Fcgr1a (Fc fragment of IgG receptor Ia)

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Gene: Fcgr1a (Fc fragment of IgG receptor Ia) Ictidomys tridecemlineatus

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Symbol:

Fcgr1a

Name:

Fc fragment of IgG receptor Ia (Ensembl:high affinity immunoglobulin gamma Fc receptor I)

RGD ID:

12679447

Description:

ENCODES a protein that exhibits leukotriene receptor binding (ortholog); INVOLVED IN antibody-dependent cellular cytotoxicity (ortholog); antigen processing and presentation of exogenous antigen (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class I (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); calcinosis (ortholog); Experimental Arthritis (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Fc fragment of IgG, high affinity Ia, receptor (CD64); high affinity immunoglobulin gamma Fc receptor I; high affinity immunoglobulin gamma Fc receptor IB; LOC101966442

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	21,085,119 - 21,114,589 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	115,450 - 145,785 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	115,552 - 144,970 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

calcinosis (ISO)

Experimental Arthritis (ISO)

Experimental Liver Cirrhosis (ISO)

gastrointestinal stromal tumor (ISO)

heart valve disease (ISO)

Hyperalgesia (ISO)

juvenile rheumatoid arthritis (ISO)

Kidney Reperfusion Injury (ISO)

parathyroid carcinoma (ISO)

PERITONEAL GLIOMATOSIS (ISO)

retinal degeneration (ISO)

RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES (ISO)

rheumatoid arthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibody-dependent cellular cytotoxicity (IEA,ISO)

antigen processing and presentation of exogenous antigen (IEA,ISO)

antigen processing and presentation of exogenous peptide antigen via MHC class I (IEA,ISO)

cell surface receptor signaling pathway (IEA,ISO)

defense response to bacterium (IEA,ISO)

Fc-gamma receptor signaling pathway (IEA)

phagocytosis, engulfment (IEA,ISO)

phagocytosis, recognition (IEA,ISO)

positive regulation of phagocytosis (IEA,ISO)

positive regulation of phagocytosis, engulfment (ISO)

positive regulation of type IIa hypersensitivity (IEA,ISO)

positive regulation of type III hypersensitivity (IEA,ISO)

receptor-mediated endocytosis (IEA,ISO)

regulation of immune response (IEA,ISO)

response to aldosterone (ISO)

response to bacterium (IEA,ISO)

response to epinephrine (ISO)

response to estradiol (ISO)

Cellular Component

external side of plasma membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

high-affinity IgG receptor activity (IEA)

IgG binding (IEA)

IgG receptor activity (IEA)

leukotriene receptor binding (ISO)

protein binding (ISO)

transmembrane signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Fcgr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	21,085,119 - 21,114,589 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	115,450 - 145,785 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	115,552 - 144,970 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FCGR1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	149,782,694 - 149,800,609 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	149,782,671 - 149,791,675 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	149,754,250 - 149,772,165 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	148,020,912 - 148,030,698 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	146,567,360 - 146,577,146	NCBI
Cytogenetic Map	1	q21.2	NCBI
CHM1_1	1	151,150,820 - 151,160,644 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	148,906,840 - 148,924,747 (+)	NCBI		T2T-CHM13v2.0

Fcgr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	96,190,225 - 96,201,285 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	96,190,225 - 96,201,285 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	96,282,909 - 96,293,969 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	96,282,909 - 96,293,969 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	96,086,832 - 96,097,892 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	96,368,314 - 96,379,374 (-)	NCBI		MGSCv36	mm8
Celera	3	97,711,230 - 97,722,291 (-)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	41.72	NCBI

Fcgr1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	186,539,941 - 186,548,941 (-)	NCBI		GRCr8
mRatBN7.2	2	183,851,075 - 183,860,077 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	183,851,077 - 183,859,994 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	191,514,627 - 191,523,542 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	189,313,778 - 189,322,712 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	184,147,164 - 184,156,079 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	198,430,536 - 198,439,453 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	198,430,530 - 198,458,041 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	217,916,295 - 217,925,212 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	191,095,026 - 191,103,942 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	191,057,780 - 191,066,696 (-)	NCBI
Celera	2	176,378,627 - 176,387,543 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

FCGR1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	100,047,861 - 100,056,851 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	99,802,796 - 99,811,784 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	125,127,073 - 125,136,911 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	128,805,436 - 128,815,227 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	128,805,484 - 128,814,220 (+)	Ensembl	panpan1.1		panPan2

FCGR1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	59,073,139 - 59,102,023 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	59,092,933 - 59,102,015 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	58,541,116 - 58,550,066 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	60,070,040 - 60,098,863 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	60,089,692 - 60,098,850 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	58,939,430 - 58,948,415 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	59,023,178 - 59,032,132 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	59,749,960 - 59,759,005 (+)	NCBI		UU_Cfam_GSD_1.0

FCGR1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	99,233,611 - 99,242,586 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	99,233,632 - 99,242,531 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	108,773,630 - 108,782,529 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FCGR1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666038	13,502,010 - 13,510,802 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005331417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040287490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000029258 ⟹ ENSSTOP00000022593

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936580	115,450 - 145,785 (+)	Ensembl

RefSeq Acc Id:

XM_005331417 ⟹ XP_005331474

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	21,085,120 - 21,114,589 (+)	NCBI
SpeTri2.0	NW_004936580	115,552 - 144,970 (+)	NCBI

Sequence:

show sequence

GGCCAGTCCGGTGACAGTCTGTGCCCACGCTGCCACTCCGCGCGGGCTCGGCTCTGGATTTTAC
TGCTCGCCAGCTTGGAGGTGATATGTGGCTCTTGACAGCTCTGCTCCTTTGGGTTCCAGCTGGT
GGGCAAGTGGACCCCACAAAGGCAGTGATCACCTTGCAGCCTCCGTGGGTAAGTGTGTTCCAAG
ATGAACAGGTCACCCTATTGTGTGAGGGGCCGCAACGGCCTGGAGACAACTCCACACGGTGGTT
TCTCAACGGCACAGCCATTCAGACCTCGACCTCCAAGTATAGCATCACTGCAGCGAGGGTCAGT
GAGAGTGGAGAATACAGGTGCCAGACAGGTCTCTCGGTGCCAAGTGACCCTGTACAGCTGGAAA
TCCGCAGAGATTGGCTGCTACTCCAGATCTCTAGCAGAGTCTTCACTGAAGGAGAACCTCTGAC
TTTGAGGTGTCATGCATGGAAGAATAAGCTGGTGTACAATGTGCTTTTCTACCAAAATGGCAAA
GCTTTTCAGTTTTCTCCTCGGAATTCTGAATTTACCATTCAGAAAACCAACACAAGTCACAATG
GCGTCTATCACTGCTCAGGCCTGGGAAGACATCGCTACACATCAGAGGGAGTAACTGTCACTGT
GAAAGAGCTGTTTTCAGTTCCTGTGCTGAGAGCATCCTTGTCACTCCCCGTCCTGGAGGGGAAC
CTGGTCACCCTGAGCTGTGAAACCATGCTGCTGCTCCCAGAGAGGGCTGGCCTGCAGCTGTACT
ACTCCTTCTACGTGGGCAGCAAGACCCTAGTGGACAGAAACGCATCCTCCGAGTACCAGATTTT
AACTGCTAGAAGAGAGGACTCCGGTTCCTACTGGTGTGAGGCAGTCACAGAAGATGGGAACATA
CTGAAGCGCAGCCCTGCCTTGGAGCTTCAAGTGCTGGGCCTCCAGTCGCCAACTCCTGTCTGGT
TTAACATCCTTTTCTATCTATCAGTGGGAATAATATTTTTGGTGAACACTGTTCTCTGTGTGAA
GATACATAAAGAACTGCAAAGAAAGAAAAAATGGAATTTAGAAGTTTCTTTGGCTTCAGATTCT
GGGAAGAAAGTAACTTCCCACCTTCAAAAAGATAGATATTTAGAAGAAGAGGTGAATTGTCTGG
AACAACAAGAACAGCCTCAAGAAAAAGCACAACAGAAGAATCCCTAGGAAGGAGGACAGCGGCA
ACTCAGGGGCGGCCATAGATCTGGACTGCCACTGTCCCTTCCTCTCTGTGGGAGCACTGAGGCA
CAAACTCCCCAAAGTTGAAGTGCCCTAGAATTGTGGGTCCCATGGCACGTAACTGCTAAATAAA
GAAAATACATGAGCTGA

hide sequence

RefSeq Acc Id:

XM_040287490 ⟹ XP_040143424

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	21,085,119 - 21,114,589 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005331474	(Get FASTA)	NCBI Sequence Viewer
	XP_040143424	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022593.2
GenBank Protein	KAG3281428	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005331474 ⟸ XM_005331417
- Peptide Label:	isoform X2
- UniProtKB:	I3NDZ6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWLLTALLLWVPAGGQVDPTKAVITLQPPWVSVFQDEQVTLLCEGPQRPGDNSTRWFLNGTAIQ TSTSKYSITAARVSESGEYRCQTGLSVPSDPVQLEIRRDWLLLQISSRVFTEGEPLTLRCHAWK NKLVYNVLFYQNGKAFQFSPRNSEFTIQKTNTSHNGVYHCSGLGRHRYTSEGVTVTVKELFSVP VLRASLSLPVLEGNLVTLSCETMLLLPERAGLQLYYSFYVGSKTLVDRNASSEYQILTARREDS GSYWCEAVTEDGNILKRSPALELQVLGLQSPTPVWFNILFYLSVGIIFLVNTVLCVKIHKELQR KKKWNLEVSLASDSGKKVTSHLQKDRYLEEEVNCLEQQEQPQEKAQQKNP hide sequence

RefSeq Acc Id:	XP_040143424 ⟸ XM_040287490
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSSTOP00000022593 ⟸ ENSSTOT00000029258

Protein Domains

Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000028518	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029258.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_Fc_receptor	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	Immunoglobulin	UniProtKB/TrEMBL
NCBI Gene	LOC101966442	ENTREZGENE
PANTHER	HIGH AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR I-RELATED	UniProtKB/TrEMBL
	IMMUNOGLOBULIN FC RECEPTOR	UniProtKB/TrEMBL
Pfam	Ig_2	UniProtKB/TrEMBL
	PF00047	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	IGc2	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	I3NDZ6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	Fcgr1a	Fc fragment of IgG receptor Ia	LOC101966442	high affinity immunoglobulin gamma Fc receptor I	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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