1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of LONP1 protein CTD PMID:17337753 1,2-dimethylhydrazine multiple interactions ISO RGD:734454 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LONP1 mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression ISO RGD:734454 6480464 Ethinyl Estradiol results in increased expression of LONP1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:734454 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LONP1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:734454 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LONP1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of LONP1 mRNA CTD PMID:22298810 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of LONP1 protein CTD PMID:26597043 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of LONP1 mRNA CTD PMID:22504374 aflatoxin B1 decreases expression ISO RGD:734454 6480464 Aflatoxin B1 results in decreased expression of LONP1 mRNA CTD PMID:19770486 aflatoxin B2 decreases methylation ISO RGD:734453 6480464 aflatoxin B2 results in decreased methylation of LONP1 intron CTD PMID:30157460 aldehydo-D-glucose multiple interactions EXP 6480464 LONP1 protein affects the reaction [SRT1720 inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of ACO2 protein]] more ... CTD PMID:31639451 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of LONP1 protein CTD PMID:31639451 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of LONP1 mRNA CTD PMID:16483693 benzo[e]pyrene decreases methylation ISO RGD:734453 6480464 benzo(e)pyrene results in decreased methylation of LONP1 intron CTD PMID:30157460 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of LONP1 mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LONP1 mRNA CTD PMID:30816183 bisphenol A increases expression ISO RGD:734453 6480464 bisphenol A results in increased expression of LONP1 mRNA CTD PMID:29275510 bisphenol A affects expression ISO RGD:734453 6480464 bisphenol A affects the expression of LONP1 mRNA CTD PMID:30903817 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with tributyltin] results in decreased expression of LONP1 mRNA CTD PMID:31129395 bisphenol A affects methylation ISO RGD:734454 6480464 bisphenol A affects the methylation of LONP1 promoter CTD PMID:27334623 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of LONP1 mRNA CTD PMID:15056800 butan-1-ol multiple interactions ISO RGD:734453 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of LONP1 mRNA CTD PMID:29432896 carbon nanotube multiple interactions ISO RGD:734453 6480464 [Nanotubes, Carbon co-treated with calfactant] results in decreased expression of LONP1 protein CTD PMID:23026733 CCCP increases expression ISO RGD:734453 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of LONP1 mRNA CTD PMID:28940366 choline multiple interactions ISO RGD:734454 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LONP1 gene CTD PMID:20938992 chromium(6+) affects expression ISO RGD:734454 6480464 chromium hexavalent ion affects the expression of LONP1 mRNA CTD PMID:28472532 cisplatin decreases expression ISO RGD:734453 6480464 Cisplatin results in decreased expression of LONP1 mRNA CTD PMID:27392435 cobalt dichloride increases expression ISO RGD:734453 6480464 cobaltous chloride results in increased expression of LONP1 mRNA CTD PMID:19376846 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of LONP1 mRNA CTD PMID:24386269 coumestrol increases expression ISO RGD:734453 6480464 Coumestrol results in increased expression of LONP1 mRNA CTD PMID:19167446 cyclosporin A increases expression ISO RGD:734453 6480464 Cyclosporine results in increased expression of LONP1 mRNA CTD PMID:20106945 more ... D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of LONP1 protein CTD PMID:31639451 D-glucose multiple interactions EXP 6480464 LONP1 protein affects the reaction [SRT1720 inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of ACO2 protein]] more ... CTD PMID:31639451 dicrotophos increases expression ISO RGD:734453 6480464 dicrotophos results in increased expression of LONP1 mRNA CTD PMID:28302478 efavirenz multiple interactions ISO RGD:734453 6480464 efavirenz results in increased expression of and affects the localization of LONP1 protein more ... CTD PMID:28940366 efavirenz increases expression ISO RGD:734453 6480464 efavirenz results in increased expression of LONP1 mRNA CTD PMID:28940366 efavirenz increases response to substance ISO RGD:734453 6480464 LONP1 protein results in increased susceptibility to efavirenz CTD PMID:28940366 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of LONP1 mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:734453 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of LONP1 mRNA CTD PMID:29432896 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of LONP1 mRNA CTD PMID:30307764 finasteride increases expression EXP 6480464 Finasteride results in increased expression of LONP1 mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of LONP1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:734454 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 folic acid increases expression ISO RGD:734454 6480464 Folic Acid results in increased expression of LONP1 mRNA CTD PMID:25629700 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of LONP1 mRNA, Gentamicins results in increased expression of LONP1 protein CTD PMID:22061828 glucose decreases expression EXP 6480464 Glucose results in decreased expression of LONP1 protein CTD PMID:31639451 glucose multiple interactions EXP 6480464 LONP1 protein affects the reaction [SRT1720 inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of ACO2 protein]] more ... CTD PMID:31639451 ivermectin increases expression ISO RGD:734453 6480464 Ivermectin results in increased expression of LONP1 mRNA CTD PMID:28942281 ivermectin increases expression ISO RGD:734454 6480464 Ivermectin results in increased expression of LONP1 mRNA CTD PMID:28942281 L-methionine multiple interactions ISO RGD:734454 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LONP1 gene CTD PMID:20938992 menadione affects expression ISO RGD:734453 6480464 Vitamin K 3 affects the expression of LONP1 mRNA CTD PMID:20044591 methapyrilene decreases methylation ISO RGD:734453 6480464 Methapyrilene results in decreased methylation of LONP1 intron CTD PMID:30157460 methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of LONP1 mRNA CTD PMID:22504374 N-methyl-4-phenylpyridinium increases expression ISO RGD:734454 6480464 1-Methyl-4-phenylpyridinium results in increased expression of LONP1 mRNA, 1-Methyl-4-phenylpyridinium results in increased expression of LONP1 protein CTD PMID:22776087 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of LONP1 mRNA CTD PMID:28801915 nitrogen dioxide multiple interactions ISO RGD:734453 6480464 [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene more ... CTD PMID:27448387 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of LONP1 protein CTD PMID:31369848 ochratoxin A multiple interactions EXP 6480464 HSPA9 protein affects the reaction [ochratoxin A results in decreased expression of LONP1 protein] CTD PMID:31369848 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of LONP1 mRNA CTD PMID:25729387 oxidopamine increases expression EXP 6480464 Oxidopamine results in increased expression of LONP1 mRNA CTD PMID:12486162 paracetamol affects expression ISO RGD:734454 6480464 Acetaminophen affects the expression of LONP1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:734453 6480464 Acetaminophen results in decreased expression of LONP1 mRNA CTD PMID:25704631 paracetamol affects response to substance ISO RGD:734453 6480464 LONP1 gene polymorphism affects the susceptibility to Acetaminophen CTD PMID:26104854 perfluorononanoic acid increases expression ISO RGD:734453 6480464 perfluorononanoic acid results in increased expression of LONP1 mRNA CTD PMID:32588087 resveratrol increases expression ISO RGD:734454 6480464 resveratrol results in increased expression of LONP1 protein CTD PMID:25505154 rotenone increases expression ISO RGD:734453 6480464 Rotenone results in increased expression of LONP1 mRNA CTD PMID:28940366 rotenone increases oxidation EXP 6480464 Rotenone results in increased oxidation of LONP1 protein CTD PMID:30951809 silver atom increases expression ISO RGD:734454 6480464 Silver results in increased expression of LONP1 mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:734454 6480464 Silver results in increased expression of LONP1 mRNA CTD PMID:27131904 stavudine affects expression ISO RGD:734453 6480464 Stavudine affects the expression of LONP1 protein CTD PMID:27041070 sulindac decreases expression EXP 6480464 Sulindac results in decreased expression of LONP1 mRNA CTD PMID:24136188 sunitinib increases expression ISO RGD:734453 6480464 Sunitinib results in increased expression of LONP1 mRNA CTD PMID:31533062 tenofovir disoproxil fumarate affects expression ISO RGD:734453 6480464 Tenofovir affects the expression of LONP1 protein CTD PMID:27041070 tetrachloromethane increases expression ISO RGD:734454 6480464 Carbon Tetrachloride results in increased expression of LONP1 mRNA CTD PMID:31919559 thapsigargin increases expression ISO RGD:734453 6480464 Thapsigargin results in increased expression of LONP1 mRNA, Thapsigargin results in increased expression of LONP1 protein CTD PMID:22378314 , PMID:28940366 thapsigargin increases expression ISO RGD:734454 6480464 Thapsigargin results in increased expression of LONP1 mRNA CTD PMID:28942281 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of LONP1 mRNA CTD PMID:25729387 tributylstannane multiple interactions EXP 6480464 [bisphenol A co-treated with tributyltin] results in decreased expression of LONP1 mRNA CTD PMID:31129395 troglitazone increases expression ISO RGD:734454 6480464 troglitazone results in increased expression of LONP1 protein CTD PMID:18495193 tunicamycin increases expression ISO RGD:734453 6480464 Tunicamycin results in increased expression of LONP1 mRNA, Tunicamycin results in increased expression of LONP1 protein CTD PMID:22378314 , PMID:29453283 tunicamycin increases expression ISO RGD:734454 6480464 Tunicamycin results in increased expression of LONP1 mRNA CTD PMID:28942281 urethane decreases expression ISO RGD:734453 6480464 Urethane results in decreased expression of LONP1 mRNA CTD PMID:28818685 valproic acid increases expression ISO RGD:734453 6480464 Valproic Acid results in increased expression of LONP1 mRNA CTD PMID:23179753 , PMID:29154799 valproic acid affects expression ISO RGD:734453 6480464 Valproic Acid affects the expression of LONP1 mRNA CTD PMID:25979313 zidovudine affects expression ISO RGD:734453 6480464 Zidovudine affects the expression of LONP1 protein CTD PMID:27041070
Biological Process aging IEP 2303495 RGD cellular protein-containing complex assembly IMP 633879 RGD cellular response to oxidative stress ISO RGD:734453 1624291 (PMID:17420247) RGD PMID:17420247 chaperone-mediated protein complex assembly IBA PANTHER:PTN000005479 , SGD:S000000118 13792537 PMID:21873635 GO_Central mitochondrion organization IEP 1580666 RGD mitochondrion organization IBA FB:FBgn0036892 more ... 13792537 PMID:21873635 GO_Central mitochondrion organization ISO RGD:734453 1624291 (PMID:15683722) RGD PMID:15683722 oxidation-dependent protein catabolic process ISO RGD:734453 1624291 (PMID:12198491) RGD PMID:12198491 protein quality control for misfolded or incompletely synthesized proteins IBA PANTHER:PTN002464028 , SGD:S000000118 13792537 PMID:21873635 GO_Central proteolysis IDA 1580665 RGD proteolysis ISO RGD:734454 1624291 (MGI:2655856, PMID:12657466) RGD MGI:2655856 , PMID:12657466 proteolysis involved in cellular protein catabolic process ISO RGD:734453 1624291 (PMID:17420247), (PMID:8248235) RGD PMID:17420247 , PMID:8248235 response to aluminum ion IEP 2303407 RGD response to hormone IEP 1580666 RGD response to hypoxia IEP 633879 RGD response to hypoxia ISO RGD:734453 1624291 (PMID:17418790) RGD PMID:17418790 Cellular Component cytosol IEA UniProtKB:P36776 , ensembl:ENSP000003538261600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:734453 1624291 RGD GO_REF:0000052 mitochondrial matrix IDA 2303495 RGD mitochondrial matrix IBA PANTHER:PTN000005479 more ... 13792537 PMID:21873635 GO_Central mitochondrial matrix ISO RGD:734453 1624291 (PMID:12198491) RGD PMID:12198491 mitochondrial nucleoid ISO RGD:734453 1624291 (PMID:18063578) RGD PMID:18063578 mitochondrion IDA 1580665 RGD mitochondrion ISO RGD:734454 1624291 (MGI:2655856, PMID:12657466) RGD MGI:2655856 , PMID:12657466 mitochondrion ISO RGD:734453 1624291 (PMID:8248235) RGD GO_REF:0000052, PMID:8248235 nucleoplasm ISO RGD:734453 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:P36776 , ensembl:ENSP000003538261600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function ADP binding ISO RGD:734453 1624291 (PMID:14739292) RGD PMID:14739292 ATP binding ISO RGD:734453 1624291 (PMID:14739292) RGD PMID:14739292 ATP-dependent peptidase activity IDA 1580665 RGD ATP-dependent peptidase activity ISO RGD:734454 1624291 (MGI:2655856, PMID:12657466) RGD MGI:2655856 , PMID:12657466 ATP-dependent peptidase activity ISO RGD:734453 1624291 (PMID:14739292), (PMID:17420247), (PMID:8248235) RGD PMID:14739292 more ... ATP-dependent peptidase activity IBA MGI:MGI:1921392 more ... 13792537 PMID:21873635 GO_Central ATPase activity ISO RGD:734453 1624291 (PMID:14739292) RGD PMID:14739292 ATPase activity ISO RGD:734454 1624291 (MGI:2655856, PMID:12657466) RGD MGI:2655856 , PMID:12657466 DNA polymerase binding ISO RGD:734453 1624291 UniProtKB:P54098 (PMID:14739292) RGD PMID:14739292 G-quadruplex DNA binding ISO RGD:734453 1624291 (PMID:18174225) RGD PMID:18174225 identical protein binding ISO RGD:734453 1624291 UniProtKB:P36776 , UniProtKB:P36776-1 (PMID:14739292), (PMID:25574826) RGD PMID:14739292 , PMID:25574826 mitochondrial promoter sequence-specific DNA binding ISO RGD:734453 1624291 (PMID:9485316) RGD PMID:9485316 mitochondrial promoter sequence-specific DNA binding NOT ISO RGD:734454 1624291 (MGI:2655856, PMID:12657466) RGD MGI:2655856 , PMID:12657466 mitochondrial promoter sequence-specific DNA binding ISO RGD:734454 1624291 (MGI:2655856, PMID:12657466) RGD MGI:2655856 , PMID:12657466 mitochondrial promoter sequence-specific DNA binding NOT ISO RGD:734453 1624291 (PMID:9485316) RGD PMID:9485316 protein binding ISO RGD:734453 1624291 UniProtKB:P02666 , UniProtKB:Q96RR1 (PMID:14739292), (PMID:24520911) RGD PMID:14739292 , PMID:24520911 sequence-specific DNA binding ISO RGD:734453 1624291 (PMID:14739292) RGD PMID:14739292 serine-type endopeptidase activity IEA EC:3.4.21.53 1600115 GO_REF:0000003 UniProt GO_REF:0000003 single-stranded DNA binding IBA MGI:MGI:1921392 , PANTHER:PTN000005479 13792537 PMID:21873635 GO_Central single-stranded DNA binding ISO RGD:734454 1624291 (MGI:2655856, PMID:12657466) RGD MGI:2655856 , PMID:12657466 single-stranded RNA binding ISO RGD:734453 1624291 (PMID:14739292) RGD PMID:14739292
Gene-Chemical Interaction Annotations
