Fcgr1a (Fc gamma receptor 1A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fcgr1a (Fc gamma receptor 1A) Rattus norvegicus
Analyze
Symbol: Fcgr1a
Name: Fc gamma receptor 1A
RGD ID: 1309912
Description: Enables leukotriene receptor binding activity. Involved in several processes, including positive regulation of phagocytosis, engulfment; response to aldosterone; and response to estradiol. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of retinal degeneration. Orthologous to several human genes including FCGR1A (Fc gamma receptor Ia); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fc fragment of IgG high affinity Ib receptor; Fc fragment of IgG receptor Ia; Fc fragment of IgG, high affinity Ia, receptor (CD64); Fc fragment of IgG, high affinity Ib, receptor; Fc fragment of IgG, high affinity Ib, receptor for (CD64); Fc gamma receptor Ia; Fc receptor, IgG, high affinity I; FcgammaRI; Fcgr1; Fcgr1b; high affinity IgG Fc receptor, subunit beta; high affinity immunoglobulin gamma Fc receptor I; high-affinity immunoglobulin gamma Fc receptor I; LOC295279
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,539,941 - 186,548,941 (-)NCBIGRCr8
mRatBN7.22183,851,075 - 183,860,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,851,077 - 183,859,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,514,627 - 191,523,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,313,778 - 189,322,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,147,164 - 184,156,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,430,536 - 198,439,453 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,430,530 - 198,458,041 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,916,295 - 217,925,212 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,095,026 - 191,103,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,057,780 - 191,066,696 (-)NCBI
Celera2176,378,627 - 176,387,543 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
ethylbenzene  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
maleic acid  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metam  (ISO)
methimazole  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage. Fet NG, etal., Nephrol Dial Transplant. 2012 Aug;27(8):3149-55. doi: 10.1093/ndt/gfr792. Epub 2012 Mar 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats. Li YN, etal., J Neurosci Res. 2008 Dec;86(16):3556-65. doi: 10.1002/jnr.21810.
5. Fcγ Receptor I-Coupled Signaling in Peripheral Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis. Liu F, etal., Arthritis Rheumatol. 2020 Oct;72(10):1668-1678. doi: 10.1002/art.41386. Epub 2020 Sep 6.
6. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. Maresco DL, etal., Cytogenet Cell Genet 1998;82(1-2):71-4.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats. Sarvari M, etal., PLoS One. 2014 Feb 13;9(2):e88540. doi: 10.1371/journal.pone.0088540. eCollection 2014.
13. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Serezani CH, etal., Blood. 2009 Oct 8;114(15):3316-24. doi: 10.1182/blood-2009-01-199919. Epub 2009 Aug 5.
14. CD64-directed immunotoxin inhibits arthritis in a novel CD64 transgenic rat model. van Vuuren AJ, etal., J Immunol. 2006 May 15;176(10):5833-8.
15. Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. Wu CL, etal., Shock. 2009 Sep;32(3):276-85.
Additional References at PubMed
PMID:8889548   PMID:9551950   PMID:10556798   PMID:11911823   PMID:11911824   PMID:12477932   PMID:12947022   PMID:15169676   PMID:15712658   PMID:16836651   PMID:18322202   PMID:18642700  
PMID:23791745   PMID:31640731  


Genomics

Comparative Map Data
Fcgr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,539,941 - 186,548,941 (-)NCBIGRCr8
mRatBN7.22183,851,075 - 183,860,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,851,077 - 183,859,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,514,627 - 191,523,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,313,778 - 189,322,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,147,164 - 184,156,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,430,536 - 198,439,453 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,430,530 - 198,458,041 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,916,295 - 217,925,212 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,095,026 - 191,103,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,057,780 - 191,066,696 (-)NCBI
Celera2176,378,627 - 176,387,543 (-)NCBICelera
Cytogenetic Map2q34NCBI
FCGR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,782,694 - 149,800,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,782,671 - 149,791,675 (+)EnsemblGRCh38hg38GRCh38
GRCh371149,754,250 - 149,772,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,020,912 - 148,030,698 (+)NCBINCBI36Build 36hg18NCBI36
Build 341146,567,360 - 146,577,146NCBI
Cytogenetic Map1q21.2NCBI
CHM1_11151,150,820 - 151,160,644 (+)NCBICHM1_1
T2T-CHM13v2.01148,906,840 - 148,924,747 (+)NCBIT2T-CHM13v2.0
Fcgr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,190,225 - 96,201,285 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,190,225 - 96,201,285 (-)EnsemblGRCm39 Ensembl
GRCm38396,282,909 - 96,293,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,282,909 - 96,293,969 (-)EnsemblGRCm38mm10GRCm38
MGSCv37396,086,832 - 96,097,892 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,368,314 - 96,379,374 (-)NCBIMGSCv36mm8
Celera397,711,230 - 97,722,291 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.72NCBI
FCGR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21100,047,861 - 100,056,851 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,802,796 - 99,811,784 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,127,073 - 125,136,911 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11128,805,436 - 128,815,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1128,805,484 - 128,814,220 (+)Ensemblpanpan1.1panPan2
FCGR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,073,139 - 59,102,023 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,092,933 - 59,102,015 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,541,116 - 58,550,066 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,070,040 - 60,098,863 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,089,692 - 60,098,850 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,939,430 - 58,948,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,023,178 - 59,032,132 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,749,960 - 59,759,005 (+)NCBIUU_Cfam_GSD_1.0
Fcgr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,085,119 - 21,114,589 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580115,450 - 145,785 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580115,552 - 144,970 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCGR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,233,611 - 99,242,586 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,233,632 - 99,242,531 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,773,630 - 108,782,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FCGR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603813,502,010 - 13,510,802 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fcgr1a
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:83
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000028780
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
D3Nds11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,851,285 - 183,851,389 (+)MAPPERmRatBN7.2
Rnor_6.02198,430,746 - 198,430,849NCBIRnor6.0
Rnor_5.02217,916,505 - 217,916,608UniSTSRnor5.0
RGSC_v3.42191,095,236 - 191,095,339UniSTSRGSC3.4
Celera2176,378,837 - 176,378,940UniSTS
Cytogenetic Map2q34UniSTS
D3Nds11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,851,285 - 183,851,474 (+)MAPPERmRatBN7.2
Rnor_6.02198,430,746 - 198,430,934NCBIRnor6.0
Rnor_5.02217,916,505 - 217,916,693UniSTSRnor5.0
RGSC_v3.42191,095,236 - 191,095,424UniSTSRGSC3.4
Celera2176,378,837 - 176,379,025UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 5 12 5 1 6 11
Low 3 35 50 36 7 36 8 11 74 34 35 8
Below cutoff 6

Sequence


RefSeq Acc Id: ENSRNOT00000028780   ⟹   ENSRNOP00000028780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,851,077 - 183,859,994 (-)Ensembl
Rnor_6.0 Ensembl2198,430,537 - 198,439,454 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082450   ⟹   ENSRNOP00000072723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2198,430,530 - 198,458,041 (-)Ensembl
RefSeq Acc Id: NM_001100836   ⟹   NP_001094306
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,539,941 - 186,548,857 (-)NCBI
mRatBN7.22183,851,076 - 183,859,993 (-)NCBI
Rnor_6.02198,430,536 - 198,439,453 (-)NCBI
Rnor_5.02217,916,295 - 217,925,212 (-)NCBI
RGSC_v3.42191,095,026 - 191,103,942 (-)RGD
Celera2176,378,627 - 176,387,543 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102048   ⟹   XP_038957976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,539,941 - 186,548,401 (-)NCBI
mRatBN7.22183,851,075 - 183,859,534 (-)NCBI
RefSeq Acc Id: XR_005500264
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,540,201 - 186,548,941 (-)NCBI
mRatBN7.22183,851,362 - 183,860,077 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094306 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58810 (Get FASTA)   NCBI Sequence Viewer  
  AAL08010 (Get FASTA)   NCBI Sequence Viewer  
  EDL85633 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028780
  ENSRNOP00000028780.4
RefSeq Acc Id: NP_001094306   ⟸   NM_001100836
- Peptide Label: precursor
- UniProtKB: A0A0B4J2J0 (UniProtKB/TrEMBL),   A6K367 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072723   ⟸   ENSRNOT00000082450
RefSeq Acc Id: ENSRNOP00000028780   ⟸   ENSRNOT00000028780
RefSeq Acc Id: XP_038957976   ⟸   XM_039102048
- Peptide Label: isoform X1
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3P6-F1-model_v2 AlphaFold A0A0G2K3P6 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691580
Promoter ID:EPDNEW_R2105
Type:multiple initiation site
Name:Fcgr1a_1
Description:Fc fragment of IgG receptor Ia
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02198,439,466 - 198,439,526EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309912 AgrOrtholog
BioCyc Gene G2FUF-52039 BioCyc
Ensembl Genes ENSRNOG00000021199 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028780 ENTREZGENE
  ENSRNOT00000028780.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7364883 IMAGE-MGC_LOAD
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
KEGG Report rno:295279 UniProtKB/TrEMBL
MGC_CLONE MGC:188236 IMAGE-MGC_LOAD
NCBI Gene 295279 ENTREZGENE
PANTHER HIGH AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR I-RELATED UniProtKB/TrEMBL
  IMMUNOGLOBULIN FC RECEPTOR UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
PhenoGen Fcgr1a PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021199 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0B4J2J0 ENTREZGENE, UniProtKB/TrEMBL
  A6K367 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-05 Fcgr1a  Fc gamma receptor 1A  Fcgr1a  Fc gamma receptor 1a  Name changed 629549 APPROVED
2022-05-05 Fcgr1a  Fc gamma receptor 1a  Fcgr1a  Fc gamma receptor Ia  Name changed 629549 APPROVED
2021-11-04 Fcgr1a  Fc gamma receptor Ia  Fcgr1a  Fc fragment of IgG receptor Ia  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Fcgr1a  Fc fragment of IgG receptor Ia  Fcgr1a  Fc fragment of IgG, high affinity Ia, receptor (CD64)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Fcgr1a  Fc fragment of IgG, high affinity Ia, receptor (CD64)  Fcgr1  Fc receptor, IgG, high affinity I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-23 Fcgr1  Fc receptor, IgG, high affinity I  Fcgr1b  Fc fragment of IgG, high affinity Ib, receptor for (CD64)  Data merged from RGD:2600 737654 APPROVED
2005-12-06 Fcgr1  Fc receptor, IgG, high affinity I  Fcgr1_predicted  Fc receptor, IgG, high affinity I (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fcgr1_predicted  Fc receptor, IgG, high affinity I (predicted)      Symbol and Name status set to approved 70820 APPROVED
2004-09-10 Fcgr1b  Fc fragment of IgG, high affinity Ib, receptor for (CD64)    Fc fragment of IgG, high affinity Ib, receptor  Name updated 1299863 APPROVED
2002-11-06 Fcgr1b  Fc fragment of IgG, high affinity Ib, receptor    high affinity IgG Fc receptor, subunit beta  Name updated 625702 APPROVED
2002-06-10 Fcgr1b  high affinity IgG Fc receptor, subunit beta      Symbol and Name status set to approved 70586 APPROVED