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Gene: Inpp5e (inositol polyphosphate-5-phosphatase E) Rattus norvegicus
Symbol: Inpp5e
Name: inositol polyphosphate-5-phosphatase E
RGD ID: 620478
Description: Exhibits inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate phosphatase activity. Involved in negative regulation of phosphatidylinositol 3-kinase signaling and negative regulation of translation. Localizes to cytoplasm; plasma membrane; and ruffle. Biomarker of obesity. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E); PARTICIPATES IN phosphoinositide metabolic pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate 5-phosphatase; Pharbin; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SEC16 homolog A; SEC16 homolog A (S. cerevisiae); Sec16a
Homo sapiens (human) : INPP5E (inositol polyphosphate-5-phosphatase E)  HGNC  Alliance
Mus musculus (house mouse) : Inpp5e (inositol polyphosphate-5-phosphatase E)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Inpp5e (inositol polyphosphate-5-phosphatase E)
Pan paniscus (bonobo/pygmy chimpanzee) : INPP5E (inositol polyphosphate-5-phosphatase E)
Canis lupus familiaris (dog) : INPP5E (inositol polyphosphate-5-phosphatase E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Inpp5e (inositol polyphosphate-5-phosphatase E)
Sus scrofa (pig) : INPP5E (inositol polyphosphate-5-phosphatase E)
Chlorocebus sabaeus (African green monkey) : INPP5E (inositol polyphosphate-5-phosphatase E)
Heterocephalus glaber (naked mole-rat) : Inpp5e (inositol polyphosphate-5-phosphatase E)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.033,843,307 - 3,856,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,843,307 - 3,855,981 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,204,535 - 9,217,246 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,568,909 - 4,582,653 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.134,570,005 - 4,582,079 (-)NCBI
Celera34,036,112 - 4,048,786 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Inpp5e
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620478
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.