Armcx2 (armadillo repeat containing, X-linked 2) - Rat Genome Database

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Gene: Armcx2 (armadillo repeat containing, X-linked 2) Rattus norvegicus
Analyze
Symbol: Armcx2
Name: armadillo repeat containing, X-linked 2
RGD ID: 1359132
Description: Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human ARMCX2 (armadillo repeat containing X-linked 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ALEX2 protein; armadillo repeat-containing X-linked protein 2; LOC367903; similar to armadillo repeat protein ALEX2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X97,980,662 - 97,985,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,980,660 - 97,985,552 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,654,873 - 99,659,646 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X103,171,433 - 103,176,206 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X100,667,987 - 100,672,760 (-)NCBIRnor_WKY
Rnor_6.0X105,617,383 - 105,622,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,617,385 - 105,622,156 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,506,649 - 105,511,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,260,901 - 122,266,470 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X122,334,335 - 122,339,903 (-)NCBI
CeleraX99,020,283 - 99,025,056 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Kurochkin IV, etal., Biochem Biophys Res Commun 2001 Jan 12;280(1):340-7.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Smith CA, etal., Dev Dyn 2005 May;233(1):188-93.
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Armcx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X97,980,662 - 97,985,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,980,660 - 97,985,552 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,654,873 - 99,659,646 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X103,171,433 - 103,176,206 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X100,667,987 - 100,672,760 (-)NCBIRnor_WKY
Rnor_6.0X105,617,383 - 105,622,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,617,385 - 105,622,156 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,506,649 - 105,511,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,260,901 - 122,266,470 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X122,334,335 - 122,339,903 (-)NCBI
CeleraX99,020,283 - 99,025,056 (-)NCBICelera
Cytogenetic MapXq32NCBI
ARMCX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,655,281 - 101,659,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX101,655,281 - 101,659,850 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,910,267 - 100,914,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,796,923 - 100,801,519 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX101,430,845 - 101,435,442 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,717,786 - 90,722,384 (-)NCBIHuRef
CHM1_1X100,804,126 - 100,808,723 (-)NCBICHM1_1
T2T-CHM13v2.0X100,099,916 - 100,104,489 (-)NCBIT2T-CHM13v2.0
Armcx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,704,891 - 133,709,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,704,894 - 133,709,970 (-)EnsemblGRCm39 Ensembl
GRCm38X134,804,142 - 134,809,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,804,145 - 134,809,221 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,338,681 - 131,343,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X130,150,511 - 130,155,358 (-)NCBIMGSCv36mm8
CeleraX117,689,899 - 117,695,175 (-)NCBICelera
Cytogenetic MapXE3NCBI
Armcx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,756,429 - 7,758,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,756,032 - 7,760,573 (-)NCBIChiLan1.0ChiLan1.0
ARMCX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X100,984,392 - 100,988,995 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0X90,855,629 - 90,860,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARMCX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,517,183 - 75,521,486 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,517,407 - 75,519,218 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,937,039 - 76,941,529 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,937,039 - 76,941,484 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,501,328 - 74,505,818 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X76,161,775 - 76,166,267 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,924,469 - 75,928,961 (-)NCBIUU_Cfam_GSD_1.0
Armcx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,820,100 - 62,825,624 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936813649,463 - 655,013 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARMCX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,213,947 - 83,224,391 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X83,213,939 - 83,218,601 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,075,719 - 97,085,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARMCX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,972,285 - 89,975,126 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606514,902,697 - 14,907,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Armcx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624902863,592 - 865,532 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624902861,362 - 865,926 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Armcx2
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:382
Count of miRNA genes:231
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000029511
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
UniSTS:238078  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X97,982,617 - 97,982,920 (+)MAPPERmRatBN7.2
Rnor_6.0X105,619,339 - 105,619,641NCBIRnor6.0
Rnor_5.0X105,508,605 - 105,508,907UniSTSRnor5.0
RGSC_v3.4X122,263,653 - 122,263,955UniSTSRGSC3.4
CeleraX99,022,239 - 99,022,541UniSTS
Cytogenetic MapXq34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 9 6 2 6 1 1 74 22 34 4 1
Low 3 15 47 34 17 34 7 9 13 7 7 7
Below cutoff 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029511   ⟹   ENSRNOP00000030098
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,980,660 - 97,985,213 (-)Ensembl
Rnor_6.0 EnsemblX105,617,385 - 105,622,156 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096671   ⟹   ENSRNOP00000078959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,980,670 - 97,985,552 (-)Ensembl
RefSeq Acc Id: NM_001014274   ⟹   NP_001014296
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,980,662 - 97,985,435 (-)NCBI
Rnor_6.0X105,617,383 - 105,622,156 (-)NCBI
Rnor_5.0X105,506,649 - 105,511,422 (-)NCBI
RGSC_v3.4X122,260,901 - 122,266,470 (-)RGD
CeleraX99,020,283 - 99,025,056 (-)RGD
Sequence:
RefSeq Acc Id: XM_008773429   ⟹   XP_008771651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,980,662 - 97,985,523 (-)NCBI
Rnor_6.0X105,617,383 - 105,622,209 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001014296 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771651 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81886 (Get FASTA)   NCBI Sequence Viewer  
  EDM07000 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001014296   ⟸   NM_001014274
- UniProtKB: Q642B5 (UniProtKB/TrEMBL),   D4A765 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771651   ⟸   XM_008773429
- Peptide Label: isoform X1
- UniProtKB: Q642B5 (UniProtKB/TrEMBL),   D4A765 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030098   ⟸   ENSRNOT00000029511
RefSeq Acc Id: ENSRNOP00000078959   ⟸   ENSRNOT00000096671
Protein Domains
Arm_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q642B5-F1-model_v2 AlphaFold Q642B5 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701937
Promoter ID:EPDNEW_R12461
Type:multiple initiation site
Name:Armcx2_1
Description:armadillo repeat containing, X-linked 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X105,622,175 - 105,622,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359132 AgrOrtholog
BioCyc Gene G2FUF-1670 BioCyc
Ensembl Genes ENSRNOG00000025705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030098 ENTREZGENE
  ENSRNOP00000030098.5 UniProtKB/TrEMBL
  ENSRNOP00000078959 ENTREZGENE
  ENSRNOP00000078959.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029511 ENTREZGENE
  ENSRNOT00000029511.6 UniProtKB/TrEMBL
  ENSRNOT00000096671 ENTREZGENE
  ENSRNOT00000096671.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108660 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  DUF634 UniProtKB/TrEMBL
KEGG Report rno:367903 UniProtKB/TrEMBL
MGC_CLONE MGC:93762 IMAGE-MGC_LOAD
NCBI Gene 367903 ENTREZGENE
Pfam DUF634 UniProtKB/TrEMBL
PhenoGen Armcx2 PhenoGen
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt D4A765 ENTREZGENE
  Q642B5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4A765 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Armcx2  armadillo repeat containing, X-linked 2  LOC367903  similar to armadillo repeat protein ALEX2  Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC367903  similar to armadillo repeat protein ALEX2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression down-regulated in a variety of epithelially derived human tumors suggesting a role in tumor suppression 1556584