Slc17a8 (solute carrier family 17 member 8) - Rat Genome Database

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Gene: Slc17a8 (solute carrier family 17 member 8) Rattus norvegicus
Analyze
Symbol: Slc17a8
Name: solute carrier family 17 member 8
RGD ID: 628870
Description: Enables L-glutamate uniporter activity and chloride channel activity. Involved in several processes, including L-glutamate transmembrane transport; cochlea development; and regulation of acetylcholine uptake. Located in several cellular components, including axon; cytoplasmic vesicle; and dendrite. Biomarker of Parkinsonism; cochlear disease; sciatic neuropathy; transient cerebral ischemia; and trichinosis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8); PARTICIPATES IN auditory mechanotransduction pathway; glutamate signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; solute carrier family 17 (vesicular glutamate transporter), member 8; vesicular glutamate transporter 3; Vglut3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8725,881,557 - 25,936,837 (-)NCBIGRCr8
mRatBN7.2723,994,212 - 24,049,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl723,994,217 - 24,048,079 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx725,988,747 - 26,042,586 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0728,151,175 - 28,205,018 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0727,928,480 - 27,982,327 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0730,215,231 - 30,274,993 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl730,216,104 - 30,274,984 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0730,314,804 - 30,371,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4726,361,488 - 26,413,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1726,381,758 - 26,434,091 (-)NCBI
Celera721,139,735 - 21,191,778 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Boulland JL, etal., Cereb Cortex. 2009 Jan;19(1):241-8. doi: 10.1093/cercor/bhn077. Epub 2008 May 22.
2. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. Boulland JL, etal., J Comp Neurol. 2004 Dec 13;480(3):264-80.
3. Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats. Chung EK, etal., Neurosignals. 2006-2007;15(5):238-48. Epub 2007 Apr 13.
4. Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism. Eriksen J, etal., Neuron. 2016 May 18;90(4):768-80. doi: 10.1016/j.neuron.2016.03.026. Epub 2016 Apr 28.
5. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Fremeau RT Jr, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14488-14493.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. Gras C, etal., J Neurosci 2002 Jul 1;22(13):5442-51.
8. The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone. Gras C, etal., Nat Neurosci. 2008 Mar;11(3):292-300. doi: 10.1038/nn2052. Epub 2008 Feb 17.
9. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. Harkany T, etal., J Neurosci. 2004 May 26;24(21):4978-88.
10. Glutamate co-transmission from developing medial nucleus of the trapezoid body--lateral superior olive synapses is cochlear dependent in kanamycin-treated rats. Lee JH, etal., Biochem Biophys Res Commun. 2011 Feb 11;405(2):162-7. doi: 10.1016/j.bbrc.2010.12.129. Epub 2011 Jan 5.
11. Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. Llorente IL, etal., Brain Res Bull. 2013 May;94:90-7. doi: 10.1016/j.brainresbull.2013.02.006. Epub 2013 Feb 28.
12. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Martin-Ibanez R, etal., Eur J Neurosci. 2006 Feb;23(4):1063-70.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3. Ormel L, etal., Glia. 2012 Sep;60(9):1289-300. doi: 10.1002/glia.22348. Epub 2012 May 9.
16. Temporospatial expression and cellular localization of VGLUT3 in the rat cochlea. Peng Z, etal., Brain Res. 2013 Nov 6;1537:100-10. doi: 10.1016/j.brainres.2013.09.019. Epub 2013 Sep 21.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum. Riedel A, etal., J Chem Neuroanat. 2008 Dec;36(3-4):177-90. doi: 10.1016/j.jchemneu.2008.06.003. Epub 2008 Jun 19.
23. The auditory hair cell ribbon synapse: from assembly to function. Safieddine S, etal., Annu Rev Neurosci. 2012;35:509-28. doi: 10.1146/annurev-neuro-061010-113705.
24. Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina. Stella SL Jr, etal., Brain Res. 2008 Jun 18;1215:20-9. doi: 10.1016/j.brainres.2008.03.038. Epub 2008 Apr 1.
25. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Tukey DS, etal., Mol Brain. 2013 Jul 9;6:32. doi: 10.1186/1756-6606-6-32.
26. Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats. Yang CQ, etal., Dig Dis Sci. 2012 Apr;57(4):865-72. doi: 10.1007/s10620-011-1970-x. Epub 2011 Dec 9.
Additional References at PubMed
PMID:12384506   PMID:14648683   PMID:14681932   PMID:14751290   PMID:14984406   PMID:15142960   PMID:15714284   PMID:15820620   PMID:16182324   PMID:17612597   PMID:18222609   PMID:18358609  
PMID:18925658   PMID:19191347   PMID:19467322   PMID:19699779   PMID:20034056   PMID:20836994   PMID:21375596   PMID:21853059   PMID:21957077   PMID:22374223   PMID:23633129   PMID:24316448  
PMID:25780293   PMID:27458190   PMID:29375045   PMID:34321562  


Genomics

Comparative Map Data
Slc17a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8725,881,557 - 25,936,837 (-)NCBIGRCr8
mRatBN7.2723,994,212 - 24,049,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl723,994,217 - 24,048,079 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx725,988,747 - 26,042,586 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0728,151,175 - 28,205,018 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0727,928,480 - 27,982,327 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0730,215,231 - 30,274,993 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl730,216,104 - 30,274,984 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0730,314,804 - 30,371,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4726,361,488 - 26,413,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1726,381,758 - 26,434,091 (-)NCBI
Celera721,139,735 - 21,191,778 (-)NCBICelera
Cytogenetic Map7q13NCBI
SLC17A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812100,357,074 - 100,422,055 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12100,357,074 - 100,422,055 (+)EnsemblGRCh38hg38GRCh38
GRCh3712100,750,852 - 100,815,833 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361299,275,125 - 99,339,968 (+)NCBINCBI36Build 36hg18NCBI36
Build 341299,253,461 - 99,318,305NCBI
Celera12100,416,121 - 100,481,106 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1297,811,908 - 97,876,895 (+)NCBIHuRef
CHM1_112100,716,885 - 100,781,879 (+)NCBICHM1_1
T2T-CHM13v2.012100,318,500 - 100,383,494 (+)NCBIT2T-CHM13v2.0
Slc17a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391089,409,882 - 89,457,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1089,409,882 - 89,457,115 (-)EnsemblGRCm39 Ensembl
GRCm381089,574,020 - 89,621,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1089,574,020 - 89,621,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv371089,036,765 - 89,083,994 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361089,003,819 - 89,051,048 (-)NCBIMGSCv36mm8
Celera1091,564,557 - 91,621,586 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1044.99NCBI
Slc17a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540536,063,688 - 36,115,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540536,063,688 - 36,115,312 (+)NCBIChiLan1.0ChiLan1.0
SLC17A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210108,418,745 - 108,485,542 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112108,415,176 - 108,481,943 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01297,935,177 - 98,001,240 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112101,342,113 - 101,405,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12101,342,113 - 101,405,844 (+)Ensemblpanpan1.1panPan2
SLC17A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11539,443,790 - 39,489,988 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1539,443,518 - 39,486,595 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1539,811,154 - 39,867,358 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01540,095,889 - 40,152,069 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1540,106,972 - 40,150,689 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11539,364,747 - 39,409,505 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01539,459,835 - 39,516,030 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01539,733,977 - 39,790,150 (+)NCBIUU_Cfam_GSD_1.0
Slc17a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494520,425,587 - 20,475,772 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649213,435,848 - 13,486,169 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649213,436,136 - 13,486,173 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC17A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl583,741,715 - 83,800,808 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1583,741,641 - 83,809,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2587,686,292 - 87,696,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC17A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11195,673,205 - 95,740,037 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1195,674,195 - 95,739,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037149,304,943 - 149,371,896 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc17a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247507,345,557 - 7,396,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247507,345,411 - 7,396,445 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc17a8
327 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:178
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000010207
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6
Low 1 28 25 4 25 58 7 6
Below cutoff 2 18 29 16 14 16 8 10 10 14 14 4 8

Sequence


RefSeq Acc Id: ENSRNOT00000010207   ⟹   ENSRNOP00000010207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl730,216,104 - 30,274,984 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl730,216,595 - 30,244,673 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092527   ⟹   ENSRNOP00000075876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl723,994,217 - 24,048,079 (-)Ensembl
Rnor_6.0 Ensembl730,216,104 - 30,274,984 (-)Ensembl
RefSeq Acc Id: NM_153725   ⟹   NP_714947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8725,881,557 - 25,935,410 (-)NCBI
mRatBN7.2723,994,217 - 24,048,079 (-)NCBI
Rnor_6.0730,216,106 - 30,274,984 (-)NCBI
Rnor_5.0730,314,804 - 30,371,888 (-)NCBI
RGSC_v3.4726,361,488 - 26,413,820 (-)RGD
Celera721,139,735 - 21,191,778 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078509   ⟹   XP_038934437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8725,881,621 - 25,936,837 (-)NCBI
mRatBN7.2723,994,212 - 24,049,498 (-)NCBI
RefSeq Acc Id: NP_714947   ⟸   NM_153725
- UniProtKB: Q8K1Q1 (UniProtKB/Swiss-Prot),   Q7TSF2 (UniProtKB/Swiss-Prot),   A6IFR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075876   ⟸   ENSRNOT00000092527
RefSeq Acc Id: ENSRNOP00000010207   ⟸   ENSRNOT00000010207
RefSeq Acc Id: XP_038934437   ⟸   XM_039078509
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSF2-F1-model_v2 AlphaFold Q7TSF2 1-588 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628870 AgrOrtholog
BioCyc Gene G2FUF-34488 BioCyc
Ensembl Genes ENSRNOG00000007581 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055020290 UniProtKB/Swiss-Prot
  ENSRNOG00060022095 UniProtKB/Swiss-Prot
  ENSRNOG00065022388 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000092527 ENTREZGENE
  ENSRNOT00000092527.2 UniProtKB/Swiss-Prot
  ENSRNOT00055034654 UniProtKB/Swiss-Prot
  ENSRNOT00060038306 UniProtKB/Swiss-Prot
  ENSRNOT00065038191 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 266767 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VESICULAR GLUTAMATE TRANSPORTER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc17a8 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007581 RatGTEx
  ENSRNOG00055020290 RatGTEx
  ENSRNOG00060022095 RatGTEx
  ENSRNOG00065022388 RatGTEx
Superfamily-SCOP MFS general substrate transporter UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IFR4 ENTREZGENE, UniProtKB/TrEMBL
  A6IFR5_RAT UniProtKB/TrEMBL
  Q7TSF2 ENTREZGENE
  Q8K1Q1 ENTREZGENE
  VGLU3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K1Q1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc17a8  solute carrier family 17 member 8  Slc17a8  solute carrier family 17 (vesicular glutamate transporter), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc17a8  solute carrier family 17 (vesicular glutamate transporter), member 8  Slc17a8  solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Slc17a8  solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8  Vglut3  vesicular glutamate transporter 3  Symbol and Name updated 1299863 APPROVED
2003-02-27 Vglut3  vesicular glutamate transporter 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to nerve terminals in hippocampal pyramidal and granule cell layers 625707
gene_domains a polytopic membrane protein 625707
gene_evolution highly homologous to Slc17a7 (VGLUT1) and Slc17a6 (VGLUT2) 625707
gene_expression expressed in neurons of the striatum, hippocampus, cerebral cortex, and raphe nuclei; concentrated over synaptic vesicle clusters present in both asymmetrical and symmetrical synapses; present in all cholinergic interneurons of the striatum, and in seroto 625707
gene_expression low level expression in liver, kidney and brain with specific expression in cerebral cortex, amygdala, hippocampus, hypothalamus, striatum; protein expression seen in pyramidal cell and dentate gyrus granule cell layers in hippocampus, interneuron-like c 625707
gene_function sodium-independent inorganic transporter of glutamate 625707
gene_function H+-dependent , vesicular glutamate transporter 628464
gene_process mediates exocytotic glutamate tranfer to synaptic vesicles for neurotransmission 625707
gene_process involved in to glutamate transport to synaptic vesicles 625707
gene_product member of the Na+-dependent inorganic phosphate transporter family 628464
gene_protein 588 amino acids 625707