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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphonoformic acid
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Accession:CHEBI:127780 term browser browse the term
Definition:Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Synonyms:exact_synonym: dihydroxyphosphanecarboxylic acid oxide
 related_synonym: Formula=CH3O5P;   Foscarmet;   InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6);   InChIKey=ZJAOAACCNHFJAH-UHFFFAOYSA-N;   SMILES=OC(=O)P(O)(O)=O;   carboxyphosphonic acid;   foscarnet;   phosphonomethanoic acid
 alt_id: CHEBI:45085;   CHEBI:8158
 xref: CAS:4428-95-9;   DrugBank:DB00529;   Drug_Central:1241;   KEGG:C06456;   KNApSAcK:C00000800
 xref_mesh: MESH:D017245
 xref: PDBeChem:PPF;   PMID:11576919;   PMID:15182735;   PMID:16858125;   PMID:19213941;   PMID:19288498;   PMID:21056575;   PMID:21566148;   Reaxys:1756501;   Wikipedia:Foscarnet
 cyclic_relationship: is_conjugate_acid_of CHEBI:60268;   is_conjugate_acid_of CHEBI:91254


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phosphonoformic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Foscarnet inhibits the reaction [Phosphates results in decreased expression of AKT1 mRNA] CTD PMID:23308213 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 multiple interactions ISO Foscarnet inhibits the reaction [Phosphates results in increased expression of DMP1 mRNA] CTD PMID:20185895 NCBI chr14:6,889,851...6,923,961
Ensembl chr14:6,889,856...6,900,733
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked multiple interactions ISO Foscarnet inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA] CTD PMID:18500657 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions
increases import
EXP Foscarnet inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]
SLC16A1 protein results in increased import of Foscarnet
CTD PMID:10579682, PMID:10714609 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc20a1 solute carrier family 20 member 1 decreases activity
multiple interactions
increases expression
ISO
EXP
Foscarnet results in decreased activity of SLC20A1 protein
Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A1 mRNA]
Foscarnet results in increased expression of SLC20A1 mRNA
CTD PMID:15641067, PMID:17438129, PMID:23308213 NCBI chr 3:121,725,204...121,739,160
Ensembl chr 3:121,725,859...121,739,173
JBrowse link
G Slc20a2 solute carrier family 20 member 2 multiple interactions ISO Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A2 mRNA] CTD PMID:23308213 NCBI chr16:74,318,287...74,408,030
Ensembl chr16:74,317,899...74,408,030
JBrowse link
G Slc23a2 solute carrier family 23 member 2 multiple interactions ISO Foscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA] CTD PMID:12788230 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Foscarnet inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 protein] CTD PMID:12788230, PMID:17383965, PMID:18412142 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stc1 stanniocalcin 1 increases expression EXP Foscarnet results in increased expression of STC1 mRNA CTD PMID:17438129 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        solvent 16475
          formic acid 7881
            phosphonoformic acid 9
              CMP-5'-phosphonoformic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        monocarboxylic acid 17425
                                          formic acid 7881
                                            phosphonoformic acid 9
                                              CMP-5'-phosphonoformic acid 0
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