marker Load Pipeline
RH 3.4 Map	8	1191.4	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229052	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000042114 ⟹ ENSRNOP00000044696

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,589,706 - 109,601,480 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,679,278 - 117,691,071 (+)	Ensembl

RefSeq Acc Id:

NM_001004250 ⟹ NP_001004250

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,468,223 - 118,479,968 (+)	NCBI
mRatBN7.2	8	109,589,735 - 109,601,481 (+)	NCBI
Rnor_6.0	8	117,679,328 - 117,691,073 (+)	NCBI
Rnor_5.0	8	117,030,932 - 117,042,820 (+)	NCBI
RGSC_v3.4	8	113,955,930 - 113,967,675 (+)	RGD
Celera	8	108,883,471 - 108,895,222 (+)	RGD

Sequence:

show sequence

AGATGGCGGCGTCCGCAGTCTGCCGAGCGGCCTGCTCTGGGACGCAAGCGCTACTTCGCACCTG
CCGCTCGCCGGCCCTGCTGAGGCTACCTGCCTTGCGGGGTACCGCAACCTTCGTCCAGGCCCTC
CAGAGCGTGCCGGAGACACAGGTCAGCGTATTGGACAACGGGCTGCGTGTGGCCTCGGAGCAGT
CCTCGCATCCTACCTGCACGGTGGGAGTGTGGATTGACGTTGGCAGTCGCTATGAGACTGAGAA
GAACAATGGAGCAGGCTACTTTTTGGAACATCTGGCTTTCAAGGGAACAAAGAACCGTCCTGGC
AATGCCTTAGAGAAGGAGGTAGAGAGTATTGGCGCCCATCTTAATGCCTACAGCACTCGGGAGC
ACACTGCTTACCTCATCAAGGCACTGTCCAAGGACCTGCCAAAAGTTGTGGAGCTCCTGGCAGA
TATTGTGCAGAACATTAGTCTGGAAGACTCGCAGATCGAGAAGGAGCGAGATGTGATCCTGCGG
GAGATGCAGGAAAACGATGCCTCTATGCAGAATGTAGTCTTCGATTACCTGCATGCAACAGCAT
TCCAGGGCACACCTCTAGCCCAGGCTGTGGAGGGGCCCAGTGAGAACGTCAGGAGGCTGTCGCG
CACAGACTTGACTGACTACCTCAGCAGGCACTACAAAGCTCCCCGAATGGTGCTGGCTGCCGCT
GGAGGGGTGAAGCACCAGCAGCTGCTAGACCTTGCCCAGGATCACTTCAGCAGTGTCTCCCAGG
TGTATGAAGAAGACGCTGTACCTAGTATAACTCCATGTCGCTTCACTGGCAGTGAGATCCGACA
TCGGGATGATGCCCTGCCCTTGGCCCATGTGGCCATTGCAGTAGAGGGACCTGGCTGGGCTAAC
CCAGACAACGTGGCTCTCCAAGTGGCCAATGCCATCATAGGCCACTATGACTGCACTTACGGTG
GTGGAGTGCACCTGTCCAGCCCGCTGGCTTCCGTTGCTGTAGCTAACAAGCTTTGCCAGAGTTT
CCAGACCTTCAACATCTCCTACTCTGAGACCGGGTTGCTGGGCGCACACTTTGTCTGTGATGCC
ATGAGCATCGATGACATGATCTTCTTCCTGCAAGGCCAGTGGATGCGCCTGTGCACCAGCGCTA
CAGAGAGTGAGGTGACTCGGGGCAAAAACATCCTTAGGAATGCCTTGATATCTCATTTGGATGG
CACCACCCCTGTGTGTGAAGACATTGGTCGCAGCCTCCTGACTTATGGCCGCCGCATCCCTCTG
GCTGAGTGGGAGAGCCGGATTGAGGAGGTGGATGCCCAGATGGTTCGAGAGGTTTGCTCCAAGT
ACTTTTATGACCAATGTCCAGCAGTGGCTGGATATGGCCCCATCGAACAGCTCTCAGACTACAA
CCGGATTCGCAGTGGCATGTTCTGGCTGCGCTTCTAGGCAGGAAGTCTGCGCAGGCAGGCAGCA
GGGCGGGGCCGGGGACTCGGGGTCCCTGCCACAGACGCCACTCCTGCTGCTCAGCTGTGTGCAG
CCAGTTACCACCAATAAAGTCCTATTGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004250	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78923	(Get FASTA)	NCBI Sequence Viewer
	EDL77131	(Get FASTA)	NCBI Sequence Viewer
	EDL77132	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000044696
	ENSRNOP00000044696.2
GenBank Protein	Q68FY0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001004250 ⟸ NM_001004250
- Peptide Label:	precursor
- UniProtKB:	Q68FY0 (UniProtKB/Swiss-Prot), A6I395 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAASAVCRAACSGTQALLRTCRSPALLRLPALRGTATFVQALQSVPETQVSVLDNGLRVASEQS SHPTCTVGVWIDVGSRYETEKNNGAGYFLEHLAFKGTKNRPGNALEKEVESIGAHLNAYSTREH TAYLIKALSKDLPKVVELLADIVQNISLEDSQIEKERDVILREMQENDASMQNVVFDYLHATAF QGTPLAQAVEGPSENVRRLSRTDLTDYLSRHYKAPRMVLAAAGGVKHQQLLDLAQDHFSSVSQV YEEDAVPSITPCRFTGSEIRHRDDALPLAHVAIAVEGPGWANPDNVALQVANAIIGHYDCTYGG GVHLSSPLASVAVANKLCQSFQTFNISYSETGLLGAHFVCDAMSIDDMIFFLQGQWMRLCTSAT ESEVTRGKNILRNALISHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIEEVDAQMVREVCSKY FYDQCPAVAGYGPIEQLSDYNRIRSGMFWLRF hide sequence

Ensembl Acc Id:

ENSRNOP00000044696 ⟸ ENSRNOT00000042114

Protein Domains

Peptidase M16 C-terminal Peptidase M16 N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FY0-F1-model_v2	AlphaFold	Q68FY0	1-480	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696318

Promoter ID:

EPDNEW_R6842

Type:

multiple initiation site

Name:

Uqcrc1_1

Description:

ubiquinol-cytochrome c reductase core protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	117,679,312 - 117,679,372	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303314	AgrOrtholog
BioCyc Gene	G2FUF-29104	BioCyc
BioCyc Pathway	PWY-3781 [aerobic respiration I (cytochrome c)]	BioCyc
	PWY-7279 [aerobic respiration II (cytochrome c) (yeast)]	BioCyc
BioCyc Pathway Image	PWY-3781	BioCyc
	PWY-7279	BioCyc
Ensembl Genes	ENSRNOG00000032134	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000042114	ENTREZGENE
	ENSRNOT00000042114.5	UniProtKB/Swiss-Prot
Gene3D-CATH	Metalloenzyme, LuxS/M16 peptidase-like	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7106265	IMAGE-MGC_LOAD
InterPro	Metalloenz_LuxS/M16	UniProtKB/Swiss-Prot
	MPP/UQCRC_Complex	UniProtKB/Swiss-Prot
	Pept_M16_N	UniProtKB/Swiss-Prot
	Peptidase_M16_C	UniProtKB/Swiss-Prot
KEGG Report	rno:301011	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93712	IMAGE-MGC_LOAD
NCBI Gene	301011	ENTREZGENE
PANTHER	CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	METALLOPROTEASE	UniProtKB/Swiss-Prot
Pfam	Peptidase_M16	UniProtKB/Swiss-Prot
	Peptidase_M16_C	UniProtKB/Swiss-Prot
PhenoGen	Uqcrc1	PhenoGen
RatGTEx	ENSRNOG00000032134	RatGTEx
Superfamily-SCOP	SSF63411	UniProtKB/Swiss-Prot
UniProt	A6I395	ENTREZGENE, UniProtKB/TrEMBL
	A6I396_RAT	UniProtKB/TrEMBL
	Q68FY0	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-09-28	Uqcrc1	ubiquinol-cytochrome c reductase core protein 1	Uqcrc1	ubiquinol-cytochrome c reductase core protein I	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Uqcrc1	ubiquinol-cytochrome c reductase core protein I	Uqcrc1	ubiquinol-cytochrome c reductase core protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Uqcrc1	ubiquinol-cytochrome c reductase core protein 1			Symbol and Name status set to approved	1299863	APPROVED
2005-02-14	Uqcrc1	ubiquinol-cytochrome c reductase core protein I			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways