Tk2 (thymidine kinase 2) - Rat Genome Database

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Gene: Tk2 (thymidine kinase 2) Rattus norvegicus
Analyze
Symbol: Tk2
Name: thymidine kinase 2
RGD ID: 1309279
Description: Enables deoxycytidine kinase activity and thymidine kinase activity. Involved in deoxycytidine metabolic process and thymidine metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Orthologous to human TK2 (thymidine kinase 2); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291824; thymidine kinase 2, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819713,043 - 737,345 (+)NCBIGRCr8
mRatBN7.219708,859 - 731,786 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19708,891 - 730,924 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19704,627 - 728,266 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,471,427 - 1,495,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019746,645 - 770,284 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.019917,203 - 939,236 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19917,203 - 939,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019918,115 - 940,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419667,538 - 689,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.119667,549 - 687,995 (+)NCBI
Celera19704,113 - 726,111 (+)NCBICelera
Cytogenetic Map19p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mitochondrial myopathy of childhood associated with mitochondrial DNA depletion and a homozygous mutation (T77M) in the TK2 gene. Mancuso M, etal., Arch Neurol 2003 Jul;60(7):1007-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The Kinetic Effects on Thymidine Kinase 2 by Enzyme-Bound dTTP May Explain the Mitochondrial Side Effects of Antiviral Thymidine Analogs. Wang L, etal., Antimicrob Agents Chemother. 2011 Jun;55(6):2552-8. Epub 2011 Mar 28.
Additional References at PubMed
PMID:10571069   PMID:12865426   PMID:14651853   PMID:18434326   PMID:18467430   PMID:18614015   PMID:20544526   PMID:32345222  


Genomics

Comparative Map Data
Tk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819713,043 - 737,345 (+)NCBIGRCr8
mRatBN7.219708,859 - 731,786 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19708,891 - 730,924 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19704,627 - 728,266 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,471,427 - 1,495,068 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019746,645 - 770,284 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.019917,203 - 939,236 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19917,203 - 939,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019918,115 - 940,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419667,538 - 689,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.119667,549 - 687,995 (+)NCBI
Celera19704,113 - 726,111 (+)NCBICelera
Cytogenetic Map19p14NCBI
TK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381666,508,003 - 66,550,291 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1666,508,003 - 66,552,544 (-)EnsemblGRCh38hg38GRCh38
GRCh371666,541,906 - 66,584,194 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,100,846 - 65,141,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 341665,102,150 - 65,141,816NCBI
Celera1651,048,477 - 51,090,888 (-)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1652,417,828 - 52,460,239 (-)NCBIHuRef
CHM1_11667,949,084 - 67,991,494 (-)NCBICHM1_1
T2T-CHM13v2.01672,302,296 - 72,344,586 (-)NCBIT2T-CHM13v2.0
Tk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398104,953,323 - 104,975,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8104,953,317 - 104,975,190 (-)EnsemblGRCm39 Ensembl
GRCm388104,226,691 - 104,248,592 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,226,685 - 104,248,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv378106,750,591 - 106,772,458 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,115,829 - 107,137,665 (-)NCBIMGSCv36mm8
Celera8108,458,148 - 108,480,018 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Tk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543323,075,879 - 23,106,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543323,075,930 - 23,106,281 (-)NCBIChiLan1.0ChiLan1.0
TK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21875,964,824 - 76,066,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11681,884,382 - 81,980,928 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01646,793,679 - 46,868,508 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11665,928,102 - 65,970,315 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1665,928,102 - 65,970,315 (-)Ensemblpanpan1.1panPan2
TK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,730,514 - 82,758,153 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,729,150 - 82,756,457 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,717,914 - 82,746,541 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0583,166,221 - 83,194,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl583,165,990 - 83,194,859 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,989,245 - 83,017,866 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0582,682,588 - 82,711,197 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0583,314,763 - 83,343,390 (+)NCBIUU_Cfam_GSD_1.0
Tk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934942,713,833 - 42,737,734 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647516,851,184 - 16,875,133 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647516,851,380 - 16,875,195 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,226,425 - 27,255,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,226,421 - 27,255,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1552,202,040 - 52,272,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl552,204,605 - 52,243,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604723,661,691 - 23,713,215 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474619,902,287 - 19,955,455 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474619,902,232 - 19,953,113 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tk2
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:139
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000017269
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017269   ⟹   ENSRNOP00000017269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19708,891 - 730,910 (+)Ensembl
Rnor_6.0 Ensembl19917,203 - 939,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102642   ⟹   ENSRNOP00000081774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19708,891 - 730,924 (+)Ensembl
RefSeq Acc Id: NM_001106166   ⟹   NP_001099636
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,321 - 737,339 (+)NCBI
mRatBN7.219708,891 - 730,910 (+)NCBI
Rnor_6.019917,203 - 939,221 (+)NCBI
Rnor_5.019918,115 - 940,133 (+)NCBI
RGSC_v3.419667,538 - 689,556 (+)RGD
Celera19704,113 - 726,111 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097539   ⟹   XP_038953467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,296 - 735,748 (+)NCBI
mRatBN7.219708,859 - 729,388 (+)NCBI
RefSeq Acc Id: XM_063277836   ⟹   XP_063133906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,294 - 737,345 (+)NCBI
RefSeq Acc Id: XM_063277837   ⟹   XP_063133907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,296 - 737,345 (+)NCBI
RefSeq Acc Id: XM_063277838   ⟹   XP_063133908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,473 - 737,345 (+)NCBI
RefSeq Acc Id: XM_063277839   ⟹   XP_063133909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,296 - 737,345 (+)NCBI
RefSeq Acc Id: XM_063277840   ⟹   XP_063133910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819713,043 - 737,345 (+)NCBI
RefSeq Acc Id: XR_005496623
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,297 - 734,784 (+)NCBI
mRatBN7.219708,859 - 728,355 (+)NCBI
RefSeq Acc Id: XR_010059973
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819715,297 - 733,269 (+)NCBI
RefSeq Acc Id: NP_001099636   ⟸   NM_001106166
- UniProtKB: D3ZGQ2 (UniProtKB/TrEMBL),   A6JXX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017269   ⟸   ENSRNOT00000017269
RefSeq Acc Id: XP_038953467   ⟸   XM_039097539
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000081774   ⟸   ENSRNOT00000102642
RefSeq Acc Id: XP_063133910   ⟸   XM_063277840
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133906   ⟸   XM_063277836
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133907   ⟸   XM_063277837
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133909   ⟸   XM_063277839
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133908   ⟸   XM_063277838
- Peptide Label: isoform X3
Protein Domains
Deoxynucleoside kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGQ2-F1-model_v2 AlphaFold D3ZGQ2 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700914
Promoter ID:EPDNEW_R11438
Type:multiple initiation site
Name:Tk2_1
Description:thymidine kinase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.019917,211 - 917,271EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309279 AgrOrtholog
BioCyc Gene G2FUF-6635 BioCyc
BioCyc Pathway PWY-7199 [pyrimidine deoxyribonucleosides salvage] BioCyc
BioCyc Pathway Image PWY-7199 BioCyc
Ensembl Genes ENSRNOG00000012853 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017269.5 UniProtKB/TrEMBL
  ENSRNOT00000102642.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Deoxynucleoside_kinase UniProtKB/TrEMBL
  Deoxyribonucleoside_kinase UniProtKB/TrEMBL
  DNK_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:291824 UniProtKB/TrEMBL
NCBI Gene 291824 ENTREZGENE
PANTHER DEOXYNUCLEOSIDE KINASE UniProtKB/TrEMBL
  THYMIDINE KINASE 2, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam dNK UniProtKB/TrEMBL
PhenoGen Tk2 PhenoGen
PIRSF DNK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012853 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZTL4_RAT UniProtKB/TrEMBL
  A6JXX0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGQ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Tk2  thymidine kinase 2  Tk2  thymidine kinase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tk2  thymidine kinase 2, mitochondrial   Tk2_predicted  thymidine kinase 2, mitochondrial (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tk2_predicted  thymidine kinase 2, mitochondrial (predicted)      Symbol and Name status set to approved 70820 APPROVED