Slc7a8 (solute carrier family 7 member 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Slc7a8 (solute carrier family 7 member 8) Rattus norvegicus
Analyze
Symbol: Slc7a8
Name: solute carrier family 7 member 8
RGD ID: 619904
Description: Predicted to enable several functions, including neutral L-amino acid transmembrane transporter activity; peptide antigen binding activity; and secondary active transmembrane transporter activity. Predicted to be involved in carboxylic acid transport and thyroid hormone transport. Predicted to act upstream of or within L-amino acid transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and microvillus membrane. Orthologous to human SLC7A8 (solute carrier family 7 member 8); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cationic amino acid transporter y+ system; cationic amino acid transporter, y+ system; L-type amino acid transporter 2; large neutral amino acids transporter small subunit 2; Lat2; Lat4; solute carrier family 7 (amino acid transporter light chain, L system), member 8; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,153,016 - 32,212,715 (-)NCBIGRCr8
mRatBN7.21528,183,013 - 28,242,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,183,015 - 28,242,717 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,021,654 - 30,081,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,168,855 - 31,229,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,418,621 - 29,478,317 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,369,245 - 33,428,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,369,216 - 33,428,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,253,908 - 37,317,161 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,800,927 - 32,860,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,816,626 - 32,876,497 (-)NCBI
Celera1527,761,265 - 27,820,961 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-leucine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methotrexate  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. Segawa H, etal., J Biol Chem 1999 Jul 9;274(28):19745-51.
Additional References at PubMed
PMID:10391915   PMID:10574970   PMID:12117417   PMID:12477932   PMID:12975385   PMID:15200428   PMID:15659399   PMID:15918515   PMID:17091765   PMID:21115085   PMID:22185814   PMID:23376485  
PMID:28560461  


Genomics

Comparative Map Data
Slc7a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,153,016 - 32,212,715 (-)NCBIGRCr8
mRatBN7.21528,183,013 - 28,242,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,183,015 - 28,242,717 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,021,654 - 30,081,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,168,855 - 31,229,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,418,621 - 29,478,317 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,369,245 - 33,428,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,369,216 - 33,428,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,253,908 - 37,317,161 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,800,927 - 32,860,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,816,626 - 32,876,497 (-)NCBI
Celera1527,761,265 - 27,820,961 (-)NCBICelera
Cytogenetic Map15p13NCBI
SLC7A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,125,295 - 23,183,660 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,125,295 - 23,183,674 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,594,504 - 23,652,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,664,344 - 22,722,689 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,664,345 - 22,693,450NCBI
Celera143,457,210 - 3,515,570 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,711,422 - 3,770,233 (-)NCBIHuRef
CHM1_11423,593,107 - 23,651,472 (-)NCBICHM1_1
T2T-CHM13v2.01417,325,945 - 17,384,328 (-)NCBIT2T-CHM13v2.0
Slc7a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,959,672 - 55,019,343 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,959,666 - 55,019,403 (-)EnsemblGRCm39 Ensembl
GRCm381454,722,215 - 54,781,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,722,209 - 54,781,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,341,052 - 55,400,723 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,676,420 - 53,736,091 (-)NCBIMGSCv36mm8
Celera1452,514,886 - 52,574,656 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.91NCBI
Slc7a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,119,378 - 37,173,310 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,119,189 - 37,171,300 (+)NCBIChiLan1.0ChiLan1.0
SLC7A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,557,789 - 24,616,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,774,274 - 23,832,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,945,123 - 4,003,574 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,041,386 - 22,100,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,040,787 - 22,100,112 (-)Ensemblpanpan1.1panPan2
SLC7A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,430,208 - 3,479,985 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,430,208 - 3,479,985 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,378,608 - 3,428,266 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,538,051 - 3,587,932 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,538,047 - 3,587,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,229,341 - 3,278,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,290,333 - 3,340,018 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,552,835 - 3,602,556 (-)NCBIUU_Cfam_GSD_1.0
Slc7a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,186,625 - 35,245,586 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,143,309 - 1,202,514 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,143,405 - 1,202,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,854,882 - 75,921,931 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,854,700 - 75,921,931 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,241,975 - 81,259,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC7A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,493,987 - 23,556,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,493,715 - 23,556,857 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,862,343 - 22,923,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,365,093 - 9,419,045 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,365,167 - 9,418,346 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc7a8
250 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:542
Count of miRNA genes:241
Interacting mature miRNAs:293
Transcripts:ENSRNOT00000019618
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
D15Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,184,746 - 28,184,880 (+)MAPPERmRatBN7.2
Rnor_6.01533,370,979 - 33,371,112NCBIRnor6.0
Rnor_5.01537,255,642 - 37,255,775UniSTSRnor5.0
RGSC_v3.41532,802,661 - 32,802,794UniSTSRGSC3.4
Celera1527,762,999 - 27,763,132UniSTS
Cytogenetic Map15p13UniSTS
RH128326  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,183,085 - 28,183,283 (+)MAPPERmRatBN7.2
Rnor_6.01533,369,318 - 33,369,515NCBIRnor6.0
Rnor_5.01537,253,981 - 37,254,178UniSTSRnor5.0
RGSC_v3.41532,801,000 - 32,801,197UniSTSRGSC3.4
Celera1527,761,338 - 27,761,535UniSTS
Cytogenetic Map15p13UniSTS
RH124773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,183,188 - 28,183,335 (+)MAPPERmRatBN7.2
Rnor_6.01533,369,421 - 33,369,567NCBIRnor6.0
Rnor_5.01537,254,084 - 37,254,230UniSTSRnor5.0
RGSC_v3.41532,801,103 - 32,801,249UniSTSRGSC3.4
Celera1527,761,441 - 27,761,587UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB024400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB904245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB918636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB925805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB942593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC961654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC976045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC983214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019618   ⟹   ENSRNOP00000019618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,183,015 - 28,242,717 (-)Ensembl
Rnor_6.0 Ensembl1533,369,252 - 33,428,942 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092160   ⟹   ENSRNOP00000072188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1533,369,216 - 33,428,973 (-)Ensembl
RefSeq Acc Id: NM_053442   ⟹   NP_445894
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,153,016 - 32,212,715 (-)NCBI
mRatBN7.21528,183,013 - 28,242,717 (-)NCBI
Rnor_6.01533,369,245 - 33,428,942 (-)NCBI
Rnor_5.01537,253,908 - 37,317,161 (-)NCBI
RGSC_v3.41532,800,927 - 32,860,797 (-)RGD
Celera1527,761,265 - 27,820,961 (-)RGD
Sequence:
RefSeq Acc Id: NP_445894   ⟸   NM_053442
- UniProtKB: Q9WVR6 (UniProtKB/Swiss-Prot),   A6KGW1 (UniProtKB/TrEMBL),   A6KGW0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072188   ⟸   ENSRNOT00000092160
Ensembl Acc Id: ENSRNOP00000019618   ⟸   ENSRNOT00000019618

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVR6-F1-model_v2 AlphaFold Q9WVR6 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699659
Promoter ID:EPDNEW_R10182
Type:multiple initiation site
Name:Slc7a8_1
Description:solute carrier family 7 member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01533,428,960 - 33,429,020EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619904 AgrOrtholog
BioCyc Gene G2FUF-13779 BioCyc
Ensembl Genes ENSRNOG00000014311 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055012104 UniProtKB/Swiss-Prot
  ENSRNOG00060025856 UniProtKB/Swiss-Prot
  ENSRNOG00065031419 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019618.5 UniProtKB/Swiss-Prot
  ENSRNOT00055020572 UniProtKB/Swiss-Prot
  ENSRNOT00060044749 UniProtKB/Swiss-Prot
  ENSRNOT00065054154 UniProtKB/Swiss-Prot
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L_AA_transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84551 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 84551 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc7a8 PhenoGen
PIRSF AA_transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014311 RatGTEx
  ENSRNOG00055012104 RatGTEx
  ENSRNOG00060025856 RatGTEx
  ENSRNOG00065031419 RatGTEx
UniProt A6KGW0 ENTREZGENE, UniProtKB/TrEMBL
  A6KGW1 ENTREZGENE, UniProtKB/TrEMBL
  A6KGW2_RAT UniProtKB/TrEMBL
  LAT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc7a8  solute carrier family 7 member 8  Slc7a8  solute carrier family 7 (amino acid transporter light chain, L system), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Slc7a8  solute carrier family 7 (amino acid transporter light chain, L system), member 8  Slc7a8  solute carrier family 7 (cationic amino acid transporter, y+ system), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc7a8  solute carrier family 7 (cationic amino acid transporter, y+ system), member 8      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc7a8  solute carrier family 7 (cationic amino acid transporter, y+ system), member 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction may form a complex with the heavy chain of the 4F2 cell surface antigen (CD98) 634080