Inpp5e (inositol polyphosphate-5-phosphatase E) - Rat Genome Database

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Gene: Inpp5e (inositol polyphosphate-5-phosphatase E) Rattus norvegicus
Analyze
Symbol: Inpp5e
Name: inositol polyphosphate-5-phosphatase E
RGD ID: 620478
Description: Enables inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate phosphatase activity. Involved in negative regulation of phosphatidylinositol 3-kinase signaling and negative regulation of translation. Located in cytoplasm; plasma membrane; and ruffle. Biomarker of obesity. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E); PARTICIPATES IN phosphoinositide metabolic pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate 5-phosphatase; Pharbin; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SEC16 homolog A; SEC16 homolog A (S. cerevisiae); Sec16a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.239,216,776 - 9,229,539 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,216,776 - 9,229,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,270,758 - 12,283,430 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,853,988 - 20,866,660 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0319,109,325 - 19,121,999 (-)NCBIRnor_WKY
Rnor_6.033,843,307 - 3,856,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,843,307 - 3,855,981 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,204,535 - 9,217,246 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,568,909 - 4,582,653 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,570,005 - 4,582,079 (-)NCBI
Celera34,036,112 - 4,048,786 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pharbin, a novel inositol polyphosphate 5-phosphatase, induces dendritic appearances in fibroblasts. Asano T, etal., Biochem Biophys Res Commun 1999 Jul 22;261(1):188-95.
2. Inhibition of 72 kDa inositol polyphosphate 5-phosphatase E improves insulin signal transduction in diet-induced obesity. Bertelli DF, etal., J Endocrinol. 2013 Apr 15;217(2):131-40. doi: 10.1530/JOE-12-0562. Print 2013 May.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Jacoby M, etal., Nat Genet. 2009 Sep;41(9):1027-31. doi: 10.1038/ng.427. Epub 2009 Aug 9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Phenotypic spectrum and prevalence of INPP5E mutations in Joubert syndrome and related disorders. Travaglini L, etal., Eur J Hum Genet. 2013 Oct;21(10):1074-8. doi: 10.1038/ejhg.2012.305. Epub 2013 Feb 6.
14. Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin. Wang F, etal., J Biochem. 2011 Jul;150(1):83-93. doi: 10.1093/jb/mvr037. Epub 2011 Mar 23.
Additional References at PubMed
PMID:10806194   PMID:28154160  


Genomics

Comparative Map Data
Inpp5e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.239,216,776 - 9,229,539 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,216,776 - 9,229,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,270,758 - 12,283,430 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,853,988 - 20,866,660 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0319,109,325 - 19,121,999 (-)NCBIRnor_WKY
Rnor_6.033,843,307 - 3,856,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,843,307 - 3,855,981 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,204,535 - 9,217,246 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,568,909 - 4,582,653 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,570,005 - 4,582,079 (-)NCBI
Celera34,036,112 - 4,048,786 (-)NCBICelera
Cytogenetic Map3p13NCBI
INPP5E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,428,619 - 136,439,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9136,428,619 - 136,439,845 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,323,071 - 139,334,297 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,442,892 - 138,454,077 (-)NCBINCBI36Build 36hg18NCBI36
Build 349136,598,907 - 136,610,093NCBI
Celera9109,837,914 - 109,848,723 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,782,431 - 108,793,343 (-)NCBIHuRef
CHM1_19139,471,271 - 139,482,699 (-)NCBICHM1_1
T2T-CHM13v2.09148,657,963 - 148,668,937 (-)NCBIT2T-CHM13v2.0
Inpp5e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,286,261 - 26,299,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,286,261 - 26,299,215 (-)EnsemblGRCm39 Ensembl
GRCm38226,396,249 - 26,409,244 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,396,249 - 26,409,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,251,769 - 26,264,708 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,218,258 - 26,231,197 (-)NCBIMGSCv36mm8
Celera226,113,925 - 26,126,902 (-)NCBICelera
Cytogenetic Map2A3NCBI
Inpp5e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,304,483 - 4,313,087 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,304,483 - 4,313,087 (+)NCBIChiLan1.0ChiLan1.0
INPP5E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,482,815 - 136,492,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,483,144 - 136,492,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09107,502,838 - 107,516,325 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
INPP5E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,061,014 - 49,071,474 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,061,968 - 49,070,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,311,690 - 48,322,149 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,937,770 - 49,948,230 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,937,821 - 49,948,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,718,526 - 48,728,777 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,012,481 - 49,022,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,059,986 - 49,070,445 (+)NCBIUU_Cfam_GSD_1.0
Inpp5e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,989,771 - 201,998,053 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366691,377,005 - 1,385,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5E
(Sus scrofa - pig)
No map positions available.
INPP5E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,763,800 - 1,776,139 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,763,865 - 1,776,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,441,443 - 3,452,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp5e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,586,848 - 1,594,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,586,003 - 1,594,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Inpp5e
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:167
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000025764
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat

Markers in Region
RH129683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,216,858 - 9,217,058 (+)MAPPERmRatBN7.2
Rnor_6.033,843,390 - 3,843,589NCBIRnor6.0
Rnor_5.039,204,618 - 9,204,817UniSTSRnor5.0
RGSC_v3.434,570,089 - 4,570,288UniSTSRGSC3.4
Celera34,036,195 - 4,036,394UniSTS
Cytogenetic Map3p13UniSTS
RH134387  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,216,516 - 9,216,696 (+)MAPPERmRatBN7.2
Rnor_6.033,843,048 - 3,843,227NCBIRnor6.0
Rnor_5.039,204,276 - 9,204,455UniSTSRnor5.0
RGSC_v3.434,569,747 - 4,569,926UniSTSRGSC3.4
Celera34,035,853 - 4,036,032UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 22 13 4 11 4 73 22 41 11
Low 2 21 44 37 8 37 8 11 1 13 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025764   ⟹   ENSRNOP00000025763
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,216,776 - 9,228,860 (-)Ensembl
Rnor_6.0 Ensembl33,844,115 - 3,855,391 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079882   ⟹   ENSRNOP00000073935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,216,776 - 9,229,450 (-)Ensembl
Rnor_6.0 Ensembl33,843,307 - 3,855,981 (-)Ensembl
RefSeq Acc Id: NM_053632   ⟹   NP_446084
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.239,216,776 - 9,229,450 (-)NCBI
Rnor_6.033,843,307 - 3,855,981 (-)NCBI
Rnor_5.039,204,535 - 9,217,246 (-)NCBI
Celera34,036,112 - 4,048,786 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233667   ⟹   XP_006233729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.239,216,776 - 9,229,539 (-)NCBI
Rnor_6.033,843,307 - 3,856,154 (-)NCBI
Rnor_5.039,204,535 - 9,217,246 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104089   ⟹   XP_038960017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.239,216,776 - 9,229,539 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446084   ⟸   NM_053632
- UniProtKB: A0A0G2K6T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233729   ⟸   XM_006233667
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073935   ⟸   ENSRNOT00000079882
RefSeq Acc Id: ENSRNOP00000025763   ⟸   ENSRNOT00000025764
RefSeq Acc Id: XP_038960017   ⟸   XM_039104089
- Peptide Label: isoform X2
Protein Domains
IPPc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVR1-F1-model_v2 AlphaFold Q9WVR1 1-648 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691906
Promoter ID:EPDNEW_R2431
Type:single initiation site
Name:Inpp5e_1
Description:inositol polyphosphate-5-phosphatase E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.033,855,981 - 3,856,041EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620478 AgrOrtholog
BioCyc Gene G2FUF-50380 BioCyc
Ensembl Genes ENSRNOG00000019039 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025763.5 UniProtKB/TrEMBL
  ENSRNOP00000073935 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025764.6 UniProtKB/TrEMBL
  ENSRNOT00000079882 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INPP5E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114089 UniProtKB/Swiss-Prot
NCBI Gene 114089 ENTREZGENE
PANTHER PTHR46625 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Inpp5e PhenoGen
SMART IPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6T4 ENTREZGENE
  F1LPS7_RAT UniProtKB/TrEMBL
  INP5E_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2K6T4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-06 Inpp5e  inositol polyphosphate-5-phosphatase E  Sec16a  SEC16 homolog A (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Sec16a  SEC16 homolog A (S. cerevisiae)  Inpp5e  inositol polyphosphate-5-phosphatase E  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Inpp5e  inositol polyphosphate-5-phosphatase E    inositol polyphosphate 5-phosphatase  Name updated 1299863 APPROVED
2002-08-07 Inpp5e  inositol polyphosphate 5-phosphatase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the plasma membrane-associated structures such as membrane ruffles 1299274
gene_domains contains well-conserved catalytic motifs for 5-phosphatase, a proline-rich SH3-binding motif, and a CaaX motif at the C-terminus 1299274