Symbol:
Uqcrc1
Name:
ubiquinol-cytochrome c reductase core protein 1
Description:
ENCODES a protein that exhibits protein-containing complex binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN mitochondrial electron transport, ubiquinol to cytochrome c; PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); FOUND IN mitochondrion; cytosol (ortholog); mitochondrial respiratory chain complex III (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1110032G10Rik; complex III subunit 1; core protein I; cytochrome b-c1 complex subunit 1, mitochondrial; MGC97899; ubiquinol-cytochrome-c reductase complex core protein 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
UQCRC1 (ubiquinol-cytochrome c reductase core protein 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Uqcrc1 (ubiquinol-cytochrome c reductase core protein 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
LOC102005965 (cytochrome b-c1 complex subunit 1, mitochondrial) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LOC100977575 (cytochrome b-c1 complex subunit 1, mitochondrial) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
UQCRC1 (ubiquinol-cytochrome c reductase core protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
LOC101956274 (cytochrome b-c1 complex subunit 1, mitochondrial) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
LOC100156879 (cytochrome b-c1 complex subunit 1, mitochondrial) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Uqcrc1 (ubiquinol-cytochrome c reductase core protein 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
UQCRC1 (ubiquinol-cytochrome c reductase core protein 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
uqcrc1 (ubiquinol-cytochrome c reductase core protein 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
COR1
Alliance
DIOPT (PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
UQCR-C1
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
ucr-1
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
MAS1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
mppb-1
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Related Pseudogenes:
Gm18969
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,936,648 - 108,949,641 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,838,661 - 108,851,686 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,793,553 - 108,806,578 (+) NCBI mm8 Celera 9 108,494,681 - 108,507,601 (+) NCBI Celera Cytogenetic Map 9 F2 NCBI cM Map 9 59.63 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(-)-epigallocatechin 3-gallate decreases expression EXP 6480464 epigallocatechin gallate results in decreased expression of UQCRC1 mRNA CTD PMID:29175576 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRC1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of UQCRC1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of UQCRC1 mRNA CTD PMID:17942748 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one multiple interactions ISO RGD:1342599 6480464 1H-(1 more ... CTD PMID:24041027 2,2,2-tetramine multiple interactions ISO RGD:1303314 6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of UQCRC1 protein] CTD PMID:19634143 , PMID:21136691 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRC1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of UQCRC1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of UQCRC1 mRNA CTD PMID:20399798 8-bromo-3',5'-cyclic GMP multiple interactions ISO RGD:1342599 6480464 tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of UQCRC1 protein] CTD PMID:24041027 8-bromo-3',5'-cyclic GMP increases expression ISO RGD:1342599 6480464 8-bromocyclic GMP results in increased expression of UQCRC1 protein CTD PMID:24041027 aflatoxin B1 increases methylation ISO RGD:1342599 6480464 Aflatoxin B1 results in increased methylation of UQCRC1 gene CTD PMID:27153756 arsane increases expression ISO RGD:1342599 6480464 Arsenic results in increased expression of UQCRC1 protein CTD PMID:21514422 arsenic atom increases expression ISO RGD:1342599 6480464 Arsenic results in increased expression of UQCRC1 protein CTD PMID:21514422 arsenic(3+) increases expression ISO RGD:1342599 6480464 Arsenic results in increased expression of UQCRC1 protein CTD PMID:21514422 atrazine decreases expression ISO RGD:1342599 6480464 Atrazine results in decreased expression of UQCRC1 mRNA CTD PMID:22378314 , PMID:27114639 atrazine decreases expression ISO RGD:1303314 6480464 Atrazine results in decreased expression of UQCRC1 mRNA CTD PMID:27114639 bilirubin IXalpha decreases expression ISO RGD:1342599 6480464 Bilirubin results in decreased expression of UQCRC1 mRNA CTD PMID:20196124 bisphenol A increases expression ISO RGD:1303314 6480464 bisphenol A results in increased expression of UQCRC1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1342599 6480464 bisphenol A results in decreased expression of UQCRC1 mRNA, bisphenol A results in decreased expression of UQCRC1 protein CTD PMID:30099677 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of UQCRC1 protein CTD PMID:24909818 bleomycin A2 decreases expression ISO RGD:1303314 6480464 Bleomycin results in decreased expression of UQCRC1 protein CTD PMID:25933445 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of UQCRC1 mRNA CTD PMID:25554681 chromium trinitrate decreases expression EXP 6480464 chromium nitrate results in decreased expression of UQCRC1 protein CTD PMID:22144121 cisplatin increases expression ISO RGD:1303314 6480464 Cisplatin results in increased expression of UQCRC1 protein CTD PMID:22023808 cisplatin decreases expression ISO RGD:1342599 6480464 Cisplatin results in decreased expression of UQCRC1 protein CTD PMID:25450742 clobetasol increases expression EXP 6480464 Clobetasol results in increased expression of UQCRC1 mRNA CTD PMID:27462272 clofibrate increases expression ISO RGD:1303314 6480464 Clofibrate results in increased expression of UQCRC1 protein CTD PMID:16470657 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of UQCRC1 mRNA CTD PMID:17585979 cobalt dichloride decreases expression ISO RGD:1342599 6480464 cobaltous chloride results in decreased expression of UQCRC1 mRNA CTD PMID:19376846 copper atom increases expression EXP 6480464 Copper analog results in increased expression of UQCRC1 protein CTD PMID:23882024 copper(0) increases expression EXP 6480464 Copper analog results in increased expression of UQCRC1 protein CTD PMID:23882024 copper(2+) increases expression EXP 6480464 Copper analog results in increased expression of UQCRC1 protein CTD PMID:23882024 copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of UQCRC1 protein CTD PMID:29617964 CU-O LINKAGE increases expression EXP 6480464 cupric oxide analog results in increased expression of UQCRC1 protein CTD PMID:23882024 cyclosporin A decreases expression ISO RGD:1342599 6480464 Cyclosporine results in decreased expression of UQCRC1 mRNA CTD PMID:20106945 disodium selenite increases expression ISO RGD:1342599 6480464 Sodium Selenite results in increased expression of UQCRC1 mRNA CTD PMID:18175754 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of UQCRC1 protein CTD PMID:21251210 doxorubicin increases expression ISO RGD:1342599 6480464 Doxorubicin results in increased expression of UQCRC1 mRNA CTD PMID:29803840 doxorubicin decreases expression ISO RGD:1303314 6480464 Doxorubicin results in decreased expression of UQCRC1 mRNA CTD PMID:28865727 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of UQCRC1 mRNA CTD PMID:26873546 doxorubicin multiple interactions EXP 6480464 sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of UQCRC1 protein] CTD PMID:21251210 elemental selenium increases expression ISO RGD:1342599 6480464 Selenium results in increased expression of UQCRC1 mRNA CTD PMID:19244175 fipronil decreases expression ISO RGD:1303314 6480464 fipronil results in decreased expression of UQCRC1 mRNA CTD PMID:23962444 flutamide increases expression ISO RGD:1303314 6480464 Flutamide results in increased expression of UQCRC1 mRNA CTD PMID:24136188 furan increases methylation ISO RGD:1303314 6480464 furan results in increased methylation of UQCRC1 gene CTD PMID:22079235 isotretinoin decreases expression ISO RGD:1342599 6480464 Isotretinoin results in decreased expression of UQCRC1 mRNA CTD PMID:20436886 lamivudine multiple interactions EXP 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA CTD PMID:17526437 , PMID:18313992 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of UQCRC1 protein CTD PMID:20797405 lead(0) decreases expression ISO RGD:1342599 6480464 Lead results in decreased expression of UQCRC1 mRNA CTD PMID:19921347 lead(2+) decreases expression ISO RGD:1342599 6480464 Lead results in decreased expression of UQCRC1 mRNA CTD PMID:19921347 LY294002 multiple interactions ISO RGD:1342599 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of UQCRC1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of UQCRC1 protein] CTD PMID:24041027 maneb multiple interactions EXP 6480464 [Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein more ... CTD PMID:23562983 N,N-diethyl-m-toluamide multiple interactions ISO RGD:1303314 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UQCRC1 mRNA CTD PMID:28659758 nefazodone increases expression ISO RGD:1303314 6480464 nefazodone results in increased expression of UQCRC1 mRNA CTD PMID:24136188 oxybenzone increases expression ISO RGD:1303314 6480464 oxybenzone results in increased expression of UQCRC1 mRNA CTD PMID:30316929 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of UQCRC1 protein CTD PMID:21329376 paraquat multiple interactions EXP 6480464 [Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein more ... CTD PMID:23562983 perfluorododecanoic acid increases expression ISO RGD:1303314 6480464 perfluorododecanoic acid results in increased expression of UQCRC1 protein CTD PMID:26168851 permethrin multiple interactions ISO RGD:1303314 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UQCRC1 mRNA CTD PMID:28659758 potassium chromate decreases expression EXP 6480464 potassium chromate(VI) results in decreased expression of UQCRC1 protein CTD PMID:22144121 propiconazole increases metabolic processing EXP 6480464 propiconazole results in increased metabolism of UQCRC1 protein CTD PMID:19714882 Pyridostigmine bromide multiple interactions ISO RGD:1303314 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of UQCRC1 mRNA CTD PMID:28659758 resveratrol multiple interactions EXP 6480464 Resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of UQCRC1 protein] more ... CTD PMID:24041027 resveratrol increases expression ISO RGD:1342599 6480464 resveratrol results in increased expression of UQCRC1 protein CTD PMID:24365713 resveratrol multiple interactions ISO RGD:1342599 6480464 1H-(1 more ... CTD PMID:24041027 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of UQCRC1 protein CTD PMID:24041027 rotenone increases expression ISO RGD:1342599 6480464 Rotenone results in increased expression of UQCRC1 mRNA CTD PMID:18191903 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of UQCRC1 mRNA CTD PMID:23186747 selenium atom increases expression ISO RGD:1342599 6480464 Selenium results in increased expression of UQCRC1 mRNA CTD PMID:19244175 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of UQCRC1 mRNA CTD PMID:30953684 sodium arsenite decreases expression ISO RGD:1342599 6480464 sodium arsenite results in decreased expression of UQCRC1 protein CTD PMID:15725613 sodium arsenite multiple interactions ISO RGD:1342599 6480464 sodium arsenite results in decreased expression of and affects the splicing of UQCRC1 mRNA CTD PMID:25879800 sodium nitrate multiple interactions EXP 6480464 sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of UQCRC1 protein] CTD PMID:21251210 streptozocin increases expression ISO RGD:1303314 6480464 Streptozocin results in increased expression of UQCRC1 protein CTD PMID:19634143 , PMID:21136691 streptozocin multiple interactions ISO RGD:1303314 6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of UQCRC1 protein] CTD PMID:19634143 , PMID:21136691 sulforaphane increases expression EXP 6480464 sulforafan results in increased expression of UQCRC1 mRNA CTD PMID:30529165 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of UQCRC1 mRNA CTD PMID:17555576 tert-butyl ethyl ether increases expression ISO RGD:1303314 6480464 ethyl tert-butyl ether results in increased expression of UQCRC1 protein CTD PMID:24090815 thapsigargin decreases expression ISO RGD:1342599 6480464 Thapsigargin results in decreased expression of UQCRC1 mRNA CTD PMID:22378314 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of UQCRC1 mRNA CTD PMID:29723566 troglitazone increases expression EXP 6480464 troglitazone results in increased expression of UQCRC1 protein CTD PMID:18495193 tunicamycin decreases expression ISO RGD:1342599 6480464 Tunicamycin results in decreased expression of UQCRC1 mRNA CTD PMID:22378314 valproic acid increases methylation ISO RGD:1342599 6480464 Valproic Acid results in increased methylation of UQCRC1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1342599 6480464 Valproic Acid affects the expression of UQCRC1 mRNA CTD PMID:25979313 vitamin E increases expression ISO RGD:1342599 6480464 Vitamin E results in increased expression of UQCRC1 mRNA CTD PMID:19244175 zidovudine multiple interactions EXP 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA CTD PMID:17526437 , PMID:18313992 zoledronic acid decreases expression ISO RGD:1342599 6480464 zoledronic acid results in decreased expression of UQCRC1 protein CTD PMID:28871336 
Gene-Chemical Interaction Annotations
