Lonp1 (lon peptidase 1, mitochondrial)

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Gene: Lonp1 (lon peptidase 1, mitochondrial) Rattus norvegicus

Analyze

Symbol:

Lonp1

Name:

lon peptidase 1, mitochondrial

RGD ID:

621598

Description:

Exhibits ATP-dependent peptidase activity. Involved in several processes, including mitochondrion organization; response to aluminum ion; and response to hypoxia. Localizes to mitochondrial matrix. Used to study brain ischemia and ischemia. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Lon; lon protease homolog, mitochondrial; lon protease-like protein; LONP; mitochondrial ATP-dependent protease Lon; protease, serine, 15; Prss15; serine protease 15

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LONP1 (lon peptidase 1, mitochondrial)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Lonp1 (lon peptidase 1, mitochondrial)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Lonp1 (lon peptidase 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LONP1 (lon peptidase 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LONP1 (lon peptidase 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lonp1 (lon peptidase 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LONP1 (lon peptidase 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	LONP1 (lon peptidase 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lonp1 (lon peptidase 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LONP1 (lon peptidase 1, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Lonp1 (lon peptidase 1, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	lonp1 (lon peptidase 1, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	PIM1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Lon	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	lonp-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	1,447,444 - 1,459,771 (-)	NCBI
Rnor_6.0 Ensembl	9	10,428,853 - 10,441,177 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	9	10,428,853 - 10,441,180 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	9,425,780 - 9,438,107 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,054,065 - 7,066,392 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

brain ischemia (IDA)

CODAS syndrome (ISO)

Dwarfism (ISO)

genetic disease (ISO)

ischemia (IDA)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

aldehydo-D-glucose (EXP)

ammonium chloride (EXP)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butan-1-ol (ISO)

carbon nanotube (ISO)

CCCP (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (EXP,ISO)

coumestrol (ISO)

cyclosporin A (ISO)

D-glucose (EXP)

dicrotophos (ISO)

efavirenz (ISO)

endosulfan (EXP)

ethanol (ISO)

fenvalerate (EXP)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glucose (EXP)

ivermectin (ISO)

L-methionine (ISO)

menadione (ISO)

methapyrilene (ISO)

methimazole (EXP)

N-methyl-4-phenylpyridinium (EXP,ISO)

nitrogen dioxide (ISO)

ochratoxin A (EXP)

oxaliplatin (EXP)

oxidopamine (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

stavudine (ISO)

sulindac (EXP)

sunitinib (ISO)

tenofovir disoproxil fumarate (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

topotecan (EXP)

tributylstannane (EXP)

troglitazone (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (IEP)

cellular protein-containing complex assembly (IMP)

cellular response to oxidative stress (ISO)

chaperone-mediated protein complex assembly (IBA)

mitochondrion organization (IBA,IEP,ISO)

oxidation-dependent protein catabolic process (ISO)

protein quality control for misfolded or incompletely synthesized proteins (IBA)

proteolysis (IDA,ISO)

proteolysis involved in cellular protein catabolic process (ISO)

response to aluminum ion (IEP)

response to hormone (IEP)

response to hypoxia (IEP,ISO)

Cellular Component

cytosol (IEA,ISO)

mitochondrial matrix (IBA,IDA,ISO)

mitochondrial nucleoid (ISO)

mitochondrion (IDA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

ADP binding (ISO)

ATP binding (ISO)

ATP-dependent peptidase activity (IBA,IDA,ISO)

ATPase activity (ISO)

DNA polymerase binding (ISO)

G-quadruplex DNA binding (ISO)

identical protein binding (IEA,ISO)

mitochondrial promoter sequence-specific DNA binding (ISO)

protein binding (ISO)

sequence-specific DNA binding (ISO)

serine-type endopeptidase activity (IEA)

single-stranded DNA binding (IBA,ISO)

single-stranded RNA binding (ISO)

References

References - curated


1.	Bakala H, etal., Eur J Biochem. 2003 May;270(10):2295-302.
2.	Delaval E, etal., Eur J Biochem. 2004 Nov;271(22):4559-64.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	GOA data from the GO Consortium
5.	Hori O, etal., J Cell Biol 2002 Jun 24;157(7):1151-60.
6.	Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
7.	Kumar V, etal., Toxicology. 2009 Jan 31;255(3):117-23. Epub 2008 Nov 1.
8.	Luciakova K, etal., FEBS Lett. 1999 Feb 12;444(2-3):186-8.
9.	MGD data from the GO Consortium
10.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	RGD automated data pipeline
12.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8248235	PMID:9485316	PMID:12198491	PMID:12657466	PMID:14651853	PMID:14739292	PMID:15683722	PMID:17418790	PMID:17420247	PMID:18063578	PMID:18174225	PMID:18598728
PMID:18614015	PMID:19946888	PMID:23858469	PMID:26316108	PMID:30053369	PMID:30625302

Genomics

Comparative Map Data

Lonp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	1,447,444 - 1,459,771 (-)	NCBI
Rnor_6.0 Ensembl	9	10,428,853 - 10,441,177 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	9	10,428,853 - 10,441,180 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	9,425,780 - 9,438,107 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,054,065 - 7,066,392 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

LONP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	5,691,834 - 5,720,572 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	5,691,834 - 5,720,452 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	5,691,845 - 5,720,463 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	5,642,845 - 5,671,176 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	5,642,844 - 5,671,176	NCBI
Celera	19	5,629,216 - 5,657,543 (-)	NCBI
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	5,452,614 - 5,480,959 (-)	NCBI		HuRef
CHM1_1	19	5,691,454 - 5,720,076 (-)	NCBI		CHM1_1

Lonp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,921,297 - 56,933,903 (-)	NCBI	GRCm39		mm39
GRCm38	17	56,614,297 - 56,626,903 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	56,614,297 - 56,626,887 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,753,720 - 56,766,326 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	56,299,420 - 56,312,007 (-)	NCBI			mm8
Celera	17	60,958,496 - 60,971,102 (-)	NCBI		Celera
Cytogenetic Map	17	D	NCBI

Lonp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	3,712,199 - 3,731,301 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	3,712,173 - 3,729,556 (+)	NCBI	ChiLan1.0	ChiLan1.0

LONP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	5,644,525 - 5,670,956 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	5,644,525 - 5,670,956 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	4,709,062 - 4,735,653 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LONP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	54,312,678 - 54,334,141 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	54,312,678 - 54,334,142 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Lonp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936588	3,265,344 - 3,287,035 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LONP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	73,266,258 - 73,286,774 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	73,266,310 - 73,286,774 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	73,788,290 - 73,808,755 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LONP1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	5,348,968 - 5,371,521 (-)	NCBI
ChlSab1.1 Ensembl	6	5,346,426 - 5,371,507 (-)	Ensembl

Lonp1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	4,494,786 - 4,516,772 (+)	NCBI

Position Markers

RH143400

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	9	10,432,518 - 10,433,277	NCBI	Rnor6.0
Rnor_5.0	9	9,429,445 - 9,430,204	UniSTS	Rnor5.0
Celera	9	7,057,730 - 7,058,489	UniSTS
Cytogenetic Map	9	q11	UniSTS

RH141449

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	1	55,974,072 - 55,974,281	NCBI	Rnor5.0
Rnor_5.0	16	38,400,536 - 38,400,745	NCBI	Rnor5.0
RGSC_v3.4	16	38,246,699 - 38,246,907	UniSTS	RGSC3.4
Celera	9	7,065,904 - 7,066,183	UniSTS
Cytogenetic Map	9	q11	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	16520166	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	29467098	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	40383872	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	40383872	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	40383872	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	45029794	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1055222	93442944	Rat
1578675	Bss17	Bone structure and strength QTL 17	3.8		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	9	1907834	15555026	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	2355722	47355722	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	2355722	47355722	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	2880977	47375681	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	2880977	47880977	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	4986095	49986095	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	4986095	49986095	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	5724254	25692342	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	63
Count of miRNA genes:	60
Interacting mature miRNAs:	63
Transcripts:	ENSRNOT00000074253
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB064323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000074253 ⟹ ENSRNOP00000066618

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	10,428,853 - 10,441,177 (+)	Ensembl

RefSeq Acc Id:

NM_133404 ⟹ NP_596895

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	1,447,444 - 1,459,771 (-)	NCBI
Rnor_6.0	9	10,428,853 - 10,441,180 (+)	NCBI
Rnor_5.0	9	9,425,780 - 9,438,107 (+)	NCBI
Celera	9	7,054,065 - 7,066,392 (+)	RGD

Sequence:

show sequence

CATGGCGGCAAGCACAGGTTACGTGCGGCTGTGGGCTGCTGCGCGGTGCTGGGTTCTGCGGCGT
CCGCTCTTGGCTGTCACCGGAGGCCGAGTCCCGAGTGCGTCCGGGTCCTGGCTGCGCCGAGGAT
GTCGGGTCTGCGACACGTCAACTCCCTGGGGCGGCCGCGTTCCTATGGGCGGGGGCCAGTGGCG
GGGGCTGTGGGACGCGGGGAGCCGCGGTGGCAGCGACGAGACCTCCGAGGGCGGCGTGGAGGAC
GGGGCCACGGCGAGCAGCGGGGAAGGCCCGGTCGTCACGGCCCTCGCGCCTATGACCGTCCCGG
ATGTGTTTCCTCACCTGCCGCTCATCGCCATCTCCCGCAACCCGGTGTTCCCGCGCTTTATCAA
GATCGTGGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTCCGCCTGGCACAG
CCGTATGTTGGCGTCTTCTTAAAGAGAGATGATAACAATGAGTCAGACGTGGTGGAGAGCCTGG
ATGAGATCTACCATACGGGAACGTTCGCTCAGATTCATGAGATGCAGGACCTCGGAGACAAGTT
GCGCATGATCGTTACAGGCCACAGAAGGATTCACATCAGCCGGCAGCTGGAGGTGGAACCAGAG
GGGCTGGAGCCAGAGGCAGAGAACAAACAAAAGTCCAGGAGGAAGCTGAAGCGAGGCAAGAAAG
AGGTCGGGGATGAGCTGGGTGCCAAGCCCCAGCTGGAGATGGTGACTGAGGCTACCAGTGACAC
ATCCAAAGAGGTGCTCATGGTGGAGGTTGAGAATGTAGCCCATGAAGACTTTCAGGTCACAGAG
GAAGTGAAGGCCCTGACTGCAGAGATCGTGAAGACCATTCGGGATATCATCGCCCTGAACCCTC
TGTACAGAGAGTCCGTGCTGCAGATGATGCAGGCAGGCCAGCGTGTGGTGGACAACCCCATCTA
CTTGAGCGACATGGGTGCCGCACTCACTGGGGCTGAGTCCCATGAGCTGCAAGATGTGCTGGAA
GAAACAAACATCCTTAAGCGGCTCTATAAGGCCCTGTCTCTTTTGAAGAAGGAGTTCGAGTTGA
GCAAGCTTCAACAGCGCCTGGGGCGTGAGGTGGAGGAGAAGATCAAGCAGACGCACAGGAAGTA
CCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAAGAGTTGGGACTAGAGAAGGATGATAAAGAT
GCCATTGAGGAGAAGTTCCGGGAACGCTTAAAGGAGCTTGTGGTTCCCAAGCATGTGATGGACG
TGGTAGATGAGGAGCTGAGCAAGCTGGCCCTACTGGACAACCACTCCTCTGAATTCAATGTCAC
TCGCAACTACCTGGACTGGCTGACGTCCATCCCATGGGGCCGGCAGAGCGATGAGAACTTAGAC
CTGGCTCGGGCCCAGTCGGTGCTGGAGGAGGACCACTATGGCATGGAGGATGTGAAGAAGCGAG
TCTTGGAGTTCATTGCAGTCAGCCAGCTCCGAGGCTCCACACAGGGCAAGATCCTCTGCTTCCA
CGGCCCACCAGGTGTGGGCAAGACCAGCATTGCACGCTCCATTGCCCGTGCCCTTGGCCGTGAA
TACTTCCGCTTTAGTGTTGGTGGCATGACAGATGTGGCAGAAATCAAGGGGCACAGGCGTACCT
ATGTGGGGGCCATGCCTGGGAAGATTATCCAGTGTCTGAAGAAAACCAAGACAGAGAACCCATT
AGTGCTGATTGATGAGGTGGATAAGATTGGCCGAGGCTACCAAGGGGACCCGTCATCAGCACTG
TTGGAGTTGTTGGACCCTGAGCAGAATGCCAACTTCCTGGACCACTACCTGGATGTGCCAGTGG
ACCTGTCCAAGGTGCTATTCATCTGCACAGCCAACGTCACTGACACTATACCGGAGCCACTAAG
GGATCGCATGGAGATGATCAATGTGTCAGGCTATGTAGCACAGGAGAAGCTGGCCATTGCAGAG
CGGTACCTGGTGCCACAGGCCCGCACCCTGTGTGGCCTAGACGAGAGCAAGGCCCAACTGTCAG
CGACAGTGCTCACTCTACTCATCAAACAGTACTGCAGGGAAAGTGGTGTGCGCAACCTGCAGAA
GCAGGTGGAGAAGGTGCTGCGCAAGGCTGCATACAAGATTGTAAGTGGAGAGGCCCAGACAGTG
CACGTGACACCTGAGAACCTGCAAGACTTTGTAGGGAAGCCAGTGTTCACAGTGGAGCGCATGT
ATGATGTCACGCCTCCTGGTGTGGTCATGGGTTTGGCCTGGACTGCCATGGGAGGCTCCACATT
GTTCGTGGAGACATCTTTAAGGAGGCCCCAGCCTAGTGGCAGCAAGGAGGACAAGGATGGCAGC
CTAGAGGTGACAGGTCAGCTAGGAGATGTCATGAAAGAGAGTGCCCGCATAGCCTACACCTTTG
CCCGTGCCTTCCTGATGGAGCAGGACCCTGAAAATGACTTTCTGGTCACATCCCACATCCACCT
GCATGTGCCTGAGGGCGCTACCCCCAAGGATGGCCCTAGTGCAGGTTGCACCATTGTCACTGCA
TTGCTGTCCCTAGCTCTGGGGCAGCCAGTGTTGCAGAACCTGGCCATGACTGGGGAAGTCTCCC
TCACTGGTAAAGTGTTGCCTGTGGGTGGCATCAAGGAGAAGACCATTGCGGCTAAGCGTGCGGG
AGTGACCTGCATCATTTTGCCTGCTGAGAACAGGAAGGACTTCTCAGACTTGGCTCCCTTCATC
ACAGAGGGCCTGGAGGTTCACTTCGTGGAACACTACCGCGACATCTTCCGAATTGCCTTCCCCC
TGCGAGAGCACCAGGAAGCACTGGCTGTGGAAAGATGATGGGGGTGCAGTGGGGTAGGGGGGTC
TTAGGACTAAATAATCATGGTGTGGTGGGGCCACAAGTACAGCTGTAAAATCATGAGTAAAAGA
AAGCCTTTCCCAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_596895	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB62423	(Get FASTA)	NCBI Sequence Viewer
	EDL83621	(Get FASTA)	NCBI Sequence Viewer
	Q924S5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_596895 ⟸ NM_133404
- Peptide Label:	precursor
- UniProtKB:	Q924S5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAASTGYVRLWAAARCWVLRRPLLAVTGGRVPSASGSWLRRGCRVCDTSTPWGGRVPMGGGQWR GLWDAGSRGGSDETSEGGVEDGATASSGEGPVVTALAPMTVPDVFPHLPLIAISRNPVFPRFIK IVEVKNKKLVELLRRKVRLAQPYVGVFLKRDDNNESDVVESLDEIYHTGTFAQIHEMQDLGDKL RMIVTGHRRIHISRQLEVEPEGLEPEAENKQKSRRKLKRGKKEVGDELGAKPQLEMVTEATSDT SKEVLMVEVENVAHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIY LSDMGAALTGAESHELQDVLEETNILKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKY LLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLALLDNHSSEFNVT RNYLDWLTSIPWGRQSDENLDLARAQSVLEEDHYGMEDVKKRVLEFIAVSQLRGSTQGKILCFH GPPGVGKTSIARSIARALGREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPL VLIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLR DRMEMINVSGYVAQEKLAIAERYLVPQARTLCGLDESKAQLSATVLTLLIKQYCRESGVRNLQK QVEKVLRKAAYKIVSGEAQTVHVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTL FVETSLRRPQPSGSKEDKDGSLEVTGQLGDVMKESARIAYTFARAFLMEQDPENDFLVTSHIHL HVPEGATPKDGPSAGCTIVTALLSLALGQPVLQNLAMTGEVSLTGKVLPVGGIKEKTIAAKRAG VTCIILPAENRKDFSDLAPFITEGLEVHFVEHYRDIFRIAFPLREHQEALAVER hide sequence

RefSeq Acc Id:

ENSRNOP00000066618 ⟸ ENSRNOT00000074253

Protein Domains

Lon N-terminal Lon proteolytic

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696454

Promoter ID:

EPDNEW_R6979

Type:

multiple initiation site

Name:

Lonp1_1

Description:

lon peptidase 1, mitochondrial

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	10,428,841 - 10,428,901	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
9	9425886	9425887	G	T	snv	IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621598	AgrOrtholog
Ensembl Genes	ENSRNOG00000046502	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000066618	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000074253	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.230.10	UniProtKB/Swiss-Prot
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot
	ATPase_AAA_core	UniProtKB/Swiss-Prot
	Lon_bac/euk-typ	UniProtKB/Swiss-Prot
	Lon_proteolytic	UniProtKB/Swiss-Prot
	Lon_Prtase	UniProtKB/Swiss-Prot
	Lon_substr-bd	UniProtKB/Swiss-Prot
	Lonm_euk	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	Peptidase_S16_AS	UniProtKB/Swiss-Prot
	PUA-like_sf	UniProtKB/Swiss-Prot
	Ribosomal_S5_D2-typ_fold	UniProtKB/Swiss-Prot
	Ribosomal_S5_D2-typ_fold_subgr	UniProtKB/Swiss-Prot
KEGG Report	rno:170916	UniProtKB/Swiss-Prot
NCBI Gene	170916	ENTREZGENE
PANTHER	PTHR43718	UniProtKB/Swiss-Prot
Pfam	AAA	UniProtKB/Swiss-Prot
	Lon_C	UniProtKB/Swiss-Prot
	LON_substr_bdg	UniProtKB/Swiss-Prot
PhenoGen	Lonp1	PhenoGen
PIRSF	Lon_proteas	UniProtKB/Swiss-Prot
PROSITE	LON_N	UniProtKB/Swiss-Prot
	LON_PROTEOLYTIC	UniProtKB/Swiss-Prot
	LON_SER	UniProtKB/Swiss-Prot
SMART	AAA	UniProtKB/Swiss-Prot
	LON	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
	SSF54211	UniProtKB/Swiss-Prot
	SSF88697	UniProtKB/Swiss-Prot
TIGRFAMs	lon	UniProtKB/Swiss-Prot
UniProt	LONM_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Lonp1	lon peptidase 1, mitochondrial	Prss15	protease, serine, 15	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Prss15	protease, serine, 15			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Prss15	protease, serine, 15			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM