Slc17a8 (solute carrier family 17 member 8)

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Gene: Slc17a8 (solute carrier family 17 member 8) Rattus norvegicus

Analyze

Symbol:

Slc17a8

Name:

solute carrier family 17 member 8

RGD ID:

628870

Description:

Enables L-glutamate uniporter activity and chloride channel activity. Involved in several processes, including L-glutamate transmembrane transport; cochlea development; and regulation of acetylcholine uptake. Located in several cellular components, including axon; cytoplasmic vesicle; and dendrite. Biomarker of Parkinsonism; cochlear disease; sciatic neuropathy; transient cerebral ischemia; and trichinosis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8); PARTICIPATES IN auditory mechanotransduction pathway; glutamate signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; solute carrier family 17 (vesicular glutamate transporter), member 8; vesicular glutamate transporter 3; Vglut3

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC17A8 (solute carrier family 17 member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc17a8 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc17a8 (solute carrier family 17 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC17A8 (solute carrier family 17 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC17A8 (solute carrier family 17 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc17a8 (solute carrier family 17 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC17A8 (solute carrier family 17 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC17A8 (solute carrier family 17 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc17a8 (solute carrier family 17 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NCCRP1 (NCCRP1, F-box associated domain containing)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLC17A8 (solute carrier family 17 member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc17a8 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc17a8 (solute carrier family 17 member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	DAL5	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	SOA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	THI73	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	FEN2	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	YCT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Caenorhabditis elegans (roundworm):	eat-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	VGlut	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TNA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	SEO1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	VHT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	23,994,212 - 24,049,498 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	23,994,217 - 24,048,079 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	25,988,747 - 26,042,586 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	28,151,175 - 28,205,018 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	27,928,480 - 27,982,327 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	30,215,231 - 30,274,993 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	30,216,104 - 30,274,984 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	30,314,804 - 30,371,888 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	26,361,488 - 26,413,820 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	26,381,758 - 26,434,091 (-)	NCBI
Celera	7	21,139,735 - 21,191,778 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nonsyndromic deafness 25 (ISO)

cochlear disease (IEP)

genetic disease (ISO)

Hyperalgesia (IEP)

Nonsyndromic Sensorineural Hearing Loss (ISO)

Parkinsonism (IEP)

sciatic neuropathy (IEP)

transient cerebral ischemia (IEP)

trichinosis (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,4-dioxane (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

5-bromo-2'-deoxyuridine (ISO)

6-propyl-2-thiouracil (EXP)

acetylcholine (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlorpyrifos (EXP,ISO)

choline (ISO)

cocaine (ISO)

dextran sulfate (ISO)

diazinon (ISO)

dichloroacetic acid (ISO)

epoxiconazole (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (ISO)

haloperidol (ISO)

L-methionine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

maneb (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenethyl caffeate (EXP)

pioglitazone (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

Triptolide (ISO)

troglitazone (EXP)

valproic acid (EXP,ISO)

vinclozolin (EXP)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IEA)

cochlea development (IEP)

L-glutamate import (IDA,IMP)

L-glutamate transmembrane transport (IMP,ISO,ISS)

monoatomic anion transport (IBA)

neural retina development (IEP)

neurotransmitter loading into synaptic vesicle (IBA,ISO)

phosphate ion homeostasis (ISO,ISS)

positive regulation of glutamate uptake involved in transmission of nerve impulse (ISO,ISS)

regulation of acetylcholine uptake (IDA,ISO)

regulation of synapse structure or activity (IBA)

sensory perception of sound (IEA)

sodium ion transmembrane transport (IEA)

sodium-dependent phosphate transport (ISS)

synaptic transmission, glutamatergic (IBA)

Cellular Component

apical dendrite (IDA)

axon terminus (IDA)

basal dendrite (IDA)

chloride channel complex (IEA)

dendrite (IDA)

excitatory synapse (IBA,IDA)

glial limiting end-foot (IDA)

multivesicular body (IDA)

neuronal cell body (IDA)

pericellular basket (IDA)

perikaryon (IDA)

plasma membrane (IEA)

synaptic vesicle (ISO)

synaptic vesicle membrane (IDA,ISO)

Molecular Function

chloride channel activity (IDA)

L-glutamate transmembrane transporter activity (IBA)

L-glutamate uniporter activity (IDA,ISO,ISS)

neurotransmitter transmembrane transporter activity (IBA)

protein binding (ISO)

sodium:phosphate symporter activity (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

glutamate signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals.	Boulland JL, etal., Cereb Cortex. 2009 Jan;19(1):241-8. doi: 10.1093/cercor/bhn077. Epub 2008 May 22.
2.	Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters.	Boulland JL, etal., J Comp Neurol. 2004 Dec 13;480(3):264-80.
3.	Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats.	Chung EK, etal., Neurosignals. 2006-2007;15(5):238-48. Epub 2007 Apr 13.
4.	Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism.	Eriksen J, etal., Neuron. 2016 May 18;90(4):768-80. doi: 10.1016/j.neuron.2016.03.026. Epub 2016 Apr 28.
5.	The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate.	Fremeau RT Jr, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14488-14493.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons.	Gras C, etal., J Neurosci 2002 Jul 1;22(13):5442-51.
8.	The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone.	Gras C, etal., Nat Neurosci. 2008 Mar;11(3):292-300. doi: 10.1038/nn2052. Epub 2008 Feb 17.
9.	Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.	Harkany T, etal., J Neurosci. 2004 May 26;24(21):4978-88.
10.	Glutamate co-transmission from developing medial nucleus of the trapezoid body--lateral superior olive synapses is cochlear dependent in kanamycin-treated rats.	Lee JH, etal., Biochem Biophys Res Commun. 2011 Feb 11;405(2):162-7. doi: 10.1016/j.bbrc.2010.12.129. Epub 2011 Jan 5.
11.	Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain.	Llorente IL, etal., Brain Res Bull. 2013 May;94:90-7. doi: 10.1016/j.brainresbull.2013.02.006. Epub 2013 Feb 28.
12.	Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra.	Martin-Ibanez R, etal., Eur J Neurosci. 2006 Feb;23(4):1063-70.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
15.	A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3.	Ormel L, etal., Glia. 2012 Sep;60(9):1289-300. doi: 10.1002/glia.22348. Epub 2012 May 9.
16.	Temporospatial expression and cellular localization of VGLUT3 in the rat cochlea.	Peng Z, etal., Brain Res. 2013 Nov 6;1537:100-10. doi: 10.1016/j.brainres.2013.09.019. Epub 2013 Sep 21.
17.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
18.	GOA pipeline	RGD automated data pipeline
19.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
21.	Comprehensive gene review and curation	RGD comprehensive gene curation
22.	Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum.	Riedel A, etal., J Chem Neuroanat. 2008 Dec;36(3-4):177-90. doi: 10.1016/j.jchemneu.2008.06.003. Epub 2008 Jun 19.
23.	The auditory hair cell ribbon synapse: from assembly to function.	Safieddine S, etal., Annu Rev Neurosci. 2012;35:509-28. doi: 10.1146/annurev-neuro-061010-113705.
24.	Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina.	Stella SL Jr, etal., Brain Res. 2008 Jun 18;1215:20-9. doi: 10.1016/j.brainres.2008.03.038. Epub 2008 Apr 1.
25.	Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens.	Tukey DS, etal., Mol Brain. 2013 Jul 9;6:32. doi: 10.1186/1756-6606-6-32.
26.	Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats.	Yang CQ, etal., Dig Dis Sci. 2012 Apr;57(4):865-72. doi: 10.1007/s10620-011-1970-x. Epub 2011 Dec 9.

Additional References at PubMed

PMID:12384506	PMID:14648683	PMID:14681932	PMID:14751290	PMID:14984406	PMID:15142960	PMID:15714284	PMID:15820620	PMID:16182324	PMID:17612597	PMID:18222609	PMID:18358609
PMID:18925658	PMID:19191347	PMID:19467322	PMID:19699779	PMID:20034056	PMID:20836994	PMID:21375596	PMID:21853059	PMID:21957077	PMID:22374223	PMID:23633129	PMID:24316448
PMID:25780293	PMID:27458190	PMID:29375045	PMID:34321562

Genomics

Comparative Map Data

Slc17a8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	23,994,212 - 24,049,498 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	23,994,217 - 24,048,079 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	25,988,747 - 26,042,586 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	28,151,175 - 28,205,018 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	27,928,480 - 27,982,327 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	30,215,231 - 30,274,993 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	30,216,104 - 30,274,984 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	30,314,804 - 30,371,888 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	26,361,488 - 26,413,820 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	26,381,758 - 26,434,091 (-)	NCBI
Celera	7	21,139,735 - 21,191,778 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

SLC17A8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	100,357,074 - 100,422,055 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	100,357,074 - 100,422,055 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	100,750,852 - 100,815,833 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	99,275,125 - 99,339,968 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	99,253,461 - 99,318,305	NCBI
Celera	12	100,416,121 - 100,481,106 (+)	NCBI		Celera
Cytogenetic Map	12	q23.1	NCBI
HuRef	12	97,811,908 - 97,876,895 (+)	NCBI		HuRef
CHM1_1	12	100,716,885 - 100,781,879 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	100,318,500 - 100,383,494 (+)	NCBI		T2T-CHM13v2.0

Slc17a8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	89,409,882 - 89,457,111 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	89,409,882 - 89,457,115 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	89,574,020 - 89,621,249 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	89,574,020 - 89,621,253 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	89,036,765 - 89,083,994 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	89,003,819 - 89,051,048 (-)	NCBI		MGSCv36	mm8
Celera	10	91,564,557 - 91,621,586 (-)	NCBI		Celera
Cytogenetic Map	10	C2	NCBI

Slc17a8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	36,063,688 - 36,115,312 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	36,063,688 - 36,115,312 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC17A8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	108,415,176 - 108,481,943 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	97,935,177 - 98,001,240 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	101,342,113 - 101,405,844 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	101,342,113 - 101,405,844 (+)	Ensembl	panpan1.1		panPan2

SLC17A8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	39,443,790 - 39,489,988 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	39,443,518 - 39,486,595 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	39,811,154 - 39,867,358 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	40,095,889 - 40,152,069 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	40,106,972 - 40,150,689 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	39,364,747 - 39,409,505 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	39,459,835 - 39,516,030 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	39,733,977 - 39,790,150 (+)	NCBI		UU_Cfam_GSD_1.0

Slc17a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	20,425,587 - 20,475,772 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	13,435,848 - 13,486,169 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936492	13,436,136 - 13,486,173 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC17A8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	83,741,715 - 83,800,808 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	83,741,641 - 83,809,472 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	87,686,292 - 87,696,625 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC17A8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	95,673,205 - 95,740,037 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	95,674,195 - 95,739,040 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	149,304,943 - 149,371,896 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc17a8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	7,345,557 - 7,396,154 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624750	7,345,411 - 7,396,445 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc17a8
327 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	266
Count of miRNA genes:	178
Interacting mature miRNAs:	208
Transcripts:	ENSRNOT00000010207
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
70207	Niddm31	Non-insulin dependent diabetes mellitus QTL 31	3.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	18169505	26029351	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	19032807	35526300	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	19654317	49753746	Rat
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	19654317	49753746	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	19654317	52888450	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	20555705	29891047	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									6
Low	1		28	25	4	25			58		7	6
Below cutoff	2	18	29	16	14	16	8	10	10	14	14	4	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ491795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY117026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000010207 ⟹ ENSRNOP00000010207

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	30,216,104 - 30,274,984 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092434

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	30,216,595 - 30,244,673 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092527 ⟹ ENSRNOP00000075876

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	23,994,217 - 24,048,079 (-)	Ensembl
Rnor_6.0 Ensembl	7	30,216,104 - 30,274,984 (-)	Ensembl

RefSeq Acc Id:

NM_153725 ⟹ NP_714947

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	23,994,217 - 24,048,079 (-)	NCBI
Rnor_6.0	7	30,216,106 - 30,274,984 (-)	NCBI
Rnor_5.0	7	30,314,804 - 30,371,888 (-)	NCBI
RGSC_v3.4	7	26,361,488 - 26,413,820 (-)	RGD
Celera	7	21,139,735 - 21,191,778 (-)	RGD

Sequence:

show sequence

GGCACGAGAAAAGCAGGAGACTTGTAAATGTTTCATAAACTTCACTCTGGGCTCCGGCCCTGGC
TGGGAGCCCATTCATAAGCCCAGGCTGCAGAGGGGCAGGTGTTCTTGGTTTCTATAGCATCGCC
CCAGGGAGAAGCTGACAGCGCCACCTGCAAGCTGAAGGAAGCAGGAGGGGCCAGGGCTGGCTTC
AGAAACTGCTGCTGGTCTCAGGACCCCTCATACACTGGAGCTCACTTTAGCTTCTCCAGCCGGC
CACAGCCAGGGATACAGGCTGTGCTCAGTCTGAGCGTGGCTGCCCGAGACAGCTGTCACAGGCT
GCTGCTCAGCCGGTAGCTTTTGCAAGGGACTGGATTCCTAGCCAGCAATTCCTCAACCAGCTTT
GTTGACTCTGAATCGAGAGGAGAGGGTTTTTCTCTTCTTAGAACATCCGAGCTGGGCTTCCCCT
CCTTTCTGATTTTAAGTAGTTCCCTCCATGAGAACTAAATTTCAAGTGTTCCTCAAGGGCAAAC
GCAGCGCCCCTGGGCTGGAGGTTCGAGAGGATGACAGCTTCTGAGGTCGCCTGCTAAGGGCTCT
GAGGTGCCTCTCCTATTGCCCCCATTCAAAATGCCATTTAACGCATTTGATACCTTCAAAGAAA
AAATTTTGAAACCCGGGAAGGAAGGAGTGAAGAATGCCGTGGGAGATTCGCTGGGGATCTTACA
AAGAAAACTCGATGGGACCAACGAGGAGGGAGATGCCATTGAGCTGAGTGAGGAAGGAAGGCCC
GTGCAGACATCCAGAGCCCGAGCCCCTGTGTGCGACTGCAGCTGCTGTGGCATCCCCAAGCGGT
ACATCATCGCTGTCATGAGTGGCCTGGGATTCTGCATTTCCTTTGGGATTCGGTGCAACCTTGG
AGTGGCCATTGTGGAAATGGTCAACAATAGCACTGTGTATGTGGATGGGAAACCGGAAATCCAG
ACAGCACAGTTTAACTGGGATCCAGAGACGGTGGGTCTTATCCATGGATCTTTTTTCTGGGGTT
ATATTGTGACACAAATTCCCGGTGGCTTCATTTCAAACAAGTTTGCTGCTAACAGGGTCTTTGG
AGCTGCCATCTTCTTGACGTCAACCCTGAACATGTTCATCCCTTCCGCGGCCAGGGTGCATTAC
GGCTGTGTCATGTGTGTGAGGATTTTGCAGGGTCTGGTGGAGGGTGTGACCTACCCAGCCTGCC
ACGGGATGTGGAGTAAGTGGGCACCTCCCCTGGAGAGAAGTCGTCTAGCCACAACCTCTTTTTG
TGGTTCCTATGCCGGGGCAGTCGTTGCTATGCCCCTTGCAGGAGTATTGGTGCAGTACATTGGC
TGGGCCTCTGTCTTTTATATTTACGGGATGTTTGGAATTATTTGGTACATGTTTTGGCTGCTGC
AGGCTTATGAGTGTCCAGCAGTTCACCCAACAATATCCAATGAAGAACGGACCTACATAGAGAC
AAGTATAGGAGAAGGCGCCAACTTGGCCAGTCTGAGCAAATTCAACACACCATGGAGAAGGTTT
TTCACATCCTTGCCTGTCTATGCCATTATTGTGGCAAACTTTTGTAGAAGCTGGACCTTCTATT
TGCTCTTAATAAGTCAGCCTGCTTACTTTGAAGAGGTCTTTGGGTTTGCAATAAGTAAGGTGGG
TCTCTTGTCAGCTGTCCCACACATGGTGATGACAATCGTGGTACCCATTGGAGGACAACTGGCT
GATTATTTAAGAAGCCGAAAGATTTTGACCACAACTGCTGTCAGAAAGATCATGAATTGTGGAG
GCTTTGGCATGGAGGCAACCTTGCTCCTGGTGGTTGGGTTTTCCCATACCAAAGGAGTGGCTAT
CTCCTTCCTGGTGCTTGCTGTAGGATTTAGTGGCTTTGCAATTTCAGGTTTCAATGTCAACCAC
CTGGACATTGCTCCACGATATGCCAGCATCCTCATGGGGATCTCAAATGGCGTGGGAACCCTCT
CTGGAATGGTTTGTCCCCTCATTGTTGGTGCAATGACAAAGCACAAGACCCGGGAAGAATGGCA
GAATGTGTTCCTCATAGCAGCCCTGGTGCACTACAGTGGAGTCATCTTCTACGGGGTCTTTGCT
TCTGGGGAAAAACAGGACTGGGCTGATCCAGAGAATCTCTCTGAGGAGAAATGTGGAATCATTG
ACCAAGATGAATTAGCCGAGGAAACAGAACTCAACCACGAGGCTTTCGTAAGTCCCAGAAAGAA
GATGTCTTATGGAGCCACCACCCAGAATTGTGAGGTCCAGAAGACGGATCGGAGACAACAGAGA
GAATCCGCCTTCGAGGGGGAGGAGCCATTATCCTACCAGAATGAAGAGGACTTTTCAGAAACAT
CTTAACGTGCATCTTCCCCTCAGCTTACAACCAGAAGTCTCCACACCCATTGCTTTTCCCATAC
CTTGGCCTTCCAGGGGGCCAAATCACAGGAAAGGGGGAGACTAAATCAACAACAGAGAAGAAAA
ATGCCTTCTTACAAAGATGGGCGTATGGATCTTGGTCTCAGTTAATTAGATAGTTGATCATATT
TTTTTTGGGGGGGGGCAATTGGGCATTGGCTGTTGAGCCTTCTCTCAAAAGAACAATTTATTCA
GGAAGAAATGGCTAGAAGAATAAGGAGTGGCTTGTTGCTCAAATAAACACTGAAGAAATCCCTC
TTTGGTCTGGAGAAGAGTACATGGTGGTTGCCACCCCATCTCCAAGGATATCCATGTAGAGGAC
AATCTCTGCAACCTAATGAAGGGAATCACTCATGGGGGCCCTTGGTTGTGCCAGGTGCTTTATG
AACATTCTTATTTAACTCCCACACCCTAATATAGTTATTGTACCCATTTTACAACTAAGAACAT
TAAATGACTAGGTTGGCCCACCCAAGGTTGTCCTCTCAGAGCCAAAGCTGAGACTGGCAGATGA
CCAGGAGTTTTAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAA
GGAAGGGTTCAGTTGAGTGTAGGGTCATTTTCAATGACAAAAACAAAAGCTGGAATCAGTTGGT
TTGTGGGTAATTCCATGTTTGGTCAAGGGTGTGTGCATGCAAACGTGTATGTGCGTGTGTGTGT
GTTTGTGTGTTTGTGTGTTTGTGTGTATGTGTGTCT

hide sequence

RefSeq Acc Id:

XM_039078509 ⟹ XP_038934437

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	23,994,212 - 24,049,498 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_714947	(Get FASTA)	NCBI Sequence Viewer
	XP_038934437	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAM50094	(Get FASTA)	NCBI Sequence Viewer
	CAD37138	(Get FASTA)	NCBI Sequence Viewer
	EDM16983	(Get FASTA)	NCBI Sequence Viewer
	EDM16984	(Get FASTA)	NCBI Sequence Viewer
	Q7TSF2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_714947 ⟸ NM_153725

- UniProtKB:

Q8K1Q1 (UniProtKB/Swiss-Prot), Q7TSF2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPV
CDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPET
VGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQ
GLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGM
FGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAII
VANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILT
TTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASI
LMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADP
ENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKTDRRQQRESAFEGEEPL
SYQNEEDFSETS

hide sequence

RefSeq Acc Id:

ENSRNOP00000075876 ⟸ ENSRNOT00000092527

RefSeq Acc Id:

ENSRNOP00000010207 ⟸ ENSRNOT00000010207

RefSeq Acc Id:	XP_038934437 ⟸ XM_039078509
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TSF2-F1-model_v2	AlphaFold	Q7TSF2	1-588	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628870	AgrOrtholog
BioCyc Gene	G2FUF-34488	BioCyc
Ensembl Genes	ENSRNOG00000007581	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000075876	ENTREZGENE
	ENSRNOP00000075876.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000092527	ENTREZGENE
	ENSRNOT00000092527.2	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot
InterPro	MFS	UniProtKB/Swiss-Prot
	MFS_dom	UniProtKB/Swiss-Prot
	MFS_trans_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:266767	UniProtKB/Swiss-Prot
NCBI Gene	266767	ENTREZGENE
PANTHER	SOLUTE CARRIER FAMILY 17	UniProtKB/Swiss-Prot
	VESICULAR GLUTAMATE TRANSPORTER 3	UniProtKB/Swiss-Prot
Pfam	MFS_1	UniProtKB/Swiss-Prot
PhenoGen	Slc17a8	PhenoGen
PROSITE	MFS	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot
UniProt	Q7TSF2	ENTREZGENE
	Q8K1Q1	ENTREZGENE
	VGLU3_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q8K1Q1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc17a8	solute carrier family 17 member 8	Slc17a8	solute carrier family 17 (vesicular glutamate transporter), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc17a8	solute carrier family 17 (vesicular glutamate transporter), member 8	Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	Vglut3	vesicular glutamate transporter 3	Symbol and Name updated	1299863	APPROVED
2003-02-27	Vglut3	vesicular glutamate transporter 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to nerve terminals in hippocampal pyramidal and granule cell layers	625707
gene_domains	a polytopic membrane protein	625707
gene_evolution	highly homologous to Slc17a7 (VGLUT1) and Slc17a6 (VGLUT2)	625707
gene_expression	expressed in neurons of the striatum, hippocampus, cerebral cortex, and raphe nuclei; concentrated over synaptic vesicle clusters present in both asymmetrical and symmetrical synapses; present in all cholinergic interneurons of the striatum, and in seroto	625707
gene_expression	low level expression in liver, kidney and brain with specific expression in cerebral cortex, amygdala, hippocampus, hypothalamus, striatum; protein expression seen in pyramidal cell and dentate gyrus granule cell layers in hippocampus, interneuron-like c	625707
gene_function	sodium-independent inorganic transporter of glutamate	625707
gene_function	H+-dependent , vesicular glutamate transporter	628464
gene_process	mediates exocytotic glutamate tranfer to synaptic vesicles for neurotransmission	625707
gene_process	involved in to glutamate transport to synaptic vesicles	625707
gene_product	member of the Na+-dependent inorganic phosphate transporter family	628464
gene_protein	588 amino acids	625707

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)