Abca7 (ATP binding cassette subfamily A member 7) - Rat Genome Database

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Gene: Abca7 (ATP binding cassette subfamily A member 7) Rattus norvegicus
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Symbol: Abca7
Name: ATP binding cassette subfamily A member 7
RGD ID: 1303134
Description: Predicted to enable ATPase-coupled transmembrane transporter activity; apolipoprotein A-I receptor activity; and floppase activity. Predicted to be involved in several processes, including phospholipid transport; positive regulation of transport; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including apical plasma membrane; phagocytic cup; and ruffle membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in Alzheimer's disease 9. Orthologous to human ABCA7 (ATP binding cassette subfamily A member 7); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7; ATP-binding cassette, sub-family A, member 7; ATP-binding cassette, subfamily A (ABC1), member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,342,092 - 10,362,094 (-)NCBIGRCr8
mRatBN7.279,691,452 - 9,711,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,691,449 - 9,711,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,573,976 - 12,592,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,449,312 - 14,467,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,310,438 - 12,328,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,742,433 - 12,762,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,742,433 - 12,762,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,912,155 - 12,932,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,203,983 - 11,222,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,203,982 - 11,222,960 (-)NCBI
Celera77,867,206 - 7,885,960 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Abca7RatAlzheimer's disease  ISORGD:16017758554872ClinVar Annotator: match by term: Alzheimer disease, early onsetClinVarPMID:25741868|PMID:25807283|PMID:26141617|PMID:27066581|PMID:28097223|PMID:28492532|PMID:36133075
Abca7RatAlzheimer's disease 9  ISORGD:16017758554872ClinVar Annotator: match by term: ALZHEIMER DISEASE 9, LATE-ONSET | ClinVar Annotator: match by term: more ...ClinVarPMID:25741868|PMID:25807283|PMID:26141617|PMID:27066581|PMID:28097223|PMID:28492532|PMID:28789839|PMID:36133075
Abca7Ratamyotrophic lateral sclerosis  ISORGD:16017758554872ClinVar Annotator: match by term: Amyotrophic lateral sclerosisClinVarPMID:25741868
Abca7Ratcerebral creatine deficiency syndrome  ISORGD:16017758554872ClinVar Annotator: match by term: Cerebral creatine deficiency syndromeClinVarPMID:28492532
Abca7RatContracture  ISORGD:16017758554872ClinVar Annotator: match by term: ContracturesClinVarPMID:25741868
Abca7Ratcyclic hematopoiesis  ISORGD:16017758554872ClinVar Annotator: match by term: Cyclical neutropeniaClinVarPMID:28492532
Abca7Ratfrontotemporal dementia  ISORGD:16017758554872ClinVar Annotator: match by term: Frontotemporal dementiaClinVarPMID:25741868|PMID:26101835|PMID:28097223|PMID:28400126|PMID:28789839|PMID:30924900|PMID:31836585
Abca7Ratneuromuscular disease  ISORGD:16017758554872ClinVar Annotator: match by term: Neuromuscular diseaseClinVarPMID:25741868|PMID:28492532|PMID:30210277
Abca7RatPeutz-Jeghers syndrome  ISORGD:16017758554872ClinVar Annotator: match by term: Peutz-Jeghers syndromeClinVarPMID:14970844|PMID:15188174|PMID:16287113|PMID:16648371|PMID:17924967|PMID:20623358|PMID:21118512|PMID:22382802|PMID:23399955|PMID:27550049|PMID:28303455|PMID:28492532
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Original Reference(s)
Abca7RatAlzheimer's disease  ISORGD:160177511554173CTD Direct Evidence: marker/mechanismCTDPMID:21460840|PMID:25807283
Abca7RatAlzheimer's disease 9  ISORGD:160177511554173CTD Direct Evidence: marker/mechanismCTD 
Abca7RatDisease Progression  ISORGD:160177511554173CTD Direct Evidence: marker/mechanismCTDPMID:22294766
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Original Reference(s)
Abca7RatAlzheimer's disease 9 susceptibilityISORGD:16017757240710 OMIM 

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Original Reference(s)
Abca7Rat(1->4)-beta-D-glucan multiple interactionsISORGD:15528576480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ABCA7 mRNACTDPMID:36331819
Abca7Rat(2,4,5-trichlorophenoxy)acetic acid increases expressionISORGD:155285764804642,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNACTDPMID:18579281
Abca7Rat1,2-dimethylhydrazine multiple interactionsISORGD:15528576480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of ABCA7 mRNACTDPMID:22206623
Abca7Rat17alpha-ethynylestradiol affects expressionISORGD:15528576480464Ethinyl Estradiol affects the expression of ABCA7 mRNACTDPMID:17555576
Abca7Rat17beta-estradiol decreases expressionISORGD:15528576480464Estradiol results in decreased expression of ABCA7 mRNACTDPMID:39298647
Abca7Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of ABCA7 mRNACTDPMID:27291303
Abca7Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:15528576480464Tetrachlorodibenzodioxin affects the expression of ABCA7 mRNACTDPMID:21570461
Abca7Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ABCA7 mRNACTDPMID:33387578
Abca7Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:15528576480464Tetrachlorodibenzodioxin results in decreased expression of ABCA7 mRNACTDPMID:24680724
Abca7Rat2,4-dinitrotoluene affects expressionEXP 64804642,4-dinitrotoluene affects the expression of ABCA7 mRNACTDPMID:21346803
Abca7Rat4,4'-sulfonyldiphenol decreases expressionISORGD:15528576480464bisphenol S results in decreased expression of ABCA7 mRNACTDPMID:39298647
Abca7Rat4,4'-sulfonyldiphenol affects methylationISORGD:15528576480464bisphenol S affects the methylation of ABCA7 geneCTDPMID:31683443
Abca7Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of ABCA7 mRNACTDPMID:24780913
Abca7Ratacrylamide decreases expressionISORGD:16017756480464Acrylamide results in decreased expression of ABCA7 mRNACTDPMID:32763439
Abca7Rataflatoxin B1 increases expressionISORGD:15528576480464Aflatoxin B1 results in increased expression of ABCA7 mRNACTDPMID:19770486
Abca7Ratall-trans-retinoic acid increases expressionISORGD:16017756480464Tretinoin results in increased expression of ABCA7 mRNACTDPMID:23724009|PMID:33167477
Abca7Ratalpha-Zearalanol increases expressionEXP 6480464Zeranol results in increased expression of ABCA7 mRNACTDPMID:35163327
Abca7Ratantirheumatic drug decreases expressionISORGD:16017756480464Antirheumatic Agents results in decreased expression of ABCA7 mRNACTDPMID:24449571
Abca7Rataristolochic acid A increases expressionISORGD:16017756480464aristolochic acid I results in increased expression of ABCA7 mRNACTDPMID:33212167
Abca7Ratarsane multiple interactionsISORGD:16017756480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092

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Biological Process
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Original Reference(s)
Abca7Ratamyloid-beta clearance by cellular catabolic process involved_inISSUniProtKB:Q91V241600115GO_REF:0000024UniProtGO_REF:0000024
Abca7Ratamyloid-beta clearance by cellular catabolic process involved_inISORGD:15528571624291 PMID:27472885RGDPMID:27472885
Abca7Ratamyloid-beta formation involved_inISSUniProtKB:Q91V241600115GO_REF:0000024UniProtGO_REF:0000024
Abca7Ratamyloid-beta formation involved_inISORGD:15528571624291 PMID:26260791RGDPMID:26260791
Abca7Ratamyloid-beta formation involved_inIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Ratamyloid-beta formation involved_inISORGD:16017751624291 PMID:26260791RGDPMID:26260791
Abca7Ratamyloid-beta formation involved_inISSUniProtKB:Q8IZY21600115GO_REF:0000024UniProtGO_REF:0000024
Abca7Ratapolipoprotein A-I-mediated signaling pathway involved_inIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Ratapolipoprotein A-I-mediated signaling pathway involved_inISORGD:15528571624291 PMID:12917409, PMID:20495215RGDPMID:12917409|PMID:20495215
Abca7Ratapolipoprotein A-I-mediated signaling pathway involved_inISORGD:16017751624291 PMID:14570867RGDPMID:14570867
Abca7Ratapolipoprotein A-I-mediated signaling pathway involved_inISSUniProtKB:Q8IZY21600115GO_REF:0000024Alzheimers_University_of_TorontoGO_REF:0000024
Abca7Ratapolipoprotein A-I-mediated signaling pathway involved_inISSUniProtKB:Q91V241600115GO_REF:0000024Alzheimers_University_of_TorontoGO_REF:0000024
Abca7Ratcholesterol efflux involved_inISORGD:15528571624291 PMID:27472885RGDPMID:27472885
Abca7Ratcholesterol efflux involved_inIBAMGI:1351646|PANTHER:PTN002710138|UniProtKB:Q8IZY21600115GO_REF:0000033GO_CentralGO_REF:0000033
Abca7Ratcholesterol efflux involved_inISORGD:16017751624291 PMID:14570867RGDPMID:14570867
Abca7Ratcholesterol efflux involved_inIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Ratcholesterol efflux involved_inISSUniProtKB:Q8IZY21600115GO_REF:0000024Alzheimers_University_of_TorontoGO_REF:0000024
Abca7Ratcholesterol efflux involved_inISSUniProtKB:Q91V241600115GO_REF:0000024UniProtGO_REF:0000024
Abca7Rathigh-density lipoprotein particle assembly involved_inIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Rathigh-density lipoprotein particle assembly involved_inISORGD:16017751624291 PMID:14570867RGDPMID:14570867
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Cellular Component
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Original Reference(s)
Abca7Ratapical plasma membrane located_inISORGD:15528571624291 PMID:15520449RGDPMID:15520449
Abca7Ratcell junction located_inIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Ratcell junction located_inISORGD:1601775|UniProtKB:Q8IZY2-11624291 RGDGO_REF:0000052
Abca7Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Abca7Ratcell surface located_inISSUniProtKB:Q91V241600115GO_REF:0000024Alzheimers_University_of_TorontoGO_REF:0000024
Abca7Ratcell surface located_inISORGD:15528571624291 PMID:12917409, PMID:20495215RGDPMID:12917409|PMID:20495215
Abca7Ratcytoplasm located_inISSUniProtKB:Q91V241600115GO_REF:0000024UniProtGO_REF:0000024
Abca7Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Abca7Ratcytoplasm located_inISORGD:15528571624291 PMID:27472885RGDPMID:27472885
Abca7Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Abca7Ratearly endosome membrane located_inIEAUniProtKB-SubCell:SL-00931600115GO_REF:0000044UniProtGO_REF:0000044
Abca7Ratendosome located_inIEAUniProtKB-KW:KW-09671600115GO_REF:0000043UniProtGO_REF:0000043
Abca7Ratglial cell projection located_inISORGD:15528571624291 PMID:27472885RGDPMID:27472885
Abca7Ratglial cell projection located_inISSUniProtKB:Q91V241600115GO_REF:0000024UniProtGO_REF:0000024
Abca7RatGolgi apparatus located_inISORGD:1601775|UniProtKB:Q8IZY2-11624291 RGDGO_REF:0000052
Abca7RatGolgi apparatus located_inIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Abca7RatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
Abca7Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Abca7Ratmembrane located_inIEAInterPro:IPR013525|InterPro:IPR0260821600115GO_REF:0000002InterProGO_REF:0000002
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Molecular Function
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Original Reference(s)
Abca7RatABC-type transporter activity enablesIEAInterPro:IPR013525|InterPro:IPR0260821600115GO_REF:0000002InterProGO_REF:0000002
Abca7Ratapolipoprotein A-I receptor activity enablesISSUniProtKB:Q8IZY21600115GO_REF:0000024Alzheimers_University_of_TorontoGO_REF:0000024
Abca7Ratapolipoprotein A-I receptor activity enablesISORGD:15528571624291 PMID:12917409RGDPMID:12917409
Abca7Ratapolipoprotein A-I receptor activity enablesIBAMGI:1351646|PANTHER:PTN002710138|UniProtKB:Q8IZY21600115GO_REF:0000033GO_CentralGO_REF:0000033
Abca7Ratapolipoprotein A-I receptor activity enablesISSUniProtKB:Q91V241600115GO_REF:0000024Alzheimers_University_of_TorontoGO_REF:0000024
Abca7Ratapolipoprotein A-I receptor activity enablesISORGD:16017751624291 PMID:14570867RGDPMID:14570867
Abca7Ratapolipoprotein A-I receptor activity enablesIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Abca7RatATP binding enablesIEAInterPro:IPR003439|InterPro:IPR0178711600115GO_REF:0000002InterProGO_REF:0000002
Abca7RatATP hydrolysis activity enablesIEAInterPro:IPR003439|InterPro:IPR003593|InterPro:IPR0178711600115GO_REF:0000002InterProGO_REF:0000002
Abca7RatATPase-coupled transmembrane transporter activity enablesIBAPANTHER:PTN000442469|RGD:631344|UniProtKB:O94911|UniProtKB:Q997581600115GO_REF:0000033GO_CentralGO_REF:0000033
Abca7Ratfloppase activity enablesISORGD:16017751624291 PMID:24097981RGDPMID:24097981
Abca7Ratfloppase activity enablesIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Abca7Ratphosphatidylcholine floppase activity enablesIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Ratphosphatidylcholine floppase activity enablesIBAPANTHER:PTN002710138|UniProtKB:Q8IZY21600115GO_REF:0000033GO_CentralGO_REF:0000033
Abca7Ratphosphatidylcholine floppase activity enablesISORGD:16017751624291 PMID:24097981RGDPMID:24097981
Abca7Ratphosphatidylserine floppase activity enablesIEAUniProtKB:Q8IZY2|ensembl:ENSP000002630941600115GO_REF:0000107EnsemblGO_REF:0000107
Abca7Ratphosphatidylserine floppase activity enablesIBAPANTHER:PTN002710138|UniProtKB:Q8IZY21600115GO_REF:0000033GO_CentralGO_REF:0000033
Abca7Ratphosphatidylserine floppase activity enablesISORGD:16017751624291 PMID:24097981RGDPMID:24097981
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Cloning of rat ABCA7 and its preferential expression in platelets. Sasaki M, etal., Biochem Biophys Res Commun 2003 May 16;304(4):777-82.
PMID:12917409   PMID:14570867   PMID:15520449   PMID:16908670   PMID:18429932   PMID:20495215   PMID:23467355   PMID:24097981   PMID:26260791   PMID:27472885   PMID:28091533   PMID:29476059  



Abca7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,342,092 - 10,362,094 (-)NCBIGRCr8
mRatBN7.279,691,452 - 9,711,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,691,449 - 9,711,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,573,976 - 12,592,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,449,312 - 14,467,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,310,438 - 12,328,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,742,433 - 12,762,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,742,433 - 12,762,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,912,155 - 12,932,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,203,983 - 11,222,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,203,982 - 11,222,960 (-)NCBI
Celera77,867,206 - 7,885,960 (-)NCBICelera
Cytogenetic Map7q11NCBI
ABCA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,040,107 - 1,065,572 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,039,997 - 1,065,572 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,040,106 - 1,065,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619991,102 - 1,016,571 (+)NCBINCBI36Build 36hg18NCBI36
Celera19970,935 - 998,554 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19812,691 - 838,952 (+)NCBIHuRef
CHM1_1191,038,376 - 1,065,164 (+)NCBICHM1_1
T2T-CHM13v2.0191,002,776 - 1,030,237 (+)NCBIT2T-CHM13v2.0
Abca7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,832,328 - 79,851,406 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,832,328 - 79,851,406 (+)EnsemblGRCm39 Ensembl
GRCm381079,996,453 - 80,015,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,996,494 - 80,015,572 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,460,360 - 79,478,317 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,400,744 - 79,418,701 (+)NCBIMGSCv36mm8
Celera1081,012,422 - 81,030,379 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Abca7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,815,562 - 6,836,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,818,002 - 6,838,177 (-)NCBIChiLan1.0ChiLan1.0
ABCA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,374,938 - 5,401,483 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,611,225 - 4,637,922 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01962,811 - 77,897 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,016,829 - 1,042,251 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,018,095 - 1,042,104 (+)Ensemblpanpan1.1panPan2
ABCA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,668,371 - 57,684,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,667,706 - 57,677,342 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,470,691 - 57,486,228 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,410,598 - 58,426,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,410,507 - 58,425,315 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,465,893 - 57,481,504 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,945,423 - 57,961,034 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,148,479 - 58,164,018 (-)NCBIUU_Cfam_GSD_1.0
Abca7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,357,348 - 217,374,569 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588461,389 - 477,229 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588460,308 - 477,382 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,357,218 - 77,375,180 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,357,161 - 77,375,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,621,720 - 77,640,442 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16792,684 - 821,522 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6792,783 - 821,375 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,035,915 - 8,121,412 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abca7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,573,130 - 7,591,038 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,572,821 - 7,592,428 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Abca7
48 total Variants

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:115
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000064886
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

1 to 10 of 15 rows
RH139906  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8710,342,140 - 10,342,477 (+)Marker Load Pipeline
mRatBN7.279,691,500 - 9,691,837 (+)MAPPERmRatBN7.2
Rnor_6.0712,742,482 - 12,742,818NCBIRnor6.0
Rnor_5.0712,912,204 - 12,912,540UniSTSRnor5.0
RGSC_v3.4711,203,950 - 11,204,286UniSTSRGSC3.4
Celera77,867,173 - 7,867,509UniSTS
RH 3.4 Map740.7UniSTS
Cytogenetic Map7q11UniSTS
BF390650  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8710,345,671 - 10,346,138 (+)Marker Load Pipeline
mRatBN7.279,695,031 - 9,695,498 (+)MAPPERmRatBN7.2
Rnor_6.0712,746,013 - 12,746,479NCBIRnor6.0
Rnor_5.0712,915,735 - 12,916,201UniSTSRnor5.0
RGSC_v3.4711,207,481 - 11,207,947UniSTSRGSC3.4
Celera77,870,704 - 7,871,170UniSTS
Cytogenetic Map7q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000064886   ⟹   ENSRNOP00000063805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,691,449 - 9,711,425 (-)Ensembl
Rnor_6.0 Ensembl712,742,433 - 12,762,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,743,992 - 12,746,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,746,039 - 12,746,952 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,742,479 - 12,746,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095800   ⟹   ENSRNOP00000095986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,691,449 - 9,711,425 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097711   ⟹   ENSRNOP00000085552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,691,452 - 9,711,425 (-)Ensembl
RefSeq Acc Id: NM_207598   ⟹   NP_997481
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,342,092 - 10,361,989 (-)NCBI
mRatBN7.279,691,452 - 9,711,353 (-)NCBI
Rnor_6.0712,742,515 - 12,761,261 (-)NCBI
Rnor_5.0712,912,155 - 12,932,147 (-)NCBI
RGSC_v3.4711,203,983 - 11,222,960 (-)RGD
Celera77,867,206 - 7,885,960 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240871   ⟹   XP_006240933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,342,092 - 10,362,072 (-)NCBI
mRatBN7.279,691,452 - 9,711,441 (-)NCBI
Rnor_6.0712,742,433 - 12,762,423 (-)NCBI
Rnor_5.0712,912,155 - 12,932,147 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240872   ⟹   XP_006240934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,342,092 - 10,362,070 (-)NCBI
mRatBN7.279,691,452 - 9,711,457 (-)NCBI
Rnor_6.0712,742,433 - 12,762,423 (-)NCBI
Rnor_5.0712,912,155 - 12,932,147 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240874   ⟹   XP_006240936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,342,092 - 10,362,094 (-)NCBI
mRatBN7.279,691,452 - 9,711,466 (-)NCBI
Rnor_6.0712,742,433 - 12,762,423 (-)NCBI
Rnor_5.0712,912,155 - 12,932,147 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594715   ⟹   XP_017450204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,342,092 - 10,362,072 (-)NCBI
mRatBN7.279,691,452 - 9,711,441 (-)NCBI
Rnor_6.0712,742,433 - 12,762,423 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078645   ⟹   XP_038934573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,342,092 - 10,362,072 (-)NCBI
mRatBN7.279,691,452 - 9,711,441 (-)NCBI
RefSeq Acc Id: XM_039078646   ⟹   XP_038934574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,344,697 - 10,362,077 (-)NCBI
mRatBN7.279,694,082 - 9,711,444 (-)NCBI
RefSeq Acc Id: XM_063263170   ⟹   XP_063119240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,344,318 - 10,362,077 (-)NCBI
RefSeq Acc Id: XR_005486558
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,345,648 - 10,362,078 (-)NCBI
mRatBN7.279,695,008 - 9,711,444 (-)NCBI
RefSeq Acc Id: XR_010052951
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,343,651 - 10,362,077 (-)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_997481   ⟸   NM_207598
- UniProtKB: Q7TNJ2 (UniProtKB/Swiss-Prot),   F1LR67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240936   ⟸   XM_006240874
- Peptide Label: isoform X1
- UniProtKB: Q7TNJ2 (UniProtKB/Swiss-Prot),   F1LR67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240934   ⟸   XM_006240872
- Peptide Label: isoform X1
- UniProtKB: Q7TNJ2 (UniProtKB/Swiss-Prot),   F1LR67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240933   ⟸   XM_006240871
- Peptide Label: isoform X1
- UniProtKB: Q7TNJ2 (UniProtKB/Swiss-Prot),   F1LR67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450204   ⟸   XM_017594715
- Peptide Label: isoform X3
- UniProtKB: Q7TNJ2 (UniProtKB/Swiss-Prot),   A0A8I6A4A6 (UniProtKB/TrEMBL)
- Sequence:
ABC transporter

Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNJ2-F1-model_v2 AlphaFold Q7TNJ2 1-2170 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695047
Promoter ID:EPDNEW_R5572
Type:multiple initiation site
Name:Abca7_1
Description:ATP binding cassette subfamily A member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,762,365 - 12,762,425EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34911 BioCyc
Ensembl Genes ENSRNOG00000012939 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064886 ENTREZGENE
  ENSRNOT00000097711 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC2_TM UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABCA UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:299609 UniProtKB/Swiss-Prot
NCBI Gene 299609 ENTREZGENE
PANTHER ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED UniProtKB/Swiss-Prot
  PTHR19229 UniProtKB/Swiss-Prot
Pfam ABC2_membrane_3 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PhenoGen Abca7 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012939 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6A4A6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASJ6_RAT UniProtKB/TrEMBL
  A6K8T5_RAT UniProtKB/TrEMBL
  ABCA7_RAT UniProtKB/Swiss-Prot
  F1LR67 ENTREZGENE, UniProtKB/TrEMBL
  Q7TNJ2 ENTREZGENE
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Abca7  ATP binding cassette subfamily A member 7  Abca7  ATP-binding cassette, subfamily A (ABC1), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abca7  ATP-binding cassette, subfamily A (ABC1), member 7  Abca7  ATP-binding cassette, sub-family A (ABC1), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Abca7  ATP-binding cassette, sub-family A (ABC1), member 7  ABCA7  ATP-binding cassette, sub-family A, member 7  Name updated 1299863 APPROVED
2005-02-14 ABCA7  ATP-binding cassette, sub-family A, member 7      Symbol and Name status set to provisional 70820 PROVISIONAL